Haemochromatosis (Iron Overload) - iron physiology, causes and pathophysiology

"Haemochromatosis is when there is too much iron in the body - iron overload. Excess iron leads to saturation of the plasma iron-binding protein transferrin . Iron begins binding to other things including albumin, citrate, acetate. This iron is referred to as non-transferrin-bound iron (NTBI), when this happens cells take up NTBI mainly liver, heart, joints and endocrine organs. Here the undergo biochemical reactions which create reactive O2 species which in turn can cause tissue damage, inflammation, and fibrosis.
Iron overload causes cardiomyopathy, cirrhosis and arthropathy.
Causes of iron overload include increased dietary intake, iatrogenic (from blood transfusion or iron transfusion, hereditary such as hereditary haemochromatosis"
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[@jenniferkempa4148]

It's amazing that you did a video explaining this. So few people have heard of it in the United States - even family physicians. It runs in my family quite extensively.

[@medlecture4838]

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[@growthzack9542]

I’ve seen countless doctors about my symptoms (internal tremors, trouble breathing upon falling asleep, chest pains, poor circulation, etc). They all attributed it to anxiety. I finally saw a holistic doctor and be immediately said it’s iron overload. Getting blood work done this week. Let’s see what happens. I need relief

[@Zerturnosrs]

Hey man are you still going through this? I just got high iron on a blood test and Ive lost 17kgs in in a few months. Was told it was anxiety too

[@growthzack9542]

@@Zerturnosrs Yes, but it doesn’t seem to be iron overload. My tests came back normal, including iron levels. The investigation continues. I have been using some new strategies that seem to be improving things for me (getting my dopamine baseline back to normal, no eating 3 hours before bed, etc). Considering that your levels are high, you should fight to rule out every possibility. It might be iron overload - most American doctors aren’t even familiar with the condition. Get as many 2nd opinions as needed for you to be 1000% sure

[@Skybluewindcool]

@@growthzack9542 Do u have iron overload ? Your Hemoglobin level is ?

[@howardmann8689]

My ferratin has dropped from 4100 to 2300 after 3 blood draws in 4 months

[@Skybluewindcool]

@@howardmann8689 What are your symptomps ?

[@leahmhoward]

Thank you for this. This disease runs in my family and even as a paramedic so little is known about it.

[@donovanlucibello379]

Stellar video, very concise and clear. Cheers!

[@jesusandmedicine1950]

Thanks for sharing this lecture. It was helpful and informative. God bless you

[@medlecture4838]

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[@brianfoley4328]

Just outstanding....great presentation...Thank You

[@salvadormercado3731]

UN VIDEO INCREIBLE!!! MUCHAS GRACIAS MASTER

[@sarahc.167]

Thank you so much. This is exactly the video I needed! Great graphics and explanation

[@medlecture4838]

kzbin.info/door/Mm0dSPawfVKMsQuEpcwvPA

[@samuraimaster99]

best video I have seen on this topic. thanks!

[@joemama-tn7zl]

By far the best explanation on you tube

[@lienbich6557]

thanks for ur video, it makes me get clearly about the hemochromatosis mechanism, hope u upload more videos about the other system, from vietnamese with luv

[@bulutewr3314]

That's amazing, thank you so much

[@ivetamosesyan4621]

You are the best. Thanks a lot👏👏👏

[@angelinawilliamson6841]

Great explanation thank u

[@andora9695]

Your work is absolutely insane ! Thank you so much :)

[@TheRustyLM]

That was great! Thank you!

[@aloevera1269]

God bless you for your work!!!

[@elcancerynosotros.7036]

Wow! Amazing synthesis of this patology. Thanks!

[@abdulmajidmuhammad15]

Your videos are very helpful really!! Thanks for the effort and all But can you please do a video on the pharmacology of Anti-biotics and anti-fungal? It'd really help

[@erfanlatoon1050]

Thank you teacher

[@elcancerynosotros.7036]

Outstanding!

[@prosperitypeace1554]

Thank you 🙏

[@shivasaipraneethbethi8150]

Good explanation

[@hothanabdi625]

Thank you from Kenya 🇰🇪

[@nicealloys]

I have just been diagnosed and have several side effects I'm just trying to understand it all thanks for the video ❤

[@user-dp5ny7ee5g]

Thank u 💙

[@Clinical1114]

Thanku sir ❤️❤️ .

[@fbluejay4194]

I hoped you'd mentioned the induced effect of inulin on hepcidin (therefor insulin resistance and predibetics are high risk)

[@1aliveandwell]

Interesting. Did check 23andme results and all neg for this. Checked as 3x's in last 2 yrs had slightly high iron, but ferritin ~34,45.. Confusing, but have read on B12 that have high labs may not be correct as antibodies can interferre with some analyzers. Need B12 (which needs B2(Se,I) to use iron, so many connections !

[@Mickymouse-lx8eb]

Very very interesting 🤨

[@user-bh3uu5sb2z]

Please discuss ditals about analysis chimestry body flouds.. As blood chimestry.. Liver function.. Kidney function..... Urin.. Stool.. Spotum

[@ArabMiracles]

very informative, THANKS

[@adsaad]

My current iron level in my blood is 165. (The normal range is 45 - 145) ug/dl. Is my level alarming? Thanks for your attention and for your videos.

[@Sundasfashion]

please one vedio for THORACIC VERTEBRA i am your student and i need your help in thoracic vertebra topic please

[@szintivideo2984]

The black tea is effective against high blood iron level. For me helped a lot, and made me healthy again.

[@marypolk9820]

Is that regular tea or a black tea????? I have high iron. I don't think I can give blood though. I do take liquid vitamin C.....

[@szintivideo2984]

Black tea ! Only black tea, nothing more! I using high dose multivitamin without iron. The zinc and copper helps reduce the iron level too. I using them too, in my multivitamin complex.@@marypolk9820

[@vonnanolan7811]

Zero data to support this

[@szintivideo2984]

Then try it ! @@vonnanolan7811

[@MrAbi123]

That’s because of oxalate dumping also don’t eat enriched/fortified foods if your iron is high

[@hicoteo]

My step dad developed iron overload as he aged. For other reasons he went on a keto diet for four months, lost 40 pounds, then continued to eat healthy. His iron problem went away.

[@qamirnamroudi5802]

Top ..

[@laurenhanlon]

My ferritin is 46 but my haemoglobin is really high? I need to raise my iron but I don’t want to raise my haemoglobin too much? What can I do?

[@RobertBrown876]

I just saw a correlation on another KZbin video that over time as your body takes out more iron. It just accumulates in the body and thus overall you have a shorter lifespan How do you... A. Remove iron that has gotten into the organs. That has accumulated acutely over the past 20-30 years B How do you minimize the effects of the biochemical reaction of the oxidative reaction that takes place once inside your cells? c. How do you reverse the damage from the oxidative reaction in the organs? (This is assuming small accumulative iron over the 20 years, this is not signifying any disease amok to any point)

[@theaprecup]

Hi, I am curious why iron would be high but ferritin would be normal.

[@XxxPYTHON]

How iron toxicity reduce by medicines, how they work please explain

[@user-pc9si7wo7o]

Thank u from Iraq 🇮🇶❤🥀

[@user-dp5ny7ee5g]

سجاجين

[@user-pc9si7wo7o]

@@user-dp5ny7ee5g شتسوين هنا اذا مو سجاجة هم 😉

[@Hadeel_Alhamad]

ايش معني سجاجين؟ 🤔

[@user-dp5ny7ee5g]

@@user-pc9si7wo7o هههه اجاني الاشعار وكلت خل اشوفه 😎

[@user-dp5ny7ee5g]

@@Hadeel_Alhamad يعني يدرسون

[@Jack-uy7ie]

What about the benefits of the mutation?

[@Brim_the_Wizard]

Tiamat bless

[@ok-kb7yz]

Armando.....the link to purchase PDF has broken. Hope you'll fix it soon. I have to purchase some PDFs soon for my exams.

[@armandohasudungan]

hmmm not sure, Check now?

[@ok-kb7yz]

@@armandohasudungan now ita opening but when i click add to cart option this happens. armandoh . org 500 Internal Server Error An error has occurred while handling your request. The most common reasons for this are: A malfunctioning script or CGI application. An invalid or inaccessible .htaccess file. Please contact the site administrator for assistance. If you are the site administrator: Enable and check your site's error log for more information. Check to make sure CGI scripts are set properly executable. Make sure CGI scripts are uploaded in Unix text file format (newline-only).

[@ok-kb7yz]

@@armandohasudungan pls fix it. My exams are Scheduled next month...... I have to revise everything within 25 days.

[@CEJM100]

It's still down 🥺 I'm hoping to purchase some pdfs as soon as it's back up

[@ok-kb7yz]

@@CEJM100 i know, but what can we do.......... Armando, pls fix it buddy.

[@daffaho4921]

Pathophysiology means study of altered physiology of host for all neet aspirant 2021 💥💣💥💣💥💣💥💣

[@KosspapiKaufman]

I think I saw something like this while passing through renal calculi Today

[@vipse1984]

Just started getting diagnosed for this...getting nervous

[@user-ze6ck5bp1v]

[21158] kim It was good because they explained it easily in a picture.

[@user-pj9ce5lb9q]

just a question, I got a bit lost when you said Hepcidin is released when iron storage is overloading which inhibits ferroportin. But if ferroportin is inhibited, does that mean iron will continue to build up in storage as ferritin instead of being released even though storage levels are high? Might be a silly question but I'm just a bit lost. Can someone please explain

[@johnherrington1110]

Your question is several months old, so forgive me if you have already figured this out… You have ferroportin exactly backwards. If ferroportin is active, it is bringing in new iron from the diet. If it is inhibited by hepcidin, this will slow or stop absorption of new iron from the diet, thereby dropping iron concentration in blood serum and eventual uptake by the liver. With no new iron coming in, stores will be used to make new RBC’s, drawing down overall supply and less production of hepcidin allowing a new iron to be absorbed from the diet, and the cycle repeats.

[@user-pj9ce5lb9q]

@@johnherrington1110 thanks. I wish I knew this before my exam 😂 figured it out the second time

[@moonbunny7380]

does anyone know why I have too much iron my doctor thinks I have this even though I haven't ate red meat in years and she also said i have low folic acid but not anemia?? I thought i had it because I dont eat red meat

[@MrAbi123]

Avoid fortified/enriched foods and have a look into oxalate dumping/toxicity

[@nicejoy9998]

My ferritin is 133, transferring saturation 51% blood iron 185 is it normal? My liver enzymes are normal.

[@MrAbi123]

Is your iron is high avoid fortified/enriched foods

[@einsteinbrother2905]

Plz put it

[@PythagorasHyperborea]

What about leaky gut syndrome as a cause? That’s another common issue.

[@bh9262]

How do you lower iron in the body?

[@MrAbi123]

Avoid enriched/fortified foods

[@kohlrabenschwanz]

Wanted to buy a poster but your shop is broken… -\~/-

[@dilawarrana5999]

😢

[@Ghaidahrb]

1:55 I heard baby crying 😢

[@einsteinbrother2905]

I want seizures explain

[@Tiberius41]

I had iron overload and I stopped my vitamin c supplement and it went away.

[@peanutt747]

Really My iron is 409

[@peanutt747]

For how much time should I stop vitamin c

[@Tiberius41]

@@peanutt747 if you have iron overload you don’t need a vitamin c supplement. Vitamin c helps process plant based iron and will increase your iron overload.

[@sanjinaershad1609]

A.I said - all doctors are fool.

[@sullypwz7864]

this video dont answer why iron overload is harmful, btw very bad letters