Michael Addition Reaction Mechanism

[@TheOrganicChemistryTutor]

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I missing missing miss

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You've been so helping that i let long ads run through so you some how get paid. Not enough but it's the least i can do to say thank you!

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Overacting 100/100

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dude, single-handedly got me an A in orgo 2. Thank you so much

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I appreciate your videos so much. You are truly saving so many people’s grades. Thank you so much for making these available.

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Thanks to this dude, I ended up with As in both orgo 1 and 2. I appreciate you sm!!

[@rambles2727]

Michael: i think im gay Michael acceptor: thats okay, Michael!

[@PunmasterSTP]

I had no idea (or totally forgot) about the difference in attack between weak and strong bases. Thanks for another very high-quality demonstration!

[@lilbanana6159]

hey! why did the weak base attack at the beta carbon and not at the carbon hving the oxygen?

[@PunmasterSTP]

@@lilbanana6159 I think that's a great question! I just googled it and found a page on LibreTexts that had this to say: If the nucleophile is a weak base, such as alcohols or amines, then the 1,2 addition is usually reversible. This means the competition between 1,2 and 1,4 addition is under thermodynamic control. In this case 1,4-addition dominates because the stable carbonyl group is retained.

[@shreemoyde7031]

I have a question. Why is not the nucleophile adding in alpha position? Why doesn't the alpha Carbon become positive since the keto group is an electron withdrawing group?

[@PunmasterSTP]

@@shreemoyde7031I think it has to do with how the electrons flow. If the nucleophile attacked and donated electrons to the alpha carbon, then the electrons from the carbon-carbon double bond would have to move onto the beta carbon, forming a carbanion. On the other hand, if the nucleophile attacked at the beta carbon, then the electrons can move up onto the oxygen, which is more electronegative.

[@nostro1940]

has nothing to do with that otherwise why would a strong base work?@@PunmasterSTP

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Getting an A for sure with this guy

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What’s crazy is that everything you’ve been posting lately I was looking for 3 months ago when I was struggling in orgo 2 😩

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[@manibhaigaming954]

good explanation bud love from INDIA

[@derrickmutuma7721]

Your videos are so helpful

[@mekdesbelete8766]

my carbonyl lecture i love you

[@lmaobuhbuh3563]

in the last step at 6:40 can I protonate the O- and then forms an enol and then the enol tautomerized into aldehyde ? (sr for bad english)

[@aiswaryanath9844]

Enolates are resonance stabilized..so that step happen faster to stabilize it. More over keto form is more stable than enol,c=o is more stable bond than c=c. Hope it helped.

[@aiswaryanath9844]

kzbin.info/www/bejne/e5jVlqdjgdWViqc A simplified chemistry channel.

[@lmaobuhbuh3563]

@@aiswaryanath9844 thank you very much

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Thank you sir you are a life saver.....can u plz do a face reveal please

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Innocent Ntuli his voice reminds me of Mark Wahlberg... I think it’s Mark Wahlberg.

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he'd probably make like 10k just by revealing his face.

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@@matthewellingsworth9238 😂😂

[@teresafernando9509]

I believe you are missing a + on the nitrogen of nitroethane at 13:16

[@yoselinelliott6744]

I was thinking the same thing! I was like do i know nothing about nitro group charges?

[@intheworldoforganicchemist7384]

Please make a video about synthesis of vitamin A by darzen condensation and reformatsky condensation

[@newchannel636-y6s]

More than awesome.very helpful..subscribed to your channel. 🙇‍♀️

[@chemist7908]

This was very informing, could you at some point do the thia-michael addition

[@shanzasalam2630]

Thank you Soo much sir 😢

[@5minchem563]

Very nice example of steric effects, which prevent the attack on carbonyl and favor michael addition’s product formation. Well done 👍🏻 I also just made a video about Michael addition and would be happy to hear honest opinions :)

[@anubhabgoswami7188]

I have a question suppose there is a leaving grp like a OME on the acceptor will 1,4 addition still be there or can the grp(OME) leave?

[@fabiocetrulo4462]

Massive legend

[@priyasharma-ki4mq]

Thanku soo much sir very nice explained

[@kashifarashidmalik6257]

Superb sir

[@gargitripathi6331]

Thank you so much sir

[@mediwise2474]

Can acrylamide and acrylic acid undergoes micheal addition

[@gaphenprojects4172]

Thanks Ganzalo

[@samriddhimishra557]

In the last ques won't the water also hydrolyse the cyanide to an acid I just got that part wrong...???

[@1.4142]

If you're named michael you should apply to the michael acceptor school.

[@kaviyarasanm7133]

Sir how to calculate pka value?

[@abouddrogo2504]

Can you add mannich reaction plz

[@adarshck3010]

Thanks

[@Inuhoozuki]

Whats the first prodcuts name o: ? Please and thank you

[@timotheus34]

I think it is called 3-(1-oxoethyl)hexane-2,6-dione but I am not 100% sure if the =O at the last carbon atome is named as a ketone or an aldehyde

[@sumitsinha4199]

Thanks sir

[@羅孟軒]

Awesome

[@akmikki3251]

Isnt there a Internal tautomerization going on instead of just adding a hydrogen? kzbin.info/www/bejne/mnbHpIVja8l-jac

[@pengpleb9523]

sup michael; patreeeeek

[@nostro1940]

wants to explain the michael reaction... 1st we need a Michael donor *DOESNT EXPLAIN WHAT A MICHAEL DONOR IS* And people wonder why chemistry is hard... it's not hard but the teachers suck