Heroin or Cocaine: Which is Deadlier?

[@cessactdm]

never once thought about trying either one, however after watching this shit I am scared shitless of ever trying it. thanks man. hopefully this feeling never fades away.

[@TommyWashow]

Coke is no big deal unless youre rich. Power of effect to cost ratio is very poor

[@sainthyde92]

@itchy is right. It’s way too expensive to really get addicted. Not ever trying heroin is a very good choice though

[@JoaquimpxoPT123]

bro that's cap

[@JoaquimpxoPT123]

@@angelblue314 It wasn't for you my cherry cupcake, have a nice day

[@JoaquimpxoPT123]

@@angelblue314 wanna link up?

[@Wolf_Ghost]

I'm an ex-speedballer. Been clean 7 years now. Was in doctorate program and left USMC for college. PTSD and an undiagnosed autism disorder made me self medicate. This stuff is no joke. Get help. I'm on a 10mg methadone program and heavy counseling. I also see a psychiatrist and accepted my autism. Never been happier. God bless.

[@bigvinnie3]

Man 10mgs you got lucky tapering will be easy(well ish) i'm on 74 mg and compared to a lot of people thats a low dose.

[@Wolf_Ghost]

@@bigvinnie3 yeah, I didn't want to go super high. They offered but I wanted to keep myself from using again. Just enough to block anything.

[@bigvinnie3]

@@Wolf_Ghost That was honestly smart on your part. I was trying to get high on my dose so i kept going up lol. It worked for a little while now I just have a huge tolerance lol.

[@Wolf_Ghost]

@@bigvinnie3 Yeah, that's what I was scared of. I didnt want get hooked on something else. Sure, methadone is safer than using, but I had to be honest to myself. We can fool our own minds with the best of intentions but still fall victim to using again. That's why therapy only works if you're honest 100%

[@Wolf_Ghost]

@@bigvinnie3 I do wish you the best of luck. Also, when coming down off methadone, I did it 1mg a day. Had no feelings. I ended up back on it because I had some desires again. But 1mg a day going down was perfect.

[@Perfectly-unperfectly]

Both theses drugs have nearly taken my life on several occasions. 4 and half years clean and more greatful than I could ever put in too words. Great video 🤙🏻

[@phillipisayev1273]

Hell yeah, keep it up man. I’m proud of you 👍

[@Perfectly-unperfectly]

@@phillipisayev1273 thanks Philip 😊

[@Freshadventures_]

That's awesome dude. I'm still in my addiction going on 13 years. It's coming to it's end. Taking Suboxone and moving out of the city to start a new life.

[@Ralle1King]

Proud of you

[@NAT-turners-Revenge]

If you're ever in southern California.... free coke is on me friend 😃

[@jhoughjr1]

I had something like heroin according to the anesthesiologist for a procedure. It was maybe the strongest euphoria ever. I felt a wave of warm fuzzy from my toes to my head and then blackness. I asked "am i dead?" s I didnt even really feel my body. They said no and things settled to basically me being immune to pain. I was conscious and could move, and could feel what they were doing, it just didnt hurt. I lifted the veil to see what they were doing and they all freaked out about "sterile field!" I realized they could have been breaking my legs with sledgehammers, and it wouldnt hurt. I've had pain relief, but never complete nullification.

[@denellwest]

🤔😱

[@RustyRedRhombus]

Oh its great for pain. Absolutely necessary in some cases. Only real time I ever felt genuine pain relief. Sad its so dangerous. Maybe we'll get something better in the future

[@jerry3790]

That’s why they call it “comfortably numb”

[@jhoughjr1]

@@jerry3790 it was very comfortable but not numb I felt them cutting and tearing it just didn’t hurt. I consider numb like benzocaine or phenol

[@jhoughjr1]

@@RustyRedRhombus I asked what will I give me being the sperg I am and he said “don’t worry it’s just like heroin” “wait what?” And blamo. It didn’t last long and when it was done I had no withdrawals or even cravings or anything . Idk what drug it actually was.

[@mooseclappin11]

Layne Staley, the lead singer of Alice in Chains, died because of a speedball overdose. He suffered from addiction for at least a decade beforehand, and wrote several gut wrenching songs about his struggle, with "Junkhead" and "Dirt" being the darkest/scariest IMO. R.I.P. Layne.

[@trambled1925]

Only in ohio💀

[@Mangoboi699]

Alice in chains has my fee favorite songs. Its also My fathers favorite band. Down in a hole, In a nutshell, And Frogs. I love the unplugged versions

[@Mangoboi699]

@@trambled1925thats not funny 😕.

[@evanpaluch6190]

Died from a speedball. Heroin and cocaine mixed and taken at the same time

[@trambled1925]

@@Mangoboi699 it kinda is

[@Mcdogmom288]

I started doing drugs since my teenage, spent my whole life fighting cocaine addiction. Also suffered severe depression and mental disorder. Not until my mom recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 8 years totally clean. Never thought I would be saying this about mushrooms.

[@ErnestoHorner88]

Can you help me with the reliable source 🙏. I'm 56 and have suffered for years with addiction, anxiety and severe ptsd, I got my panic attacks under control myself years ago and they have come back with a vengeance, I'm constantly trying to take full breaths but can't get the full satisfying breath out, it's absolutely crippling me, i live in Germany. I don't know much about these mushrooms. Really need a reliable source!! Can't wait to get them.

[@CathieGomez-mp8sk]

YES very sure of Dr.alishrooms. I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.

[@Iiisslogan-co6np]

How do I reach out to him? Is he on insta

[@JesseJason-qc7ug]

Yes he's Dr.alishrooms. Shrooms to me is a natrual healer. I know a guy who has used mushrooms in the same way and they have really helped him. mah dudes have safe trips all.

[@PriscillaLogan-by9ll]

I wish they were readily available in my place. Microdosing was my next plan of care for my husband. He is 59 & has so many mental health issues plus probable CTE & a TBI that left him in a coma 8 days. It's too late now I had to get a TPO as he's 6'6 300+ pound homicidal maniac. He's constantly talking about killing someone. He's violent. Anyone reading this Familiar w/ BPD know if it is common for an obsession with violence.

[@Freshadventures_]

I've done a lot of Coke and Heroin is definitely deadlier. I've had several overdoses on heroin and was lucky someone was around with narcan every time it happened. When I did too much cocaine I would become extremely paranoid of everyone.

[@biggussdickuss6123]

Coke to an experienced user "Cid mushrooms crystal brown" can do coke like it's smoking a cigg

[@Monicaruthcw]

Yikes. I love the way you illustrated everything; helps me visualize what’s going on. Great vid!

[@timopint1125]

besides is full of wrong information

[@cevatkokbudak6414]

​@@timopint1125Wah wah

[@chrisholt5964]

Thank you, this is not only a brilliant comparison, but an explanation of what they can do when combined. Great video.

[@wokeness420]

Crystal Meth: Hold my beer.

[@chazbarns1410]

Meth itself isnt nearly as deadly if at all. Im not saying its good, but living in the meth capital of the united states will show you people of all walks of life can use meth and you would never know it. Shit my own father used to manufacture it out of cook houses and is to this day a everyday multiple times a day user of meth. He is still somehow kicking at almost 60 years old.

[@vice.nor.virtue]

I agree with the other reply here. I've known people to wake up and smoke meth in the morning instead of drinking coffee. It immediately wakes you up and focuses you in a way a cappuccino could never do...Only thing is that it definitely is more expensive than a cappucion.

[@8pelagic610]

I worked for a professor of pharmacology that had a million dollar grant from the Department of Defense to research the abuse potentials of cocaine versus heroin. He had these huge white lab rats with electrodes protruding from the top of their head like crowns. The rats would be so stoned you could hold them in your hand and they would be limp with their eyes closed. The rats got to choose which lever to pull to get cocaine or heroin. They would pull the coke lever until they couldn't anymore. It was pretty sobering.

[@Tech_Traveler]

Any data on how many times they chose heroin?

[@biggussdickuss6123]

This test doesn't work though considering one drug is short lived.....

[@traildoggy]

Very good information. I would have liked it if you discussed Narcan and how it works to counter narcotic overdoses also.

[@Freshadventures_]

Narcan saved my life a few times. Being careless and doing crazy amounts that would kill most people. I survived and was lucky people were around.

[@bigredracingteam9642]

It has a higher affinity to the opioid receptors (so there's a higher chance it will bind to the receptors) and it's an opioid antagonist, meaning it has the opposite effects of the opioid agonists like morphine and heroin (heroin is actually converted into morphine in the brain after crossing the blood-brain barrier.)

[@morgancatherwood5665]

would be even better information if he would tell me where I can buy blow anymore that doesn't have fentanyl in it

[@3-methylindole730]

@bigredracingteam9642 Actually that’s wrong. As an antagonist of opioid receptors, narcan just blocks it and has no opposite effect. Its effect is better described by just blocking the opioid effects, and acting neutral. An inverse agonist is actually the type of substance which exhibits the opposite effects literally, and inverse agonists are not the same as antagonists.

[@nickydaviesnsdpharms3084]

The 2 drugs in a speedball may appear to cancel each other out, and certainly one would expect that to be the case, (being stimulants & depressant) but in actual fact, what occurs is they tend to potentiate each other's effects, in a process called drug synergy so they act synergistically just like how Caffiene is added to OTC headache pills with Paracetamol, they act together to produce stronger effects. Despite Caffiene not being an analgesic. However most Heroin addicts aren't aware of the pharmacology because they only care about essentials in their mind. i was a heroin addict for years and love pharmacology.

[@corkbulb2895]

Opiates and stimulates ABSOLUTELY do not cancel each other out. When taken together, they produce the most awesome high you can imagine! It is the best thing in the universe! Take heroin and Adderall together. It is to die for. No, that is to easy. Doing that is to LIVE for!

[@nBasedAce]

In the 90's my friends used to buy coke every once in a while and whenever we did it I never got high from it like they did. It didn't keep me awake or give me euphoria at all. Since I was recently diagnosed I realized that since I have ADHD it would have acted as a kind of prescription drug for ADHD instead of what was happening to my friends.

[@jhoughjr1]

Maybe you just got the cut. I know a Coke head who has ADD since childhood. He still loves it. I have ADD. ADD drugs do simulate everyone the same. The difference is the result of the stimulation. It’s why I haven’t quite smoking nicotine works as a poor man’s focus aid when used with caffeine. Not as good as medication

[@LinkinPark4Ever1996]

I know people that tried good cocaine many times in different doses and never ever felt the effect

[@TommyWashow]

youre 100% correct same goes for meth if you eat id. I was sold meth as molly a few times as a kid and i know for a fact it was straight meth cause all my friends got fucked while i organised my folders and desktop lol

[@jamessunderlandseventh7410]

Some people are just born with unusual higher resistance to certain substances

[@Jalex92]

You’d feel it but cocaine isn’t as strong as ADHD meds unless you take a lot. It’s definitely more euphoric, but it’s not as stimulating. You’ll be happier on coke, but have more energy on adderall.

[@probablycuben]

Thank you for this. My mom and her sister have been addicted to both of these drugs (separately, mom was addicted to one and aunt the other) my whole life and I was always curious what exactly went on. I knew it was used to cope, but now I see that there was more to it than just "drug feel good". They are still addicted to substances to this day-seeing the side effects in this video make me so worried for them. I hope both recover soon. I miss my mom

[@igostupidfast3]

not only did I learn but this video helped me get a basic understanding of how SSRI's work

[@J13-h6y]

It is crazy people combine the two in speedballs.

[@DanielAnderssson]

I guess the high must be great, but what a life, no Thanks

[@BradySharrett]

I can barely move after having them both. It's crazy.

[@BradySharrett]

I can barely move after having them both. It's crazy.

[@ilmxsize9840]

​@@BradySharrett get help

[@salamanderhillbillyweasel1629]

On my deathbed I’m having a fat speedball, going out with a bang

[@moistwienor4572]

It’s even worse when you realize there’s a pretty decent chance of either one being mixed with fent because they both can come in powder form

[@the_magic_max9491]

Legalization would help with that!

[@emoguy666hotmailc]

Maybe in north america .. no way would fent be in either here

[@NAT-turners-Revenge]

Fent is added just to make em more potent addictive... ergo more repeat buyers

[@bryanswijgman1856]

@@the_magic_max9491 that’s what we Europeans trying to tell you stupid American governments for years. Making it legal will fix all the people everywhere around. Why? Bc the main reason people died is bc the drugs are hand-made.

[@mikehikes710]

@@NAT-turners-Revenge not how it works. How can you have a repeat customer when they fuckin die

[@KeithCooper-Albuquerque]

Excellent video. As a former user of both, I can say your information is spot on. Please people, take heed of the information here!

[@indionopalez3716]

Its true ,Keith used to suck Cork for coke..........I seent it...✌🙂

[@thefalselemon579]

Wouldn't you say that heroin is a lot more likely to kill you in a single use though? One miscalculation and you can wind up suffocating. Cocaine takes a lot of time, money, and effort to get addicted to enough that you'll suffer life-threatening issues.

[@lukasfischer2567]

as a former user u should probably know it isnt. like heroin isnt 25 times more potent then morphin, it is just 2,5.

[@the_magic_max9491]

You should know then, that most risks exist due to prohibition. Legalization would make both drugs way safer.

[@ukuk9576]

really good information in this video! after watching this ive decided to go with heroin

[@williamroevik9746]

This goes hard

[@AstarteXVI]

Greece faced a substantial "pandemic" of heroin use in the 80's and 90's. There was a saying : "There are many drugs to use, but heroin kills". The issue was so widespread that older people at the time thought that the word "drugs" equals to heroin, to the point that if somebody was only smoking weed, they'd even call him a junkie.

[@Azqabat]

Boy, am I glad to have found your channel. Keep up the great work :D

[@SEThatered]

Nitpick: Dopamine does not cause euphoria. It forms habits. It's the group of substances called "hadonic neurotransmitters" that makes you feel euphoric. And dopamine is always there to solidify the habit that gives you the hedonic responce. To further drive the point: dopamine is also there when you experience great fear - so you would remember what scared you.

[@brooklyn8745]

underatted comment

[@WTFuToob]

I'd like to suggest a video on Freebasing. Your talent for explanation, alongside your choice of visuals , make difficult subjects much easier to comprehend. This expands your reach and helps alot more people,. Well done..

[@t4ryntino]

Love this channel. Was litteraly watching in math college. Great vid ❤️

[@Vinx-tripsOninstaSells]

Look up☝️🍄✅ that handle he got DMT LSD psilocybin MDMA psychedelic Shrooms Chocolate bars🍄.💊.🔌.🍫.🍄....

[@sashboo1370]

Nice video! Just letting you know that 0:59 your dopamine drawing is missing a couple letters and at 1:30, the picture you say is dopamine, is actually deoxyepinephrine.

[@MorpheusSL]

It should also be said dopamine doesn't cause the feeling of pleasure, but rather the "wanting" of the drug. The endorphin system is more responsible for "pleasure". Cocaine and other drugs release endogenous endorphins also fun fact

[@snubdawg1386]

@@MorpheusSL so when somebody says...."this give me a quick dopamine hit"....it's wrong? ...."this give me a quick endorphin hit" ???....is right?

[@MorpheusSL]

@Snub Dawg It's a tad more complex than that but yes. Here's a few things from the dopamine wiki, under functions then under pleasure; While dopamine has a central role in causing "wanting," associated with the appetitive or approach behavioral responses to rewarding stimuli, detailed studies have shown that dopamine cannot simply be equated with hedonic "liking" or pleasure, as reflected in the consummatory behavioral response However, opiate drugs such as heroin and morphine produce increases in expressions of "liking" and "wanting" behaviors.[57] Moreover, animals in which the ventral tegmental dopamine system has been rendered inactive do not seek food, and will starve to death if left to themselves, but if food is placed in their mouths they will consume it and show expressions indicative of pleasure. Endorphins are our bodies natural opioids. But in most simplest terms yes dopamine = wanting, endorphins = liking

[@snubdawg1386]

​@@MorpheusSL ok thx ....it's strange because if this is true it contradicts some literature....i always say i'm dopamine addicted .....but that true definition would mean i'm endorphine addicted and produce high amounts of dopamine because i'm craving 24/7 for years?! ....at the same time i have no cravings for food or sex or substances, which means inactive dopamine system....but as soon as i start, i can't stop

[@xtakeroflifex7957]

Would of been cool to go in-depth on how why these 2 drug are extremely addictive

[@darkscienceyt]

I probably will in the future. Truth be told, I didn't want to make this a +15 minute video

[@lunariclunestra8335]

@@darkscienceyt I could legit listen to you for 50 minutes+- Very good video.

[@ashesofhopesinabonfireofdr6341]

@@darkscienceyt make sure to include their side effects too so people can understand the gravity of the situation. Heroin makes your teeth fall out and leaves you looking like a zombie.

[@TheNikotin33]

@@lunariclunestra8335 I agree but the algorythm must be pleased at all costs

[@Psychx_]

Short version: They cause a massive release of Dopamine and cause your nerves to produce a protein called Delta-FosB, which not only makes your dopaminergic neurons less sensitive to weaker stimuli, but also leads to a restructuring of neural connections that facilitates further substance seeking behaviour. Delta-FosB takes ridiculously long to get removed from the cells, so it just keeps piling up during regular substance use. The effective breakdown of this protein can only be accomplished via abstinence. Its high half-life is one of the reasons, why people may feel like shit and feel no motivation/drive or reward (not even from other, previously rewarding things, like eating, doing sports, accomplishing something, etc.) even months after a withdrawl; this also contributes to a high chance of relapse.

[@mr.midnight1078]

I'll stick to my caffeine, thanks.

[@geraldhicks9535]

Very well put together video Dark Science!

[@darkscienceyt]

Thanks!

[@ZeRO-zx9zy]

The problem is foremost the purity of them as street drug, if you would have a pharma company selling it, there would be far fewer deaths and post symptoms.

[@akubuirocharles3390]

Facts... Street drugs have no regulations and no Morality behind it

[@caucasusdweller]

and more addicts

[@ZeRO-zx9zy]

@@caucasusdweller more addicts than nicotin, alcohol and coffein i doubt it

[@DCxSkateboarding]

​@@caucasusdwellernah. It's easier to get help from a doctor of you also get the drugs from a doctor. No one is going help on the street.

[@elevan2760]

This was a really good video. Have you done an episode on Acid?

[@Sergii-k8g]

You really need to do another videos on how exactly these drugs create addiction and on long-term effects of usage as well.

[@skylerb2218]

Euphoria is not a natural state of mind and is usually only found in drug use and bipolar disorders. You'll never get the high drugs provide in regular life. Your mind knows this, in response it throttles down your reward center and causes the drug to lose its euphoric effects. Now your brain is adapted to the drug so when the drug is absent, you get withdrawals. Now the brain has to attempt to go back to baseline and during this time there is an absence of the drug that boosts those neurotransmitters..Now you've got less than normal so you'll be super fatigued, depressed and unmotivated...these symptoms drive a person to use again just to feel "normal". The other driver of addiction is using drugs to numb emotions and to escape, this is where people who quit for long periods of time get moments of weakness where they take the drug again to eliminate that emotional pain. Once you're an addict it doesn't actually ever go away. That temptation for euphoria and escape is always there. This is why it's such common advice to never start, once you get that euphoria going you'll never forget that feeling and it's tempting to chase it.

[@creepage1]

Drug addiction is usually combination of the drug itself and your situation in life. There was the experiment done with rats where they had access to water with heroin and clean water. When they were alone they would very often overdose and die from the water with heroin, but in groups they would rarely touch the water with heroin. Addiction isn't as simple as take a drug and get addicted. It's composed of multiple things stacking up. Low living conditions, toxic relationships, lack of friends and so on will lead to people using drugs as an escape mechanism and get addicted. There are also two types of addictions, psychological addiction and physical addiction. Psychological addiction can develop from anything, such as: phones, ice cream, eating sand even. Physical addictions however come from specific substances that will have a withdrawal, during withdrawal the symptoms experienced are reverse of the effects of the drug. Not allowing dopamine reuptake definitely helps these drugs be more addictive since it makes you think "why should I go make relationships or do work if the dopamine I'll be rewarded with is a lot less than snorting a line of white powder". But just because a drug makes you feel good doesn't immediately make it addictive. LSD for example makes people feel good too, but it also helps people quit smoking and alcohol and other addictions. Drugs don't cause addiction, shitty life conditions do.

[@OtavioFesoares]

They create addiction by increasing the amount of receptors that the substance binds to. Sometimes your body will also decrease it’s natural production of the neurotransmitters affected by the drug. It’s at that point where you’ll feel the need to increase the dose to feel normal. That effect is called tolerance.

[@OtavioFesoares]

Long-term effects vary from drug to drug. Cocaine definitely strains the heart and may lead to sudden cardiac arrest, heart attacks, stroke, atrial fibrillation, and you will end up with a hole on your septum that might get infected. Opioids and opiates (morphine, codeine, heroin, oxycodone, hydrocone, etc) will give you an overdose, most likely. If you don’t then you’ll experience nasty withdrawals when trying to quit and while it may be lethal in some cases, it usually isn’t and starts to subside in 2 to 6 weeks. If your preferred route of administration is via injections, you are at a greater risk of infections and gangrene, loss of limbs (due to gangrene), collapsed veins, blood clots, liver disease (especially with heroin). If you share needles, you increase your chances of acquiring HIV and hepatitis. Benzodiazepines and alcohol will act on the GABA receptors. Alcohol will have an effect on the liver and will destroy it. Your immune function will decrease, heart function will decrease, you will be at a greater risk of GI bleeds and anaemia, kidney disease, electrolyte imbalance (due to decreased kidney function), diabetes, severe dehydration. Benzodiazepines are safe-ish on the long term, but tolerance builds up fairly quickly and quitting cold-turkey can straight-up kill you from a grand-mal seizure. Same with alcohol and barbiturates. Some benzodiazepines might impair liver function as well.

[@nutbastard]

The simple explanation: They feel really good, and when they wear off, you feel really bad. If you've ever been really hungry to the point where finding food is all you can think about, then you have some idea of what it's like. Long term you have the direct health problems, and between the two cocaine is worse of the two, but you also have the indirect effects like malnourishment, as both of these drugs suppress appetite. Other self care tasks take a back seat as well, like brushing your teeth and bathing. Last thing I'll mention is specific to cocaine and other stimulants, but lack of sleep is really not good for you physically and mentally.

[@beyondlevel7866]

I used to do quite a bit of cocaine. Its overrated, the only thing coke makes you want to do is more coke.

[@joshylord]

Glad i rediscovered this channel. Definitely one the more interesting ones i have found 😊😊

[@whatrtheodds]

I think coke will kill you if you take it in the long term as it slowly kills your heart. The danger with heroin though is it can kill you the first time, but it's more about dose. Also loved this video 😻 Not a drug user, but can see why people get sucked into it. I hope they heal from their traumas.

[@Pizzahutbaby]

You can recover from a lot of heart damage almost completely after quitting drug. Although it will take a long time of abstinence. If I remember correctly after about 20 years of quitting smoking a pack a day your risk of heart attack is almost the same exact same as somone who has never smoked. Doing drugs for a long time can indeed damage your body but if you abstain from them long enough your body will recover. It never to late to quit.

[@Pizzahutbaby]

My grammer is equivalent to a 3rd grader.

[@Cslicksmusic91]

People have die taking cocaine just the one time as well

[@HenriFaust]

It depends on how much you take, but if you take cocaine everyday or every week, you are going to die.

[@HenriFaust]

@@Pizzahutbaby Some damage is permanent, as it is caused by wearing out the heart through overuse. It is similar to the life-shortening effect of repeated marathon running.

[@hazymorning1823]

another engaging and informative video!

[@pht851]

Finally the new PewDiePie vs Tseries

[@snakesonn]

Are you dumb?

[@ZOCCOK]

​@Al looks like it. The new kid on the block which is giving the old school a run for their money. Want to see who represents Marijuana then.

[@lombardo141]

@Al isn’t fentanyl just heroine on steroids ?

[@pastamazingminecraft]

@Al carfentanyl is coco melon

[@greenishpiss3588]

​@Al MrBeast Fentanyl Carts:

[@TylerDickeyMusic]

I'd love to see a similar video on Methamphetamine and possibly comparing it to other CNS stimulants prescribed for ADHD

[@dust-dog]

A headline about that comparison would only serve to further stigmatise people with ADD. I don't know if Adderall is supposedly similar to meth as it's not available in Australia, but if it was I'd definitely take it - dextroamphetamine does very little to improve my focus.

[@TylerDickeyMusic]

I can see where you're coming from. I'm mainly coming from a place of interest rather than trying to say that we shouldn't allow CNS stimulants because they're basically meth. I know in the US Meth can be prescribed in small doses for ADD/ADHD under the brand Desoxyn which I find interesting. I'm not sure if Vyvanse (Lisdexamphetamine) is available where you are at but I know that it has worked wonders for my ADHD @@dust-dog

[@ravenID429]

@@dust-dogWhat? No it wouldn’t, unless the headline you assumed he wanted was “people with ADHD are basically doing meth”

[@chrisgaines6369]

I've tried cocaine a few times, but thankfully I'm scared of needles so heroine was never on my radar.

[@observe_and_purport]

Great video, very informative thank you! I appreciate this channel. Aside, TIL Omar died IRL (Michael K Wiliams). It hurt seeing it happen in The Wire, and it hurts now. RIP to all these folks who do what so many others do and coped with their stress via the easy, temporary answer: drug use.

[@pookatim]

It is worth mentioning that whenever someone procures these "street drugs" there is no way to know what ingredients are in them or what the potency is. This is what has led to the sudden rise in overdoses by long term drug users when Fentanyl began to appear. It is far more potent than the usual drugs.

[@the_magic_max9491]

Legalization would help!

[@the_magic_max9491]

@@richardlyman2961 no. Please inform yourself!

[@dubjubs]

​@the_magic_max9491 We have and there are tents everywhere and massive problem that legalizing will do nothing. I'm all on board with weed, LSD, and Shrooms but this stuff is risky even if a doctor was prescribing it.

[@the_magic_max9491]

@@dubjubs You mean in Portland? Yes, of course! People from all over the US travel there because they would end up in jail anywhere else. If more states legalized/decriminalized all drugs, there wouldn't be such chaos on the streets. It is very important to legalize drugs like heroin because almost every death is a direct result of prohibition. If people knew what drug they were getting and at what dosage, they wouldn't die. Many countries, like Germany, have legalized heroin under certain conditions to prescribe it to heavy users. In these safe consumption sites, there has never been a single death from opioids! Not a single one! The problem is not the drugs themselves, but bad drug policies. Fentanyl wouldn't be such a big problem if all drugs were legal. Many people don't want to use fentanyl, but they are forced to or use it without knowing it because either there is no heroin to buy or the drugs they thought were something else are laced with fentanyl. They don't know what they're getting or how strong it is. In the illicit market, there is no standardization, no labeling, no warning on the packaging. This uncertainty is the cause of most overdoses. In the medical context, no one is dying from fentanyl. So yes, legalization would definitely help!

[@worddunlap]

It's meth and fentanyl today. The adage "Better living through modern chemistry" seems like a sick meme.

[@surkey5055]

The new "in" thing for most drug users are research chemicals. You can order them online, perfectly legal. Their effects often mimic other illegal drugs, but with RCs you just get what you want whenever you want with no need to speak with anyone.

[@dark_fire_ice]

As someone with schizophrenia, I'll never understand why anyone would want so much dopamine. (According the Dopamine Theory, the positive systems are caused by to much dopamine and the negative symptoms are caused by the lack. Evidence is from ketamine studies and studies on anti psychotics)

[@grungeisdead8998]

Because it feels good

[@dark_fire_ice]

@@grungeisdead8998 does it? Or is it other effects along with the dopamine. Dopamine isn't a "feel good" chemical, it's a neurotransmitter, that is responsible for many, many crucial bodily functions (Parkinson's is literally the brain unable to produce dopamine)

[@LaMereACaniche]

@@dark_fire_ice It does feel good and you're partly wrong and partly right about dopamine. Dopamine is a neurotransmitter, yes, but it also plays a massive part in the feeling of pleasure. If you have massive amounts of dopamine running free and your dopamine transporters are blocked by the drug, you'll feel euphoric.

[@dark_fire_ice]

@@LaMereACaniche interesting; I have both ADHD, and schizophrenia, both effect dopamine levels. For ADHD, the number of dopamine transporters are massively increased, and schizophrenia, well levels are never stable and elevated levels cause positive symptoms (hallucinations and the like) and depleted cause negative symptoms (catatonia etc). Hence my general confusion, for me high levels of dopamine cause a break with reality, and to exist in a nightmare. Not going to lie, but my schizoid personality (neat total anhedonia), makes the idea od some form of enjoyment, very appealing, but the how makes me feel my mind might shatter to the point of no return. C'est la vie

[@barnabaskocsi1291]

As soon as you release a nev video its a must watch for me

[@MB-xq3pq]

been there done than heroin is 10x worse addiction

[@Ad1nfernum]

One thing that wasn't addressed in the overdose stats is that there is nothing you can administer to a patient to reverse a cocaine overdose - you can only keep them cool and attempt to bring their heart rate down. One wonders, of the opioid overdose survivors who were administered Narcan, how many of them would have died had it been unavailable, and how would that change the statistics? Given that difference in treatment, it makes it very difficult to do an apples-to-apples comparison of the overdose statistics. I've never taken a speedball, but I have combined ketamine and cocaine. It's an... interesting experience, let's say. Even though they don't interact, you really do somewhat lose track of which drug is doing what, so I could definitely see taking any two intoxicants together drastically increasing the likelihood of overdosing on one or both of them. And for those who might not know, cocaine and alcohol combined is a completely different beast because they metabolize together into cocaethylene, which is more psychoactive but also much more hepatotoxic. I don't think enough people know this, and that's pretty scary because I'm sure lots of people go to the club for a few drinks, and that's where they're exposed to coke after they've already been drinking, not knowing the increased risk at which they're putting themselves.

[@l4rs047]

6:45 yeah, cocaine deaths surpass heroin deaths but compare popularity and amount of users of cocaine and heroin. on the other hand heroin (in it's pure form) has no organ-toxicity, unlike cocaine that can cause coronary artery disease.

[@vladimirlenin843]

If you take both at once Your brain takes screenshot

[@unnamedchannel1237]

Thank you for no loud music while talking

[@charlesgraves4565]

Dude there are less heroin deaths because no one uses heroin anymore. Its all fentanyl. Why leave this out?

[@samanthamarkham2816]

I used both of those drugs for 17 years. Using either one was incredible in the beginning. Soon I started using everyday, then it was all day. Losing jobs, ruining relationships and not being able to pay bills. For me, i would stay up for a few days and use the entire time. Eventually my body would give up and I would either faint from lack of food, or pass out from lack of sleep. I put myself in very dangerous situations and dealt with near death experiences. I am 1 year sober now. Unfortunately, i have many medical and psychiatric issues that I now have to cope with. I wish kids never start using and people who are using, find help and get sober.❤

[@Cavemankind_]

Fairly certain alcohol is undoubtedly the most common drug on the forefront of the human psyche. For many thousands of years, and will remain the primary drug of choice for all of mankind. Well done scientific research here though. Great journalism, sensible social data, and accurate psychopharmacology.

[@leonardmcdonald3928]

Thank you for uploading this episode of dark science

[@catatestrophe7499]

I never understood cocaine addiction. The comedown is just way too harsh.

[@johndoe5432]

I've done cocaine a few times. I stopped after one time where I was at a party. I remember doing a larger line than usual, felt fine for about 15 minutes. Then I remember walking over to a bed in our hotel room and gripping the bed post. It felt like no matter how much I breathed I couldn't get enough air, apparently I was also white as a sheet and drenched in sweat. Fortunately my brother was there and he took me to our other hotel room to sit down and cool off. Eventually I felt okay again but after that incident I haven't touched the stuff. I will say, one thing that isn't touched on much in this video is addictive properties. With heroin your body gradually develops a literal need for the substance. For my part I have never once felt a "need" for coke, it's just something I did for fun at parties. Not saying this to lessen how dangerous it can be but I've never once met a true coke addict. I have met a few heroin junkies.

[@FickFaceMcgee]

most likely you have met casual coke users. coke just seems to be normalized for people who know how to function off of it or use everyday. coke doesn’t really have many physical side effects that you can see off of a first glance. heroin on the other hand…

[@---m---]

yes, but what is the RATE of overdose? There are wayyyy more coke users than heroin.

[@dshcfh]

Yeah, and also heroin doesn't typically kill people unless it's mixed with other drugs. That part of the video was lacking in research.

[@LukeyD88]

I spent a lot of time around coke, but I never once was tempted to try it.

[@LukeyD88]

@MitchelleDavis-bh1yj are you a wannabe “instagram famous” model or something?

[@mukhumor]

Speedballing is a bit like playing Russian Roulette... you might get away with a couple of times, but there is hit with your name on it.

[@VOiDED50120]

As someone who smokes weed daily just stick to that. There are many other way safer drugs that you can try like marijuana, shrooms and LSD that can do very positive things and don't really physically harm your body like hard drugs do.

[@parallel-knight]

Can you please do a video on white phosphorus.

[@darkscienceyt]

I'll add it to my list and let my patrons vote on it

[@parallel-knight]

@@darkscienceyt cool thank you. Also this was a interesting video I really thought there would be more deaths from heroin. Although if you did are there more deaths from opioids over Cocaine then surely opioids would win.

[@Mikej1592]

so if I were so inclined to delete myself, increasing Heroin in my system till I was just so relaxed I'd stop breathing sounds like quite a ride, nice peaceful way to go

[@rush1er]

I'm from Miami and I don't do cocaine. I just like to smell it, sometimes with a straw... till like 3 in the morning.

[@ImanuelCunt]

Me too! What a weird hobby just the two of us...

[@BraydenBomb06]

big fan of both. coke is miles more acutely destructive, whereas Heroin the destruction is more or less caused by what you do to get your fix. Just talking about them both as recreational substances, never experienced addiction to either just benders

[@dragospahontu]

The eternal question. For my taste cocaine is the optimal compromise.

[@denellwest]

👌🏾

[@hubertmantz1516]

A very interesting video! Thanks!

[@christineferreira2181]

My mother died at 55 in 2012 due to a diet of alcohol and opioids. You should do a video on both. Alcohol is especially bad. It's so bad that when Covid was lockdown liquor stores were open because it is considered a necessity because withdrawal can be fatal.

[@ZOCCOK]

Alcohol is a deprressant, that too a weak one at that I don't think that withdrawal of alcohol can be lethal. Maybe it's just a Wife's tale made up by alcoholics to justify their addiction

[@Bilmonis]

@@ZOCCOK Yes, abrupt withdrawal can be lethal: en.wikipedia.org/wiki/Delirium_tremens

[@MichaeltheORIGINAL1]

@@ZOCCOK Gotta love when people talk out of their asses.

[@YachtsOnTheReg7]

Alcohol and opioids are both central nervous system depressants so taken together there is a much higher chance of dying from stopping breathing.

[@christineferreira2181]

@@ZOCCOK It's wives tale and alcohol withdrawal is very real

[@LichaelMewis]

Background music sounds like the movie Prometheus. Sounds great!

[@irathernotsay2627]

It be cool if you did a short little video(5 minutes long or even a KZbin short) about Narcan and it’s interaction with drugs. I remember watching a tv show where the ambulance used it when someone overdose and it was inhaled(?) through the nose But I love the video and the vibes you’re going for! Got a great look going on. But, I am gonna miss the old videos like what happens if you drink toilet water

[@Psychx_]

Naloxone can be applied nasally, much like other substances. From there, it can diffuse directly into the brain (the bone separating the nasal cavity and the brain is very thin and has olfactory nerves going through it). In terms of efficiency and duration until the effects start, it's closer to i.v., i.m. or rectal use than to oral application. Finding veins is hard and takes time when one has an acute opioid overdose (and hence, a very low bloodpressure, or even circulatory arrest), so the nasal route may actually be faster and more viable than performing an injection in some cases.

[@em1osmurf]

a guy next bed over in the ER got narcan. i don't know what he was using, but he screamed until his throat gave out, about 2 hrs. narcan is a sudden, total, brutal jones. no thank you.

[@Psychx_]

@@em1osmurf Well, it was either that or dying. May be a good lession for the patient to better respect his body's limits.

[@_Kovayne]

One of my neighbors kids OD'd on fentanyl and had to be Narcanned *4* *TIMES* by the popo before the ambulance got there and took him to the hospital. Crazy.

[@Psychx_]

@@_Kovayne Substances that bind strongly to their respective receptors (fentanyl) can only be meaningfully antagonized by a substance with a weaker binding affinity (naloxone) if a huge amount of that is used; What you described is pretty much normal from a receptor kinetics point of view.

[@NAT-turners-Revenge]

3:05 that woman died in 2018, she was 24, and she was actually introduced to it by her mother!

[@Vinx-tripsOninstaSells]

Lookup☝️🍄✅ that handle he got DMT LSD psilocybin MDMA psychedelic Shrooms 🍄.💊.🔌.🍫.🍄....

[@evrik78]

I was left speechless.

[@evrik78]

And shocked.

[@prapanthebachelorette6803]

Good presentation

[@NoName-ed7vo]

plase crate a video about ice(cristal math)

[@lowskill2]

So if i'm crashing on a heroin predominant speedball i can fix it with a line of coke or two?

[@coldgf637]

Could you do a video on the affects of swallowing mouth wash? I’m just curious on what happens

[@rockharddock1711]

you want a video on that?

[@patrickfitzgerald409]

@coldGF6 having a laugh.

[@adamnanney4952]

When I was 25, I got into online dating, ( that was my first mistake in this story ), I met a woman, who was 10 years older than me, I really liked her and still think about her to this day, when I saw her photos ( before her drug use and before I found out she was a former drug user ), SHE WAS BEAUTIFUL!!! I'm serious as a heart attack! She looked like a human doll. But when I met her in person, I noticed she looked different, she was still cute, but she looked 20 years her age. But it all made sense, she had difficulty with her memory, was easily confused, and you talk about paranoid, I thought I was bad, no, she had me beat. Long story short, she just wanted a sugar daddy, not a relationship, and she lied to me about violating her probation/house arrest, and being a felon about her drug use, so I had to call it off. I'm not going to lie, yeah I was devastated and it still hurts, I wish it could've worked, but like I said, she violated my trust and just used me to buy her things. Edit: duh, I forgot to mention, that she was a former heroin user, thus why I divulged this incident.

[@n0xhy]

I dont think any of his videos is monetized...

[@zyplocs]

1:35 I'd like to point out, the evidence supports dopaminergic pathways as 'wanting' pathways, not 'liking' or 'euphoric'. Wanting is directly associated with the reward system, but the "feel good" effect you are talking about originates from signaling in opioid pathways. 'Wanting' and 'liking' are two separate paradigms, and a common misconception is that dopamine = pleasure, although the evidence shows otherwise.

[@wretchedegg2208]

Very interesting. Could you also do a video about Fentanyl ?

[@lovesallanimals9948]

It kills

[@feddant0508]

This channel kick ass

[@thamirivonjaahri6378]

I believe something should also be perhaps added in terms of sociological effect, where both drugs in medium to long term alter psychological state of individual to the point, where his/hers capability of social perception degrades significantly over time. effect may vary, but in general users of named drugs will likely become excessively paranoid to the point of open hostility even towards close ones, their capability to socialise in general will diminish greatly and among other effects, such as constant dizziness when sober, confusion, panic attacks, visual and auditory hallucinations (example being one of my former classmates was heroin user and once he said he could hear his dead grandmother's voice as if in next room threatening to kill him). In the end if one doesn't die physically, he/she will definitely die spiritually and all that will be left is empty husk just craving more smack and cabable of severily harming others just to get one more dose. Just don't take this sh*t, it's never worth it.

[@pepefroglive]

That's very dangerous when combined. I never knew the science behind that.

[@ANDROLOMA]

It was pointed out to me years ago that long term heroin users such as Jimmy Page and Keith Richards could live for years. But there was no such thing as long term cocaine users. Coke's too hard on the heart.

[@OtavioFesoares]

Coke is cardio-toxic by design. But I mean, you won’t be living that long on Heroin without having an overdose.

[@ANDROLOMA]

@@OtavioFesoares Tell it to Page and Richards.

[@OtavioFesoares]

@@ANDROLOMA I wish I could. Richards is one of my idols! Page, not so much but I like some Zeppelin songs too.

[@ANDROLOMA]

@@OtavioFesoares I feel the same way, but who can top the master, the late Jimi Hendrix?

[@OtavioFesoares]

@@ANDROLOMA Hendrix was just too good. Electric Ladyland is one of my favorite albums ever.

[@germansoldier1944]

You should make more drug videos.

[@JudesChan]

I used to work for medical doctors & still stay in touch with them. I see speedballs get mentioned a lot on crime & legal dramas, one day I asked one of them which one would take effect first. She said, without hesitation, heroin. Is that true?! I didn’t think it was but after this vid, it makes sense, since it crosses the BBB easier Is it also true that you can’t really put narcotics on a “spectrum” of its potency, for example, if someone is taking oxycodone 10mg, there is really no “substitution”. By that, I mean if, for whatever reason, oxycodone 10mg & all the other strengths are unavailable, there’s no “substituting” it with, Demerol, morphine or fentanyl.

[@bigredracingteam9642]

That's not true. That's like saying there's no substitute for vodka or whisky - an alcoholic might prefer one over the other, but if they can't get their hands on that the next thing will do. It's the same with drug users facing withdrawal - they'll take whatever opioid they can find to stop it.

[@chemlearner2721]

And also thought people say this opioid is however many times more powerful than this other one I thought it all boils down to a relation of morphine equivalents, so the strength of morphine being the meter stick.

[@therideneverends1697]

depends how they are ingested, if the heroin is injected in a vein than it will hit before snorted cocaine does, if the cocaine is also injected they will both start very shortly after injection, if both are snorted the cocaine will hit first. the danger here is that cocaine wears off MUCH quicker than heroin while also encouraging reckless behavior, meaning someone on coke and heroin can take more heroin than they would otherwise, in an amount that would cause and overdose without the stimulant in their system. but the cocaine keeping their body from relaxing to the extent of shutting down only lasts 30 min to an hour while the heroin lasts up to 8, this is why so many overdose deaths are from mixing cocaine and to a lesser extent amphetamines (since they last 6 to 16 hours depending on which one) because people dont realize the stim is whats keeping their nervous system signaling

[@JudesChan]

@@bigredracingteam9642 That’s not what I meant. I was tasked to ask a pharmacist about changing an elderly patient’s medication. She had shingles & was unfortunate b/c she had long-term nerve pain afterwards. Initially, the doc prescribed Percocet, but the patient could not tolerate the heart palpitations from the caffeine in it & it made her nauseated. Doc next prescribed her the fentanyl patch (lowest strength) but to cut it in half otherwise it would be too strong. She found half the patch, 6mcg, too strong, so she had me ask the pharmacist if there was something in btwn. He said no b/c you can’t put the different narcotics on a scale like that. He said there is no in-btwn b/c while 10mg of oxycodone & 6mcg of fentanyl will alleviate some pain, they don’t work the same way & the body metabolizes them differently. Of course, if someone is addicted to narcotics, \they will take codeine if it was available, just to take the edge off, but that’s recreational use

[@JudesChan]

@@chemlearner2721 That’s a good point. Whenever I hear that, I tend to think they are cautioning those who are not taking it under the supervision of a medical doctor. So if a person is a recreational heroin user, they should heed the warning & not take 10 oxycodone pills at once b/c there’s no guarantee that they’ll get the euphoric feeling they’re looking for & it’ll kill you

[@noneofyourbizness]

Heroin is NOT usually taken by injection, except by those addicted to it , where it is almost ALWAYS how it's taken.

[@Psychx_]

Alcohol can have as severe and devastating effects; it just takes a bit longer to become addicted to it. IMO the classification of substances into 'hard' and 'soft' as a way to claim that one is more "evil" than another is completely nonsensical.

[@the_magic_max9491]

It is

[@DanielAnderssson]

No its not. Hard/soft drugs makes sense, even if it is a spectrum.

[@Psychx_]

@@DanielAnderssson And yet the very "soft" drug tobacco kills more people each year than pharmaceutical grade opioids.

[@the_magic_max9491]

@@DanielAnderssson hardness is a mechanical property...

[@DanielAnderssson]

@@the_magic_max9491 Well you might be a smartass now but keep taking your hard drugs

[@dizzyspinner648]

"Neutrally charged" does not compute. A charge can only be positive or negative.

[@josephpacchetti5997]

All valid information, there are also studies that have been done on the effects sugar and chocolate associated with the reward center of the brain, and that they produce similar effects but to a lesser degree, Thank you for posting.

[@jhoughjr1]

So does hugging your loved ones. Better regulate them too

[@seanlevoy9446]

Sucrose has caused more human misery than all ilicit drugs combined..

[@187Blackheart]

I love the kamehameha/galick gun smoke in the intro

[@kurtisgonzales37]

Now I know what these drugs are doing to me! Thank you dark science!!!

[@vdub7090]

Very accurate, but i think you should have mentioned fentanyl....theres no more heroin out there. I've been clean for almost 3 years and I hated the last 5 years after fentanyl hit the scene. It was like losing the love of my life.

[@Hannah-fh6ip]

l'll refer this mycologist who helped me treat my depression and anxiety, check him out he also guide newbies on proper trips moments.

[@Hannah-fh6ip]

[@novatripps]

[@Hannah-fh6ip]

He's on Instagram

[@davidthomerson751]

Heroin is more dangerous. Both can kill you. But when you're overdosing on cocaine, you know it. You're like, " Oh shit! My heart is pounding! Get me to the ER!". When you're overdosing on heroin, you don't even know you're in the world. Unless someone finds you and they they have narcan, it's game Over.

[@Stellarainn]

Exactly

[@david-csmhaltero77]

You often have no time to do anything when you fall on the ground, have seizures and lose consciousness during a c od

[@JZT-JZT]

It’s what & how much they cut the product with.

[@Diesel257]

Heroin. Next question.

[@las13-oy5zc]

What about methemphentamine? Is is dangerous as well and the mechanism of action is the same?

[@rickstandish6690]

WoW. Just discovered this channel. Awesome. You got a new subscription. 🥂 Cheers

[@Asmodeus66613]

Them speedballs are what killed Lane Staley stay away from that shit and may he Rest in Peace

[@canineuniversity1015]

Or perhaps narcan was introduced and widely provided is why Heroin lost its lethality over time compared to cocaine. And cocaine is now laced with fenty

[@michaeldog3459]

Much better when used together in the same syringe, addict 14 years, clean 10👍

[@Kabooom22]

Walter White is significantly saddened