FREE USMLE/COMLEX Question Bank | Question #49

[@matthewwilcox2942]

First semester in med school is almost over and this is the first time I was able to arrive to the correct answer with the correct thought process. Thank you for the resources!

[@DirtyMedicine]

Great job!

[@WhyNot-si4pj]

Uncouplers of oxidative phosphorylation like 2,4 dinitrophenol (DNP) ==> enhanced metabolism , increased oxygen consumption & heat production WITHOUT essentially disrupting the electron transport chain OR increasing the NADH/NAD ratio . BUT with time ; the increased oxygen consumption can NOT compensate for the increased metabolism & the subsequent surge in the NADH + H levels in the mitochondria ==> eventual increase in NADH/NAD ratio ==> increased Lactate / pyruvate ratio ==> mild LACTIC ACIDOSIS . That MILD lactic acidosis is NOT sufficient to cause a WIDE anion gap metabolic acidosis , but rather a NORMAL anion gap metabolic acidosis . Lord knows best .

[@__GGlove]

Is this for usmle step 1 or 2

[@tau2791]

Thank you Sir.

[@salo7328]

Super

[@taskeenhyder703]

nothing just saying hi dirty ..love u