Homologous Recombination & Holliday Junctions

[@antiantifa1313]

Insane work. Thanks man. Your video is still helping people 13 years later!

[@EcommerceProsperity]

I couldn't help but spit a lil freestyle while watching the video

[@khachikkhachikyan9634]

Felix Page same here!

[@lianbenton9174]

I guess im randomly asking but does anyone know of a way to log back into an Instagram account..? I stupidly lost my login password. I would love any tips you can give me.

[@abrahamizaiah3171]

@Lian Benton instablaster ;)

[@aichahanif5230]

Lmaoooooooooooooooooooooooooooooooooooo

[@antiantifa1313]

@@lianbenton9174 this comment reminds me of times when the internet was a cooler place

[@mrigayu]

How long I have been searching for such an animation! Really really well done!

[@QS30]

Incredible video. Thanks for taking the time to illustrate this process in such an easy-to-understand way. Subscribed.

[@elitegaming4262]

1 hour lecture summarized in a minute :) thanks a lot

[@medinabaitemirova8833]

This video explained me what two professors and a textbook couldnt Thank you!

[@afizz27]

no joke. the most... .awesome vid ever. thank you so much.

[@tphan219]

at 1:11 , the top strand should have the black end to the left and yellow end to the right. Other than that, very useful video!

[@parharn]

I think the crossover product is not correct! The top strand should be small velvet to the left and long yellow to the right! Or I didn't get it?!

[@BigMamaMarcus]

Yep, you're absolutely right.

[@tianjingzhao8980]

Yes you're right

[@silent_anon404]

Glad to know I'm not going crazy

[@fromTheRitztoTheRubble]

thanks, I was about to cry

[@gabrielagreste]

A vertical cut to holliday junction causes the rotation of DNA strands. The crossover product is correct.

[@OneofTheseEchoes]

Whilst the middle of the orange and blue strands have 'crossed over' it is non-crossover as the rest of the chromosome is the same as before. The orange DNA (depending on where it has come from - sister chromatid/homologous chromosome) should be pretty much identical to the corresponding blue DNA so it won't make too much of a difference that it is in a separate strand as it is only a small section of DNA, although mutations may arise,

[@jeanetteg7618]

This is so helpful! I actually understand it now, which is great lol (seriously, why are textbooks so confusing?).

[@krypticphoenix]

DUDE!!!!!! Holy shit, I've been battling to understand the crossing over and this video showed it in a way that gave me that EUREKA moment. Thanks a million!

[@1217angela]

Thank you so much! I'm 1st year in med studies and this was a big help :)

[@brunafadul6779]

This saved my life. Thank you so much!

[@raddior]

i'm in medecine studies and it help me a lot ! thank you guy !

[@MrRoperete]

I did suscribe for the beat. Simple, clear, and cool animated.

[@TheAnusha26]

The top most strand cleaved should have had yellow short segment and long purple/blue segment and vice versa for the bottom most strand.

[@_microbialworld_]

thank god i found this video. i was stuck understanding it by A A' a a' .

[@NorthPoleMan91]

very helpful. exactly what i was looking for. thanks

[@thatissmashing]

Where it says 'non-crossover products' surely the light blue strand would go back to its original position, as by moving to the orange strand surely that is a crossover product. I'm not sure any help would be great :)

[@mankim2405]

crossover part is so confusing!

[@TheFightmaster22]

Bc it's wrong

[@gehadsamir5663]

1:06 I can't understand how that cleave would result in the final model 1:10

[@mar9en]

Dangit, I wish you had animated the actual cutting and crossing instead of just showing the new products. I have trouble visualizing what is linking to what to get these new sequences. :(

[@anigroegm.eeknay2771]

Same!

[@AswinSSoman]

simple and elegant... i like the MUSIC....

[@simrannisha8793]

Appreciate the effort.... Commenting for algorithm..

[@katiemallalieu1750]

Thank you this was really helpful for visualization

[@nizar5426]

short condense and clear

[@mattschaich]

I love this music

[@vuhkhyhg3334]

SUCH A BOMB VIDEO THANKS

[@salimasemo7671]

* twerks instead of studying * good music out there and great work! thanks alot

[@necoshitame]

waou !! ta vidéo est géniale, tu m'aide beaucoup merci merci !! :D (thanks a lot, I love you !! I have been spending hours to try to get this systema !! )

[@Ichneumonidae2]

really diggin this

[@purpearl1]

very nice and useful thank you

[@thefenerbahcesk4156]

Nice explanation. Got a final in 12 hours for genetics.

[@khachikkhachikyan9634]

im not gonna ask for the instrumental's name because you guys will just say darude-sandstorm

[@muntahaa1]

Darude-sandstorm

[@kirpalpanacer2638]

Did you find the song name by any chance?

[@francescogallo4562]

@@kirpalpanacer2638 yes, it's Darude-Sandstorm

[@kirpalpanacer2638]

Darude-sandstorm

[@kirpalpanacer2638]

@@francescogallo4562 Aaah I get it. It's darude - sandstorm

[@A156992000]

great video and more clear to me

[@stephensack9776]

Wow! this video is Awesome!

[@lenaxdeng3202]

Thank you so much for making this video! It really helps with my revision :^)

[@MyUsernameForReal]

Thanks so much for posting this!

[@monalimukherjee1031]

Helpful video.. 👌

[@Salamimalicum]

Very nice!

[@Dramko]

Awesome video

[@deanstastic]

Nice work but there are a few mistakes. 1st, there is no experimental evidence that Dmc1 and Rad51 bind on opposite sides of a break. 2nd, the free 3' ends after resection are invading the wrong strands. The yellow should pair with the dark blue and the orange with the light blue (assuming the top DNA strands are in the same 5'-3' orientation as the bottom ones). 3rd, after crossover, the top most strand has become inverted:it should finish with dark blue on left and yellow on right (at 1'10'')

[@omgggitsnotme]

Thanksssssss a lot This is awesome Ive been tryna understand this and i did finally

[@MrPotanton]

Thanks for that!

[@anondoggo]

Excellent video, thank you for your help. It would have been nice if the top strand was not reversed and the cross-over product didn't happen so quickly though, but anyways I get it now.

[@bryancstephens]

Best yet.

[@priyankagunduboina9680]

I love you for this 😭

[@DipanGhosh]

Nice way to make an animation. Great!!

[@MCBeee]

Forgot the Rad52 and Rad59 proteins that help. I like it though.

[@aami325]

thank you for making this!

[@thatissmashing]

Thanks pal, unfortunately this never came up in my exam :(

[@Fanijan995]

this is super cute and also helpful 😏

[@blessdog5392]

yr super cute, what is you phone #. can i take you to the ballet? chopin?

[@sebbe91]

thanks, great video :)

[@matsherzog3647]

Ruv proteins: Am I a Joke to you?

[@adamrossouw]

i think the very top strand has just been placed the wrong way around, ie 3' is in 5' position and 5' in 3' position

[@saku.raphie]

you are amazing thanks

[@zzgspzz]

best biology video i've seen in a very long time, thank you!

[@rockyfei521]

Is there something wrong? in 1:12, the deep blue fragment in the first row should be putted in the head of the first row

[@lilyrc1]

Wow!! that was very helpful!! Thanks!! :)

[@21MWTF]

what a tune

[@mary._.yamborghini]

this is pretty dope

[@Dayumhesgood]

sick vid

[@keef920]

Lifesaver!

[@tankst4r113]

merci elsa

[@DanitaOnly]

amazing :D thank you so much!

[@BrittanyJonesLinares]

Very Cute!

[@OughtaBeFun]

AWESOME!

[@smburgessca]

Pretty good until crossover resolution. You shouldn't get heteroduplex on the two ends of the top chromatid. Problem comes in between 1:07 and 1:08.

[@rascolnikovtube]

Perfetto! Got it

[@kadral]

Looking for the author of this music, some chill beats. Please respond :-)

[@darrelbigdaddywhite]

Would God like his design better? Would he dwell there in with the changes? Is not the body Gods temple?

[@corywantstoknow]

thank you!

[@FairyGammy]

Thanks a lot ;)

[@emrekarabayr1446]

👏👏

[@aidanye8530]

goat

[@Nadanada-uz7ki]

Merciii

[@NanySofia]

BAM!

[@dannyholley]

Dope.

[@blessdog5392]

they really hold your hand through it. for the slow learners like us:)

[@alcyonecrucis]

choon!!!

[@TheZelda1231]

hot beat

[@suandipratama8344]

Holy fuck....it is helpful

[@williamgustafssonknutsson5542]

Which are the red enzymes in the end?

[@niloofarkh4779]

perfect

[@NahinAndroid]

SIR ACTUALLY THIS IS NOT TWO HOLLIDAY JUNCTIONS MY PROFESSOR SAID IT IS ONLY ONE PLEASE CORRECT YOUR VIDEO

[@xiangli6707]

Good music

[@mrinedible88]

Touch my cheddar, feel my beretta...

[@TeeAyEye]

i love you

[@gornjane]

This is not correct! Mre11 (part of the MRX complex) has 3' to 5' exonucleolytic activity while Exo1 does 5' to 3' resection. As a result, you get bidirectional resection resulting in 3' ssDNA tails. What you show here is MRX complex with 5' to 3' exonucleolytic activity.

[@masonreynoso3077]

Cool

[@melissamasserant1716]

Your crossover products are inaccurate.

[@southWarped]

Damn what is the track playing ? song ?

[@Naweedtv]

thank you based god

[@izziekidd8478]

I don't understand why the first cleavage gives 'non-crossover' products as one of the strands in each chromosome is now made up of some DNA from the other??

[@muhannadraad519]

What is the mean BAM and MRX ??

[@zsofiakoltai9434]

That's the szostak modell :((

[@abtintari153]

can someone ID the song pls

[@ms.hardcandy9021]

what's the name of this beat? who made it?

[@remybln6962]

COUMOUL EN FORCE !!!!

[@Elias.M92]

J'aurais jamais cru voir un cartésien par ici. Bon courage ! (Un ex-cartésien)

[@Biomations]

Haha! No more comic sans... promise.