Friedel-Crafts Alkylation

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[@martinweiss5355]

Realy helpful thx. I´m from germany and there was no problem understanding you. So well done !

[@martinweiss5355]

Anyone an idea about the +M - effect ? Its relevant for my Test tomorrow.

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And thus, a legend was born. Destined to get yelled at by James Tour, take on many challenges such as flat earth, electric universe, young earth creationism, and having to repeat basic scientific observations 50 times only to get demonized.

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Pass the exam?

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Awesome explanation , thanks for it

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Ur going to hell

[@ramashamyleh9431]

Thanx prof. All respect for u

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Good

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thank you professor Dave

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i love the new intro

[@mireamema162]

Yor are reallly incredible and a lifesaver(THANK YOU) Although I do have a question: Does a multiple substitution happen here?

[@MiddleTN_Cubaris]

You are clutch, my good sir

[@gehtdinixan1935]

where does the H comes from at 2:45? that is also attached to the ring next to the alkyl fragment

[@ProfessorDaveExplains]

every carbon in a benzene ring has one hydrogen, they are just implied unless needed for the mechanism

[@gehtdinixan1935]

Stupid me ugh, thanks!

[@stickanimation9888]

You are coming from the last video

[@krishnapanigrahi2235]

thank you so much

[@pleaseunsubscribeme8533]

Y amine doent undergo fridel craft alkylation? Is there any other compounds other than amine and phenol?

[@ProfessorDaveExplains]

the group with a lone pair will interact with the lewis acid catalyst before the alkyl chloride has a chance to

[@muramasa7537]

Nice ! My book had only 1 line n the figures n didnt understand but now after watching this i do !

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Professor is a big lad.

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Thank you

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you're the man

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I´m writing my exam from home while watching this xd

[@lauravaranasi6911]

helpful!

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Love you prof ❤️

[@karenopt]

Also, when is rearrangement needed for Electrophilic Aromatic Substitution?

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First video? 😮

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[@medifectious]

You see how you said chlorine has 6 valence electrons and aluminium has 4 valence electrons should the chlorine not be negative because it has more electrons. If not why is that? It's at 1:15

[@ProfessorDaveExplains]

Random Help In the catalytic complex, chlorine will have a formal positive charge because it's showing 6 electrons in the lewis dot structure, one per bond and two lone pairs, compared to its typical valence of 7. One fewer electrons means a positive charge. Aluminum shows 4 electrons, one per bond. Its typical valence is 3 so this has a formal negative charge.

[@medifectious]

You mean one lone pair right or there would be 8 valence electrons 0-0

[@karenopt]

Why do we restore aromaticity? What is the significance?

[@lauravaranasi6911]

very helpful**

[@exoinvadedmymind1006]

What's the limitations I don't get them do u have a video of them 😭😭 polyalkylation and carbocation rearrangement

[@anshumaanshukla7443]

sir, do u have any videos that might help me with understanding the +m effect?

[@Kurosaka]

the mesomeric effect? hmm

[@user-eh9lc4wp2c]

​​@@Kurosakayeah

[@kuntalkoley3107]

Sir, what you are discussing is Friedel craft alkylation. Have you made any vedio on acylation?

[@ProfessorDaveExplains]

yep, i did!

[@rygalindo]

If the benzene ring already has a substit. group on the ring that does not prevent the reaction, I'v been told that it adds to the meta position, is this correct?

[@ProfessorDaveExplains]

the regioselectivity of an electrophilic aromatic substitution reaction on a monosubstituted ring depends on the identity of the substituent, check out my clip on o/m/p directors!

[@Shugenjya]

Thanks for the explanation, But i have a question. Why does the chloroalkene wants do bond with the AlCl3?

[@ProfessorDaveExplains]

just a Lewis acid-base reaction! chlorine's got lone pairs, aluminum is electron-deficient.

[@ashutoshdash5965]

What are you doing now brother

[@Aadi129]

What are hybrid orbitals of phenol amine tetra di phosphate ????

[@tiannamurray792]

Hello Do you have a video for Friedel-Craft Acylation?

[@ProfessorDaveExplains]

nope but it's essentially the same reaction just with an acid chloride instead of an alkyl chloride!

[@fatimaalkwndy9673]

but what is the difference between this and halogenation?

[@ProfessorDaveExplains]

this is alkylation

[@fatimaalkwndy9673]

like if I had a question on the test that says to explain the mechanism of the reaction with the same catalytic complex that we used in the halogenation how would I know its not Friedle reaction? I know my question is kinda stupid but I have a test tomorrow and I am soooo nervous

[@ProfessorDaveExplains]

@@fatimaalkwndy9673 alkylation will require an alkyl chloride, so R-Cl + AlCl3 you know it is alkylation

[@fatimaalkwndy9673]

thank u sssso much sir you're life savior

[@ankushvasireddy8871]

This day marks the birth of Jesus

[@abhishekchunduri8285]

Sir, and why can't Vinyl halides and Aryl halides undergo Friedel Crafts Alkylation..whereas...a double bond involving molecule like Acyl group..undergo Fridel Craft Acylation..??

[@ProfessorDaveExplains]

it's because friedel-crafts alkylation involves the formation of a carbocation on the alkyl fragment as an intermediate in the mechanism, and carbocations are highly unlikely to form on sp2 carbons.

[@abhishekchunduri8285]

Thanks

[@mohammadasifkhan3087]

why hydroxylation take place at the end of Friedel craft acylation?

[@ProfessorDaveExplains]

+Asif Khan Mohammad no hydroxylation, there's a carbonyl group that was already present in the acyl chloride.

[@jeff-freehoke8012]

There was no music. wtf

[@abdulbasitkhan2589]

can we use Iodine in this

[@ProfessorDaveExplains]

nope just chlorine

[@bw6329]

May Allah bless u

[@chem.chemistry1122]

🎉

[@broccoli1020]

the question is how much should AlCl3 be used in this reaction?

[@quinflierman7024]

1 on1

[@saptarshisahoo5075]

Can anybody explain me mechanism of Blanc chloromethylation?

[@ProfessorDaveExplains]

+Uzumaki Saptarshi the oxygen interacts with the zinc atom to form an oxonium species, which is highly electronegative. this intermediate is what the arene reacts with.

[@MuhammadHamza-fl7rn]

please use full representation its hard to understand those I'm not saying I don't know that but its easy the other way

[@ProfessorDaveExplains]

i'm not sure what you mean.

[@MuhammadHamza-fl7rn]

nvm

[@manoharsharma9468]

@@ProfessorDaveExplains I think he means its diffucult to undestand the structure orbitally

[@abhishekchunduri8285]

Sir, can u please do a video on Friedel Crafts Acylation??..it really is confusing ...only u can explain it in a crystal clear way...

[@ProfessorDaveExplains]

it's very similar to the alkylation! you can google the mechanism and email me if you have any questions.

[@Smaileymaile]

What's the difference of alkylation and aceylation

[@ProfessorDaveExplains]

acylation adds an acyl group!

[@ballights445]

5 years later...

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God this makes law school seem so easy in comparison lol

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Can you make a video on acetylation?

[@ProfessorDaveExplains]

i'll put it on the list!

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never saw it! i hope he is handsome.

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[@Eric-sq4hd]

don't you mean chlroine is contributing 6? therefore has a +1 well done. only video on this done in 3 min.

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[@ProfessorDaveExplains]

sorry i don't speak that!

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[@avelandara3823]

thank you