Glycosaminoglycans and Proteoglycans

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You, with Hank and JOhn Green, and lots of others are step by step are the factors that are changing the world. Spending time spreading high quality knowledge. Thank you

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ur an idiot t maz u should study what your teacher says dumbass

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stfu, you're here for this video too, dickbrain.

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LUUUUL

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dang professors do'n't teach in medical school too!!

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@Paul Mayer Thats beyond ignorant ahaha. You have no clue how hard the material is in medical school. This is something they would spend 5 minutes on in a lecture and the rest is up to you to learn. You would be blessed to have a doctor who goes above and beyond to learn the material!

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You helped me through a few courses in my undergrad studies; and now you are helping me through veterinary school as well! Easily my favorite and the best KZbin instructor!

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hello i 'm a french guy and it is the clearest lecture i ever seen, that was great !

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Andrey is phenomenal! Thanks for all your help throughout school, man!

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Truly a fantastic lecture, clear, concise and well planned. Thank you very much for posting this!! Something that was made rather confusing has now been cleared up so easily by your one video! :)

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YOU ARE AN ANGEL SIR THANK YOU! I'm cramming for biochem and you are a total lifesaver

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Very informative! I'm most likely gonna forget what I just watched but you're amazing dude :)

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In one word "spectacular" lecture.

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This guy and Ninja Nerd are the best dudes on KZbin

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Fascinating! The human body is an incredible design.

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WTFFF I FEEL LIKE I SHOULD BE PAYING YOU for actually understanding my lesson, absolutely perfect, I love u, u high quality precise boy❤

[@ElanaSl]

Thanks so much! Usually I love my text book but with this I had no idea what it was saying, now I do. Thank you again.

[@backstreetfan2887]

This is very good information. I had heard of proteoglycans but now I understand so much more about their structure and function.

[@gayleallawan2790]

Thank you so much. I am able to understand this topic even more. You explained it really well. Good job!

[@Andrew07025]

Perfect lecture; both equally enjoyable and insightful. Very much appreciated sir, thank you

[@姜周禮]

Making hard part turning easy.I have benefited greatly from your vedio. thanks a lot!

[@onaposcar3870]

wow! i have never understood like this before, i just love the way u explain your things, thanks for the time

[@WhyNot-si4pj]

08:46 You mentioned that the negative charges on the disaccharide repeats of chondroitin 6 sulfate & keratan sulfate within the aggrecan molecules are responsible for the non covalent interaction between water & aggrecan ! Well , water is not a positively charged molecule to form IONIC BONDS to the negatively charged aggrecan molecules . But it'd rather form HYDROGEN BONDS with water molecules through the hydroxyl groups present in the polysaccharide chain of the aggrecan !

[@sudiptajana1854]

That may be possibility..but non covalent bond is also possible because Oxygen is electronegative atom and for this reason there are partial positive charge on the two hydrogen attached to that oxygen. So these two hydrogen can form ionic interaction with negative charged sulfate ion. Don't you think this is right?

[@WhyNot-si4pj]

@@sudiptajana1854 Negatively charged sulphate groups would rather form ionic bonds with other positively charged molecules ! Sulphate groups are hydrogen donors in their own right ; while hydrogen bonds are by far the most common kind of bonds between water & other molecules !

[@sudiptajana1854]

@@WhyNot-si4pj sulfate group are hydrogen donor?I don't think so..they don't have any hydrogen attached to them..and still if you think it's H bond acceptor..then I would say F,O,N are.. Secondly, water loves to form hydrogen bond but it makes ionic bond as well (like the NaCl solution..)

[@WhyNot-si4pj]

@@sudiptajana1854 Sulphate ions are the conjugate bases of sulphuric acid & monohydrogen sulphates are the conjugate bases of their monobasic salts . So the sulphate radicals (SO4 - - ) result from the proton donating activity of the sulphuric acid giving it its acidic properties . Sodium chloride (NaCl) does NOT ionize water in solution as it's a NEUTRAL salt .

[@divaroshan3797]

You are so precise at this.

[@georgiam.300]

Hi, I think you may have made a mistake with referencing heparin. The disaccharide is supposed to be heparan sulfate (composed of uronic acid and glucosamine). I only wanted to let you know because my professor made a point that it was not the same as heparin which is used in IVs for hospital patients as an anticoagulant. Other than that, this video was really helpful - thanks!

[@mohamedbabiker6653]

Georgia Molnor you are right, but it's the best natural form of anticoagulant in the body

[@TheIraqiforce]

Lol this is where I got confused

[@LukasoCZ]

Heparin is a GAG composed of disaccharides as well (namely iduronic acid and glucosamine) and one of its function is to prevent the coagulation to spread. Heparan sulfate is a GAG composed of glucuronic acid and 2x sulfated glucosamid. It`s a component of basal membranes and cell membrane structures. I don`t think he has made any mistake. The structure and function of heparin is written correctly, according to what i know.

[@محمدالأحمد-ع4ف7ش]

This is a very wonderful work 👏 🙌 😀

[@actionpotential915]

Very helpful discussion. Watching it on 23/06/2021 Tomorrow is my biochemistry xm😌

[@basharalselwialselwi5172]

Thank you for explaining ..is to easy...شكرا جزيلاً

[@arodot9268]

Wonderful explanation and drawings. They are super helpful

[@자연건강식]

Excellent lecture. it was great. Thank you a lot...

[@PacificHustler]

very nice lecture!!! clear and concise..well done.

[@payalkhandelwal1788]

thank you for explaining it so clearly.

[@JulianaBarberi]

Thank you! This is a really good explanation

[@ellios5734]

thank you veryyyy much always watching your videos

[@imogenclairexo]

This is a great lecture, v well explained!!

[@AnthonyBaroud]

Awesome video, extremely helpful for college cell biology!

[@moejousef1253]

Great delivery of the topics! thanks man

[@phitchayapaprompalad8926]

Thank you so much! This is really helpful for my intromed class.

[@manny_k2988]

great explanation, might just help me pass engineering

[@Szceith]

I was taught that the reason that the glycosaminoglycans attract water is because they attract positive ions and that it's the osmotic pressure attracts the water.

[@chisomemmanuel6160]

Thank you for breaking this for me to understand well. It's well will your soul bro ❤️

[@JKun-bm8km]

you explain it really good , wow

[@hassnaeelmouddene2280]

it was really an informative video . thank you so much

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I really enjoyed your presentation buddy

[@ashumedico12]

U LOOK LIKE LEONARDO DE CAPRIO...AND ALSO SOUND LIKE HIM..THANX AGAIN

[@rajuljain3017]

This video was very clear! Can u pls add some more videos on detailed extracellular matrix.

[@nermeenellayen9856]

Informative and clear , thank you

[@esratarig1414]

Amazing lecture , Thanks a lot

[@futuregym7903]

Absolutely great

[@DorkaBeriTutorials]

thank you for clear explanation

[@dr.poojanpatel7625]

This was totally awesome!! Thanks a lot sir!!

[@Manikaim]

Amazing sir, as always... Great help. Thankuuu

[@holzkopp5181]

Love you regards from Pakistan

[@adarshrao3815]

Thank you AK 🇮🇳🇮🇳🇮🇳

[@theclassroomdoc]

Amazing explanation, thansk!!

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thank you for share you knowledge !!!! you are the best

[@HarshitKumarSinghAnine]

Thaks for wonderful lecture

[@kareemcarzan23]

What is best for stem cell that need consumption in cell culture?...!

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I'm so thankful :( really I don't know what to say but u make it clear for me. THANKS A LOT.

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let me leave a comment here today so after 6 years someone can remind me that i finally am a dr😭

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Thank you Sir!.....this really helped.

[@wardalyasmeeb7035]

Thanks my dear .yes i watched this video that talk about cell membrane itis very helpful for me but i ask about more delials about cholesterol .

[@AKLECTURES]

Ward Alyasmeeb Go to my website, watch the lecture on "Glycolipids and Cholesterol" in the biochemistry section.

[@wardalyasmeeb7035]

AK LECTURES thanks ,so much my great teacher .God bless you

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You are a rock!

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Lol AK is out here making sure I get through PA School

[@AKLECTURES]

For sure! :)

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Chemistry sounds so much better in english than in german :D

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Splendid!!!!!!

[@معاداةالشهادةد]

Thank you I. Studying for nbde1

[@rachealmphande727]

Leaving a commen incase i become a doctor after after 4years from now

[@tg6769]

I have heparan sulfate deficiency - what would this cause symptom-wise? I am constantly fatigued. Headaches. Dry eyes

[@hamiltonkate1]

Thank you SO MUCH!

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Love from Pakistan ❤️❤️❤️❤️❤️❤️❤️❤️

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excellent. .....thank you so much

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Thank you 💕

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I miss yr videos 😭♥️♥️♥️

[@pablo9471]

Thank you sir.

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Wow !!! So good

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Thank u so much sir 🙏🙏 ♥️

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u are the best

[@afonsomalheiro]

Great video

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Sir please make a video on ELASTIN

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Great great great video

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I love you, man!

[@헤린송-o7i]

thank you so much ,

[@sucsacademy]

Thanks Dr

[@jorgeitalo8753]

i think i'm in love ♥

[@yousefbabikian6953]

Do you mean Heparin or heparan

[@fairyprincess1599]

what are the types of proteoglycan? plzz reply

[@sanketpanchal077]

Thank you sir

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Lovely ❤️

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God bless ya

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You're amazing !!!

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thank you so much

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thank you!!!!

[@wardalyasmeeb7035]

Please ..i need video about cholesterol

[@AKLECTURES]

Ward Alyasmeeb Don't we all :) I have a video on cell membranes where I talk about the role that cholesterol plays. You should check that out on my website.

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THANK YOU SOOOO MUCHHH!!!!!!!!!!!

[@bru4844]

really great information but the pacing back and forth is giving me anxiety lol

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OMG THANK YOU

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THANK YOUUUU!