How bacteria "talk" - Bonnie Bassler

View full lesson: ed.ted.com/lessons/how-bacteri...
Bonnie Bassler discovered that bacteria "talk" to each other, using a chemical language that lets them coordinate defense and mount attacks. The find has stunning implications for medicine, industry -- and our understanding of ourselves.
Talk by Bonnie Bassler.

[@Lili-yz6xf]

Timestamps/vocab: Vibrio Fischeri- 3:09 Bioluminescence- 4:09 Quorum sensing- 7:13 Intraspecies communication- 9:18 Interspecies communication- 10:49 Esperanto/ a universal communication molecule- 11:31 A new approach to antibiotics- 13:45 Quorum sensing in bacteria- 14:43 The gang- 17:11

[@vishnuyella5058]

Goat

[@casey-gt8nl]

LETS GOOOOO

[@evanpalmer3594]

That was one of the best explained TED talks I've ever heard

[@soniabarrett]

I absolutely agree with you! Really great job!

[@kaitlinmatrix6473]

The way she speaks about the young researchers is amazing. Genuinely made me tear up! I don't know what I'd do if my PI talked about me like this

[@maevedarly]

I know 🙌🏾

[@anraiduine1483]

Man that symbiosis with the squid is just wild!!

[@angelikahainz1665]

Die ganze belebte Welt besteht aus Symbiosen, würden sie sich auflösen, blieben nur noch wenige Einzeller übrig. app.you-publish.com/render/index/guideStaticId/58606d6c62d6789939176d5f/type/pdf?fbclid=IwAR0UbB6irSbNdT7tI_usHAVa9k0Pi-bggaUhKnneavhTj5SRe5sD6kMduss Lesestoff

[@mientrant3615]

Not just the great information she gave but also how incredible she talked smoothly energetic non-stop in the whole speech.

[@gopikapj4255]

i love the way she present the topic, it makes curiosity in learning about that subject.

[@osmosisjones4912]

You should see my movie Osmosis Jones

[@srimansrini]

Ms. Bonnie Bassler gives one of the riveting talk about how Bacteria communicate with each, a study that will propel the future of medicine. This is one of the finest studies ever conducted and hats off to the Princeton team of young innovators.

[@pseudomonas69]

Doctor Bonnie Bassler........

[@RitaPizzi]

Prof. Bonnie Bassler

[@DubbedDemon]

I thought I was watching this at 1.5x speed for a second

[@hdb80]

She's passionate, and has a TON of info to give in next to no time.

[@marieahlin1718]

Yes, I thought about how much she must've practised with a stopwatch to get all info in, in time 😀💪💪💕

[@ValeriePallaoro]

Wow ... I thought it was perfect timing. Gave me everything and conclusions at each steps to allow me to go on to the next step with her. Nicely done.

[@RondaldJames8]

I'm watching it on 2x, and it's wonderful, still coming thru clear ❤

[@mabelspeaks8019]

Thank you for attributing the students who are doing this important work. So often the students who do research as part of a class don’t know that other students are being directed and taught by amazing instructors-some of whom- may not be as diligent about honoring them early on.

[@tutentDotCom]

I got excited about this just from listening to Bonnie talk about it. At first I thought she was nervous, but then I realized it was just her and her excitement for her subject. And her down-to-Earth analogies made it incredibly easy to understand. Thanks so much for sharing this presentation. I learned a lot!

[@oinkbaamoo]

Fascinating subject. Brilliant speaker.

[@osmosisjones4912]

You should see my movie Osmosis Jones

[@ValeriePallaoro]

I love the conclusion; that the conversation can go both ways. Her team are developing both - away to stop bacteria from talking to each other (protect us from them) and a way to encourage their conversationability (protect them from us) It could so easily have just gone the one way. Nicely done. And much appreciated.

[@syncflame]

Here I am sitting in micro class, imagining bacteria sharing memes :D

[@patrickfaas2329]

Bonnie Bassler is wonderful.

[@kittenforbunny]

Absolutely f'ing excellent talk!!!!!!!!!

[@jerkman4jesus]

Its the twentieth century and our most breakthrough discoveries are still happening because we saw a light. Excellent research, groundbreaking discovery and I hope what will be the foundation of our medical treatment of the future.

[@AbhilashNairSpartnax]

21st but yeah

[@fernandoartiles9875]

Amazing! A very passionate scientist, an incredible and enthusiastic teacher! A "must see"!

[@oliverlittle5028]

She adapted the Dazed & Confused quote: "Thats the awesome thing about high school girls; as I get older, they stay the same age". Fantastic speech Ms Bassler!

[@gracecy8010]

wow i didn't know bacteria were so complicated this was a very good talk. I understood it well.

[@thenightking7167]

This must be the absolutely most wonderful presentation in TED's history. Dr. Bassler, you are a remarkable human being, and scientist. Thank you, a quadrillion times, for acknowledging the invaluable contributions of every member in your lab. That was an indescribably beautiful gesture. 🧬🔬

[@rachelcitizen4703]

Wow!! What a fantastic presenter and she explains it so clearly. Excellent. Thank you heaps for the upload.

[@JackSparrow-ld6rz]

Everything about this speech was superb. I really enjoyed everything she had to say. Really was one of the most entertaining talks that I actually really liked.

[@HS-wl6bu]

I got so touched at the end when she recognised her brilliant "gangs". People sometimes forget to acknowledge but she didn't.

[@BerkeHitay]

9:36 Species specifities! My favorite moment in any Ted Talk!

[@LionTheHeart]

This lovely intelligent lady is definitely in the right career. Fascinating! Thank you

[@HeCtorCapitalCe]

They don't always give a standing ovation, everyone chooses as (s)he wants. It's just a testimony of her speaking abilities and the riveting facts she brought forward. You can dislike any speaker and their subject, but for me this format is of so much value.

[@MosesGTC]

Realised that there are more bacteria around me, in and on me than my body cells.. and these bacteria interact with the environment, and my cells...hmm where does my "self" begin, and end? Interconnected, inter-dependant, all one organism..?

[@karencorkery5574]

Fascinating how Bonnie can initiate such excitement and curiosity about cellular structure and their existence. Makes me hungry for more.

[@F00d5tamp]

Fantastic video!! I love the way bonnie describes things.

[@Kerrsartisticgifts]

The best Ted talk ever!

[@TheStallion1319]

great talk enjoyed her enthusiasm and the valuable information and the advancements they achieved

[@michellewilliams736]

Her passion is so inspiring!!!

[@soniabarrett]

I really loved this, one of the best TED Talks as Bonnie did such an amazing job of explaining the journey of bacteria so simply so that one one can understand it. Really great!

[@muhammadsiddiqueafridi8358]

You know what last night I was reading about quorum sensing and read many kinds of stuff to get know about that but in vain, and yes now I got to know what quorum sensing is exactly. thanks for such a mesmerizing way of your explanation

[@racekarts]

A super excellent talk Bonnie, thank you

[@rolo1363]

I'm really surprised this isn't more famous, it's so cool!!

[@dilliganesh.m.3915]

Your lecture is soo energetic. I felt learning something new. Your talk is very informative and it's amazing discovery.

[@ShallowBeThyGames]

Never thought of other "friendly" bacteria, always thought that "probiotic" stuff, while having an element of validity was blown out of proportion regarding it's benefits. Suppose I should do a little research on it, starting to find this whole immunology and virology quite interesting. Thank you very much for setting me straight.

[@cathysissens9248]

Phenomenal speech! Beautifully explained and riveting! Had me hooked from the intro...

[@haileywilson6596]

That was the best TED talk I've ever heard

[@user-gn7yt9fw5n]

I think it is the best explanation of Quorum sending i have ever seen thunks a lot

[@Abominatrix650]

I have to do an essay on bacterial biofilms and communication plays a big part of it. This video is great at helping me!

[@superbere]

Wow. I am a few years late to this video but this was one of the most interesting videos Ive come across on youtube. She is fantastic.

[@VeVoRose]

Mind is blown love this stuff!

[@Hemel29]

beautifully articulated and amazing persona !! thank you for doing what you do.

[@mikemeriwether9495]

This assignment was very balls, I love balls.

[@salahhe]

One of the best Ted's. Good job!

[@ajnjmar1]

Amazing! Well done Bonnie and well done Bonnie's gang at Princeton.

[@LDWcoment]

Great talk , best Ted-ed i have seen .And they are all pretty amazing.

[@CarolRadway]

Wonderful, mind expanding talk.

[@zachrawlings6523]

Soo many interesting facets of this talk. Love it

[@MohammadAhmad-fi3pt]

She seemed so surprised when everyone stood up for her!

[@lillazyboi]

My question is: Just like how bacteria can build resistance to antibiotics, can they also counter the quorum sensing block? Bacteria are very smart

[@avinashsunder5176]

+lillazyboi actually, they have the potential to develop resistance - but it would probably (and hopefully) happen only after widespread commercialization and overuse of the QS blocks. Then we would have to discover the next anti-bacterials..

[@lillazyboi]

Thanks!

[@richardeldridge8335]

+lillazyboi I don't think in can be countered. Bacteria immunity is the result of non-immune bacteria dying off. The survivors don't develop resistance, they already have it. As she stated in the video, antibiotics select for immune bacteria. What is happening here is that a molecule is blocking the receptor to the quorum sensing molecules. It would have to develop a brand new receptor, and at the exact same time, develop a brand new communication molecule, and that's never going to happen. And, hypothetically, if it did, you'd only need to block that new receptor.

[@iluan_]

They could by developing mutations that change the type of molecules that control quorum sensing as well as their corresponding receptors. Which is good news since that would require a lot of changes instead of just requiring getting a plasmid or two, which is the case in the resistance mechanism of many current antibiotics.

[@hdb80]

Good question.

[@euneillabrador3154]

I am currently learning this in my Microbial Biotechnology class. She made this topic more interesting for me to understand!

[@DaRealFiberOptix]

awesome. i love the metaphors you can draw from knowledge about bacterial systems

[@fractalico]

Lady, you are brilliant and charming...you explained so graciously a fascinating and profound aspect of life!

[@thisone45]

I love this stuff. Just the idea of giving a person with a fatal bacterial disease time enough to fight it off is amazing. I could be wrong but it also seems possible to allow a person to go on living a normal life while suppressing a disease indefinitely if they couldn't beat it outright.

[@diegofernandoecheverrigarc52]

Prof. Bonnie Bassler and team, thanks a lot for your excellent presentation. Is there any evidence or examples of these "communication molecules" in processes (digestion, immunity, vitamin synthesis etc) mediated by the human microbiome? thanks!

[@8906384]

That was an awesome talk!!

[@brianfoley4328]

I've seen Prof. Bassler on another You Tube channel....she's brilliant.

[@BxSquared]

She is so passionate! Love it!

[@GoPieman]

She doesn't relate to bacteria like "some complex animal". She doesn't say they're more important than animals. She uses expressions like "talk" to put across her message in a more fluid way, and adds some fun...nobody actually thinks bacteria talk or can think at all. She's excited because these are important scientific conclusions, understanding interaction and the game changer that is to manipulate bacteria like this.

[@CarineFrisch]

Beautiful. Thank-you. And very interesting: stuff I never heard about .....

[@threebythestreet]

POV: You are watching this video because your connections academy Unit in Health Sciences is telling you to answer 5 questions based on what this Ted Talk.

[@nathanhasbani7877]

Very interesting and such an articulate speaker

[@bdhome2010]

Respect from BANGLADESH. Thank you for such explanation.

[@VegaChastain]

The main thing that scares me about GM and GE foods is that any DNA from them that isn't denatured by our stomach acid (this can be a lot depending on the health of stomach secretions, which tend to be quite unhealthy in an Americanized diet plan) ends up being absorbed by the bacteria that inhabit our intestines. These bacteria are imperative to many processes within us, and are integral to our immune system, vitamin B and K absorption, and many more important processes. It is estimated that these gut flora have around a hundred times as many genes in aggregate as there are in the human genome. This is what you want Monsanto to be experimenting with? :-/

[@shakilDaud]

Great for a understanding, knowledge on the Bacteria and works good for a basic understanding the most important living beings that bless and trouble you by being around you.

[@amanlitt8386]

for how excited and passionate she was throughout the entirety of her talk, her outro was pretty meek. Thats us science nerds for ya

[@eniamrahc73]

Really interesting talk! Excellent speaker as well. Would love her to be one of my microbio professors.

[@aaliya9652]

The best Ted talk ever 👏

[@yocahuna]

Wonderful presentation on so many levels. Naturally, the ones i focus on demonstrate the PANACEA system: the idea of independent holons that make up a holarchies, data exchange, cooperation and emergent effects. The sovereignty of bacterial communities is recognized and a NPV index is assigned to them. (Don't envy who has to count them.)

[@h7oslo]

Great presentation ! Tnx to George L. for the link ! rc

[@Zaris1021]

attentive to the end.. awesome speaking! well done

[@vinitajagtap1918]

Really awesome talk

[@saldasinkope3002]

A small update on the fact about the resident microbes and the human cells- It's more like 1:1 ratio between them not 1:10.

[@lillazyboi]

+Jānis Galdkājis True. My microbio professor just told us this lol.

[@nikop4617]

1.3:1

[@squidb8]

So if we tamper with inter-species communication, would that affect beneficial bacteria also?

[@michaelbrown1396]

Absolutely Awesome!!!

[@AbhilashNairSpartnax]

Impressive how a minute stuff takes on a host million times its size

[@stevedunn90]

TEDtalks is the actual organisation that runs all of these lectures. This channel is an editorial of videos that are educational, so people that are interested in specific areas can get related videos. There are loads of different TED channels, but all are fed from TEDtalks.

[@rogercorneau4379]

Great talk

[@wwitsel]

What an excellent explanation

[@D3sertst0rm]

Another possible mechanism is what Vincent W, very well said, the enzyme production trigger might be associated not only with quantity but also with density.

[@taracheng345]

Fascinating!

[@patricksullivan6264]

Einstein chose Princeton. Dr. Bonnie Bassler chose Princeton. Total geniuses.

[@yasminazaadeh4177]

Just when I was beginning to think anti biotic resistance would wipe us out.

[@samreads]

In any case that would never happen. Just as some bacteria evolve anti-biotic resistance, there would always be some humans who'd be naturally able to resist that bacteria. So while the "weak" humans would die off, the survivors would thrive and their future generations would be naturally resistant to that bacteria. And the circle of life would continue exactly as if nothing ever happened.

[@haripanditparanjpe30]

This fantastic presentation was around 6 yrs ago but still nowhere near new line of antibiotics. Why ?

[@TheKillerGamesTkg]

I'm sorry to say but it has its reasons that anything that involves human trials and such take a really really long time 10, 20 or more years

[@santiagogonzalezbenjumea9880]

Amazing talk

[@jdh9120]

Great video had to share.

[@CLEANDrumCovers]

This was fascinating.

[@qed47]

excellent argument !!!

[@alecchvirko6578]

That was fantastic.

[@hdb80]

Woah, this is fascinating.

[@spokehedz]

If half of the teachers in this country were like her, I have no doubt that we wouldn't be falling behind on our education scores.

[@rmt2171]

Love this!

[@elisabetabaltaretu4259]

Excellent explains..congratulations

[@D3sertst0rm]

I did not miss your bigger point. You did mine. I do read books, search the web and watch tons of hour long documentary series and yes there's not nearly as much information on an 18 minute clip. However there's a lot of diferent ways to retain information and/or being able to integrate that information with previous or future acquired knowledge (topic too long). In any case, any thing from this 20 min clip will be more valuable than your next reality show/soap opera can offer.

[@subhamsinha9817]

Excellent video 👍👍

[@senanallahverdiyev5270]

stunning.

[@kritikachoudhury2188]

MIND=BLOWN!!!