Hemolytic Anemia - CRASH! Medical Review Series

[@sheikhtaj2057]

Nice and smooth explanation.. Thanks If pdf of the lecture is provided in the description it would be more helpful.. ☺️

[@mike1950gm]

This will be worth reviewing again and again...thanks for a very detailed video.

[@DrDinooshDeLivera]

Thank you Dr Bolin, awesome lecture!

[@LyubomirLalovMulti]

This was great, been searching for "thyroid gland imbalance" for a while now, and I think this has helped. You ever tried - Yannabarn Vanish Thyroid - (do a search on google ) ? Ive heard some unbelievable things about it and my m8 got cool success with it.

[@monicacarolinaalcarazgueva1133]

GRACIAS! THE BEST VIDEO

[@christiemaequives8384]

great! thank you for this wonderful video.

[@azizmarshal9438]

In iraq we call G6PD deficiency (favism) it is so common especially during winter, we eat a lot of fava beans

[@Mrkimo272]

Dear prof.Paul Bolin from where I study regarding the PNH it says that it is due to a somatic mutation in a gene PIG-A (phosphatidyl Inositol Glycan complementation group A) mapped on chromosome X which codes the enzyme that catalyze the first reaction in the biosynthesis of the molecule glycosyle phosphatidylinositol but it does not say anything regarding if it is inherited disease or not what do you think ? thanks in advaced for all your videos

[@Gameztop10]

Is management of pnh now not ravulizumab or eculizumab?. Thanks Dr Bolin for your awesome videos

[@ekhlassramadan6385]

in G6PD the site of destruction intravascular so there is no splenomegaly

[@josefarodriguez3227]

thank You!

[@drmathias9248]

excellent

[@bomhayhay]

thanks

[@user-lf2rw4nx1v]

thank you

[@simpson-qk6yd]

HAM Test is out now

[@mikkelbakjensen2350]

24:42 DJ Khalid or Paul Bolin?

[@drte19]

How can you tell the difference between AIH and Hereditary spherocytosis?

[@dhoom387]

drte19 it will have high MCVH and by peripheral blood smear ... you can also do osmotic fragility test...

[@prabhatsharma1697]

Increased Osmotic fragility in both..so do coomb's test which is positive in AIHA but negative in hereditary spherocytosis

[@waelwm4331]

comps test

[@muhammadfawad4094]

Via coombs test

[@ericac2355]

Can you comment on the differences in labs between intravascular and extravascular hemolytic anemias? I am struggling to make sense of what to expect in both scenarios and why (i.e. isn't haptoglobin only low in intravascular because in intravascular, the heme is released into the bloodstream, whereas in extravascular, the heme is never really outside a cell it's within macrophages being broken down into bilirubin?) Thank you for this video!

[@muhammadfawad4094]

Haptoglobin is reduced in intravascular hemolysis, but is usually normal in extravascular hemolysis.

[@zuhairyassin505]

basically you can have anything anywhere thats really helpful

[@eddiehoare3488]

Hi

[@nischalbhati6561]

💯💯

[@caterscarrots3407]

But blood loss can also cause IDA(Iron Deficiency Anemia) and in fact I have heard that if you are loosing blood, this is the mechanism by which you get Iron Deficiency Anemia: At first you actually get into a state of polycythemia as red blood cell production is ramped up. Then this triggers more iron to be stored by ferritin or blocked by hepcidin. The polycythemia quickly goes away as you continue to bleed and once you stop bleeding, red blood cell production is still elevated but these cells are now much smaller than normal. This is Iron Deficiency Anemia. So how would you know if they have low hemoglobin from blood loss because of Iron Deficiency Anemia or Hemolytic Anemia? And couldn't Hemolytic Anemia cause Iron Deficiency Anemia?

[@muhammadfawad4094]

1. Chronic blood loss results in microcytic anemia due to iron deficiency, while hemolytic anemia usually causes normocytic anemia. Also, haptoglobins are reduced in intravascular hemolysis. 2. Intravascular hemolysis can cause iron deficiency because you would lose hemoglobin in urine which contains iron.