Exotic Sources of Cancer Medicines: Total Synthesis of Glionitrin Natural Products (Organic Chem)

[@yannikesser3957]

this channel is the perfect example of quality over quantity

[@totalsynthesis]

Question to the audience: Many of you watch my videos on mobile phones. Would you like much bigger graphics (for example, when showing synthesis schemes) for better viewing experience on smaller displays? Let me know your thoughts!

[@knivesnico8775]

Phone posters must suffer

[@mateuszhess4549]

That would be great if you made them bigger, I do indeed have some trouble seeing the catalysts over the arrows. On another note, great video as always!

[@totalsynthesis]

@@knivesnico8775 lmao

[@fukpoeslaw3613]

yes, and also make the phone manufacturers make bigger screens!

[@madansharma2700]

Yes bigger graphics please.

[@knivesnico8775]

A new total synthesis video, this makes the serotonin happen, very good.

[@samueldeschwanden3065]

Always a pleasure to have you whisper concentrated quality content in my ear. The ratio between the amount of videos you are uploading to the amount of people subscribing to you is clearly displaying the effort you are putting into it. Keep up the outstanding work!

[@totalsynthesis]

A S M R

[@definetlynotacomment1184]

Great video! I did not expect that the synthesis would have that few steps. I came for the synthesis, but the learning all about the microbial environment in mines was very interesting. Have a nice weekend man.

[@Wojan2137]

5:17 As a chemist working with pesticides, I have to point out that agent orange was a mixture of 2,4-D and 2,3,4-T herbicides. Dioxins were present in agent orange because TCDD is a side product in the synthesis of 2,3,4-T. 2,4-D is still commonly used today

[@totalsynthesis]

Well spotted, thanks

[@leliondemer]

Thank you for the new video Total synthesis NUMBA ONE!!!!!

[@MarkRLeach]

Small correction about agent orange & dioxin: “Agent orange is a mixture of equal parts of two herbicides, 2,4,5-T and 2,4-D. In addition to its damaging environmental effects, traces of dioxin (mainly TCDD, the most toxic of its type) found in the mixture have caused major health problems for many individuals who were exposed, and their offspring.” From Wikipedia

[@knivesnico8775]

🤓

[@levtrot3041]

You are THE BEST person at showcasing syntheses on youtube i know about, why don't you post more frequently ?I assume that quality has something to do with it

[@flaplaya]

4:54 Dioxins are easily my favorite class of man made toxin. I didn't know bacteria could metabolize them... Please more like this 🙏

[@vinaykadam3935]

Highly appreciated for making these videos. True gem on this platform. Keep doing this, excellent job.

[@totalsynthesis]

Thank you!

[@jasonking8144]

Again, you are one of my favorite resident youtube scientists. Thank you for this video.

[@flaplaya]

Nature's little micro reactors are mind boggling.. Many mechanisms still not elucidated by the best.. The cyclizations especially epoxide cyclization are particularly fascinating to me. Yes biggest molecule size possible please. Other channels lost me because I can't see the molecular design. Great work here

[@francescoliberatori2598]

Thank you for your contents, this channel is great. Keep it up!

[@mattsoutback59]

I waited so long, and boy was it worth it! Great video, I gotta show this to my professor

[@damankharoud5034]

Awesome video! Really enjoyed it!

[@Mr.Cucumba]

Thank you once again for this high quality content. Always interesting to get to know background information and summeries from the field of organic chemistry and life science.

[@90klh]

Etizolam is the devil my friend. Be well

[@ridgeylagan3606]

The key C-S quaternary stereogenic centre formation is pretty cool! Good work!

[@victordonchenko4837]

The bitter struggle between two microbes in an acid mine drainage site is the gritty mafia show we all want.

[@alexandraschneider5651]

Fantastic work as usual! Thank you for posting again!🔥🔥🔥

[@bagniacz3264]

Great video. But I gotta say this - tetrachlorodibenzodioxine is not Agent Orange. It doesn't have much effect on plants, which was the point of the whole operation. Dioxines were byproducts of process in which Agent Orange was synthetised. They were essentially unwanted impurities, but nobody cared to purify stuff that was a weapon of war, plus back then people didn't really know how toxic they are anyways. On paper actual Agent Orange was a mixture of dichlorophenoxyacetic acid and trichlorophenoxyacetic acid, which are herbicides.

[@totalsynthesis]

Thank you - you are absolutely right! Funny when contaminants become more important than the intended active substances

[@lucazsy]

Oh boi, this is so interesting but so complicated.

[@kafkayash2265]

You make really great content!! You should try making a video on synthesis of mifepristone from norethisterone!!

[@s.t.5993]

You build the diketopiperazine core and then you do : S8, NaHMDS, to install the final bridge. Less fancy but less steps also.

[@romainbonnot87]

Freaking awesome content. How much work goes into this organic boi

[@chanheosican6636]

Yes, taxol and colchine are quite interesting. I imagine making taxol chemically would be very tricky with lots of steps required.

[@manajitdas7619]

Great job Dear, Thank you so much

[@jasonqlwilliams]

Where dd you get that marine natural product bar graph from?

[@totalsynthesis]

www.mdpi.com/1660-3397/12/8/4539

[@jasonqlwilliams]

@@totalsynthesis Thank you Sir!

[@chanheosican6636]

Taxol yield from genetically modified e coli with the taxol type gene may be a lot easier than purifying it from the leaves since taxol concentration is only 0.001% for the leaves. Shelf life of taxol at minus 80 degrees C is 6 months or so.

[@Cloveis]

I’m gonna subscribe so I can continue getting schooled

[@totalsynthesis]

🤣💕

[@mrknife666]

Ok I understood about 1/10 th of the video. But the organic chemisty is awesome! And I want to thank you for puting the image of Trump cheering on a fight between a bacteria and a fungus into my mind.

[@chanheosican6636]

I tried purifying yew leaves with ethanol and 25% Acetic acid. I heated it carefully to 50 degrees but some boiling eventually occurred and destroyed the product!

[@jiangyongguo]

Hello my friend, may I ask if your company needs anti-cancer drugs- (Including formula, raw materials, semi-finished products)? I am from China.

[@totalsynthesis]

Nope but thanks for asking haha

[@jiangyongguo]

@@totalsynthesis Our domestic company supplies anti-cancer drugs- (Including formula, raw materials and semi-finished products). Your company will reproduce it and make it a more valuable product.

[@lorenzmayer7734]

instant like and comment for the algorithm

[@totalsynthesis]

🔥🔥🔥

[@alenmeier3663]

Algorithm comment 🔥

[@90klh]

Ahhhhh yall thats crazy!!!! Co- cultures? The idea of having chemisty be done by microbes has aleays fascinates me. The idea that there are chemicals that could only be formed if theres two microbes sharing an environment is crazy

[@totalsynthesis]

It's really amazing!