Friedel Crafts Alkylation and Acylation Reaction Mechanism - Electrophilic Aromatic Substitution

[@TheOrganicChemistryTutor]

Final Exams and Video Playlists: www.video-tutor.net/

[@SquatSimp]

In case anyone was wandering like me: there is no inherent difference in the mechanism of Friedel Crafts Alkylation vs Acylation. The difference is one is the addition of a alkyl group and the other is the addition of an acyl group. In case you don’t know what that means (I didn’t lol!) an acyl group has a double bonded oxygen whereas an alkyl group does not. Good luck! And thanks for the upload man- this video helped me out tremendously.

[@peachdumpling9053]

Michael Carnahan and you need an acid like HCl to get rid of the oxygen right?

[@VipinSingh-xq4tt]

Good analysis of reaction

[@MinaColaco]

The difference is that an acyl group does not undergo rearangement, so if there is a product you need from alkylation, but the group would rearange, simply take an acyl group and after adding it to the ring, break the c=o bond with An acid as said in 17:29 and you are done 🤟🏻

[@skyeblue5134]

literally the answer I was looking for. Thanks #inorganicexam

[@TotalGamer2100]

Good one mate thx

[@anandai3480]

Wow... How did my prof make this sound so convoluted and difficult... and hearing you explain it it's so straight-forward.

[@GM.Nobody]

well shit, I'm having this in high school. 0 explanations given.

[@RRtIIT]

This question at 11:58 was asked in jee adv 2022! Thanks man i finally understood why propyl benzene is not the major product

[@PravallikaKolluru]

This is an eamcet q as well

[@nword683]

This is easy as shit brother If you don't know this then you have issues in rearrangement of carbocation 😊

[@davidlei6354]

@@nword683 lmfao

[@Unknown-xe6ni]

​@@nword683he gave jee advanced, you didn't. What's even the point?

[@leolegendesports7277]

Bro you gave me back my confidence ggs brother would never forget you if I get a good college this time

[@paoboonjinnz]

omg I finally understand why highly activating and deactivating groups cause no rxn. thank you!!

[@tarierann9997]

There is a mistake in 16:22, it is supposed to be tertbutylbenzene instead of isopropylbenzene

[@sensation1162]

他不小心畫錯了 畫太快了八!

[@whatever9506]

@@sensation1162 100%

[@sravanboi4205]

@@sensation1162 learn english

[@donut8979]

@@sravanboi4205 youtube has provided the translation feature for a reason.

[@sravanboi4205]

@@donut8979 humans have been given brains for a more important reason

[@melevane6871]

this helped me alot !!!!my exam is next week and i was looking to good explanation like that . thanks alot💕💕💕✨✨

[@aamalrahim5597]

Hydride shift! Right! That's exactly what I needed to know.

[@Marsha_du_]

Thank you so much for all your videos. Honestly I understand everything perfectly when I am watching your videos. Its so helpful and easy explained. Wouldn't know how to write my OC exam without it. Thank you !!

[@johnblacksuperchemist2556]

GREAT VIDEO......he always says something that makes me think. You could use the mozingo reduction also to get rid of the carbonyl after acylation. Also for F.C. acylation you need at least a stoichiometric amount of catalyst cause the catalyst form dative bonds forming complexes with carbonyl oxygens (their lone pair electrons) so the catalyst is not regenerated. Throwing some ice water in at the end of the reaction will break the adduct

[@marbellaguerra9085]

Your videos are amazing!!!! They help me so much. But the volume is always so low. It's so hard to hear on my computer. When ads go by, they are so much louder than your videos. But anyways thank you for all you do.

[@julietawadrose7878]

I Love you so much !!! thank you, thank you, thank you! you are amazing and Your videos are the best !!! I would be dying in my class if weren't for you and your videos. You have such a great talent for teaching. My professor sucks and he loves to waste time he's been driving me mad !!

[@ShubhamKumar-qc1fy]

World best chemistry chanel

[@Encrylius]

Vinyl halides and aryl halides do not react in Friedel-Crafts alkylation. B/C the carbocations derived from those halides are highly unstable and do not readily form. THANKS!

[@Ruchibiswas2]

Amazingly explained. Loved it.

[@mubarak4768]

Great..love from india

[@kinglerdreamer6921]

At 16:30 you went from a iso propyl to t-butyl ...is that correct, I thought only the double bond would form

[@kinglerdreamer6921]

I'm assuming it's a minor error. Thanks for the video, appreciate it!

[@minjinseo3681]

Yes there would be formation of double bond; however, it should be tertbutyl, not iso.

[@G_Primo]

Much appreciate for this video! Will you make another video for intramolecular Friedel-Crafts alkylation and acylation? Thanks!

[@jesusmrosario-claudio4104]

Thank you once again.

[@zaindanish9942]

Very helppppfuulllll.... Thanks a lot!😇😇😇

[@KBH4]

your voice man like wow xd really good 👌 lol

[@samsonjoseph1908]

It's a nice work thnk u

[@GuruprakashAcademy]

Good Lecture.

[@santicruz4012]

14:42 Why does the base (Cl-) attacks the hidrogen instead of the carbocation?

[@حسينحميد-ذ5ث1ق]

Thank you very much doctor

[@chiyengokambinda9717]

your're the best

[@shyn1614]

Just a quick question... at around 4 minute, Cl- is a really weak base, how does it take H away? Thx!

[@grungepunk34]

you said that the methyl chloride wouldn't work the first way, but could you use the Acylation method with the ketone oxygen to form a methyl branch on the benzene?!

[@uttarandas]

Isn't there any general form of these reactions?

[@kaustubhsharma963]

brilliant

[@gavink6437]

Shouldn’t benzene’s double bond present in the form of ring ?

[@vihaangoel3157]

BELISSIMO!

[@alexsosa6588]

why do we use that form of acyl?

[@sumitraturi7791]

Toooo good

[@TheMrAnnihilator]

You mentioned that NO2 will prevent alkylation from occurring, but what about acylation? Can acylation still occur via meta-addition if NO2 is present?

[@minjyoo6807]

No, it can not occur considering that a nitro group is an Electron Withdrawing group, a positive charge will be resonating. The alkylation is prevented from occurring because positive charge simply does not react with another positive charge. In the case of acylation, you are also forming a carbocation ('+' charge) which will not react like in the case of the alkylation reaction.

[@MoolaPrakruthi]

Will alkylation occur in p-nitro toluene?

[@karman103batth4]

No I guess

[@kartikpal9138]

In which grade are you studying this....

[@Qaiou]

YEAAAAA

[@g.ramanareddy576]

audio is low!

[@lendva95]

Friedel Crafts in practice: kzbin.info/www/bejne/gYK9ioCchZZ8mbM

[@lendva95]

Here's a video for this reaction: kzbin.info/www/bejne/gYK9ioCchZZ8mbM

[@obaayaaedunyah]

voice always too low