Extranodal Rosai-Dorfman Disease 101...Explained by a Pathologist

[@JMGardnerMD]

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

[@missknowall]

Worth watching over and over. You are sure to get something new out of it every time.

[@americobrilhante1]

Good tip on the nuclear aspect in Rosai-Dorfman. I do Zielh-Neelsen in almost all histiocytic proliferations.

[@JMGardnerMD]

That’s not a bad idea. I once saw a mycobacterial pseudotumor that Gad áreas closely mimicking rosai Dorfman. Maybe I will make a video of that case one day.

[@drsupriyadhar7619]

thank u so much...very lucidly explained indeed! Very rarely I find such nice videos. Please post some more in the future!

[@HealingSunHouse]

My 16 hear old godson just got diagnosed with it. He had several biopsies which show non cancerous which is good but his lymph on neck, bladder, stomach and groin is swollen. He has constant diarrhea and fatigue. It is debilitating

[@AliJapanLife]

One of my relatives we suspect has the same issue, she is 11 years old. It is been a year now and she still has the same issue on her neck. what is worrying is she has difficulty breathing at night every day. Does your godson experience the same issue? and how is his situation now?

[@HealingSunHouse]

@@AliJapanLife he actually is at a good baseline now. Started on new meds that mimic chemo and he’s doing ok

[@AliJapanLife]

@@HealingSunHouse That is good! 🙏🏻 A quick question, does he has difficulties to breathe at night while sleeping?

[@HealingSunHouse]

@@AliJapanLife no, his didnt affect breathing. His affect was swollen glands. By groin and neck...it was more painful and cumbersome versus anything. He had trouble walking. Lemme ask my friend what meds finally worked because he was on a lot of steroids then tapered down amd is stable now...

[@actionpropertygroup3310]

Please let me know the meds. My 16 yr old son has also been diagnosed. It was actually on his skull, inside and outside​@@HealingSunHouse

[@madhudewan8207]

Great cases described with terrific images.

[@kazumithumargondalia9171]

Why it has to be so easy and as clear as water wen teacher is Dr Jerad... Thanks 😊

[@karenzhaayala8705]

Buenos días, lamentablemente no se nada de inglés, solo me metí a los comentarios para poder entender algo al momento de traducir . Tengo 31 años y me detectaron esa enfermedad pero gracias a Dios a mi me salio en las piernas 🦵 me hicieron biopsia tbn , tengo hasta el momento 3 lesiones pero 1 de ellas es muy grande a crecido durante 6 años y al momento de operarme se dieron cuenta k había 2 tumores juntos y solo pudieron sacar 1 ya que el otro compromete mucho una vena . Estoy tomando corticoides, me dijeron que eso me ayudara a ir disolviendo los tumores, Es cierto eso ? Tengo que dejar de comer algo?

[@atmanfisal79]

Again, very informative and organized, I regret not attending your session in Cairo!

[@JMGardnerMD]

Hopefully I will have the chance to return to Cairo to lecture again in the future. I love Egypt!

[@BlueAngel681]

just got diagnosed with Rosai Dorfman. Two tissue extractions done (in different areas) and sent off to Mayo to confirm.

[@hunnybee0923]

I was recently diagnosed as well. How are things going for you?

[@janusjevanalles]

@@hunnybee0923 So was my wife, she found a facebookgroup for patients that was helpful to share experiences

[@hunnybee0923]

Jeroen Willem Van Hove thank you for your response. Do you know the name of the group?

[@janusjevanalles]

hunnybee0923 Rosai dorfman aka sml

[@EastBayG209]

Good afternoon, I watched a few videos on your rosai dorfman topics. Is it true that rosai dorfman, without delving in deeper, can mimic SLE and Kikuchi Fujimoto, at least from the lymph biopsy view? I have an ANA and dsDNA negative patient with all lupus features that had a basic node biopsy done (they didn’t delve) that was simply ruled as sinus histiocytosis

[@JMGardnerMD]

The term “Sinus histiocytosis” by itself is just a non specific reactive finding seen in lymph nodes in a wide variety of settings. It is not the same as Rosai Dorfman (sinus histocytosis with massive lymphadenopathy). I am not a lymph node pathology expert, but I’m not aware of Kikuchi or SLE having lymph node findings that would closely mimic RDD.

[@EastBayG209]

@@JMGardnerMD thank you so much for your reply!

[@guilldrmobritos3551]

Hermosos casos.congratulations!!!

[@ImmunoANT]

Great explnation, great tutorial, as usual, including the plamsa cells. Do you enumerate IgG/IgG4 for those plasma cell? Thank you

[@JMGardnerMD]

No I don’t do any IgG or other plasma cell stains in rosai Dorfman disease.

[@RaulRodriguez-sh6vb]

Very good explanation as always

[@missknowall]

Very informative and eloquent, as always.

[@mohammadashab3301]

How u differentiates it from infectious mononucleosis

[@AKK105]

If this virus appeared in the tongue, what kind of medicine or tablet can I take?

[@ramneekbindra2305]

At 5:02 what's the wo d..imperi policis? Couldn't get

[@JMGardnerMD]

Emperipolesis

[@SandhyaRamachandran]

a v nice presentation; thank you...if they are foamy histios, would they also be CD68 positive?

[@JMGardnerMD]

Yes they are CD68 positive like other histiocytes

[@shritikshrihan9143]

Thankyou so much sir for posting these valuable videos..

[@AmineAmine-bi3mk]

Please answer me doctor,i don't knew speaking ans wrighting very much but this us not a problem, doctor is this dease a cancer or tumor or no?'im from algeria . Thank you

[@JMGardnerMD]

No it is not cancer.

[@yomenroumieh3882]

Thank you alot. What a great lecture!

[@uzmazafar2245]

Great tips!!

[@alivasahu2784]

Thanks a lot. So much helpful 🙏

[@DrMSPath_11]

Please add castleman class.

[@JMGardnerMD]

Great idea! I’m not a hemepath expert but I am friends with some. I’ll see if one of my colleagues wants to do a collaborative video with me about Castleman

[@DrMSPath_11]

@@JMGardnerMD that would be of utmost help. Thank you. You are a great teacher.

[@zainabnasir8943]

Thanks 🙏🏻

[@TheYoga1212]

Doctor pls help me . My son has rosai dorfman has leison in brain what treatment to take no one knows in India plz assist

[@JMGardnerMD]

I’m so sorry to hear this. I have never seen a case of Rosai Dorfman involving the brain actually. I also do not know much about treatment of Rosai Dorfman as I am a diagnostic doctor not a treating doctor. Can you have him seen by a major medical center in India like Tata Memorial? MD Anderson in the USA also has experts in Rosai Dorfman and would be a good place I’d you are unable to find help in India. Best wishes for healing to him!

[@TheYoga1212]

Jerad Gardner, MD thank you so much for your time Dr . We seen in Apollo and they said for kids it’s a first time to see .sure doctor will try there .

[@mizvita]

@@JMGardnerMD where is doctor Anderson located?

[@ansumanpattanaik17]

Is this disease cause Cancer ??

[@JMGardnerMD]

No.

[@ansumanpattanaik17]

@@JMGardnerMD is this cause T.B ??

[@harigupta8728]

@@ansumanpattanaik17 no

[@glorianne6108]

I have that

[@roshchinoy]

Gig

[@exodusblaze3623]

I have this disease

[@osasamadasun3785]

My son has it too, does it go away

[@exodusblaze3623]

@@osasamadasun3785 its different for everyone, for me unfortunately it hasn’t

[@KyrieW]

It would be amazing if you did a video on IgG4 dz Dr Gardner!

[@roshchinoy]

IgG4 disease