Health Talks Episode 1: The Longevity Benefits of Acarbose and Rapamycin

[@stevefantastics6595]

Wow, what a great video. I watch a lot of these Health and Longevity videos and I love your style of presentation. You're very concise and get right to the actionable information which we are looking for. Thank you so much for the video and count me as a new subscriber. 😁

[@inspirationalleadersstrivi2640]

Thank you for the information on Acarbose , I switched from Metfirmin to Acarbose because of side effects . With using Acarbose once or twice a day my glucose level has dropped to 93 from 110 + I have no side effects from Acarbose .

[@ericastanton2010]

how about miglitol instead of acarbose? Miglitol apparently better tolerated, less gi side effects because absorbed small intestine, better hga1c and wt loss reduction.

[@Sharperthanu1]

Cancer cells also eat glucose (sugars and starches).For more information please Google:Glucose hungry cancer cells. Professor Brian Cox.Also please Google: The Warburg effect.

[@espinosalexis]

Dear Dr. Elana Miller, So, is it well known that bodybuilders suffer of early on-set of age related diseases such as CVD and Cancer? Could you please add links to the studies showing this? (Either here or in your blog.) This is important because recently many highly qualified gurus of lifespan interventions (like Peter Attia, Matt Kaeberlein) are focusing on muscle growth as, maybe, the best strategy for an extending health- life- span in humans, apart from taking Rapamycin. So it is very important for us if you can guide us to the limiting point where building muscle turns to be detrimental rather than beneficial. BTW. List of references in your blog is horrible! Could you please list references as usual (by author, year, journal, etc.) and add your comment about it on the side if you prefer. Just your comments on the list is terrible. Thanks

[@gethealthspan]

We communicated this poorly in the video. The implication was that body builders taking exogenous IGF-1 or other growth factors tend to see a higher rate of pathologies. It is important to note that an elevated level of IGF-1, whether due to exogenous administration or endogenous overproduction due to poor diet, has been associated with several pathologies, including an increased risk of cancer, cardiovascular disease, and overall mortality. While muscle growth is indeed a healthy aspect of physical fitness, it is important to maintain a balance and avoid excessive levels of IGF-1 that may lead to potential health risks. Walter Longo's work on this subject is particularly interesting. www.ncbi.nlm.nih.gov/pmc/articles/PMC8844108/

[@wpmitra7251]

Acarbose leads to muscle mass reduction and strength reduction.

[@espinosalexis]

Dear Dr. Elana Miller, I believe that the ITP project is flawed. What I mean with this is, I think the diet given to the mice is a prone-to-sickness diet, which I would never choose for a longevity project. On the contrary, the diet I would choose would be an optimal diet for mice, which is an OMNIVORE animal, by the way. From the result section of the Acarbose paper, I conclude that the control group is a metabolically sick group of mice. Sick by feeding and not by age. So, of course, medicine given to treat metabolic sickness are good candidates to extend life span. But ITP was supposedly design to find compounds for longevity and not for curing metabolic illnesses due to bad diet. Right? Besides Acarbose, another Type 2 Diabetes drug has also shown "very good results" in the ITP experiment: Canagliflozin. So. My first question is: Had the ITP experiment became an experiment for treating Type 2 Diabetic mice? Acarbose is a great tool for treating metabolically ill mice (and humans). But, do we really want metabollically ill mice due to diet as a control group for a longevity experiment? It surprise me that the control chow decided for such an important project is a metabolically-damaging chow rather than an ideal diet for an OMNIVORE animal. It is a shame, because now we really do not count with an age-related ill group, but simply a sick population due to life style and bad food. My second question is, Could you please add a link to the details of the food and the basic ingredients from where the chow was made? (Either here or in the references in your blog. Please post a comment when done.) Also, if available, could you post the papers that show the decision criteria for this flawed diet? Many thanks, AE PS. Yes, I know, my hypothesis needs the additional explanation about why metformin did not work in the ITP. But still, I think it is evident that the control group is not sick by age but by diet. PS2. I already sent this comment to the ITP and Dr. Richard Miller a year ago, but I received no reply. I hope Dr. Elana can think a bit about this give us her opition but also ask the question to ITP related people and receive a reply. And, hopefully can share that response with us. Here or in a future video. Also, hopefully, someone from the ITP becomes aware of this video and comment and could answer directly in the chat. PS3. I do not even give chow to my doggies, it's common sense that metabolic health of an animal eating US chow all their life will suffer.

[@espinosalexis]

(Original comment has been edited/reformatted) Thanks.