Gene Silencing mechanism

Gene Silencing - This lecture explains about the gene silencing mechanism by antisense RNA technology. Antisense RNA and RNA interference mechanisms are used to control the expression of desired genes in cell and it can be used to degrade target RNA so that the expression of proteins can be prevented.
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[@KT-mp4pk]

Best videos ever! Not even our university instructor in Canada explains this well. But your voice seems different a bit in this video.. :) Thanks for your efforts!

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[@poetxaastha]

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I can't explain that how much I understand to clear the ..concept to sea yr video ...a great way of learning ..

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Thank you.

[@tofayelahmed4900]

Excellent

[@shubhangimehta2467]

HHeyy Sir!! I mean how well you explain..no words for you! i hav been watching your videos since so long..i jst learn frm your videos nd hav been getting gud marks in all my semesters! Thankyou so much..:) I keep on sharing your videos wd my frnz too:)

[@suradentist8966]

great 😍👍🌼

[@festusruth6284]

Thank you sir. I have been following your videos and they have been helpful.

[@shomusbiologyofficial]

Glad to hear that you are getting benefit from the videos

[@livinghope8039]

Simply delivered knowledge - Thank you, dear!

[@shomusbiologyofficial]

You're welcome

[@nibeditasinku6520]

+3 1st year se Apke vdo dekh rahi honn, abb Main final year student hoon ,sare video bahat hinn helpfull hai, support you from odiaha. Thank you very much sir.

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[@siddhantpratapsingh385]

Thank for explaining,that was awesome

[@shomusbiologyofficial]

Glad you liked it

[@rashmiranjanojha8283]

Thank you sir for explaining this chapter very well... Now it will very easy for me to understand the concept...😄😄 Your videos are always helpful to me...❤️

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[@ankitayadav1123]

Soon you will have 1 M subscriber 🎊🎊🎊 and I will also be a part of that 1 M 💞 congratulations

[@vijayanagpurkar3875]

Very helpful video sir 👍 thank you

[@shomusbiologyofficial]

Glad to hear that you're getting benefit from my lectures

[@payalmodi4705]

thank u sir... ur all vedio are very nice and very useful to my study.ur presentation is excellent..

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@Megha-ij8eo]

Thank u so much sir for sharing this video...I really needed it.....😊👌👌👌

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@apurbachowdhury403]

Excellent video to understand the gene silencing

[@shomusbiologyofficial]

Thank you so much for appreciating my efforts

[@mayukhroy5393]

This Video was Helpful, Sir.

[@shomusbiologyofficial]

Thabk you

[@DrSanjeevPandey]

So many errors are there in this video...RNase H degrade RNA in an RNA-DNA hybrid. In this case an RNase L has been cited to act rather than RNase H. Now a days it is said to reside in the Dicer.

[@prashantkumar11827]

Sir can we use GENE EDITING through that molecular scissor means complete removal instead of GENE SILENCING . CAN U PLZ EXPLAIN RELATIONSHIP B/W THESE TWO TECHNOLOGIES

[@rasmisarkar6190]

Thank you so much sir for this useful information......

[@shomusbiologyofficial]

You're welcome

[@nileshm3200]

and how do we decide the sequence of mRNA or that particular gene so that we can synthesize antisense RNA to target that gene for gene silencing??

[@bsstudents8640]

thnx bht acha lec tha

[@doctorofmedicine1113]

i studied gene silincing on book i was confused later why mRNA is degredaded later .... Watching ur video i got it's importance .. Ur legend Dear ...

[@shomusbiologyofficial]

Thank you. Glad you liked my lectures. Please subscribe and share

[@archanadas3417]

It's the best explanation❤️

[@shomusbiologyofficial]

Thank you

[@sanaahmad8521]

Sir Mera aik question h kindly clear kerdy antisnes RNA Jo h wo just m RNA ko hi target kerta r RNA i Jo target kerta h genes r DNA ko

[@Abdullah-jy9dh]

Excellent Sir👍👍

[@shomusbiologyofficial]

Thank you

[@madhusambhutapatnaik923]

Thank you for such a nice explanation ..help me in my seminar presentation 🥰

[@shomusbiologyofficial]

You're welcome

[@deepeshpatel687]

Very thankful to you sir

[@shomusbiologyofficial]

You're welcome

[@charlesoad5890]

Will gene silencing work for sufferers of Thalassemia?

[@Drunicornioazul]

Good! From Mexico! Thx a lot :)

[@user-lq2mv7yf5b]

I have just heard of this concept, I have an ask can/ how can this be performed in an alive plant like in a natural area? Thanks

[@payelbasu1321]

Sir pls make a separate video on VIGS ......

[@merik6131]

Yes pls sir .will be grateful

[@umamaheswari7412]

Tq soo much sir

[@shomusbiologyofficial]

You're welcome

[@sammaher6662]

Sip plz rpl, why iue body to do knock doen mRNA. How we get complementary RNA. Is the antisense RNA ave no effect?hiw RNAase H decide irs target?

[@soumyaranjanmahanta9127]

Thank you so much 😊 Sir🙏

[@shomusbiologyofficial]

You're welcome

[@DrSanjeevPandey]

RNAi or the double stranded RNA technology does not degrade the DNA, it infact degrades the specific mRNA against which the antisense RNA or the double stranded RNA has been incorporated in the cell. But in this lecture it is being said many a times that the DNA is degraded. which is completely incorrect.

[@biologybasicsbyn.k.c.1744]

Dr. Sanjeev Pandey, he is actually confused, he think he has done all the learning, nothing is left.

[@lolohsn2515]

mRNA is degraded* not the DNA

[@jayeshbodkhe6156]

@@biologybasicsbyn.k.c.1744 better you watch your channel only 2 video with 1 subscriber lol NKC

[@shanzaynafees279]

Laaaik log 😲😲,,,,, hmain kB itna knowledge ho gaya 😳😳

[@TV-gv2ic]

thank u sir

[@shomusbiologyofficial]

You're welcome

[@botanicalconcept5889]

Thanksss sir.... Always....

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@botanicalconcept5889]

Yes...You are the inspiration of life.... Thanksss sir... Always....

[@sandhyashukla5781]

you are saying that if SOD 1 is mutated or fails to function then it may leads to ALS due to reactive oxygen species which mainly affect brain cells. Why there is need to silence this gene. Suppose if u have already ROS in our body it may affect brain cells which also leads to ALS. How is it possible sir???Please explain.

[@imaneimi346]

what is the difference between siARN and miARN

[@sharadaaysolatokala4446]

Grt vdo really helpfulll. In which hospitals is gene silencing practised. Pls let me knw. Thq

[@shomusbiologyofficial]

Not in hospitals

[@meenakshisakthi5747]

Pls sir speak loudly it is very useful

[@sudipadhikari6216]

i am higly intrested in genetic engineering and molecular biology .....plzz recommend top books for very topics..thank you

[@SambitPatra1]

Cell biology by Gerald Karp

[@praveenthanu6309]

Nice

[@shomusbiologyofficial]

You're welcome

[@nischith1]

Sir ur class is too much helpful for me. is there a video of Bio-genesis of Ribosomes

[@shomusbiologyofficial]

No. I will make one soon

[@bandishbaishali1901]

How heritable silencing of Gene can be occurred without a change in their coding sequence?

[@nikhilakumari2721]

Is this equal to genomic imprinting ??

[@tanvisharma812]

what is the difference between gene knock off and gene knock out

[@soumyamishra8990]

Nyc

[@nishantupadhyay01]

Patanjali Rice, Very NYC

[@biogenomistry6109]

Plz sir make a video on epigenetics....coz there is no any kind of good lecture here on youtube so far.. For students

[@shomusbiologyofficial]

Okay. I will consider that

[@Rajasthanmarathonclasses]

Shomo sir. you are a best teacher of science and your method are best but pls you are use hindi language

[@rukaiyamemon9908]

Why only Rnase H degrade orginal mRNA why new design is not degraded

[@asadkhn2003]

Sir can you kindly make a full video on ( mechanism of gene silencing in eukaryotes )

[@shomusbiologyofficial]

Okay

[@asadkhn2003]

Thank u so much sir

[@asadkhn2003]

I have presentation on this I so confused how to make it. I always watch your videos and make my assignments from it. U are the one who always help me thank u so much❤

[@lolohsn2515]

correction plz: mRNA is degraded instead of DNA

[@humanawaz8552]

Sir I can not understand how can we find out this is my gene of interest

[@red8527]

If you disrupt a gene (by inserting a transgene), then observe what was the effect on the phenotype, you'll identify the gene's function. How to identify the gene you've disrupted? Simple. Use a probe for the transgene you inserted & isolate the segment. The sequences on both sides of the transgene will be the gene disrupted. This is known as gene tagging.

[@supreethgowda3308]

Sir please can you make a vedio on virus induced gene silencing

[@shomusbiologyofficial]

Okay

[@aniruddhrabari2542]

Please can you give me the reference paper of this

[@shomusbiologyofficial]

Sorry didn't recall

[@Rapture-Ready888]

You need to turn on the closed caption cause I can't understand what you are saying. Also, what does luciferase do to our DNA??

[@user-xj9wg8vf9o]

❤❤

[@shomusbiologyofficial]

Thank you

[@saidharani6731]

🙏🙏🙏🙏🙏🙏🙏🙏

[@eshikabera6416]

Somu da aktu jore bolun please 🙂

[@shomusbiologyofficial]

It's the fault of the mic. I always speak loud

[@suneelkumar-bb5mt]

Sir Hindi me video banao

[@shomusbiologyofficial]

Sorry

[@suneelkumar-bb5mt]

OK sir

[@biologybasicsbyn.k.c.1744]

Plesae focus on the topic, additional informations are too much added, length of vedio also irritated. Points might be focused as Definition : Gene silencing Brief history of the topic Procedure Applications Current aspects.

[@shomusbiologyofficial]

+Basic Biology Brilliants sorry friend. I don't make robotic videos

[@king-sterbrands378]

This is the highest foolishness.... Man as ever done. Shutting off the Gods gene.

[@shantimoyjibon9686]

বেশি ইংরেজি ঝেড়ে নিজের মাতৃভাষায় বল বাবুমশাই।

[@shomusbiologyofficial]

Gadha date ta dekh. Tor social media te jonmo o hoyni tokhon.