HIV Life Cycle | HHMI BioInteractive Video

[@ethellochrose6531]

Honestly, I have so much respect for animators. I'm a 2nd year medical student and this video has been so so helpful. Great job, guys!💫👏

[@Zoronoa_Roro_03]

Damn you’re doing this in second year ??? I’m doing this in year 13, hopefully I get into medicine soon, still waiting on Uk offers :(

[@huiioyasin1070]

1st year ma ap ky kitny marks hn

[@luxxerpolman470]

@@Zoronoa_Roro_03 ikr, I’m doing this in grade 11 and I’m just 15

[@pdevine999]

Its a good job students have animators to create viruses and then funded studies to create a backstory for the particles . Without that your simply studying something that never existed .

[@SoLoGLidez]

@@pdevine999 are you hinting that this is all bs? if so that’s funny

[@mntonja]

I just wish I had KZbin and the internet back in high school. It gets much easier to understand these concepts when you see them in action as opposed to reading about it.

[@inuahead1218]

How do u know this really happens. Virus being in a cell in a live host. How can this cycle be seen? In a live person? In this detail.?

[@thegodofmoneymaking]

@@inuahead1218microscopes probably

[@debayan19]

One of the best descriptive animated video in KZbin for a viral infection cycle. A piece of advice cum request: Please make similar animated videos on different viruses like HBV, HSV, HCV, POLIOVIRUS, CORONAVIRUS, MYXOVIRUS, etc.

[@sehoraneratau4375]

Cant express how helpful this video was,. Thank you so much, you are doing The Lords work for sure

[@vanajasrimbbtc2769]

such a great visualization...thank you so much for scientist for finding all these complex process....

[@Lavenderlouvesx]

This video really made me understand the lifecycle of hiv

[@abcmaniabcmani9361]

💯💯💯💯 I am pre medical student and get many help from this animation I am thankful of animators🥰🥰🥰🥰🥰

[@priyankasangasani6954]

Topic wise crystal clear visualisations 👌

[@MrEthanhines]

Now, can you make the same highly detailed video on Sars-Cov2? Showing the spike protein and ace2 receptor and conformational change in spike protein by TMPRSS2 and endocytosis along with the viral RNA dependant RNA polymerase, and the way the host ribosome sometimes frameshifts to read either ORFA/B and then proceeds to create negative strand subgenomic rnas, and how replication-transcription complexes are created and how they prevent interferon-α from being expressed and how non-structural proteins downregulate host immune responses. And finally how a low cost drug could prevent certain steps in viral replication

[@Matthew-yc6nx]

Such as adenosine nucleoside analogues and protease inhibitors?

[@thegodofmoneymaking]

No need. HIV is worse than Sars-Cov

[@hulyagizemozkan184]

best intensive and clear explanation, thank you!

[@Daniman-nk2vj]

Nice pic

[@vicente5942]

Important to mention, is the fact that CD4 receptor is not exclusive to T helper cells. The CD4 receptor is in T helper cells, macrophage , dendritic cells, and others.

[@Matthew-yc6nx]

That's correct, however the main target cells of HIV-1/2 are CD4 expressing T-Helper leykocytes.

[@Ciaran55]

I started reading more and more about the immune system and these things we call viruses. But that only makes me want to ask more and more questions. For one thing, how does a strand of genetic material even know how to get into the nucleus? Do viruses need energy, and what are 'proteins' exactly? Rambling aside, thank you for the video! Life is incredibly complex

[@kallashnykov]

Well a strand of genetic material is information. The virus has all the information necessary for it to get into the cell and multiply embedded in its dna. Proteins are biomolecules that carry functions inside a living being.

[@bigpardner]

@Unique Pros Sperm have motility

[@bigpardner]

Why would a virus need energy for if it is not a living thing? Nothing in this animation has ever been observed has it? Doesn't that make it all theoretical?

[@pdevine999]

@Abhiyanshu Chaudhary ribosomes probably don't even exist , I bet they never learned you about the work of Harold Hillman , they have turned something way too complicated for the human brain to understand or observe into simple materialistic blocks or repeatable information , the problem is is that its 99% wrong.

[@biointeractive]

Which 1% is right? Just asking

[@shahmohshafi6103]

This video is really awesome and a great way to clear the concepts

[@Dr_SteveK]

Brilliant, very brilliant depiction and quite concise. Thank you

[@biointeractive]

You're very welcome!

[@JoaoVictor-dw2ci]

This video is magnificent to understand the whole process happening !!! amazing

[@Jindy2]

Excellent clip - very clear and well explained. Thanks!

[@nighteyes.5455]

Leaving a comment for the algorithm. This was great, 10/10.

[@t.r.4496]

Somebody figured all this out with a microscope, all I can say is bravo.

[@Eman_Puedama]

Did they? I doubt it, because that's not how it was 'isolated'.

[@coneyworks8791]

Most viruses are too small to be seen with a typical light microscope however can be seen with a electron microscope. But I quite agree, still bravo :)

[@eeltauy]

I'm just speechless!

[@Karan-wz7pt]

this is spooky and mind-boggling at the same time

[@buddy8998]

being A Neet Aspirant I have Watch This Video About 10 times...lol Before every test i Watch it Insted Of reading NCERT

[@librarieskim8569]

Finally, i finally understand this thing thanks to your amazing animated video and your explanation. Thanks a alot

[@biointeractive]

Glad it helped!

[@Folkmarev]

Wow! Clear and amazing explanation, thank u so much

[@librarieskim8569]

I subscribe a channel after a long time, can't miss your videos

[@yangjiansir]

So complex how do the scientist find such process?

[@williamcahyadi]

Curiosity

[@thundaga4005]

By forming hypotheses and testing them against laboratory experiments, repeated over and over again.

[@kotsaris87]

By doing science.

[@razvanboasca1146]

Because they made it.

[@shafiulismam5334]

Biochemistry X Genetics

[@zubaireditz5900]

The best of best video

[@Alathar27]

Thanks so much.. Alot of work has been accomplished for me

[@biointeractive]

You are so welcome

[@minahalriazbutt121]

thank u so much sir for such a best video.......it is really helpful in understanding the whole process which would otherwise be very difficult to learn

[@biointeractive]

You are most welcome

[@vladimirvondracek7570]

Excelent video, thank you

[@biointeractive]

You are welcome!

[@tayyabasehar1561]

Thank u so much for this kind of act

[@FELISCATY]

Animation is a intuitive way of learning And for instance substitutes long perpetual lectures in just a few couple of time .

[@Dr.Iftekharbaloch]

Very informative. What happens to 2nd RNA strand?

[@sina8398]

when HIV enters the cell both of RNA's form a double stranded viral DNA , and that DNA will go and stick to the host DNA. so that will cause a long-life infection because scientist are not able to remove that viral DNA from the host DNA

[@natalierobinson177]

I would have done so much better in highschool if the internet was around. It’s hard for me to grasp these concepts without a visual ❤❤❤ really helping me in college

[@vishnujwalapuram1415]

Excellent Video with good Voice description !! it is shocking to see how many activities inside our body happens with such high precision. what direct Virus to do all these ? the whole ego of any organism is reflected in the form of multiplication of itself. Is Virus doing the same ?

[@Cleeon]

Chemical reaction, by the natural law, all creature programmed to keep their existence, they just want to stay "immortal" or exist

[@bigpardner]

If virus is not alive it is not an "organism" is it?

[@gsnaveen1218]

Really a good video sir.... Hyped my curiosity ❤

[@InfinixHotPlay-vn6cv]

Animation is the best way of learning.

[@rudygarcia2567]

Agree 100 percent. Nice video. I only have 1 question why can't the body detect Hiv during the early phase or upon entry? I have a theory which could be extremely wrong- because Hiv is so unique- the body of course can detect Hiv. However during early immune response Hiv can easily elude this by giving up its receptor sites( gp 120). The immune system would stop attacking the virus because it only attacks virus with antennas or gp 120. In the absence of gp 120 it would shut down. Then Hiv would grow back its gp 120 if threatened again it would give it up again. The process would go on and on until it reaches its target tcells. By then it's checkmate.anyway it's just a theory which is probably wrong anyway. I just wish people with Hiv aids will be healed soonest.

[@puteripelangi3388]

@Unique Pros yup

[@Sophia-gc5yz]

Thanks for this video! Helped me out with my genetics class.

[@fatamajolly6012]

Excellent video

[@shafiulismam5334]

make more technical videos like this pls

[@mobinshafeian2711]

incredible video, this video was super good for my school project

[@thandolwethuntombela8691]

best video on the internet me thinks!

[@yersinia3510]

I thought CCR5 coreceptor is required for HIV to enter macrophages? Based on my source, it is CXCR4 that is required for HIV to enter T-lymphocytes particularly T-helper cells. Can you please enlighten me?

[@Matthew-yc6nx]

Some strains of HIV utilise the CCR5 corepector, some use the CXCR4 coreceptor, and some use both. This is called HIV-tropism. Some people are co-infected with both CCR5 and CXCR4 trophic viruses. This is known as HIV superinfection.

[@andrashajdu]

Its amazing that we are able to understand this

[@junepadi4362]

Now that we understand it, how do we neutralize it, permanently.

[@Matthew-yc6nx]

​@@junepadi4362bNAB's? Latency reversal agents?

[@Static_Symphony]

Really interesting video. Thanks for posting! :)

[@biointeractive]

Glad you enjoyed it!

[@gscreations8680]

Man, God Is Incredible! How He Programmed All These Functions In Our Body. Stay Blessed Everyone.

[@Matthew-yc6nx]

No this is just how we evolved.

[@Dr.Iftekharbaloch]

2:06 Single stranded DNA is again reverse transcribed? Since the single stranded DNA is used as a template for synthesis of 2nd strand of DNA so can we call it reverse transcription?

[@biointeractive]

Good point, that shouldn't be considered reverse transcription I don't think. Many of these animations will be re-narrated so we will check that. Thanks!

[@Dr.Iftekharbaloch]

@@biointeractive It would be better to narrate the polymerase and nuclease activity of reverse transcriptase..

[@thokling361]

The process is described by the narration (and subsequently the video) as a single operation and by the incorrect enzyme. It appears that DNA polymerase synthesises two single DNA strands from one, and DNA ligase joins two single DNA strands into one by joining DNA sugars on each strand together.

[@Dr.Iftekharbaloch]

@@biointeractive Still not re narrated...

[@biointeractive]

Thanks for bumping this. Turns out that reverse transcriptase does indeed make a double-stranded DNA molecule out of the single-stranded DNA. Using the phrase "reverse transcribed" is misleading, I agree, but reverse transcriptase is indeed the enzyme that does it. If we ever re-record this narration (the current one was taken from a live lecture) we will keep this in mind. "Reverse transcriptase (RT), also known as RNA-dependent DNA polymerase, is a DNA polymerase enzyme that transcribes single-stranded RNA into DNA. This enzyme is able to synthesize a double helix DNA once the RNA has been reverse transcribed in a first step into a single-strand DNA." From: www.sciencedirect.com/topics/neuroscience/reverse-transcriptase

[@kidspremieretv]

Thank you 💗 sir, This video are really very helpful for me , in this video we are easily and clearly understand.

[@tinabrahim7085]

Great video!

[@ahmadbhaiyat3015]

Agreed

[@biointeractive]

Thanks!

[@TheWa4er]

It would be great to see a similar video about how modern HIV medicines works

[@antonioacevedo5200]

I am no expert by any means, but I just watched another video where it explained that medications specialize in preventing one or more of the sequences that occur during the replication processes of HIV. What I wonder is if these retroviruses eventually die of old age.

[@roo6784]

Antonio Acevedo Unfortunately no, viruses cannot be killed. Viruses are non living microorganisms that contain genetic coding (DNA, RNA, etc). However, a virus can only thrive if it invades a host, they cannot live independently. Once a virus binds its receptors to cells, they hijack the genetic instructions and multiply in vast numbers, unless a medication is taken to prevent the receptors from binding. But it would be difficult to predict a viral invasion because symptoms will not start until after the damage has already been done (Which in this case, would be the virus hijacking the genetic coding of an individual and multiplying).

[@bigpardner]

@@roo6784 In one sentence you say "viruses are non living microorganisms ". If non living they are not microorganisms are they? Organisms and microorganisms are living things. How can a virus invade a host if it is not living? How can it can or cannot "live independently" if it is not a living thing, an organism? How can something have a reproductive cycle if it is not alive?

[@biointeractive]

www.sciencenews.org/article/viruses-alive-coronavirus-definition

[@joaosayeg]

The RNA is not converted in DNA, it's used as a mold to create DNA. Is that right?

[@الخيرفينا-ر3ن]

Very helpful, thanks

[@biointeractive]

Glad it was helpful!

[@MDmasumBilla-c1c]

Thank you so much for tha amazing video ❤

[@jonathanmwanzia1804]

wonderful one

[@biointeractive]

Many thanks

[@AbdullahSwati-i2r]

I subscribed your channel bcz of this beautiful video, thanks! If you add more detail like from how it enters our body + for macrophage i.e. CXCR4 …… its budding off and destroying the cell membrane. Again Thanks for you👍

[@mortadhaqasim959]

Well done 👏🏻

[@marcayalde1953]

10/10 animation, W

[@Matthew-yc6nx]

1:27 This video is inaccurate. The capsid is not shed upon fusion into the cytoplasm. The capsid travels intact from the cytoplasm and is imported into the nucleus through nuclear pores by nuclear import proteins. Reverse transcriptase happens while the RNA is still inside the capsid, and the capsid does not uncoat until the reverse transcriptase process has complete (inside the nucleus) and the viral DNA is then ready to integrate itself into the host DNA.

[@jaethegoddexx]

This was great to follow along

[@noorain_fathima]

Superbbb

[@Thaofficialsensei]

It’s as if the viruses are computer coded they come with their own installation software and everything 😮

[@maniblue707]

very usefull

[@АньЛыу]

thank you so much for that amazing video

[@biointeractive]

Glad you liked it!

[@ozdevil4564]

How does Prep works?

[@alfmerck6262]

It creates chemicals that disrupt the virus's reproduction at all of the various stages described in the video.....1) it prevents the HIV entering the cell.....2) those that do enter the cell are then stopped from reverse-transcriptions....3) those that manage RT then get prevented from cleaving the DNA....and so on.

[@Guidingstar-h2i]

Thank u so much Sir❤❤❤

[@knightshade6232]

do viruses move on their own do they have some mechanism to fly around or swim like bacteria??? if they do move this can require energy so they must eat but they do not eat?????????? can someone answer....

[@happyrick-c1327]

Yes

[@bigpardner]

Aren't viruses not alive, not a living thing, not an organism? If that is the case how could they move? How can something not alive have a reproductive cycle?

[@alfmerck6262]

It's all chemical rection. Remember, there are millions/billions of HIV roaming around the body, and about 1-4% of them get the job done (against about 1500 immune cells per cubic mm). So its not about 'eating' its about chemical reactions.

[@dr.archanamane]

​@@alfmerck6262explained well.. Can you further elaborate what happens to remaining 99-94% viruses if only 1-6% get the job done..

[@basisTermium]

i dont get how the virus know when too bud off?

[@jetrogutierrez1356]

The virus budds out once it has all the correct protiens to mature into an infectious hiv virus. Then it will mature outside of the cells after peotease does its job.

[@warriork4802]

The best one 👏👏😊

[@shafiulismam5334]

Hi Biointeractive, make one like this for corona virus

[@sarwatfatima4946]

well explained

[@LOZtwilit]

Would it be possible to destroy those receptors somehow? If the virus can't replicate wouldn't it expire past the incubation period? I'm asking in all seriousness.

[@NotoriousPyro]

You'd die if you destroyed those receptors. They're used in immune response.

[@jamesjohnson1050]

Some HIV medication work by blocking the receptors on the virus.

[@Matthew-yc6nx]

​@@jamesjohnson1050Like Maraviroc, Enfurvitide and Ibalizumab?

[@wolfpackflt670]

Soo.....why not just use crisper to change the "keys" on the helper-t cells so that the virus can't enter?

[@biointeractive]

Main issue is changing the receptor enough to make it unrecognizable to the virus but still maintaining its regular function. (And that's assuming we get CRISPR working in humans)

[@KunglawAdy]

@@biointeractive man.... looking at this is like human body is just complex functional super computer with doing complex computation

[@moulya.s5066]

Tq fr d information

[@luislanga]

How does all that stuff move into the right place to do all that

[@sharafallmai8140]

Thank you

[@shivamghosh7019]

Can multiple hiv virus enter same cd4 cell ?

[@jaylxxxi1908]

Its like cells are biological computer machines.

[@gjzztrrettmmggrrertzhgyena4950]

Thanks Sir🖐💖💖💖💖

[@inuahead1218]

How do u know this really happens? How can u study life cycle of virus which are within a cell in a live human. ?

[@Bigdave123]

Why can't the body detect all of this happening inside?

[@Matthew-yc6nx]

It can. Sometimes CD4 cells compromised by HIV can self-destruct, either by apoptosis or pyroptosis. This self-destruction mechanism is one of the major causes of CD4 cell depletion where HIV infection progresses into AIDS (CD4 count of less than 200 per uL of blood).

[@mcdonnell-douglasdc-1087]

EXCELLENT.

[@syntacticcave9514]

Very interesting

[@ilyasyo6079]

thnk you very mutch

[@IhsanullahAwan-k2n]

Thanks😊

[@yaranady9860]

Perfect ❤️

[@matman7691]

Can anyone explain like I'm five? How would reverse transcriptase be able to read the single strand of DNA? I have it in my head that reverse transcriptase only interacts with RNA. Am I simply incorrect in thinking this?

[@biointeractive]

Transcription is making RNA from a DNA sequence. That's why this is reverse transcriptase: it makes DNA from an RNA sequence.

[@ZKhan782]

What? You are only five and studying this 😨

[@ZKhan782]

From where other glycoprotein of virus com from on cell surface

[@sugarbrownies8080]

what happens to the other rna asit is double rna

[@dr.k.nandhakumar]

How to create similar animation video

[@leonak7654]

Smart virus and scary !

[@Matthew-yc6nx]

Not smarts, just evolution and selection

[@joeyng1282]

One question why HIV virus only targeting the T Helper cells but not other types of cells?

[@scrullybrully751]

Because the virus binds to a protein (CD4) that is only present in T helper cells. The HIV only has the "key" for a kind of "door" exclusive of T helper cells, while other cells have other kinds of "doors".

[@dr.archanamane]

​Does it sound that hiv won't be present in tissues where cd4 receptors are absent...

[@reeja478]

Neet aspirants are here😁

[@omarsantiago2826]

excelente

[@DrAriba-rt8zo]

How are you all doing today?

[@80sbrunnette]

crazy, its as if it has a mind of its own!!

[@sandrodream5418]

This is incredible only got the cold create this perfection

[@rawandahhan8866]

Perfect!!

[@bluespark7182]

how the hell did this get in my recommended, the yt algorithm is weird

[@bobleclair5665]

at what point with all these covid boosters given do we start noticing reverse transcriptase, the bi or the trivalent

[@Matthew-yc6nx]

Only retroviruses use reverse transcriptase.

[@taniaratobilskaja-obreiter4616]

Классные видео! Сделайте pleas субтитры на русском oder auf Deutsch.