Fructose Metabolism

​​SUPPORT/JOIN THE CHANNEL: / @dirtymedicine
My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.

[@Champselysse]

Important to remember that hexokinase can convert fructose to F-6-P to be used in glycolysis which is one of the reasons fructokinase deficiency is so benign :)

[@atlantic7949]

Exactly

[@hamsaaldebakey3090]

I just saw this concept tested in a UW question. Thank you!

[@makeeblah]

another tiny detail to add, since in aldolase b deficiency, you have wasting of energy, the body's ATPs are depleted so much that all you are left with is ADP. Being in this low energy state, body tries to make ATP so that it can carry out other functions that need it. So it combines two ADPs : ADP+ADP=> ATP+AMP. SO ATP is formed but a AMP is left behind as a result. AMP is then acted upon by AMP deaminase to form IMP..which through a series of steps lead to uric acid prod. So you'd also get hyperuricemia in the setting of aldolase b deficiency. this is why patients with gout are advised to decrease their fructose intake.

[@krishvasa7644]

Damn, thanks a lot for this comment!!!

[@josephvu7775]

Fellow bootcamp viewer? ❤

[@makeeblah]

@@josephvu7775 you know it!

[@amankaur6456]

these videos are absolutely amazing, I never ever ever thought I would be able to retain biochem for usmle until I found this gem of a youtube channel. THANK YOU DirtyUSMLE for changing my life!!!

[@ss11304]

amazing video and I am absolutely loving the biochem series. I've been hoping you'd upload biochem videos and my mind was blown when I saw all of them uploaded at once yesterday! I have watched so many videos trying to understand biochem, and you are the only one that has put it all together so I get the big picture finally. Thank you so much for what you do, and I will 100% be donating once I take my USMLE. also one way I remember the enzymes is fructoKINDase - so its the nicer more benign disease (which also kinda correlates to galactoKINDase deficiency, which is the more benign of the two galactose deficiencies) and Aldolase B = "B" for BAD disease (also I didn't make those up myself, but I can't remember where they are from)

[@issacgeorgy8289]

Wow

[@kato0291]

Key fact from my most recent NBME--fructokinase deficiency can cause infertility in men (though I'm not sure why...)

[@AjayJani4170]

Sperm relies primarily on fructose and has a glut5 transporter

[@nory7684]

Because sperm prefers fructose for energy…not glucose

[@Ramora-hu2wb]

YOU ARE AMAZING THANK YOU SO SO MUCH , I'M A MED GRADUATE AND I HAVE NEVER EVER UNDERSTOOD BIOCHEM LIKE I DID AFTER WATCHING THIS SERIES , IM SO HAPPY AND GRATEFUL YOU ARE AWESOME LITERALLY

[@hajaramuhammad2989]

Best biochemistry video I have ever watched. Thank you ❤️

[@eddiedann6472]

Woahhhh!!! Super super cooool. God Bless you n your loved 💕 ones. Thank you 🙏 sooooo much.

[@pramujisinggihriyanto6901]

Very useful n complete presentation on fructose path ways....

[@prachipriya8772]

amazing , it was difficult for me to remember these concept , i was not able to solve the question of biochem , this video helped me a lot .

[@kudakwashemalombola2755]

I love this guy

[@debanikchakrabortty5713]

In Vasudevan there's only written F-1-Phosphate will inhibit Glycogen Phosphorylase....Here your video make me the sense why....Thank you 🥳🥳🥳❤🌸

[@doctorn4910]

You save my life!!

[@didijaja8973]

Best video of fructose metabolism ever !!!!!

[@sarahgaratli2182]

THANK U SO SO MUCH

[@ankita2170]

Your all video are awesome. ...more than awesome thanks u grear

[@Hussein4081]

Bro you’re the best 🙌

[@subiriobwogo9020]

Amazing teacher. Thanks. I like the pneumonics

[@anouded]

You made it easy, thank you :))

[@OthmanMatar]

Thank you

[@DrA902]

Remember Aldolase B the type effects- we have aldolase A,B,C work in glycolysis (high yield)

[@adnankhan201]

Thank u king 🖤👑🖤

[@dimaxxi1426]

thank you

[@1412Z]

Thanks!

[@unays]

amazing

[@minimaletasiamina7174]

Thanks

[@xaaboopinkly]

Thanks sir ❤

[@draziza8448]

thank you so much sir

[@alevelsdemystified3410]

please make videos on the metabolism of individual amino-acids❤️

[@sofiatariq7891]

U save my life n money too.

[@phll0640]

Nam Mo Quan The Am Bo Tat 🙏🙏🙏 Thank you so much for these amazing video ,, God bless you and your family.

[@nikhitakumar]

This video really puts the dirty in medicine ;) love you and love it

[@user-ho7md4ek4z]

Thank you for wonderful explanation.

[@ramadhanoruch8463]

Fantastico..

[@monasingh-theo2859]

All fruits have fructose..the reason for sweetness...fructose also has kinds...different in different fruit kind....sugar is from sugarcane ...the fructose...the simplest sugar..we process, make it complex ..

[@andrewfiorentino2350]

The goat

[@rian11282]

I am sooo upset i found this play list A DAY before my final in biochem. I needed this 😢

[@pramodthapa2517]

Hi good day! Would you mind not can you post some Endocrine HY dirty video plzzz💊🙏🙏... thank you so much all of this 😍😍😍

[@alevelsdemystified3410]

Why is there jaundice, hepatomegaly, renal dysfunction and hyoeruricemia in HFI?

[@ayakhairy9352]

Awesome! But excuse me, Is hereditary fructose intolerance same as fructose 1,6 diphosphatase deficiency?

[@AkireHarris]

Lol just missed a question on this yesterday, good looks

[@chazwyman8951]

What about the production of uric acid and lipogenesis which Richard Johnson talks about?

[@YounesShatat]

thank you , but may i ask where will aldolase B deficiency patients get glucose for glycolysis ?

[@chewingcorn]

This video is God Damn Gucci. Thank you for saving my biochem points on Step 1!

[@DirtyMedicine]

Thank you for being a Dirty Medicine member!

[@lailaadwan1762]

🙌🙌🙌🙌

[@dyananasif1097]

Why not eat glucose in aldolase B deficiency? Can't eat fructose, sucrose, and sorbitol

[@its_Dr.Glass-Man]

Subscribe at first sight!!❤

[@aperson3317]

I added the mnemonic to my flashcards on quizlet and it turns out you can't add profanity in there

[@johnnytable9217]

Can i eat lemons ?

[@espanadorada7962]

You can definitely still consume glucose w aldolase B deficiency…

[@HairRival]

You keep saying "either" for the breakdown of F1P, but that is not true. It is a 6 carbon moiety that must break down into 2 unequal 3 carbon moieties, one containing the phosphate group and the other not so much (perfectly analogous to the action of Aldolase A, except the substrate has one less phosphate). Any plans to update/redo this video?

[@ameenah6472]

Because of that one mistake?

[@lexv4894]

Having a Ton of fructose in your blood is not any problem! Are you sure?

[@rayniac211]

11:27 Glucose can convert itself to fructose? What? How?

[@adnankhan201]

👍

[@user-hm7rt5vq1p]

🥰🥰

[@faisalmanan4516]

Hi, really enjoyed your beautiful videos! Thank you so much! Do you have a email?

[@DirtyMedicine]

[e-mail]

[@faisalmanan4516]

@@DirtyMedicine hi, did you receive my email? thanks

[@ankitprashar3448]

Is that you?

[@pomegranatejuice9364]

Yes

[@agh6452]

🙏🙏🙏🙏🙏💐💐💐💐😥

[@sondralee8539]

G = Freak ma son ry!! Fructose No Good. Nearly All Fruit No Good.

[@imranrashik7234]

Dirty you should sell t shirts with your apple logo i would buy like 30 of those :)

[@drkrunalpatelortho]

If you really want to go dirty on this Use this F..ck F..ck F..ck Ahh God Damn Guicy

[@cellulenodale4305]

you are the best sweet little dirty

[@lillianotuokwu7876]

❤❤❤

[@medfox09]

Thanks

[@sarahgaratli2182]

Why isn't glycogenesis impaired in HFI as well?