Friedel-Crafts Alkylation

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[@martinweiss5355]

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[@martinweiss5355]

Anyone an idea about the +M - effect ? Its relevant for my Test tomorrow.

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Awesome explanation , thanks for it

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i love the new intro

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thank you professor Dave

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Professor is a big lad.

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thank you so much

[@lauravaranasi6911]

helpful!

[@mireamema162]

Yor are reallly incredible and a lifesaver(THANK YOU) Although I do have a question: Does a multiple substitution happen here?

[@muramasa7537]

Nice ! My book had only 1 line n the figures n didnt understand but now after watching this i do !

[@Jorge-sv6pk]

you're the man

[@abd2002]

First video? 😮

[@karenopt]

Why do we restore aromaticity? What is the significance?

[@karenopt]

Also, when is rearrangement needed for Electrophilic Aromatic Substitution?

[@sulafaalsammarraie9681]

You are the besttttt love you my lifesaverrrrr

[@namanemo5591]

Love you prof ❤️

[@pleaseunsubscribeme8533]

Y amine doent undergo fridel craft alkylation? Is there any other compounds other than amine and phenol?

[@ProfessorDaveExplains]

the group with a lone pair will interact with the lewis acid catalyst before the alkyl chloride has a chance to

[@bryannabueno2064]

why am I payin all this money for school and learn nothing but KZbin is free

[@kuntalkoley3107]

Sir, what you are discussing is Friedel craft alkylation. Have you made any vedio on acylation?

[@ProfessorDaveExplains]

yep, i did!

[@julianlidberg7590]

I´m writing my exam from home while watching this xd

[@lauravaranasi6911]

very helpful**

[@chem.chemistry1122]

🎉

[@broccoli1020]

the question is how much should AlCl3 be used in this reaction?

[@quinflierman7024]

1 on1

[@ballights445]

5 years later...

[@abdulbasitkhan2589]

can we use Iodine in this

[@ProfessorDaveExplains]

nope just chlorine

[@gehtdinixan1935]

where does the H comes from at 2:45? that is also attached to the ring next to the alkyl fragment

[@ProfessorDaveExplains]

every carbon in a benzene ring has one hydrogen, they are just implied unless needed for the mechanism

[@gehtdinixan1935]

Stupid me ugh, thanks!

[@jeff-freehoke8012]

There was no music. wtf

[@exoinvadedmymind1006]

What's the limitations I don't get them do u have a video of them 😭😭 polyalkylation and carbocation rearrangement

[@abhishekchunduri8285]

Sir, can u please do a video on Friedel Crafts Acylation??..it really is confusing ...only u can explain it in a crystal clear way...

[@ProfessorDaveExplains]

it's very similar to the alkylation! you can google the mechanism and email me if you have any questions.

[@tiannamurray792]

Hello Do you have a video for Friedel-Craft Acylation?

[@ProfessorDaveExplains]

nope but it's essentially the same reaction just with an acid chloride instead of an alkyl chloride!

[@ankushvasireddy8871]

This day marks the birth of Jesus

[@rayyvon18]

Can you make a video on acetylation?

[@ProfessorDaveExplains]

i'll put it on the list!

[@OneInnerDepth]

Yes Please!

[@Shugenjya]

Thanks for the explanation, But i have a question. Why does the chloroalkene wants do bond with the AlCl3?

[@ProfessorDaveExplains]

just a Lewis acid-base reaction! chlorine's got lone pairs, aluminum is electron-deficient.

[@ashutoshdash5965]

What are you doing now brother

[@fatimaalkwndy9673]

but what is the difference between this and halogenation?

[@ProfessorDaveExplains]

this is alkylation

[@fatimaalkwndy9673]

like if I had a question on the test that says to explain the mechanism of the reaction with the same catalytic complex that we used in the halogenation how would I know its not Friedle reaction? I know my question is kinda stupid but I have a test tomorrow and I am soooo nervous

[@ProfessorDaveExplains]

@@fatimaalkwndy9673 alkylation will require an alkyl chloride, so R-Cl + AlCl3 you know it is alkylation

[@fatimaalkwndy9673]

thank u sssso much sir you're life savior

[@bw6329]

May Allah bless u

[@SchizoaffectedGamer2112]

What ?

[@sanjoosona]

😂😂😂😂

[@Smaileymaile]

What's the difference of alkylation and aceylation

[@ProfessorDaveExplains]

acylation adds an acyl group!

[@rygalindo]

If the benzene ring already has a substit. group on the ring that does not prevent the reaction, I'v been told that it adds to the meta position, is this correct?

[@ProfessorDaveExplains]

the regioselectivity of an electrophilic aromatic substitution reaction on a monosubstituted ring depends on the identity of the substituent, check out my clip on o/m/p directors!

[@MuhammadHamza-fl7rn]

please use full representation its hard to understand those I'm not saying I don't know that but its easy the other way

[@ProfessorDaveExplains]

i'm not sure what you mean.

[@MuhammadHamza-fl7rn]

nvm

[@manoharsharma9468]

@@ProfessorDaveExplains I think he means its diffucult to undestand the structure orbitally

[@mohammadasifkhan3087]

why hydroxylation take place at the end of Friedel craft acylation?

[@ProfessorDaveExplains]

+Asif Khan Mohammad no hydroxylation, there's a carbonyl group that was already present in the acyl chloride.

[@medifectious]

You see how you said chlorine has 6 valence electrons and aluminium has 4 valence electrons should the chlorine not be negative because it has more electrons. If not why is that? It's at 1:15

[@ProfessorDaveExplains]

Random Help In the catalytic complex, chlorine will have a formal positive charge because it's showing 6 electrons in the lewis dot structure, one per bond and two lone pairs, compared to its typical valence of 7. One fewer electrons means a positive charge. Aluminum shows 4 electrons, one per bond. Its typical valence is 3 so this has a formal negative charge.

[@medifectious]

You mean one lone pair right or there would be 8 valence electrons 0-0

[@anshumaanshukla7443]

sir, do u have any videos that might help me with understanding the +m effect?

[@Kurosaka]

the mesomeric effect? hmm

[@user-eh9lc4wp2c]

​​@@Kurosakayeah

[@abhishekchunduri8285]

Sir, and why can't Vinyl halides and Aryl halides undergo Friedel Crafts Alkylation..whereas...a double bond involving molecule like Acyl group..undergo Fridel Craft Acylation..??

[@ProfessorDaveExplains]

it's because friedel-crafts alkylation involves the formation of a carbocation on the alkyl fragment as an intermediate in the mechanism, and carbocations are highly unlikely to form on sp2 carbons.

[@abhishekchunduri8285]

Thanks

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anybody 2019

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Any one 2021

[@Aadi129]

What are hybrid orbitals of phenol amine tetra di phosphate ????

[@Eric-sq4hd]

don't you mean chlroine is contributing 6? therefore has a +1 well done. only video on this done in 3 min.

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Can anybody explain me mechanism of Blanc chloromethylation?

[@ProfessorDaveExplains]

+Uzumaki Saptarshi the oxygen interacts with the zinc atom to form an oxonium species, which is highly electronegative. this intermediate is what the arene reacts with.

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[@ProfessorDaveExplains]

sorry i don't speak that!

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[@avelandara3823]

thank you