Why MDMA did NOT get FDA approval
15:09
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@baby_king9ine
@baby_king9ine 2 күн бұрын
Humans are too damn smart for their own good 😂
@Plancksized
@Plancksized 3 күн бұрын
This is my favorite watchlist to be on. That double mannich reaction is peak organic chemistry
@totalsynthesis
@totalsynthesis Күн бұрын
They had it all figured out already a century ago :)
@JonathanJoestarJuicefest
@JonathanJoestarJuicefest 9 күн бұрын
Honestly if it works in humans as advertised, side effects would be an acceptable risk.
@UK1987.
@UK1987. 11 күн бұрын
(The paper was published in Nature)
@totalsynthesis
@totalsynthesis 11 күн бұрын
Yep I nicely typoed that
@jamiemoore1056
@jamiemoore1056 14 күн бұрын
Any halogens besides iodine are toxic stop using them unless you want to become 3m and their pfas
@jamiemoore1056
@jamiemoore1056 15 күн бұрын
A keto genic diet shows the most promise in glios
@tylersmith1749
@tylersmith1749 17 күн бұрын
The best chemical ever synthesized. Not meant for daily or even monthly consumption but for when you need a new perspective.
@tylersmith1749
@tylersmith1749 17 күн бұрын
Legalize and regulate. Id entertain acid again if I had lab test that came with the final product. Back in the day that wasn't needed.
@SodiumInteresting
@SodiumInteresting 19 күн бұрын
This and the 6 bonded carbon. Both interesting videos. Keep up the great content!
@totalsynthesis
@totalsynthesis 18 күн бұрын
Thanks!
@kenhaze5230
@kenhaze5230 19 күн бұрын
Who looks at that structure (temozolomide) and thinks "no reason to suspect THAT'S explosive!" I'm a neuro PhD and that's still one of the more explosive looking molecules I've seen lol.
@totalsynthesis
@totalsynthesis 18 күн бұрын
Hahah I swear
@AdinathJichkar
@AdinathJichkar 21 күн бұрын
At 24:28 why was NaOCl used after nabh4 reduction?
@marcuslima1370
@marcuslima1370 21 күн бұрын
How do you get 3D drawings of molecules in your presentation?
@Nah_Bohdi
@Nah_Bohdi 22 күн бұрын
Fascinating.
@LunamLegionam
@LunamLegionam 23 күн бұрын
what the sigma
@wosmahl
@wosmahl 23 күн бұрын
Im surprised they had to heat the selenoxide elimination. Ive dont it few times and it was always happening at very mild conditions, even under 0°C
@tejavardhanpilla4039
@tejavardhanpilla4039 25 күн бұрын
Like your videos please continue to do videos like this ❤❤❤
@totalsynthesis
@totalsynthesis 24 күн бұрын
Thanks this means a lot!!
@tejavardhanpilla4039
@tejavardhanpilla4039 24 күн бұрын
@@totalsynthesis I'm a 2nd year bsc chemistry Student from india ❤️, your videos are useful and good to understand 😀
@Robert_McGarry_Poems
@Robert_McGarry_Poems 25 күн бұрын
How much of those "fifth and sixth" bonds are just part of an illusion created by the resonance structure in the benzene?
@totalsynthesis
@totalsynthesis 25 күн бұрын
The bonds with ring atoms are all illusions to some part, as they are just ~0.5 "bond equivalents" each!
@Robert_McGarry_Poems
@Robert_McGarry_Poems 13 күн бұрын
I just read an interesting article about triel bonding pentacoordinate carbon... 😊 It seems carbon is a big fan of imaginary electrons.
@RagedGecko
@RagedGecko 25 күн бұрын
This is definitely novel for organic chemistry, but in the world of inorganic with more complex orbital configurations, there has been such thing as a -6 Carbon state and it's actually all over... your lawn. FeMoCo
@totalsynthesis
@totalsynthesis 25 күн бұрын
True
@chadkline4268
@chadkline4268 26 күн бұрын
I think this is because we are not understanding electron shells. They are 2D bubbles of charge densities, and they are not purely atomic. They can encompass functional groups, and the charges are shared amongst groups. They're not like Legos. More like static electricity on a balloon, but with spin, angular monentum, and area densities.
@kenbrady119
@kenbrady119 26 күн бұрын
Well said - even this old would-be chemist understood most of it. Good to know that the molecules of life have some flexibility.
@pepsimaru
@pepsimaru 26 күн бұрын
Carbon is blessed
@A.H.房
@A.H.房 26 күн бұрын
Anyway it's amazing…
@jamiemoore1056
@jamiemoore1056 26 күн бұрын
What would it's use be?
@totalsynthesis
@totalsynthesis 26 күн бұрын
Nothing 😂