From axon damage to disease: common mechanisms in neurodegeneration

Claire Le Pichon, PhD, is an investigator in the Division of Intramural Research at the Eunice Kennedy Shriver National Institute of Child Health and Human Development. She earned her PhD in Biological Sciences from Columbia University in 2007, then joined the Translational Neuroscience group at Genentech, where she worked on several pipeline targets for neurodegenerative disease, including the axon injury signaling kinase DLK. She started her laboratory at the NIH in 2016, where she employs a multidisciplinary approach to investigate cellular mechanisms underlying neuronal dysfunction and degeneration, using mice and iPSC-derived neurons as model systems.
Talk description: Dr. Le Pichon will present work on axon injury signaling as a common pathway in neurodegeneration, as well as current efforts to understand fundamental differences between vulnerable and resilient populations of motor neurons in ALS.