Fasting | How Fasting Affects Insulin | Peripheral Insulin Resistance- Thomas DeLauer

Click Here to Subscribe: Bit.ly/ThomasVid
Website: ThomasDeLauer.com
Get the Apparel I Wear at www.Hylete.com
Fasting | How Fasting Affects Insulin | Peripheral Insulin Resistance- Thomas DeLauer
Study - Journal of Clinical Endocrinology and Metabolism:
Glucose and glutathione (GHS) metabolism was studied after 12 and 60 hours of fasting on two occasions: with and without aspirin (6 g/d) t. 6 healthy lean men participated and, as mentioned, underwent 60 hours of fasting with or without aspirin (approximately 6 g/d). Fasting decreased insulin-mediated peripheral glucose uptake by 46% after 60 h and Aspirin did not alter this effect of 60 hours of fasting on insulin sensitivity. GSH concentration decreased during fasting, but the fractional synthetic rate of GSH was unaffected either with or without aspirin. Fasting did not affect inflammatory parameters, although aspirin increased soluble TNF receptors I and II. Researchers concluded that prolonged fasting induces profound peripheral IR - in contrast to type 2 diabetes mellitus, high-dose salicylate does not affect fasting-induced peripheral IR.
www.ncbi.nlm.n...
Why Does this Occur?
Generally, prolonged fasting (greater than 48 hours) in humans is accompanied by a reduction in insulin sensitivity, elevated plasma FFA levels, elevated intramuscular fat levels, but also an increase in whole-body fat oxidative capacity. Furthermore, prolonged fasting-induced insulin resistance is not accompanied by hyperglycemia or hyperinsulinemia, factors that have been suggested to cause mitochondrial dysfunction in diabetes. It could therefore be anticipated that despite the development of insulin resistance, mitochondrial function is maintained to accommodate increased fat oxidation during prolonged fasting. Conversely, if (lipid-induced) insulin resistance or factors associated with the insulin-resistant state do cause mitochondrial dysfunction, it’s believed a reduction in mitochondrial function with prolonged fasting would occur. Prolonged fasting, however, is a physiologic condition in which insulin resistance develops to spare glucose for utilization by the brain, and increased FFA levels are accompanied by increased fat oxidation. Prolonged fasting-induced lipid accumulation and insulin resistance are considered to be a functional physiologic response. As mentioned, reduced insulin sensitivity saves carbs for the central nervous system, being obligate for glucose and not requiring insulin for its uptake, whereas increased lipid availability at the same time can serve as a direct available energy source for the muscles and is paralleled by an enhanced fat oxidative capacity.
FFA & Mitochondria:
Elevated plasma free fatty acids induce insulin resistance through activation of Jun NH(2)-terminal kinase and nuclear factor-kappaB inhibitor kappaB kinase, which leads to hyperphosphorylation of the insulin receptor substrate type 1 (IRS1).
Study - Diabetes:
In this study, FFA levels were increased approximately ninefold after 60 hours of fasting in healthy male subjects, leading to elevated intramuscular lipid levels and decreased muscular insulin sensitivity
These findings confirm that the insulin-resistant state has negative effects on mitochondrial function. Given the low insulin and glucose levels after prolonged fasting, hyperglycemia and insulin action can be excluded as underlying mechanisms, pointing toward elevated plasma FFA and/or intramuscular fat accumulation as possible causes for the observed reduction in mitochondrial capacity. The increased exposure of skeletal muscle mitochondria to elevated levels of free fatty acids (FFA), seen in insulin resistance and type 2 diabetes, has been suggested to interfere with proper mitochondrial function. The acute elevation of plasma FFA by lipid infusion is accompanied by down-regulation of the transcriptional co-activator peroxisome proliferator-activated receptor gamma coactivator-1α (PGC1α) and other genes involved in mitochondrial metabolism.
diabetes.diabet...
References:
1) Van der Crabben SN , et al. (n.d.). Prolonged fasting induces peripheral insulin resistance, which is not ameliorated by high-dose salicylate. - PubMed - NCBI. Retrieved from www.ncbi.nlm.n...
2) Peripheral Insulin Resistance and Impaired Insulin Signaling Contribute to Abnormal Glucose Metabolism in Preterm Baboons. (n.d.). Retrieved from www.ncbi.nlm.n...
3) Intermittent Fasting Increases Peripheral but not Hepatic Insulin Sensitivity | American Diabetes Association. (n.d.). Retrieved from professional.d...

[@TabithaEnglish]

I’m on day 5 of fasting and my glucose has gone from 63 to 94. I’m glad I found this video!

[@strawberryme08]

i wish mine would get that low. geez. i wake up to 120 ish after 8 hours of not eating. i got tested and its high insulin and high glucose and i know i have adrenal issues so its high cortisol. ugh..

[@MohamedWanis_Elruemi]

@@strawberryme08 Hi. Are you diabetic? I have the same thing here

[@tripptank]

Thomas is a genius; He know's we'll have to watch most of his videos more than once if we want to catch everything. Professional KZbinr right here.

[@judybanks133]

So interesting! I'm 3 days into a prolonged fast (fat adapted). I noticed my glucose rose to 66 and keytones dropped to 3.2 after a 5 mile afternoon walk. By the evening, my glucose dropped to 49 and keytones rose to 5.5. The body is so incredibly flexible! Loving the content you put out there. My vote is to keep it "technical".

[@BeeCrashful]

Great timing ! I planned to do a 3-4 days fast and this video encourages me to do so :) And if someone dare say it's not healthy... i have all the arguments needed now ! Thanks Thomas !

[@ZachSilverberg]

As a type 1 diabetic myself, I found this very helpful. The longest fast I have been able to do is 57 hours. This gave me some ideas. Thank you Thomas for sharing you knowledge!

[@bomerboy1]

hi there your awesome im in canada just found out i got dibetes im watching lots of your video im cuting out carbs and doing this keto stuff your talking about i love it its been a week i lost 11lbs feel great keep in mine im a big guy weigh like 330 lbs i got a long way to go but im learning everyday with your help thanks alot and im 50 years old next week again your great ill be watching thanks thomas

[@dana102083]

Keep up with your electrolytes! You're in the danger zone and easy to not add enough..sodium, potassium and magnesium. I'm in Canada too, in Edmonton. Good luck!

[@pohkeee]

Keep watching and thank your lucky stars, because you’ve found your godsend...

[@Durtly]

Do your research and make sure you're getting enough (but not TOO MUCH) Magnesium, Potassium, and Sodium. Also look into Apple Cider Vinegar as an appetite suppressant, it's helped me get through some craving periods.

[@wesszajna2597]

Good luck... check out Dr. Eric Berg videos too!!!!!! it will help

[@MsDestinedtoReign]

Wes Szajna Doc is my Godsend, Lost 110lbs with Doc’s advice. 👏🏻

[@Reaperaxe9]

Thomas, your videos have been on absolute point lately. Please keep showing people the science and justification of efficient nutrition and growth!

[@MariniFacey]

Kushal Jaligama I agree! I love hearing about the science/wisdom and the process our bodies go through!

[@falcon4strokeflyer]

This answers the conundrum I’ve been experiencing. Type 2 diabetic, three weeks in Keto, IF 16-8, and trying to reduce meds. Glucose levels actually rising to concerning levels during fasting and very minimal carb intake. Working out 5 days a week, I’ve lost 20 lbs in three weeks. Feel great, but I’m wondering if my next A1C will be better or reflect these elevated glucose levels.

[@jonwelch564]

What was your result? I'm curious to know, as it shocked me how high my glucose levels were after a 4 day fast. It took time for them to recover.

[@stanislouse4168]

Jeesh ... a pound a day??? I go for 1 lbs. a week MAX.

[@Biohackthefat]

I get my clients into extended fasting after 11 weeks of working with me and it always Amazes them when they take their fasting blood sugar and ketone tests. We calculate out the GKI and then compare to the GKI when they were Intermittent Fasting and the difference is amazing to see. It isn’t uncommon for the body to produce more glucose from the glycerol backbone of the fat molecule. I’ve also experienced this for myself Thomas. As at times throughout a fast my glucose will be elevated beyond what Is was throughout my Intermittent Fasting protocol. Good video here! Thanks for sharing!

[@kendrms]

When I fast beyond 48 hours my glucose always drops below 70mg/dL and ketones will rise above 3mmol. Does this mean my body is not receving the added flexibility?

[@jz362]

New to this, how do you test for these things?

[@MohamedWanis_Elruemi]

Nice comment. May I ask if you are diabetic or not? I am not diabetic and I have been on IF for the last 3 months.. my fasting blood sugar was always in the normal range.. but all out of sudden the last 3 days my fasting blood sugar elevated between 100 - 122 and it goes back to normal 2/3 hours after food

[@HatefulXP]

The mitochondria is the powercell of the house.

[@Durtly]

TESLA branded Mitochondria are the best Mitochondria because fashion.

[@The8lueSpirit]

* The cell is the mitochondria of the powerhouse.

[@TacticalDimples]

Wait a second..

[@cassandramensah206]

Mitochondria is the powerhouse of the cell.

[@milkyshakes]

Hol up

[@bighurt5367]

I needed to hear this. I broke my fast and when I check my blood about an hour later and it had spiked to 144. Then few hours later it dropped to 78. Away I needed to hear this, thanks!!

[@vesperal2]

I think this is your best video. You should do one with Dr. Jason Fung on the material shown here.

[@juliamontalvo9717]

Thomas thank you for this video. It means a lot to me. I'm currently fasting for weight loss and to get rid of my diabetes for good.

[@whowhy9023]

Carnivore diet works much better than fasting.

[@naturalnia432]

Great video! I just completed an 85 hour fast was very concerned about why my blood sugar rose so high after refeeding. I read a scientific article that explained and then watched your video, which elaborated and broke down the information perfectly. It all makes sense now. Thank you!

[@MohamedWanis_Elruemi]

Hi. Are you diabetic? I have the same issue after being on IF for almost 3 months

[@sourinmaiti]

Hey Thomas, you are doing an awesome job. Can you put more videos on same topic? Elevated morning blood sugars during fasting is scary. If not explained properly, people will get scared and run away from keto and fasting. I do 20- 4hour(eating) fasting every day and see 115 avg blood sugars every morning 8am. That comes down by lunch. Appreciate your awesome work here.

[@DDooMRooMM]

Brother, you are amazing with this stuff. Im breaking a 48 hr fast later today then I'm starting a 60 hour fast Monday. Thank you so much for the time you dedicate to us. Love you!

[@musicboy2003]

Wow, a great deal of fascinating and useful information! I’m type 2 using IF and weight training to help control blood glucose for going on four years now. It’s working and, at 65, I’m becoming a better version of myself. My resolution for 2019 is to do more 3-5 day fasts (did two last Fall) and this video, along with your vids on dry fasting, are a real inspiration. God bless you, Thomas!

[@lindatsl]

I started low carb and intermittent fasting in May this year (2021). By late June and early July I managed to get my FBG to the 5s. Then suddenly starting 1st week of August my FBG spikes up to high 6s and low 7s. I was depressed and wondered what have gone wrong. Thank God I found this video. Am going to continue with occasional fasting and go low carb as a lifestyle change. Blood pressure stayed below 120/80 though

[@arianasilesia2500]

100% true after being in ketosis for 5 years my body is so flexible and able to handle carb incredibly well. I practice fasting of 24 hours. And now regardless of what I eat I can have a full eating day of the worst junk carbs massive amounts of sugar and my blood sugar is incredible it does not spike it stays at 4.7 no matter what I eat. It is the most amazing thing. Prior to doing keto and fasting 5 years ago i used to be at 6.8 blood sugar.

[@robrae14]

You're lucky I don't think that's true for all.

[@nickbardan3867]

@@robrae14 when you're young, everything is easier

[@stanislouse4168]

If you were a diabetic, they would consider 7.0 a GREAT level to maintain.

[@SiimLand]

If you're not going to eat a bunch of carbs, then it doesn't matter if you have mild peripheral insulin resistance

[@rachkate76]

Says a fragile dudebro kid who shits on high grade probiotics in other countries because he's dirty he can't get them where he lives. Sounds about right. 😑

[@jackmacellan3183]

@@rachkate76 Wat?

[@madcircle7311]

@@rachkate76 nani

[@madcircle7311]

@Siim Land make a video about this Am confused as hell

[@narchodiaz]

We'll look who it is. Welcome siim land. I can't wait for your next video.

[@SeanLunny]

Thanks for all your help as usual Thomas

[@kenweidemoyer2221]

Your videos are good , and your advise is good . Do video on exercise how to get the most out of your work out and how long too wait after eating.

[@lemonginger001]

most underrated channel !! Respect for you !!

[@artofmagic1317]

Hey Thomas, I love your vids. First of all, I had an accident 1 year ago, got myself at 125 kg(275lb) and in 6 months I managed to get on 92.5 kg(204lb). I'm pretty proud of myself. *edit: I'm 1.94 m or 6.4 ft You say that fasting doesn't cause dizziness, but combined with keto I had some very bad days, worst of them was when I almost fainted in a bus. Oh well, you know.... Things we do to get what we want. Any advice on what to do to avoid this small problems, I don't really want to faint at work if it's possible. As for food, idk if I can call it an true keto because I adjusted it to my lifestyle. I mean I eat fat meat, fat cheese, eggs, sunflower seeds, pumpkin seeds and that's about it. Every day from 1400 to 1800 calories. Have a nice day, and thx for doing this videos, you were one of those that convinced me to try fasting and rly changed my life

[@alikhalid76dxb]

Yes. Agreed. I also learnt same things by going on fasts. Short fast increases insulin sensitivity and longer fast burns more fats but increases blood sugar. For example on first day fast bsugar dropped to 80 and then following days came back to 100. Diabetic need a mix of long n short to reverse it in few days. Cheers

[@BeccaLozierTrumpet]

I've been a Keto-IF girl for about 4 months and it gets easier and easier to stay in fat-mode. In the beginning, 50-80 g of carbs would set me back days. Now, it's a matter of hours and I'm back. I rarely eat that many carbs, but if i DO, it's super easy to get back in the fat flow.

[@briancrane7634]

Tom you are strong, fit AND SMART! A rare combination. Really enjoy your vids! Thanks!

[@KeeperOfKale222]

I sensed this video coming. Thanks for all the research! The fact that it lets your mitochondria work less means it could potentially be a powerful way to increase longevity. I remember doing some reading that over stimulating your mitochondria leads to always feeling tired. (eg elderly people falling asleep all the time) 🤔

[@j7m7f]

Hi there! I'm on OMAD for 6 weeks (no one plate, not keto - I eat everything). I had never any issues with blood glucose level (BGL) before (fasting BGL always below 90), although I ate a lot of sugar (sweets, cakes, etc...). To get some background: I'm 42yo. My top weight was about 230 pounds(5'10"), 215 when started OMAD. Now I'm just below 200. After 2 weeks on OMAD I've made blood tests and BGL was 94 after 18h of fasting! So I started my own BGL measurements and I've found that now my BGL usually raises above 100. Even up to 120. It is not the dawn effect, as I'm measuring it usually before eating (4-6 pm) and before sleeping. I've also made more detailed measurements - every 30mins after eating (1500-2000kcal). My BGL after 0,5 to 1h was up to 140-150, then after 1,5-3 hours dropped below 100 and then was rising again up to 105-115. BTW, I've noticed SOME dawn effect, as after wake up I have BGL around 115. But it somehow explains why I'm almost never lazy in the morning - I get up with out any need to snooze. Because of BGL I've just started to mix OMAD with IF - I'm eating a bit of fruits and nuts (about 300kcal) for about 8 hours and then have my big meal. BGL seems to drop below 100 before the meal. So it seems to work better for my BGL. I would rather like to be back to OMAD, as it allows to easier control hunger for me. And I think it works better for weight loss. My first idea is that it might be caused by insulin-resistant liver or higher cortisol. During my first 2 weeks of OMAD I felt A LOT of energy and kind of "speed up" or even kind of specific anger or "aggression". Later it stabilized. But generally I always easy get stressed, although I've got quite peaceful life and not stressful job. E.g. My blood pressure measured by a medic is high up to 150/100, but when I measure it myself it was usually below 130/90 and now even below 120/80. Should I be concerned about my high BGL on OMAD?

[@AgentClaytonWebb]

I was told by my pharmacist doing keto and OMAD that for the first weeks my liver would release extra stored glucose and this would stop after a few weeks, and it did. Now, I don't have any sugar spikes, but I do find at times I'm mildly hypoglycemic 3.3 mmol or 60, even though I'm not diabetic. Still losing weight and feeling great, but mindful to check my sugar numerous times during the day, just to be safe.

[@littlevoice_11]

Does this elevation in blood sugar during the fast (due to insulin resistance) increase inflammation and the damage caused by high circulating glucose?

[@freequest]

I do a mix of 16/8 and OMAD mostly OMAD as my lifestyle is pretty full on at times you know being a photographer and all that plus working out. But I have learned to listen to my body and sometimes my body tells me to fast usually 3-4 days its great I call it my little cleansing reset. The body is an amazing machine I marvel at times at how efficient it is litrally the most incredible thing is yourself. (:

[@funkndrucked]

The title was troubling until I WATCHED the video. Very cool to learn about the CNS and brain use of glucose. Thank you young man.

[@Greenumbrella-2024_April]

I remember reading a line in my biology book in 10th standard, which says mitochondria is powerhouse of every cell. Now I'm getting a better understanding of that line in every metabolic health related KZbin channels.

[@CameronAshley]

I'm surprised you never mentioned glucagon.. making glucose from fat. Isn't that where a lot of fasted glucose comes from?

[@dana102083]

I saw a great video on glucagon on high intensity health the other day,check it out! 100%

[@colleenkaralee2280]

I hope Thomas is up to date on Dr. Jason Fung's books about insulin and fasting.

[@David-fs7by]

Glucagon makes glucose from glycogen, not from fat

[@Indasaid]

Solid science behind adaptability and the benefits of a blended fasting approach (IF and longer term)

[@Jjones24680]

Type 1 Diabetic here 22 years. Been Fasting/keto for over a year, OMAD for over 7 months. I have experienced a plethora of various blood glucose patterns that have been a delight learning about. I would be very keen to answer questions about my current experience to this point. My last A1c from my blood work was 6.4 and my endo was amazed. I go days where I use Basal insulin only and under 20 units. To days where I have around 40-60 units in a 70/30% Basal/Bolus spread.

[@abitoffblacksmithing9985]

Dude type 1 and a A1c of 6.4 frickin Awesome!! The power or fasting and allowing the body to work and correct its self!! Amazing!

[@Jjones24680]

@@abitoffblacksmithing9985 Craziest thing I have noticed. Sometimes my sugar will be at a point where before this lifestyle change I would feel shaky, sweaty, and your typical symptoms of low blood sugar. My sugar can go as low as 50mg/dL now and I have zero symptoms of low blood sugar and feel absolutely great. No need to worry either, I take so little insulin that it is impossible for me to dip low enough to the point of concern. I typically used to feel the symptoms of low blood sugar around 70-80 mg/dL. Now it takes it around 40-55 before nay symptoms occur.

[@abitoffblacksmithing9985]

@@Jjones24680 that is amazing !! My wife was type 2 and she reversed it with high fat and low carb lifestyle changes I myself have lost 150lbs and I was definitely pre diabetic !! My wife's A1c is 4.5 now and it used to be 8.4 and even higher! Keep it up man!!!!! The human body is amazing!! Cheers!!

[@dana102083]

Did you change to keto with your doctor's blessings or did you do it alone? Ivan imagine alot would freak out over it! I'm a nurse, I'm curious how you started your journey and what it entailed :)

[@Jjones24680]

@@dana102083 I did it alone. I started with just intermittent fasting and healthier eating. I started doing more and more research and eventually got to a point where I felt so much better and was achieving so much, I just kept going. I am so adapted to burning fat now that even if I have a day of eating 3000 calories of McDonald's, I flush all that water and am back in ketosis within 24-36 hours. I am absolutely amazed at what my body can do. I have gone 72 hours without food as a diabetic with my blood sugar controlled entirely by my basal delivery on my pump. Blood sugar too low? Turn my basal insulin off, and it will rise ever so slightly. Blood sugar climbing ever so slowly? Turn my basal delivery up from .8 units an hour to 1.2 units. There are days where I do not take a single bolus delivery and simply turn my basal up to 2.2-3 units/hr 30 minutes before eating. The lowest amount of insulin I can recall using in a day entirely by basal was 16.5 units. This is with consuming a single 2750-3250 calorie meal. Human body FTW.

[@andrewrivera4029]

Gonna watch this a few more times, great video Thomas!

[@paulam1596]

Great video.. this gave me a great perspective of what was happening why my sugar was high during a prolonged fast.. keep up the good work!!

[@nnr2dm243]

It's all very very mind blowing-the stuff that's known about the human body today,all I can really say is when I think I've got a slight handle on things,i get lost and have to keep educating myself.

[@MissDeb-jq6nz]

I love this guy's videos!! I am always encouraged by his in-depth scientific reasoning. Superb!

[@Carmen-ex3nr]

Thank you so much for explaining this! I also noticed higher blood sugar levels after fasting and couldn't understand why this happens.

[@stanislouse4168]

Makes sense. Triglycerides increased 101% on my lipid panel over the month before. This was after a 26 hour fast and exercising for 1.5 hours at the end of the fast to dump out glycogen, just for the hell of it. What I was really interested in was fasting insulin and fasting glucose. The Dr. freaked and wanted to put me on statins. I told her what I did to prove (as an ultra endurance athlete) that I was fat adapted, but she didn't get it. Asked if she ever considered measuring my Tri/HDL ratio @ 1.3 Crickets.

[@snipeuallday]

dude I freaking love your informational videos I've been about 30 pounds overweight for about 4 years and really want to know how the body works and become a healthy individual THANK YOU SO MUCH!

[@JR-nw1li]

Mitochondria is the powerhouse of the cell, it's literally the only thing I learnt at school

[@dawnturner8663]

How do you know if you are insulin sensitive? I deal with a few things. I weigh 260 with borderline high blood sugar,. I have MS and and not very mobile and I have fatty liver disease as well. I also have been trying to do the keto diet but I have no gall bladder. Does this matter? Does anyone have any thoughts on the best way to move forward with these issues

[@kaymuldoon3575]

Dawn Turner I would suggest following Dr Eric Berg here on KZbin and watch his videos. He has a lot of useful information, including keto, fasting and how to heal fatty liver. He also talks about what to do if you don’t have a gall bladder. Here’s a good place to start: kzbin.info/www/bejne/aGXNmqeaiZyta5o

[@avfan967]

Why do people keep asking questions here like he’s going to personally answer you. He doesn’t. Stop asking these dumb questions

[@petithibou1891]

Man I m addicted to your channel ! So instructive !

[@Jobla2000]

Very interesting. Never heard about this before and love the science of fasting.

[@MariniFacey]

This is amazing, insightful information! Thanks again Thomas! This is cool to study!

[@kaiseri.4641]

Because of Fasting, I can buy finally a Mercedes. Fasting change my life .

[@aswin5868]

Nomercy Nomercy lol one of the bigggest advantage of fasting other than the health benefit lol

[@watchmanbaruch1207]

Dnt buy the Mercedes trash car Buy a Tundra or something

[@kaiseri.4641]

@@watchmanbaruch1207 nah man I am from the East Europe and here Mercedes is the car. 😀

[@kaiseri.4641]

@@aswin5868 Yeah man I am saving every month 600 euro, because of fasting. It is about 7000 euro every year.😀

[@watchmanbaruch1207]

@@kaiseri.4641 Save your money and buy an used truck

[@Yellowjacket45Wall]

Although this sounds logical I have experienced this many times and since I used to be diabetic I became concerned that just as you stated that I was losing the ability to uptake the sugar but what I have discovered is that as I fast and drink a lot of water it seems that the cells would rather hold onto the water than let in the glucose so I get the spike but if I fast and cut water intake my glucose goes down

[@mikecreativision]

I really like that you still develope and learn! Good attitude!

[@vickibacon7489]

Thank you, it always bothered me that though nothing is going in my blood sugar was high, thx

[@PottsV1]

This is what I love about this channel. We all know you favour keto and fasting but when you notice something that looks off you investigated it. As it goes your discovery fell on the side of fasting but I'm 100% sure if your discoveries had brought up warning signs about fasting you still would've been making this video to let us know. It's not about promoting fasting or keto, it's about promoting what's best for us. It just happens that currently they appear to be the answer.

[@xandersmith-davila8731]

Hi Thomas, do you have any information on the effects of fasting for people with type 1 diabetes (juvenile diabetes, not caused by prolonged insulin resistance)? My sister is interested in trying out IF, but doesn't know how it will work for her, due to the impact of diabetes on the endocrine system. I'm sure there are a lot of us who would be really interested in a video about that.

[@jonthomas9708]

Excellent clarifying information after reading that "starvation" increases insulin resistance

[@MsNeither]

I think we have to be very careful with the concepts. Starvation as you named it is not fasting. The former is something out your control and the latter is something you are willing to and, indeed, you are doing always under certain parameters: it is on your own control. The first one applies and happens when you do not have to eat whereas the second one you restrain your calories intake for your own will.

[@Nitronerd]

My glucose does increase during intermittent fasting, 12-20 hrs. I wondered why. 60-hr fasting glucose nose dives. This vid helps to understand.

[@MohamedWanis_Elruemi]

Hi. May I ask if you are diabetic? And have you got this issue solved as I am having the same thing here.... I am not diabetic and I have been on IF for the last 3 months 18 to 20 hours fasting.. my fasting blood sugar was always in the normal range.. but all out of sudden the last 3 days my fasting blood sugar elevated between 100 - 122 and it goes back to normal 2/3 hours after food

[@erichaynes7502]

Wow, that's a lot of info but you did a great job of summarizing it at the end and it really helps me understand a lot!

[@MrJaybast]

IF 20/4 5x/week(not during the weekend) with keto plus fasted cardio first thing in the morning and fasted resistance training before ending the fast..240 lb/6ft and endomorph body type..recommendation for calories a day, fast breaker, and last meal...goal weight is 200 lb

[@MrJaybast]

is this even a good combination?

[@duanem.174]

Another great informative video Thomas! Thanks!👍

[@Chris-mi1tt]

Additionally, Dr Inigo San-Millan & Dr Peter Attia have both explained that the main purpose of Zone 2 training is to have your mitochondria adapt to fat burning and clearing out lactate. Mitochondria adaptation to fat burning and clearing out of lactate is what all the elite endurance athletes are trying to achieve by training at a zone 2 level for 80% of the time: Kenyans, Norwegians, and Tour de France Cyclists.

[@MiekaFastingWeightLoss]

Thumbs up for teaching me today Thomas. I am on a prolonged fast right now.

[@miekaford7926]

Love your name.

[@nazariydmyterko1941]

Wisdom of its finest! Nice job as always!

[@bonniejones36]

Thank you so much! I have been experiencing this very thing and it was Puzzling my Medical Doctors...

[@Adamkilla9000]

I learned this in med school

[@SisterSandraElziraThomas]

You are awesome and beautiful. I'm an RN and you explain it so well. You and Dr. Berg and Dr. Fung are my absolute best. Thank you and God bless you and your family.🙏

[@JFWienecke]

Thomas, I have been on a ketogenic lifestyle for 21 months. After my last 3 day fast starting on 3/5, I have been intermittent fasting. What I have noticed is that my ketone levels have been over 0.8 to 1.7 since then. However I have noticed at times a combination of glucose levels of 104 - 106 along with the above ketone levels. For example yesterday after a light dinner at 7:00 pm the day before, then playing tennis in the morning for 2 hours (singles) and when I measured by blood at 11:30 am, by glucose was 110 and my ketone was 1.2. In the past, my ketone level would never be this high unless my glucose level was 85 or lower. Can you explain this? Where is the glucose coming from?

[@DurvalLacerda]

Correct me if I'm wrong, but isn't OMAD perfect for "curing/fixing" insuline resistance because you only have ONE spike of insuline a day?

[@deltadoc6702]

Perfect timing as I’ve been experiencing this exact thing since going to 20/4 IF. I also notice it will be higher the higher percentage of fat grams I eat the day before. Still kinda freaks me out as I was on the verge of being diabetic before beginning my KETO/IF protocol and lost 40lbs. A1C is the true snapshot of your insulin sensitivity and diabetes. Thanks for the research Thomas!

[@Lamentor219]

Life is a pendulum. The more energy you put into one side, the more it'll transfer to the other. We're always aiming for that point of balance within ourselves. Fasting and eating are important opposites that we need to maintain balance with. Really interesting topic.

[@paulgosselin5311]

Thomas****** Sometimes you miss the overall point of fasting which is health so when discussing use of sugar free drinks it is best to avoid them all together despite being ok for ketosis they negate any positive effect of over all health because they are poison to the body ( especially aspartame). Your ginger recommendation is great albeit fresh ginger is not processed (like your suggested ginger crystal supplement ) , can easily be converted to any form to assist in satiety and is cheap(whole foods). When you mention stevia realize that in the solid form has maldextose which is sugar and stevia is best used in moderation in the liquid form only. Keep an open mind you are doing well Thanks for your genuine effort.

[@SigmaPathfinder]

Hey Thomas can you do a video on why people say if you are doing a bodybuilding bulk it is easier to build muscle while eating carbs? I know you can build muscle while on keto but why easier with carbs? It is a question that I’ve always wanted someone to address!

[@SigmaPathfinder]

myron gains Thanks brother, wasn’t quite sure if he had or not. As you know he’s got a ton of vids!

[@1023kdawg]

Carbs are anti-catabolic. Insulin gets a bad rap, but absolutely has it’s purpose.

[@SigmaPathfinder]

Kade Silbaugh I’ve always been a big guy and stronger than the average guy, and knows how to gains massive amounts of muscle. But gained a lot of fat in the process and never knew how to cut correctly. I’ve been doing keto which is great but I’m thinking about eating those carbs again to go on a bulk hopefully the right way this time 😂

[@solanoaguirre6188]

You need insulin to deliver aminoacids for your cells, so eating cabs can help you build more muscle.

[@SigmaPathfinder]

Solano Aguirre I think what my problem was before was that I mixed carbs with fat too often and instead of the insulin shuttling amino acids from the protein it shuttled fats in instead. It’s kinda different going back to a “normal” diet from being in keto for so long and I’m almost afraid to eat carbs for the fear of putting on too much fat 😅.

[@thomashewittknewit5510]

Loving the new videos as always I learn quite a bit from your channel tbh very professional. Thanks again for sharing with us.

[@ameliacarey3315]

How does this impact A1C?

[@oa2621]

For the holidays I went off my Keto and OMAD routine for 12 days. I ate about 5 pints of Ben and Jerry. Cakes and pastry. Rice, bread and a whole bunch of other kinds high carb foods...I gained 15 lbs in 12 days.(water and inflammation) When I went back I had .6 Ketone blood reading in 1 day of OMAD. I was SHOCKED. I thought I would be out of ketosis for sure and would take me 1 week to get back. Afterwards 1 day of Dry fast...1 day of water fast. 2 days of Bone broth...my weight went back to normal.

[@sylvieherard4880]

Thank you so much for all the amazing info! This information is hard to find.

[@Mountainlion25]

Hi Thomas, new subscriber :) I have dabbled in IF in the past when i was 3 stone lighter, but after watching your videos over the last two days, realised how wrong i was doing things! coming to the end of a 24hr fast now and i have the RIGHT food to break fast on standby!!! Thank you for sharing all you know! its more valuable than you think! Dan

[@brownpunk1794]

Need to lower my glueghost.thanks sir

[@davidkay2987]

How often should I fast with insulin resistance?

[@cpk2GIRL]

This is a great point / counter-point video & references on Metabolic Flexibility by way of Fasting. Nice job! Thx for always including your literature search.

[@jxg151]

The more longer fasts that are done, does it not then get riskier and riskier when we eat carbs after the fast? Blood sugar could progressively spike to higher and higher levels, especially when we break the extended fasts.

[@davidjones4063]

Good video, You missed the the even bigger changes or reversal if you deplete the glycogen from some larger muscles while fasting. It forces the muscle to accept the glucose to recharge the muscles glycogen store. This works great for me as my glucose drifts significantly while fasting (Diabedic) otherwise.

[@FLJD427]

Excellent. This explains my basil glucose elevation. I often now see fasted glucose of 104-106 mg/dL doing 5x OMAD per week and fasted gym. Previously I was pre diabetic II but reversed it 2 years ago and routinely got to 80-90 mg/dL fasting glucose. Even at higher fasted glucose I am still producing reasonable ketones even in this higher glucose context at around 1 mmol/L. I presume though that my Glucose-Ketone Ratio (GKI) is not as low so I get less autophagy and anti-cancer effect unless I go to extended fasting.

[@AlessandroArnulfo]

Hi Jim, I’m in a very similar situation. Pre-diabetic 1.5 years ago, got into Kito and 20:4 for 5 days a week and 2 OMAD. Initially my glucose level was going very low: 70-80. Kitones 2-3. Recently the glucose climbed up in the 95-105 and ketones down to 0.7-1 I have been wearing a freestyle libre so I know my glucose value and can compare with the past. I wanted to do an insuline test to make sure it is still low. I’m also interested to know if because of this we have less benefits on autophagy and potentially to fight cancer. I’m 2 year free 💪

[@Meuc-bs1yz]

Important! Many times you state that Stevia won't break a fast but Dextrose will. Does this mean I'm breaking my fast when adding Stevia in the Raw to my green tea? Thanks Thomas!

[@MariahFan09]

Yes! Got to get the stevia that doesn't have dextrose

[@christophermeade7565]

But how will my A1C number improve if the blood sugar is always high because of fat adaptation?

[@nickm8808]

Hi Thomas, great video, appreciate the science. Thanks also for your feedback on a thumbs up to add pushups (30-40 reps) and crunches with my endurance training (treadmill due to winter in DC area). I’m 50, generally fit, looking to lose 15 lbs of fat at this point. Seen a few requests for adding muscle mass on Keto for weight loss (sans carb cycling). As part of such a video, would appreciate more information on differentiating low rep (ok on Keto as I recall) weight training, normal 6-12 reps per set (to be avoided as I recall from one of your excellent discussions), and higher rep (again ok as I recall). Thanks again Thomas for sharing the research and appreciate the integrity of how you select the products you recommend as a part of these awesome clips!

[@Codester91670]

So it's good for everything but cholesterol then basically? Or does the Cholesterol level out to normal limit range?

[@jamiepayne3373]

I started keto since I got gestational diabetes and sometimes my sugar is high even with insulin, I hope this goes away...5 weeks till baby 👶

[@andrehalim469]

If the glucose is not needed for cells other than brain and nervous system then why is it high? Wouldnt it be low and within parameter ie below 100? And why is a1c relatively high as well 5.7 indicating on avg glucose level is high. Fasting insulin is super low tho.

[@sandraibrahim43]

I just a quick which doesn't have have to do with this video. Im a nurse and I've been in the healthcare system for 20 years. Typically a good hospital promote patient care and patient safety based on Evidence Based Practices which is constantly revolving. I was watching your older videos and was curious if the information you spoke about still hold true to today because as we know science has shed new light on what we once thought was true. Just curious. I love your channel especially the science aspect. Keep up the good work! Hope you and the family are doing well.🤗

[@AH-ik3pv]

So when intermittent fasting, do you do it every day? I normally fast 16-18 hours each day but am I supposed to take a break? I would like to lose weight, I need to, but I really want to get into better shape for the health benefits rather than looks. I’m also trying to conceive with hormonal issues so I don’t want to do anything too crazy that will make an already difficult task impossible. Thank you Thom. I have shared your channel with many and really appreciate the scientific information in a way we can understand.

[@AH-ik3pv]

DieWithUrBootz On Thank you! I can definitely add coconut oil, I love that stuf. But, what is an xeoestrogen (sp?)

[@belizeguy]

Excellent ! Sure am noticing the surprise weight loss of after fasting. Works for me ! This was another great video . Thanks

[@Merzui-kg8ds]

Both the Tesla and the Lamborghini use a lot of energy. The difference is not the amount of energy used, it's the source of energy used.

[@dennisb7930]

Wow amazing Thomas this is so cool,it's amazing what the human body can do!Thanks again

[@TheRlulow365]

I’m type 2 and I fast 24 hours twice a week and I recently noticed my noon test was higher than my morning test and it was freaking me out. THANKS for the info!

[@kevinharvey9585]

Good Morning how long have you been fasting? and has it helped your A1C numbers gotten better?

[@pam5389]

Type 2 diabetic but was told a long time ago I was insulin resistant but was never explained what it meant. When I fast my blood sugars go down and usually better than or as good as long acting insulin that I take.

[@rohanronad6569]

You are a well read guy Thomas! Kudos.....thanks for the video.

[@christophiluslovingchristb5441]

I have declared war on diabetes 2. I have, 2 months ago, been dx w/ insulin resistance (diabetes 2) and am just learning to read my meter. I know it's not just about blood sugar but changing a lifestyle. I have one inquiry. I have started to go to the gym. When my blood sugar is in the 200's, is it okay to walk on a treadmill at that time, & how low do the numbers need to be before I get on an elliptical machine? I normally, on the elliptical, go about 4.5 mph. That's my normal speed on that machine. Is 200 too high to be going at that speed on an elliptical?

[@TechNoir666]

4 years keto with insulin resistant PCOS. I fast 12-16 hours most days due to convenience. Am I doing my body a disservice with all of this unintentional fasting? 1200 calorie diet with less than 20g net carbs pretty consistently.

[@godsstandards]

What's the best type of intermittent fasting to increase insulin sensitivity?

[@oa2621]

the longer you go without eating the better.

[@godsstandards]

Thanks, but that's not intermittent fasting.😕

[@oa2621]

Jeffrey Hoffmann 16 hrs fast is better than 14 hrs...20 hrs fast better than 16...23 hrs fast is better than 20 hrs. If that is not intermittent fasting then I am confused.

[@godsstandards]

If a 23hr fast is better than 20, is 30 better than 23? Is a 40hr fast better than 30? Is a 60hr fast better than 50? Thomas stated that long-term fasts decreased insulin sensitivity, but short-term fasts increased insulin sensitivity. I know people who fast 21 days, some 30 days, some that only eat every 48hrs. The study Thomas cited claimed that those who fasted for 60hrs decreased insulin sensitivity. At what point does a fast become short-term? 48hrs? What's the best type of intermittent fasting to increase insulin sensitivity?

[@oa2621]

Jeffrey Hoffmann my understanding is that anything under 24 hrs is intermittent fasting