How CRISPR lets you edit DNA - Andrea M. Henle

[@257js6]

Wow just 70 year ago we discovered DNA and now we can change the genome of an organism!

[@stormblaster6781]

25 / 7 but we still can’t cure cancer

[@AxyDC]

It was actualy Made in 2015 so yea

[@jvan9581]

It's 2019 y'all! You'll see people flying with wings soon!

[@akes9793]

Cin scientifically speaking, human with wings is very impractical. The wings have to be so huge to lift our body and it will be exhausting to fly. And plus the fur can bring so many diseases and will be so hard to maintain. Iron suits for me please.

[@marios1861]

@@akes9793 as an electrical engineering student, I'll work hard for your request sir!

[@ckute92]

I love that as a now former Sickle Cell patient, I have benefitted from this research. Just 5 years later

[@TheSassleburger]

Yay! Makes me so happy.

[@hserieshooligan1997]

Is it good yeah?

[@non6129]

so you are permanenttly cured?

[@reference_realistic]

Wow!

[@minnolinath7188]

I had to watch this twice because I was completely transfixed on how absolutely amazing the animation is and didn't hear a single word of the actual lesson. I demand a lesson on animation now, Ted.

[@_blank_3737]

Crisper is literally revolutionary 🤨

[@enchoshi4596]

ikrrr

[@comadyboy.up43]

Anyone else obsessed with the Hidden DNA Potential from shirlest? It opened my eyes to possibilities I never knew existed. Life feels so much richer now. Give it a look!

[@Redawesomeoby]

Cas9: Tries to defend its bacteria Humans: Reverse engineer Cas9 to defeat viruses and bacteria Cas9: Well, I guess I am working with them now.

[@gasparg643]

time to make inmune papayas and spider goats

[@lancetheking7524]

@@gasparg643 already existing flying spiders in Brazil: *laughs*

[@Ienteredmynamecorrectly]

If you can't beat um’, join um’.

[@giantqueermess264]

thats fair lol

[@chanieweiss4288]

@Redawesomeoby Oy vey. Sadly I don't trust all humans. Some genius will either goof up terribly if they're not as smart as they think, or do something awful intentionally if they are as smart as they think.

[@JustinY.]

It just works

[@safir2241]

Justin Y. Ah, always Justin time.

[@EvanRustMakes]

That's how CRISPR works! lvl 1 RNA lvl 100 DNA

[@bananabeansyoho7781]

Hello Justin

[@IgneousGorilla]

Did you know Araki drew the cover art for Cell magazine once? Not kidding, look it up

[@novelnouvel]

Did you even sleep?

[@lovelylittlegirl3332]

I have Sickle-Cell Anemia and just heard about the UK approving of a new genetic therapy that engineers the bone-marrow to stop it from producing Sickled Cells. I didn’t understand how that was possible but what do you know, my favorite educational channel already made a video about it 4 years ago! Love this video and thank you for enlightening me❤

[@ggukiemonster]

You can get through this ❤❤

[@jankiprasadsoni6793]

I too was wondering about genetic modifications a few days ago and here I'm thanks to yt feed

[@ts7308]

Hello, I am currently participating in a conference called Speak Up, its located in Sarajevo and has been organised by my school. Im in the committee for designer babies, especially crispr. Could you possibly share your experience while getting medical treatment? it would really help my committee defend our topic in the debate that will be held at the end of the conference.

[@sagarmrao6861]

This video makes it so simple. But really it's very complex

[@boss_niko]

yeas it is

[@mambodog5322]

We're literally just hacking into ourselves at this point. I'm in.

[@FedJimSmith]

Very soon we will hack the very nature of reality

[@mambodog5322]

@@FedJimSmith Yes, I would like to discover the cheat codes for everything

[@thechimp8045]

Mambodog 532 what’s the money cheat code?

[@mambodog5322]

@@thechimp8045 That's why I would like to discover them.

[@varshapremarajan9837]

U guys should watch Ted ed's BIOHACKING vedio

[@pr.yanshi]

I admire Ted ed lessons a lot

[@tedchirvasiu]

Thx

[@Aarnyx]

@@tedchirvasiu are you ted edx?

[@morbibros]

"Every living thing is defined by its jeans."-TED Ed 2019

[@Melecie]

genes*

[@manasgujral2929]

@@Melecie r/woOosh

[@Melecie]

Manas Gujral what if i told you you just got woooshed, not me, that post was supposed to be a wooosh

[@manasgujral2929]

@@Melecie You just got double woooshed xd. And I got that you don't know the correct and crispy meaning of woooosh. ;)

[@manasgujral2929]

@@Melecie you're hit on reddit 🔥😂

[@player-nr.50000]

00:07 Why did the single cell look like a Dictator ?

[@stickman8459]

LuMbAgO

[@BlackIGO]

Ogulcan U lmaoo

[@christian_swjy]

pareidolia is at play in your head bruh

[@GXHSJ]

Cells are Aryans

[@girltalk08]

Someone said it

[@YarnYawn]

The animation is amazing....

[@nashiPAGE]

I'm excited for the future of genetic medicine.

[@huburgalula4031]

"what makes you, you?" "my genes" "so if i change your genes, are you still you?"

[@averageillegalmemesdealer]

Damn, deep. But I feel that apart from our genes, our experiences and memories make us too. So changing our genes but retaining past memories would still make us, us, right?

[@hijeffhere]

Or is it?

[@akuapipim8219]

There's a video on epigenetics if you want to know more on this question and then better answer it for yourself.

[@yecto1332]

Hey vsauce

[@datboy038]

Yes just different

[@pujanbudhathoki9913]

So, In some decades, we can probably customize ourselves like the sims?

[@jeromealday614]

Hopefully. Gotta rid of my f-ing gigantic nose. Or elongate my tiny banana.

[@stalionv4587]

@@jeromealday614 *Nice, just... nice.*

[@pujanbudhathoki9913]

@marios gianopoulos yesssss, that's what I want the world to be like.

[@mugodasimon]

So I wonder if it can change any ones race?

[@peterpandit8625]

Y is the comments section in KZbin always memes and jokes?😂

[@srijanshekhar]

Finally, a video with easiest yet most comprehensive approach towards explanation the CRISPR- Cas9 technology. Thank you !

[@sea5205]

The animation is so soothing...

[@funsometimes]

Mark my words: The first superhero/supervillian will be made via CRISPR.

[@Moss_knight00]

It's actually kinda possible in the not so far future... it's fun to teorize eheh

[@udaykadam5455]

I am expecting super soldiers like Captain America... Whatever we will have mutants.

[@tobijames4698]

I want to be the first test subject for superpowers. I don't care if I'm a hero or a villain.

[@Dasani_water_drinker]

Gates already exists

[@btsmochimi7924]

then stan lee would be ahead of his time

[@BlackWoldxD]

This is really interesting and may help many people with genetic disorders. Thanks for sharing, TED-Ed.

[@colinkean1085]

Thank you so much. I am not good at molecular biology and you helped me put so many of these pieces together to help me understand the process

[@josephzavala3205]

Hello, thank you for this video. I have been looking at other videos to grasp the concept of CRISPR but felt difficult. I believe your narrative approach paired with the visual representation helped.

[@midolamani4536]

2:20 CAS9: OMAE WA MOU SHINDIERU bacteria: NANI!!!!?!

[@ameymorshed4744]

You know that omae wa mou shindieru means I’m already dead

[@joselynjoseph9954]

The video is brilliant! Beautifully shot and edited, captivating the viewers attention throughout the video. Kudos to the TED-ED team😁

[@livangooday]

Intellia therapeutics could also be successful

[@StrawberryFeildsforNever]

I just hope this doesn’t get too out of hand. Like everyone is tall, blonde hair, blue eyed. Differences make humans humans. “When everyone is super, no one is” -syndrome But I do like that this can help in the medical field. And yes, I did credit the villain from incredibles. what about it?

[@zpardus]

I don't care if someone's super, or special. Those are human made-up terms. But you are right that if everyone was the same it'd be bad. You're just right for the wrong reason. :) Scientifically, this is bad because diversity is the key to survival. There is no perfect genome because genomes are context-sensitive. This is why eugenics leads to extinction. However, what if the technology was used to add more diversity, instead of removing existing diversity? As the number of genomes in a population approaches infinite, the number of possible extinction events that population can survive approaches infinite. It might seem scary, but that could lead to an extinction-proof human species-complex, or as close to extinction-proof as is logistically possible. Added bonus, we could actually colonize other worlds instead of just talking about it. Just send variants already suited to that world. Cost would be about 1/1,000,000,000,000'th the cost of terraforming.

[@RK-ep8qy]

zpardus whatever we do should be done with caution and moderation, manipulating the natural order of things has caused climate change and the extinction of many animals on our behalf. I just hope we don’t become reckless. With CRISPR and iPS we could change everything for the better or lose ourselves in the process.

[@morbibros]

That depends who's asking? (Your name)

[@marcmartinez4140]

We could cure cancer

[@marcmartinez4140]

@Augusto Jose Go back to mexico

[@benjaminrennicke]

Who controls this, has more power than anybody in history ever had..

[@rozkaz661]

Some of the most beautifull animation on this channel yet! Great job

[@poweroffriendship2.0]

*Rice Krispies wants to know your location*

[@AKilahVamp]

LMAOOOOO

[@ameymorshed4744]

LOLOLOLOL

[@rickandelon9374]

Thank you Ted-Ed for such a vivid and beautiful animation.I understood everything!

[@fatimaaidibi1]

This helped me so much with my year 12 biology assignment on genetic technologies.

[@mid7699]

It is future. I too have it in syllabi.

[@marcelloascani]

amazingly explained and animated!

[@westfield90]

First video where I finally understood this. Thank you. But it does go against what the mainstream media has been touting which is that this is cheap, fast and super accurate. I believe you rather than them

[@bottasheimfe5750]

So many great possibilities with this stuff! I am super excited for the next few decades of genetic modification research!

[@breadandbutter644]

This is the Greatest Discovery in the Field of Genetic Engineering till now. 👏 👏

[@pranavlimaye]

meme. review.

[@pranavlimaye]

gene*. review.

[@MegaYujing]

one of my favourite topics in uni, made me so inspired :)

[@mid7699]

Yes, me too. I m thinking of pursuing research.

[@hadilballa6545]

And finally, I have understood what CRISPR is really about !!!

[@ekinoner2830]

Honestly could've mentioned the first CRISPR-edited human babies born in PRC, Lulu and Nana.

[@salmaelmahallawy4339]

Her voice is soooo relaxing♥️♥️

[@safir2241]

Your animations are amazing! I hope you get a sponsor from someone big!

[@AnanyaShetty_]

They don't do the animation. Someone does it for them and it varies in every video. They need funds to pay the animators and make the videos.

[@safir2241]

I know, but these videos belong to them.

[@dracotitanfall]

TED-Ed is someone big by itself, there not some channel run by one guy, it's an official company channel

[@Kookie-zv4bu]

Ted ed IS someone big

[@waffleisnice]

hats off the the animator , veryyyy smooth and clean looking animation

[@ASLUHLUHC3]

Oh and by the way, a Chinese scientist has already genetically modified a human fetus

[@fitrianhidayat]

That's because they're less concerned about ethics

[@stalionv4587]

Tsonima

[@a-note76]

That’s how the western world is getting behind china

[@dpapaioannow]

@@fitrianhidayat he's in jail for 3 years and etchics is a social construct,it's what you make it to be

[@melodykuromibebbies2138]

lol source??

[@XOPOIIIO]

Anti-GMO apologetics are hindering technological progress.

[@raysofaten5826]

They will never stop it from being used.

[@celesteforslund4186]

Nope, I'm witnessing 2-legged GMO walking all around me due to the vaccine

[@elladay9081]

i couldnt focus on the video - the animation is just mesmerising!

[@happyrainbow125]

One step closer to being immortal.

[@suhinakanda7956]

fr

[@canadian97]

@Rustydingomingo unless we discover the multiverse so we can jump from universe to universe forever…although, forever sounds like such long time is kind of scary.

[@danielwilson7308]

I'm going to put this in a way most people can understand. What this is, it's like being able to identify words of a different language in a very large book, removing the same word throughout the whole book, replacing it with whatever word you choose & thinking the book will still make sense or retain context afterward.

[@safir2241]

Can it fix my parent’s marriage

[@safir2241]

Pardon

[@efraim6960]

I'm sorry son

[@hariharanb3253]

You mean you? It probably could

[@phillip7731]

I would type F now, but this is actually making me sad

[@jocandyish4249]

Oof

[@samkarr8918]

Finally a video on CRISPR

[@matthewnorman2951]

Crispr is to human progress what the Manhattan Project was to clean energy. Genetically changing a person so they're healthier sounds like an amazing goal but I fear that is not what this technology will ultimately be used for.

[@endofsight9841]

This all will lead to a Brave New World future. Transhumanism, genetic engineering, etc etc. Things can and will go wrong eventually.

[@user-vp6cq4sv3d]

You're right. If I had the time and money I'd let certain qualified individuals take as much time as they need turning me into a human capacitor.

[@blob5634]

Finally a vid on Crispr

[@papafranku8799]

I wish to be a doctor and help the word to find new cures with It.

[@sidbableesh]

Finding new cures? Maybe you should get into research instead

[@gekmeisje42]

Yeah you should study biomedical sciences! I studie them in the netherlands and it is the most amazing study ever!

[@sidbableesh]

A lot of people become doctors to save lives.. I feel people don't realize how many lives scientists actually save

[@n.upadhyay7478]

Get into research instead buddy. I completed my medical degree then took molecular biophysics to do research because doctors just dictate what already has been invented or discovered. I am not saying being a doctor is not exciting and fascinating but being a researcher is way more interesting and gives you that freedom to cure all diseases, and reverse aging and what all.

[@MysticOceanDollies]

Papa Franku the medical industry is corrupt. They already have cures but pharmacist earn lots of money prescribing drugs and kemo is expensive. Sadly some people care more about money than about saving lives.

[@milanbobhate4414]

It wonderful to see that Ted Ed makes these videos on current scientific affairs

[@WideCuriosity]

Although the video is interesting I feel that the details on how the 'repair' is controlled would have improved it. I feel it's still unclear, but simply stated that it's done.

[@jeonkookie8620]

Omg thank you so much. I was literally about to cry because I wasn't understanding anything of gene editing 😭

[@banwaproductions4600]

The question is... *Can it **_fix_** my **_broken heart?_*

[@royjoseph414]

It depends on wether your heart is literally hacked into pieces or is just hurting from a breakup or something lol

[@datboy038]

Yes just release some dopamine.

[@junicortez669]

I wish negative implications had been explored more in depth

[@dayanandathongam343]

The reason why i love biology is because i love my life and i want to understand it well....

[@robertofloresarzu5821]

the best explaned video about CRISPR!

[@roselineponmalar9213]

Nice work Ted ed.

[@Professor_Brie]

I’m glad I watched this video, I’m doing a last minute paper on this subject and I’d have a very hard time understanding the much more complex science articles if I didn’t have this good overview

[@BlenderBug]

I just want to save my genetic code from my 20s, and use it to replace the new bad copies from time to time. Ya know... so I can live forever. How much is that going to cost.

[@datboy038]

A lot and i mean A LOT but in the future it should go down

[@menna6144]

The animation is brilliant as always.

[@maryharvey6789]

Yet another awesome and educational video! Keep up the great work!

[@dongdong_findthedifference]

It was a kind video that gave me a good understanding of the principle of CRISPR gene scissors through cute animation. I thought 'CRISPR' was the name of the person who invented the gene scissors, but it was amazing that it was the name of a substance. It's still an incomplete technology, but I hope it can be developed quickly and cured of incurable and incurable diseases.

[@unleashingpotential-psycho9433]

Soon it will become an every day practice for people to choose the color of their babies eyes.

[@justflex6745]

@Skeptic Psychologist We are actually evolving resistancece to aids!

[@FedJimSmith]

My first born will have a Rinnegan

[@holymolymacaroni7503]

THE ANIMATION IS AMAZING

[@hafsa7951]

Cris. P bacon

[@RobertoDeMundo]

Chris. P. Bacon.

[@abhishiktaroy9773]

*It simply works speechlessly*

[@Dioxodo1]

Well, it says in 2:40 that it is precise, it is not. the number of unexpected alterations to the genome being modified it's actually pretty high, but for some reason, it is almost never brought up.

[@SG-bp4lg]

Actually you have it the wrong way around. The older methods are what caused unexpected alterations. The entire reason CRISPER is so special is that it is incredibly precise.

[@Dioxodo1]

@@SG-bp4lg yeah, but in order to be precise you have to make longer chains so it doesnt get mixed with other similar sections of the dna PS: i'm on the phone and my corrector its set to spanish cause' it's my first languaje, i hope it gets throuh

[@Dioxodo1]

@@SG-bp4lg also, i'm aware that the defect from the older metods have been reduced but not totally corrected, update me if i'm wrong

[@neuro_0e]

This is an amazing representation! Great job :)

[@itay1722]

*At an interview Interviewer: "So what programming languages you know?" Me: "Assembly, C++, CRISPR, Python..." Interviewer: "May you repeat yourself?" Me: "I said Python"

[@johnperegrin1518]

now having a literal bugs on your code is possible

[@ssiddarth]

Thank you so much Ted ed for making a video on this topic 👍😀

[@conure512]

CRISPR seems to be getting a bad rap lately. Glad to see TedEd portraying it for what it actually is, no more, no less.

[@johnblaze8774]

Yep, this completely makes sense to me

[@KINGBADASS100]

So what you’re saying is in the future we can have real life Catgirls? I’m in.

[@mambodog5322]

But there is one dark side to the ability to make catgirls... The ability to make furries

[@KINGBADASS100]

Mambodog 532 It’s worth the risk

[@blookirby2076]

Before we do that, we should first strike every furry down to the grave.

[@stalionv4587]

Can we make Jesus?

[@notthatthenamematters6163]

@@blookirby2076 i've got my shotgun

[@mishyull]

i love this style of animation so much

[@joannesalcido3144]

Terrific graphics! Great job communicating the essence of CRISPR to a general audience. Must have been a lot of fun work to produce. Just one point that may be misleading -- unless I am misunderstanding. Shouldn't the RNA and guide RNA be depicted as single-stranded molecules?

[@yashiupadhyay880]

We'll! It does edit the DNA and the chances of cleaving the rocket undesired DNA sequence questions the ethical use of CRISPR. Though it is being studied very well and the technique is being improved day by day.

[@warrenforest7417]

Concern: Can a DNA be patented? If so then this would indicate that someone can legally own this DNA? What are the implications of this?

[@freshbakedclips4659]

To be honest we don't really own our DNA, it's 50/50 from our parents, and it came from their parent's parents and so on.

[@shanayagoel]

I don't know a lot of legalities and protocols around gene editing, so this is just my opinion, but I would assume that the process to create it might get patented, and the specific drug they administer to create it might be, but I wouldn't thin the DNA segment in itself would be patented. However, if a company were to create a specific gene that was completely new and non-existent in anyone, patent it, and someone suddenly by some crazy chance has their genes mutate to produce that, I doubt there would be legal complications around their ownership since they aren't trying to commercialize it.

[@BrisbaneBroncosfan67]

I think it should be made that anything that can help people must be illegal to patent.

[@vivienyeung8043]

The animation is stunning

[@lmwilliamsjr1]

I have pretty much enjoyed all of the TED videos but I find this especially straight forward. I only wish that they spoke more about the ethical dilemma instead of just sort of casually mentioning it near the end. Of course it may be discussed further in a talk that I haven't yet experienced.

[@pearsonhill6874]

Very interesting how powerful CRISPR is and how much it can do

[@crazynature771]

So many great possibilities with this. So many horrible ones as well. Amazing and terrifying.

[@mid7699]

Stay +

[@MalaysianTropikfusion]

We already know what CRISPR is (From this video and many other articles like it). Could you guys make a video of some ongoing studies or treatments which uses the technology?

[@novafawks]

This sounds like some serious fuel for conspiracy theorists

[@miolen9212]

Anything is fuel if you look for conspiracy.

[@pranavlimaye]

Jesus Christ, that's the most accurate thing I've heard all week

[@farahanshaik8860]

This is not a conspiracy. It’s a very real possibility

[@celesteforslund4186]

@Jort Kuiper They are doing it through THE vaccine.

[@michellejones8561]

@@celesteforslund4186 yes exactly what they are doing! Don’t take it!

[@igorhcc]

The best content on KZbin! Thanks TedED!

[@samikshamendhe9292]

More videos like this please... great explanation... thanks ted :)

[@ethanmenot]

Just did a presentation on CRISPR for Hunter College, well done video!

[@sankarnaskar7564]

Can a muggle become a wizard by using CRISPR

[@jankiprasadsoni6793]

Yes

[@goodluck1070]

breathtaking. thanks Ted!

[@rempuiafanai7103]

Its always been Crisper, this Crisper that but never Crisper how. Thank you Ms.Ted Oh YEAH YEAH

[@phillip7731]

STOP

[@sunilpatil8144]

sToP

[@victherocker]

*When you're interested in the educational information but easily distracted by these marvelous animations*

[@helloall4400]

Humans globally need to spearhead that research because whichever country starts to figure it out and edit their population will usher in a new era in humanity and whichever country doesn’t embrace it more likely because of religious reasons will be left far behind.

[@davidherdoizamorales7832]

Dont mix science and politics please

[@fxithleann]

@@davidherdoizamorales7832 It's not so much politics, just ethical reasoning which people have debated about this topic?

[@dracotitanfall]

religion is the ultimate obstacle to human development

[@nicholasvsjesse]

Draco the Anime Dragon And yet it's the largest net to stop us from sliding backwards

[@loreseeker6604]

By all means, I cant wait to see who creates an unstoppable super virus, a forced mutation of the human race which sterilizes us(etc), or any other such tragedy first. The same species that can not even achieve proper management of simple ecosystems like Yellowstone park, will of course know better than a supreme being or nature how to manage the evolution of the world. Nothing could possibly going wrong. This is like giving nuclear weapons to cavemen, the only question remains is this........... how long do we have till someone misuses this technology irrevocably. Enjoy life while you can people.

[@robobrain10000]

This is a good introduction, but you can really make 2-3 more videos on the topic and discuss about the biochemical aspects of CRISPR, and how homology directed repair works, and another one using a specific example from an experiment.

[@EthanHackney]

literally just had a 3 hour genetic conference over crispr i-

[@lonewolf645]

The best of humanity. God bless those scientists. I am so thrilled for the tech.

[@Foukez]

Naive who thinks this is not already tested in humans, like when they announced dolly in 2000s, i am pretty shure the are a lot of cloned humans in the streets...

[@monserrathresendiz1797]

this is so cool, you cant deny it

[@sebastianelytron8450]

No thank you, I'd rather my DNA be soft and mushy.

[@jhanvisinghania2805]

lol

[@helloall4400]

I’d rather be a genetic super human

[@novafawks]

I like my mushii boyees

[@ADEehrh]

🙄

[@ianbarber2937]

Sebastian Elytron 🌵

[@jesuschrististherighteous4884]

Psalm 25:17-22 - "My troubles have grown larger; free me from my problems. Look at my suffering and troubles, and take away all my sins. Look at how many enemies I have! See how much they hate me! Protect me and save me. I trust You, so do not let me be disgraced. My hope is in You, so may goodness and honesty guard me. God, save Israel from all their troubles!"

[@egg2799]

So that means I can turn my eyes blue?!!!

[@the5tigers]

Your offsprings,

[@datboy038]

100% your offsprings probably yours