Grignard Reagent Reaction Mechanism

This organic chemistry video tutorial discusses how to use the grignard reagent to reduce ketones and aldehydes into secondary and tertiary alcohols. It also explains how to reduce esters and acid chlorides to alcohols using the grignard reagent.
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[@ujjwalkumarsingh5216]

Thanku sir ..I had confusion in this part

[@negar21100]

@7:03 Why didn't O get protonated at this moment? Why did it kick the OCH3 out instead?

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[@shashaniou4]

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[@ritankarmondal0411]

Can't thank you enough man! I was facing doubts in grignard reagent and this cleared everything! And a quick question. For the compound in 9:45 won't a ring expansion be more favourable before the addition of the -R group?

[@ashaydwivedi420]

this is an SNAE mechanism! rearrangement is only possible when a carbocation is formed. this reaction involves carbanion nucleophile and no carbocations are formed, so no rearrangements

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wdym

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[@billalzerouali4472]

Why is at times the h30+ is written under the arrow and other times it isnt even though its still used

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[@toxicevolution5940]

Doesnt it matter that you change the position of the CH3 Group in the first example?

[@fantasiaford1283]

So, the Ch3Ch2, we use it twice because we need the oxygen to be negative in order for it to do the proton transfer of hydronium? So it can be an alcohol?

[@GoogleAccount-mz6vn]

At 7:14 why didn't the O¯ get protonated and turned into an alcohol instead?

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[@laurensadowski2403]

9:28 are there supposed to be that many carbons attached to the grignard reagent?

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Best explanation ❤

[@bailassandijani3788]

could you please make a discussion about Reaction of Grignard Reagents with Epoxides thank you

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thank you so fucking much

[@a0927020973]

4:28 Why magnesium will insert the carbon atom?

[@ericraululyeetusdelyeetus5028]

Had to go to this video after seeing a legendary meme about the reagent. Who would've guessed a well edited clip of black'n'white daffy duck would be so funny?

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Great session

[@urvitiwari6754]

is attack by GR always SN2? is there a possibility of rearrangement or ring expansion?

[@nabiniim]

What I really want to know though is what happens to the Mg2+ and the Br- and also the H2O? 🤔😩

[@robochibi]

The MgBr is actually attached to the O- that was broken but it is not shown in the video. When an acid or hydronium is added than this attacks the MgBr bond and replaces it with a hydrogen thus giving an OH group. Your byproduct would then be a OHMgBr or ClMgBr depending on what you used to remove that MgBr group from the O- group.

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A very useful video, thanks!

[@fredt8167]

At 3:35, if we had to name this structure would be it be (A) 1-ethyl cyclohexanol or (B) 1-ethyl cyclopentanol? If its (B), why? when counting the longest chain starting with the ethyl group

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Im learning from these this one just seemed like you were going kind of fast.

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[@CR1257]

How do you know what side to put your reagent on? I keep thinking that you could choose either or because you’ll still end up with the same answer..? 08:26 I’ve seen others put their reagents on the aldehyde side and they’ve gotten it the answer right.

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[@alimuhtasham4045]

so basically grignard agent perform nucleophilic substitution ? i'm new to this i ain't getting things fast

[@sumzk]

It's technically a base which would abstract an acidic hydrogen if any. If there are no acidic hydrogens, it undergoes substitution

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Thanks

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Helped me a lot thanks

[@amirfilabs7716]

At 12:18 I believe this is an epoxide ring opening under basic conditions so the OH lands on the more substituted atom, please correct me if I’m wrong

[@emmaaustin544]

Awesome! Thank you

[@siobhanquinn4635]

I’m struggling to understand how you could only have three carbons and end up with four in the end ?

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[@RotationMan13]

How do you know of the Carbon is partially positive or negative?

[@ujjwalkumarsingh5216]

When carbon is attached to a more electronegative atom like O of N ..the more electronegative atom attracts the shared pair of electrons from the electron cloud towards itself ..so it develops partial negative charge.

[@bbannannassu]

if there is not indication that there are 2 equivalents of grignard reagent then will the product be ketone?

[@Bdots44]

would be aldehyde with only 1 equivalent of grignard

[@Bdots44]

no nvm, 1 eq of grignard means the reactant is aldehyde or ketone, but the products will always be alcohols for the girgnard reagent. 2 eq of grignard means reactant is ester or acid chloride and the product will be an alcohol with 2 R groups. For 1 eq of grignard that reacts with either aldehyde or ketone, product will also be alcohol but with only 1 R group

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THANK U

[@phenomenalphysics3548]

6:53 how do I know something is a good leaving group?

[@zhangzhengyifan6117]

the less basicity one group is ,the better it acts as a leaving group

[@ritikshukla1788]

The more stable the leaving group is as an individual the better the leaving group

[@ritikshukla1788]

(in the case of CH3O- the negative charge is on oxygen which is highly electronegative and hence the molecule is stable)

[@jeewanpreetkaur5872]

Which is individually stable that is gud leaving group

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[@madeleineguzman5025]

where did we get the 2 carbons to add to the 4 carbon chain on the last problem?

[@sukrutha8788]

thank you so much for this video! your explanation made everything easy to understand

[@shammah5976]

example 4 at 7:34 why are there 2 ch2ch3 to react with??

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[@mikedavis7636]

What if you created a grignard reagent with bromobenzene and magnesium, then bubbled carbon monoxide through the solution?

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Thank you!!