Exercise and Insulin Stimulated Glucose Uptake by Skeletal Muscle

[@joeimama]

I just watched a video of some australian scientists that have hypothesized that the insulin receptor site is functional in type 2 diabetics, but underneath its not correctly phosphoralizing IRS1/2 thus not beginning the cascade. I exercise daily and notice that my blood sugar always spikes for like 15 mins before it begins to drop. Probably because AKT doesn't get activated until I put enough stress on my muscles and/or its using up its existing glycogen stores until the stress begins. Then I can effectively drop my sugars continuing to exercise. This video is great as it visualizes the mechanism that I was wondering. Thank you.

[@FrancescoRogai]

This is why you should train high intensity, Doctor Doug McGuff explains it clearly in the book Body By Science

[@IvanBFit]

This is a SPLENDID MARVELOUS presentation! Very well done :-) Just EPIC and cutting-edge. Very well articulated and broken down. Animation was incredibly precise.

[@KennethDiazperlloni]

I fall in love with her voice.

[@colecoleman1499]

Fell*

[@tunerd1921]

THIS IS SO COOL!! The animation is amazing, always been envious of people who were amazing at science AND art... I can barely draw a smiley face. Well done! Love this video

[@tnijoo5109]

Brilliant video! Exceptionally well done.

[@Ethereal_Ghost]

wow...such an amazing video, it motivates me to exercise more as a prediabetic.

[@stefanweilhartner4415]

look into potassium or snake juice. lower cortisol which lowers gluconeogenesis. understand that every cell NEEDS to be insulin resistant from time to time

[@Acts-1322]

Exercise And whole foods + water less manufactured/processed like baked goods and juices/beverages or smoothies, some days just OMAD(One meal a day)

[@hoebeng1]

Will it affect the A1c result?

[@HousewerkRecords]

Good technical presentation. Does the same regular or rigorous exercise regime work for type 1 diabetes?

[@maskofsorrow]

Brilliant explanation and animation.

[@RIO4252]

thanks... so Nice..

[@RobyVicary]

Skipped a step at 2:30 - PIP3 activates PIP3-dependent-kinase-1 (PDK-1) which activates PKB/Akt. See: PMC3941218

[@RobyVicary]

But a good video nonetheless :)

[@deekshanyaj_3714]

The animation and explanation are very useful to understand...Thanks😃

[@drewcrawford394]

Loved it👏

[@doctormwpepper]

Thank you so much for this. Actually an amazing video with thorough information, and a very peaceful experience overall. Preparing for the USMLE and need more of this zen.

[@alejandravasquez3837]

Amazing! Thank you.

[@inigosanmillan1]

Outstanding Presentation. Congratulations and thank you very much for the effort.

[@hineskittvelvett198]

You mean we know about the tpgb going into cbgbs and transporting ttsdghgfds4s but we don't know why insulin sensitivity sometimes lowers?

[@tartanhandbag]

the techniques for working out which protein goes where and does what is just a matter of good molecular biology methods and the accumulation of several teams worth of research over some years. the actual cause for insulin resistance is so much more complicated. diabetes type 2 is one of the more complex diseases to understand. as with many "complex" diseases, it combines a number of vastly complex systems: immune regulation, vascular science, nutrition and the biochemistry of metabolism, genetics (MANY genes implicated) etc we do have some leads but it's not as simple as "this microorganism pumps out this toxin and boom - disease" this is a good start, although the paper is a little old now: www.ncbi.nlm.nih.gov/pubmed/16563942

[@GuroJeromeTeague]

According to my text book the decrease in insulin sensitivity in Type II Diabetes is caused by down regulation of cell receptors. In order to maintain proper homeostatic balance, cells that are constantly exposed to high levels of insulin caused by high level of glucose in the bloodstream will loose insulin receptors. On the reverse side, this is why low carb diets and moderate to high intensity training works to treat Type II Diabetes. Lower glucose in the blood stream leads to lower insulin in the blood stream and the cells respond by creating new insulin receptors (up regulation).

[@carmenross1077]

I like this demo reminds me of my class rather than listening to talk talk talk at least something being pictured in my brain

[@Sam-vn9jm]

Is that flight facilities in the background

[@sumitgupta4414]

great animation ...making interesting ..thank you 👍👍👍👍

[@aligrafix1985]

Fantastic way to explain!

[@saranadeem8567]

Literally FANTASTIC

[@destinationunknown4959]

She did not say how long a vigorous excercise is needed before the glucose is uptaken. A patient said he measured his glucose before a 15 min run and after and only 15 min of very fast sprinting reduced his BG by a significant amount. I am interested in knowing how long for and when does the glucose uptake stop if so. And 8f it runs out of blood glucose does it tap into Glucagon stores?

[@tnijoo5109]

Interesting!

[@loganausleyreal-eyes8090]

This is very elaborate. Well illustrated with the animation. So I guess that training in a persons state would allow for better glucose uptake due to the action potential rather than insulin driven. Depending on the severity or level of insulin resistance. And I’m wondering how Leptin comes in to play. You consume carbohydrates the night before training this Stimulates insulin as well as leptin secretion.

[@aud4837]

What Pharmaceutical Company are you representing?

[@natto84]

Wow, this was great.

[@m.m.m.c.a.k.e]

Very nice! 🎉

[@smh7192]

please make sound available on both speakers (left and right)

[@dianeladico1769]

That was PERFECT-thank you!

[@infopc-arieh6372]

Excellent ... well done ...

[@kristina9605]

This is so cool! It left me with the question of how muscles obtain energy when people are on low carb diets and aren’t consuming sugar? Do they conserve the little glucose they do have, or can fats and proteins also be converted to glucose?

[@destinationunknown4959]

Yes fat and protein then convert to glucose.

[@Moxieinmotion]

Fat gets converted to ketone bodies in the absence of insulin, OR gets put into storage in the presence of insulin. Amino acids can be converted into glucose via gluconeogenesis

[@blackswanrising2024]

Muscle burns free fatty acids or glycogen. Excess ffa is converted to ketones

[@fatemhalasfar4057]

Amazing 👏

[@christophernieves1215]

Perfect explanation!

[@aadt4604]

Great video , it makes clearly explanation

[@tobiaschristianbisgaard4628]

This video is freaking awesome! Trance voice and music made me focus haha. 5/7

[@katiemeredith]

best track!! It's Clair de Lune by Flight Facilities..

[@CaptainVelveeta]

Wow...fantastic animation...what company is this...I could really use this quality of animation in my Microbiology class right now.

[@EA-rn3tx]

This cleared up so much. Thank you!

[@antiawarenessawarenessclub]

The whispering from my left earbud gives me tingles up my spine alkhjkfgdh

[@25parneetkaur8]

All the best mam for your future videos

[@chachi_luna]

Love flight facilities, and physiology of course

[@maramadel415]

That's been pretty useful, thank you. Consider making more videos :"D

[@zyprozenin]

What about for T1 Diabetics? Some T1 patients have BS spikes after exercise

[@JohnSmith-rj2yt]

How does exercise relate to the insulin signaling pathway?

[@alanboo5664]

But sometimes I wonder after a strenous workout I have seen my CGM shows high readings..It stars giving me speech alerts. I dont understand why..?

[@destinationunknown4959]

Because it is dumping from the liver stores. Normal as far as I read.

[@MaximumMetal123]

This is awseome! So helpful thank you!

[@faisalalmutairii]

Great video 👏🏻

[@chazwyman8951]

GOsh I'd not realised how simple the process is.

[@jakecattoi4983]

amazing ASMR video

[@maduraikalatta5698]

Very nice video thanks

[@tomdelorenzo2539]

Kinda ignored all the GLUT1 transporters that all muscle cells have.

[@25parneetkaur8]

Its realy osam mam to understand action of glut 4 Which i cant ever understand by my teachers theoratically

[@danieldaneshforouz1394]

Awesome video!

[@bubbagene145]

What the ..... I'm so stoned and watching this. This is incredible.

[@khalid6050ify]

Excellent

[@CzechRiot]

The only problem is the way the woman speaks is like those hypnotic relaxation types of speeches... "feel your body relaxing... let your mind travel to another dimension... flow weightlessly through space..."

[@CzechRiot]

I mean, it's hard to focus technically in the video, as I feel like going into a trance.

[@InZainUK]

and the song too, its a bit of a banger.

[@doctormwpepper]

I love the way she talks. Soft spoken, easy on the ears. Very zen.

[@pariszar7859]

Great job !

[@prdgy132]

AMAZING VISUAL

[@JakeMarian]

How come could someone dislike this video?

[@liliancuryhadad]

Sensacional❤

[@MrPokerblot]

So skeletal muscle doesn't need insulin to use glucose at all?

[@ENGRAINING]

good video

[@JimmyDaBone]

This music is creepy. It sounds like a horror movie.

[@unknownworld9815]

i may not understand but i know exercise increases insulin sensitivity

[@joaoflaviobaeta]

Perfect!!!

[@LayZeeBro]

perfect.

[@ChildFromGeorgia]

wow great job!

[@CJVP99]

good video but whats with the demonic background music?

[@chriskim9470]

Haha, how does it sound demonic? It's mellow and chill.

[@DeadLifts4Dayz]

I’m just here to Build Lots of muscles

[@shaikfairoj5172]

👏

[@emmauya3198]

You have my maximum respect Dr Igudia, I am now negative from my type 2 Diabetes after I did the test, I wonder what might have become of me it I didn't get the herbal cure From your KZbin channel. God bless you sir.

[@swobodams]

I need a nap.

[@Sollirep]

Huh?

[@abuskard]

Very informative but a little bit creepy

[@atomicpiano]

Whaaaaaaaaat

[@ИринаКобзева-х9ж]

Пёревести на русский

[@DaBentoBox]

bruh biology is so smaht

[@toufiqenam9516]

the lady who is talking isnt deserve here.she needs to work with yoga / menatal relaxation making videos

[@moj8295]

whoever did the voice over needs to stop whistling every time they pronounce "S" you sound like a snake and it makes it incredibly hard to hear

[@emilna3212]

Great video!

[@Sollirep]

Huh?