Excitation Contraction Coupling and the Neuromuscular Junction | Skeletal Muscle Contraction

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00:00 : Introduction to video
00:40 : Review of muscle fiber excitement or action potentials (see link below for full intro video)
1:15 : Introduction to excitation-contraction coupling and starting force
1:23 : Transverse tubules spread action potentials (see link below for full video on action potentials)
2:49 : Intro to the sarcoplasmic reticulum and calcium storage
3:51 : How to release calcium from the sarcoplasmic reticulum
4:59 : Recap of steps required to release calcium
5:35 : Cross-bridge cycle--calcium and ATP cause muscle contraction
8:11 : Review of the myosin, actin, and the cross-bridge cycle that generates force
9:11 : Sliding filament theory
9:43 : How to relax a skeletal muscle cell
10:21 : Reason #1 to care
11:26 : Rigor mortis and reason #2 to care
This video is the 2nd part of a series that explains how skeletal muscles contract. We will discuss how action potentials in skeletal muscle lead to calcium release, activation of key proteins like troponin and tropomyosin, and muscle contraction or force, in a process known as excitation contraction coupling. We'll review how key proteins like DHP (dihydropyridine) and RyR (ryanodine receptor) are important to causing muscles to contract. For the first video in the series, see below:
Part 1: • Video
Full video on action potentials in neurons and muscle fibers: • Video
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