Fructose Metabolism

[@Champselysse]

Important to remember that hexokinase can convert fructose to F-6-P to be used in glycolysis which is one of the reasons fructokinase deficiency is so benign :)

[@atlantic7949]

Exactly

[@Meso3090]

I just saw this concept tested in a UW question. Thank you!

[@gautamdubey6526]

@@Meso3090sameee, me too !

[@ghayannoor6421]

The pathway explained in the video is direct, that's why fructose builds up If this pathway is disturbed cause it has to take a long route via whole glycolysis

[@makeeblah]

another tiny detail to add, since in aldolase b deficiency, you have wasting of energy, the body's ATPs are depleted so much that all you are left with is ADP. Being in this low energy state, body tries to make ATP so that it can carry out other functions that need it. So it combines two ADPs : ADP+ADP=> ATP+AMP. SO ATP is formed but a AMP is left behind as a result. AMP is then acted upon by AMP deaminase to form IMP..which through a series of steps lead to uric acid prod. So you'd also get hyperuricemia in the setting of aldolase b deficiency. this is why patients with gout are advised to decrease their fructose intake.

[@krishvasa7644]

Damn, thanks a lot for this comment!!!

[@josephvu7775]

Fellow bootcamp viewer? ❤

[@makeeblah]

@@josephvu7775 you know it!

[@az71003]

beautiful

[@leeknow8299]

wow

[@ss11304]

amazing video and I am absolutely loving the biochem series. I've been hoping you'd upload biochem videos and my mind was blown when I saw all of them uploaded at once yesterday! I have watched so many videos trying to understand biochem, and you are the only one that has put it all together so I get the big picture finally. Thank you so much for what you do, and I will 100% be donating once I take my USMLE. also one way I remember the enzymes is fructoKINDase - so its the nicer more benign disease (which also kinda correlates to galactoKINDase deficiency, which is the more benign of the two galactose deficiencies) and Aldolase B = "B" for BAD disease (also I didn't make those up myself, but I can't remember where they are from)

[@issacgeorgy8289]

Wow

[@rdance3]

From my early 20s to my early 50s, I suffered from extreme fructose intolerance. I couldn't drink regular coke/pepsi. I couldn't drink wine coolers, apple juice or pretty much anything with high fructose corn syrup. There were some fruits that were okay, like banana and berries. There were others that were border line and depended on their level of ripeness. During the 30 years, I would sometimes intake fructose on accident. It was teriible. My stomach and entire body would feel like it was on fire and I would break out in a sweat. The only thing that would fix it was regular table sugar. I found this out while researching why ripeness had such a profound effect. It had to do with fructose to glucose ratio. So, now I no longer suffer from this condition. It all changed when I had to retire due to extreme metabolic fatigue. 10 months after I retired, I realized that I had Methylation problems. I went on a robust methylation protocol and I've been much healthier ever since. I know that fixing my Methylation has made my Liver much healthier. Was this just a marker of over-all Liver health or did the Methylation, in general, have something to do with the change?

[@kato0291]

Key fact from my most recent NBME--fructokinase deficiency can cause infertility in men (though I'm not sure why...)

[@AjayJani4170]

Sperm relies primarily on fructose and has a glut5 transporter

[@nory7684]

Because sperm prefers fructose for energy…not glucose

[@Ramora-hu2wb]

YOU ARE AMAZING THANK YOU SO SO MUCH , I'M A MED GRADUATE AND I HAVE NEVER EVER UNDERSTOOD BIOCHEM LIKE I DID AFTER WATCHING THIS SERIES , IM SO HAPPY AND GRATEFUL YOU ARE AWESOME LITERALLY

[@amankaur6456]

these videos are absolutely amazing, I never ever ever thought I would be able to retain biochem for usmle until I found this gem of a youtube channel. THANK YOU DirtyUSMLE for changing my life!!!

[@kevonmccurdy3098]

My cheapest and best subscription. Dirty your videos are life saving👌and your dedication is priceless and much appreciated. Thank you bro!

[@eddiedann6472]

Woahhhh!!! Super super cooool. God Bless you n your loved 💕 ones. Thank you 🙏 sooooo much.

[@hajaramuhammad2989]

Best biochemistry video I have ever watched. Thank you ❤️

[@pramujisinggihriyanto6901]

Very useful n complete presentation on fructose path ways....

[@debanikchakrabortty5713]

In Vasudevan there's only written F-1-Phosphate will inhibit Glycogen Phosphorylase....Here your video make me the sense why....Thank you 🥳🥳🥳❤🌸

[@prachipriya8772]

amazing , it was difficult for me to remember these concept , i was not able to solve the question of biochem , this video helped me a lot .

[@DrA902]

Remember Aldolase B the type effects- we have aldolase A,B,C work in glycolysis (high yield)

[@nutritionbyelsa]

amazzzinggggg - thank you for such high quality and clear content, you give such great explanations of the pathways and then always give context for health + medicine :))))

[@didijaja8973]

Best video of fructose metabolism ever !!!!!

[@subiriobwogo9020]

Amazing teacher. Thanks. I like the pneumonics

[@ankita2170]

Your all video are awesome. ...more than awesome thanks u grear

[@nikhitakumar]

This video really puts the dirty in medicine ;) love you and love it

[@phll0640]

Nam Mo Quan The Am Bo Tat 🙏🙏🙏 Thank you so much for these amazing video ,, God bless you and your family.

[@alevelsdemystified3410]

Why is there jaundice, hepatomegaly, renal dysfunction and hyoeruricemia in HFI?

[@rayniac211]

11:27 Glucose can convert itself to fructose? What? How?

[@Hussein4081]

Bro you’re the best 🙌

[@alevelsdemystified3410]

please make videos on the metabolism of individual amino-acids❤️

[@rian11282]

I am sooo upset i found this play list A DAY before my final in biochem. I needed this 😢

[@kudakwashemalombola2755]

I love this guy

[@anouded]

You made it easy, thank you :))

[@chewingcorn]

This video is God Damn Gucci. Thank you for saving my biochem points on Step 1!

[@DirtyMedicine]

Thank you for being a Dirty Medicine member!

[@chazwyman8951]

What about the production of uric acid and lipogenesis which Richard Johnson talks about?

[@monasingh-theo2859]

All fruits have fructose..the reason for sweetness...fructose also has kinds...different in different fruit kind....sugar is from sugarcane ...the fructose...the simplest sugar..we process, make it complex ..

[@YounesShatat]

thank you , but may i ask where will aldolase B deficiency patients get glucose for glycolysis ?

[@doctorn4910]

You save my life!!

[@pramodthapa2517]

Hi good day! Would you mind not can you post some Endocrine HY dirty video plzzz💊🙏🙏... thank you so much all of this 😍😍😍

[@sarahgaratli2182]

Why isn't glycogenesis impaired in HFI as well?

[@HairRival]

You keep saying "either" for the breakdown of F1P, but that is not true. It is a 6 carbon moiety that must break down into 2 unequal 3 carbon moieties, one containing the phosphate group and the other not so much (perfectly analogous to the action of Aldolase A, except the substrate has one less phosphate). Any plans to update/redo this video?

[@ameenah6472]

Because of that one mistake?

[@ayakhairy9352]

Awesome! But excuse me, Is hereditary fructose intolerance same as fructose 1,6 diphosphatase deficiency?

[@ЕкатеринаСерикова-ф5з]

Thank you for wonderful explanation.

[@christopherwolf3134]

Wait did you say don’t eat glucose? So I can’t have potatoes, white rice etc… what can I eat?

[@aperson3317]

I added the mnemonic to my flashcards on quizlet and it turns out you can't add profanity in there

[@adnankhan201]

Thank u king 🖤👑🖤

[@dyanan25]

Why not eat glucose in aldolase B deficiency? Can't eat fructose, sucrose, and sorbitol

[@sofiatariq7891]

U save my life n money too.

[@lexv4894]

Having a Ton of fructose in your blood is not any problem! Are you sure?

[@unays]

amazing

[@AkireHarris]

Lol just missed a question on this yesterday, good looks

[@draziza8448]

thank you so much sir

[@xaaboopinkly]

Thanks sir ❤

[@andrewfiorentino2350]

The goat

[@sarahgaratli2182]

THANK U SO SO MUCH

[@OthmanMatar]

Thank you

[@1412Z]

Thanks!

[@osamaal-faqeh3462]

thanks a lot

[@ramadhanoruch8463]

Fantastico..

[@noorqaiser605]

If dirty medicine didn't exist, i would be fruct entirely!

[@johnnytable9217]

Can i eat lemons ?

[@espanadorada7962]

You can definitely still consume glucose w aldolase B deficiency…

[@minimaletasiamina7174]

Thanks

[@its_Dr.Glass-Man]

Subscribe at first sight!!❤

[@lailaadwan1762]

🙌🙌🙌🙌

[@besmiraalija8990]

ily king

[@sondralee8539]

G = Freak ma son ry!! Fructose No Good. Nearly All Fruit No Good.

[@ankitprashar3448]

Is that you?

[@pomegranatejuice9364]

Yes

[@faisalmanan4516]

Hi, really enjoyed your beautiful videos! Thank you so much! Do you have a email?

[@DirtyMedicine]

[e-mail]

[@faisalmanan4516]

@@DirtyMedicine hi, did you receive my email? thanks

[@drkrunalpatelortho]

If you really want to go dirty on this Use this F..ck F..ck F..ck Ahh God Damn Guicy

[@ΑναστασηςΠερνετζης]

🥰🥰

[@adnankhan201]

👍

[@hiiii4854]

Lase the ATP

[@hiiii4854]

❤❤❤❤❤

[@imranrashik7234]

Dirty you should sell t shirts with your apple logo i would buy like 30 of those :)

[@agh6452]

🙏🙏🙏🙏🙏💐💐💐💐😥

[@cellulenodale4305]

you are the best sweet little dirty

[@lillianotuokwu7876]

❤❤❤

[@yahyashafiq7368]

Lecture was good as always .. but your very high yield “dirty pneumonic” sucks 🤌🏻

[@dimaxxi1426]

thank you

[@medfox09]

Thanks