The potential negative side effects rapamycin | Peter Attia, David Sabatini, & Matt Kaeberlein

[@craig2316]

Heart transplant patient here, i switched from Tacrolimus to Rapamycin a week ago and wow, the mouth sores are real. I never had a history of them and had one of the worst I’ve experienced. I’m on a 2mg/day dose, way above what I understand is the longevity dose. Hopefully

[@lilytea3]

0:00: 📊 A survey was conducted comparing over 300 users of rapamycin to a group of non-users, revealing similarities in demographics and lifestyle. 3:15: 🤔 Approximately 15% of people reported mouth sores, but the reason for this is unclear. 5:58: 💡 The speaker discusses the potential benefits of using rapamycin in oral health. 8:55: 🧪 There is a potential combination effect of rapamycin with ketamine in patients with severe depression and chronic pain. 11:54: 📊 There was no evidence to suggest that rapamycin impacted the likelihood of testing positive for COVID-19. Recap by Tammy AI

[@Javier_02906]

Thank you

[@schmingusss]

You missed 7:15 depression and anxiety.

[@jpjames8044]

Yes we both got the sores in the mouth. But many many benefits obvious as far as ending for now any symptoms of autoimmune disease. Did see lower white cells but no infections. Did recover remarkably quickly and completely from surgeries, one for s.i. joint fusion, and a TuRP

[@tarangchandola5776]

Hey, very interesting with the surgery recovery im curious ? how much sooner would you say you recovered ? how did you test recovery ? via a ct scan or mri ?

[@deafdeadfishfloating]

Speaking for a 'Rapamycin user" (male, 7mg once every two-weeks), past 6 years) taken SUBLINGUAL,: no 'mouth sores' (ever), yet... when a newbie at 5mg/weekly, only once, or twice: Vertigo; lasting 20 seconds before complete recovery. Observed a female at first time 5mg indeed get mouth/throat sores. Females seem MORE sensitive IMHO.

[@xmonikerhotmailcom]

Naw, I got huge sore at back of throat after 2 weeks and I am a 53yr old dude with high normal testosterone.

[@HaMashiachSaves]

I’ve taken 5mg every Monday since June 2021 without suffering any mouth sores 😃

[@plasticshelly3762]

I got lower blood pressure and slightly mouth sores as well as I feel more tired only the day when I took it , it was and is 2 mg weekly , I am 29

[@xmonikerhotmailcom]

Way too young to be taking.

[@lizmerrick6883]

Thank you for this! I just started Rapamycin for ME/CFS. I'm confused why people would get mouth sores and only mouth sores. Isn't that a sign of overall immune impairment? I would expect a lot more serious issues if someone was getting regular mouth ulers

[@Larsonaut]

How does it work for you and your me/cfs? What are the most important things you take against me/cfs? I think similar to you that it is immune related. Rapa suppresses for example nk cells so maybe those spots are from specific viruses

[@Andrewnutrition]

new research shows that ME/CFS is often misdiagnosed bartonellosis borreliosis or babesiosis - FYI

[@Larsonaut]

@@Andrewnutrition thx! Do you have good links for that? Are there now better tests/tools to diagnose these?

[@Andrewnutrition]

@@Larsonaut you’re asking the right questions as the commonly available tests that doctors use are incredibly not accurate and often 75% of the time give a false negative. The best testing is from a private company called Igenex. Infectious disease, doctors do not treat vectorborne diseases from ticks, fleas and cats. They are corrupt. It’s very criminal and sad. Luckily there are doctors out there that treat on the IL a DS Manor and they are called lime literate medical doctors they understand that these opportunistic infections, go chronic and evade the immune system and testing. For the top research look into webinars from Robert Mozayeni MD (rheumatologist and the worlds Bartonella expert), Richard Horowitz MD (The leading borrelia physician) and Henry Lindner MD (an expert on chronic babesiosis as he treated his daughter). I know this because I had a chronic Bartonella infection undiagnosed for 18 years that was causing constant sports injuries and tendon inflammation. After a long course of intracellular antibiotics. My tendons are fine but the rheumatologist were completely clueless and said my blood work looks good. Millions and millions of people around the world and a lot of Americans are chronically ill with infections and it goes misdiagnosed due to corruption and lies in main stream medicine all fields like rheumatology, psychology, neurology, all our misdiagnosing patients that have chronic low-grade inflammation because they don’t know how to identify the root cause They just put you on pills.

[@Sulfen]

I have been on Rapamycin for almost 5 months now. I have had several allergy breakouts on my back and shoulders and scalp, mouth sores (3), I have an irregular heartbeat, I get tired easier and feel asthmatic, my chest vibrates in the middle of the night that wakes me up, I have face acne, my facial hair grows oddly fast, my family has told me I sometimes look pale, my memory is shot (I forget things). And that's off the top of my head. This medication has been nothing but nightmares for me. I had a heart transplant and this replaced my CellCept.

[@DoktaKnock]

I think you mixed something up. This is more a Longevity podcast and for example Attia takes way lower dosages than a transplant case. This is a completely other case.

[@AnthonyDefilip]

@@DoktaKnockPrevious Age and Health has a lot to do with it.

[@Mike-du1dc]

What about the recent talks about using Rapamycin to reverse artery plaque via Autophagy?

[@drizx6473]

That’s the rabbit hole I’m going down I see rapamycin, reserveatrol, spermide, Berbarine, and coffee seem the most researched stimulants for induced autophagy. I also watch a YT channel called Pottenger’s Human. Pro fasting and teaches all the mechanisms and benefits of autophagy along with ketosis.

[@xmonikerhotmailcom]

@@drizx6473 Resveratrol is junk.

[@atfinthehouse8631]

Can you cite the studies and provide the links to the actual papers and studies?

[@atfinthehouse8631]

How did you guys come to be outside of mainstream medicine and get involved with this? What organizations, universities, pharmaceutical companies etc doing these studies and publishing this information?

[@stefanallard3084]

Rapa works on NMDA, just like ketamin and agmatine, wich is why it synergize. The receptor that restore adhd/autism/depression

[@willbrink]

I don't see a link to the survey. Am I missing it? Mouth sores would be a reactivation of herpes no? If not, what is the sores caused by?

[@clintparsons3989]

Where do you get it?

[@ShastaTodd]

Fasting can produce the same effects without the problems of drugs.

[@Scottlp2]

1. What fasting protocol? 2. Based on what evidence?

[@stefanallard3084]

​@@Scottlp2are you seriously asking for evidence about fasting? Just look around.....

[@stefanallard3084]

Seems like fasting is more powerful, as rapa did nothing for my scar tissue and cellulitis. I Will combine both in the future, doing a 7-10 day fast

[@nykholas]

It's not just about fasting; you also need to maintain a low calorie intake. If you are feasting after fasting, that's not going to do much.

[@Nuvinci88]

I agree.. these longevity freaks are more likely doing harm with all the supplements. Liver damage and roller coaster affects on immune response. Btw… sores in mouth are not an acceptable side affect imo. For me , I’ll keep taking my leafy greens, polyphenols, elderberry, fasting and exercise thank you

[@sanmarzano]

I would like to know how people are taking Rapamycin...injection?...capsule?...delayed capsule?.. with lipids?

[@bill9989]

Can anyone expound on David's "FK506 mouthwash" suggestion? Is this something that is over-the-counter?

[@bill9989]

OK, I can add what I've learned: it is Tacrolimus Oral Rinse or Mouthwash. Tacrolimus is the drug name not the brand name. It appears that it is by prescription only, not OTC.

[@riceexperiment]

Even though off-label use is not illegal, it's experimental and would be better done within a controlled clinical trial, right?

[@ivanfreire]

100% right

[@schmingusss]

So rapamycin can increase anxiety and depression. Crap. That's a no go for me.

[@thea-listtv312]

info is great here but why does the interviewer seem like he is going to strike a punch on thoe two if they dont reply right? ;/ maybe just me.

[@cheungfranklin3543]

If not FDA approved usage, would the physician get sued in case of side effects? My attorney is waiting

[@bill9989]

That argument can be made for any/every off-label prescription. What's your point?

[@user-ou8pe9it8j]

They all look hunks😂❤❤❤

[@gondwana6303]

If you look at how Attia and Huberman, who are so conscious about geroprotection, have aged, they don't look so hot for their ages. The only one who looks good is David Sinclair and there I wonder if it's plastic surgery. Bryan Johnson looks like a ghoul and has had facial fillers.

[@gianfranco_maldetto_92]

Sinclair's got wrinkles on crow's feet. And his forehead moves. So, no, it seems mostly natural. The hair color may be fake, though.

[@gondwana6303]

@@gianfranco_maldetto_92 You can have crows feet even if you have multiple face lifts -- look at Pelosi.

[@lizmerrick6883]

Trying to reverse the most visible signs of aging will have limited success. Prevention is the most important factor, sunscreen/protection, hydration, drug avoidance, and trentinoin if you want to be fancy. Unfortunately, genetics will always play a huge role. Too much filler and face lifts (overly tight skin) can paradoxically make you look older as we associate that with aging. Also many of these men practice calorie restriction and while low body fat is healthier, facial fat is important for a youthful look. Bryan Johnson looked far younger before his experimentations because of his facial fat. He also has an adrogynous look, and while he claims his estrogen supplementation is not feminizing, i find that hard to believe. Ultimately, the most important thing is increased healthspan, but that's not as obviously apparant. Think of an elderly goatherd in the Himalayans who hops up and down mountains but has a dried and wrinkled face and a pot belly. These men are obsessed with their looks because it helps sell their routines.

[@gianfranco_maldetto_92]

@@lizmerrick6883 What's the point of living long if you look crappy?

[@lizmerrick6883]

@@gianfranco_maldetto_92 lol, I get it. I’d like to be attractive forever. It’s good to extend your looks for as long as you can but I promise you that when they’re gone you will still want to live. Living long isn’t just extending your time on the planet for no reason…hopefully you’ve got interest, loved ones, intellectual pursuits. I always prized my looks but talking to older people I see that most of the happy ones have a ton of hobbies, friends, traveling and enjoying the arts. And no, they aren’t pretty!