Grignard Reagent and α,β-Unsaturated carbonyl compound.

[@SoniKumari-s9b1g]

BEST explanation

[@amaanarif755]

this concept is directly asked in jee mains 2023 which was unexpected, thank you so much sir for clearing the doubt❤

[@ChemistryTheMysteryofMolecules]

Thanks for informing this to me....

[@gustavocousino8183]

always thankful to indians who make these videos lol, they make it easier to understand any topic

[@ChemistryTheMysteryofMolecules]

Thanks a lot ...

[@jeshwanthnaidu6843]

thank u so much sir it really helped, this question has come in jee mains

[@ChemistryTheMysteryofMolecules]

Thank you for this information ...

[@gunjan6420]

Sir ur doing great work

[@ChemistryTheMysteryofMolecules]

Thank you ....

[@Exmuslim-sameer-fan]

Your video is helping a lot... Thank you sir.

[@ChemistryTheMysteryofMolecules]

Glad to hear that....all the best

[@valent9260]

thaank you my random indian dude

[@ChemistryTheMysteryofMolecules]

Welcome

[@ganeshkondhareiiserpune]

Thank you sir really helpful lecture.

[@ChemistryTheMysteryofMolecules]

Most welcome...

[@souravchatterjee7860]

Thank you sir

[@ChemistryTheMysteryofMolecules]

So nice of you..

[@chinmaykulkarni9424]

सर How you desicide which is harder and which is softer bond

[@ChemistryTheMysteryofMolecules]

Please mention the time of the video about your confusion

[@nidhitiwari6325]

Thanku sir...

[@ChemistryTheMysteryofMolecules]

Welcome ..

[@santoshkumari554]

How come the acetal is formed , as the acidic medium is not present , plse explain

[@ChemistryTheMysteryofMolecules]

Please mention the time in my lecture, from where your doubts are arising.. It s helpful for me to answer.. thanks...

[@nainadhall610]

Sir if we add same steric hinderance at carbonyl carbon then alkyl lithium is added so which product is major

[@ChemistryTheMysteryofMolecules]

if it is simple carbonyl , then alkyl lithium will prefer to add on C=O (if possible). But increase in bulkiness on carbonyl carbon chances on other side reaction (like alpha-H abstraction or hydride transfer) increase. However, it is always better to comment based on some example.... and for alpha,beta-unsaturated compound first priority is 1,2-addition as alkyl lithium is hard nucleophile... but we should always see real experimental facts before making any comment or generalised statement. Did u get it?

[@adj5951]

sir, I had a doubt at 15:29 when the First compound ( Ring Structure containing =O and a double bond ) is Reacted with just RMgX ( ie Strong nu ) then 1,2 addition will take place or 1,4 addition will take place, I am confused as in my notes It is written that Hard nu gives 1,2 addition but the Same compound is given and 1,4 addition takes place ( even though it is given that hard nu gives 1,2 )

[@ChemistryTheMysteryofMolecules]

Sorry for this exceptionally late reply.. I did see this message. When there is no Copper, there will be a mixture of 1,2-addition and 1,4-addition... Between carbonyl carbon and the beta-carbon, the first one is harder due to higher charge density.. So if your nucleophile is harder (more reactive, like alkyl lithium), it will prefer to add on carbonyl carbon. Reason is reactivity (kinetic factor). Now, if you use softer nucleophile (less reactive, like R2CuLi) addition will take place at beta carbon and reason is thermodynamic. Actually C=C double bond is energetically less stable than C=O bond. Next point: Regarding the hard nucleophile but 1,4-addition. Actually, two factor are there regarding the nucleophilic addition on carbonyl compounds like steric and electronic. In all of previous discussion, we mainly focused on the electronic factor. I mean in which centre charge density is more what is nature of the nucleophile (harder or softer). But if look at the substrate, I mean steric point in the both substrate and nucleophile, that will help you to conclude why harder substance undergoes 1,4- addition.... I suggest you to look at your substrate....