How does Fasting create Autophagy?

[@batlin]

Wow. After a few years of hearing the same basic ideas repeated over and over when people discuss fasting and autophagy, this video was a breath of fresh air. Learned so much in just a couple of minutes, filling in the mechanistic picture that is usually ignored.

[@Physionic]

That’s kind of you to say, batlin. The idea of Physionic isn’t to just supply answers, but to explain the physiology/mechanisms behind the answers, hence the detail. I appreciate you speaking up.

[@lubasulpovar5081]

Thanks for great presentation. It was incenity to listen and read about fasting and blah... Comparing people with Lab rats😱. Sorry, I'm not scientist but skipping a meal for a day makes me completely sick.

[@angierobinson5570]

Just done my first 24 hrs of fasting of a 72 hrs fast going good and feel great i do this every couple of weeks 👍🏻💪🏻

[@Physionic]

Good luck!

[@angierobinson5570]

@@Physionic thanks Nicolas 👍🏻😊

[@billstrahan4791]

I saw "ATG Proteins" so I can assume from this that autophagy well help me squat deeper. Got it. Kidding aside, these videos really do a great job of communicating the subject matter. Clear, concise, some humor thrown in to keep it light. So glad I'm subscribed, and I'll be sharing links to specifics videos with some like-minded friends. Thanks!

[@Physionic]

Haha! Unfortunately, it hasn't helped my squat depth, but if it helps you, I'll be happy to hear it, Bill. Thank you!

[@KKMultes]

Very Nice! well explained, plus sense of humor!

[@Physionic]

Thanks, KK. :)

[@hellmouthisnogod1952]

Well, I am into an extended WOD fast - usually I extend it to 38 days. My question is whether there is a limit when authophagy is no longer serving a reasonable purpose and whether I should rather break the fast, let's say at mid-term, for a day or two of bone broth.

[@johnathanabrams8434]

Wait, youre saying a 38 day water fast? I don't know what WOD means. If so 38 days is crazy. Can you describe the 5 day, 10 day, 15, 20, 25, 30 day periods for us

[@rohitrathi4552]

Awesome video

[@Honeypepper.]

Question, are you the one doing all the animation in the videos? If you are, great job on the simplicity and clarity of them, it makes it better to comprehend. More traffic will soon come to this channel if you keep up these great teaching methods

[@Physionic]

Yes, I make all the graphics. It's time intensive, but especially for a subject like this - it's important to have them. I'm really glad they're paying off - thanks for letting me know!

[@rezar6894]

Thanks for your review, as always great. I had a question - if doing a 24 hour fast would one get the same benefits if they were to have some black coffee versus it being a water only fast ?

[@golddesign6698]

Thanks for being simple on a such hard topic. 🙂

[@Physionic]

My pleasure!

[@Ermude10]

Thanks! This was really informative and helped me understand the mechanisms involved in the body. Great content, keep it up!

[@kamalolama4124]

What matters the most, for me at least, is the relationship between the duration of fasting and autophagy level and types, if there are also different types

[@bobcocampo]

Any test that will show autophagy?

[@johnnyv.223]

How about meat, water and veggies, supplementing with occasional Vit K to avoid calcium plaque build-up (atherosclerosis), but forgoing cereals, beer and breads? I have had fibro for 6 years, and really need to drop my weight.

[@vincentquaglini2332]

Mate, this content was missing. Thanks.

[@robertsmyk4102]

Please explain why autophagy occurs since the liver is constantly providing nutrition under all circumstances. How do cells experience a lack of nutrition to induce autophagy if they are constantly receiving nutrition from the liver?

[@Physionic]

I don't follow? That's explained in the video. 0:53

[@georgesmith3022]

How many fasting hours are needed to activate autophagy?

[@letsmakeitagoodworld]

Wait so rhe cell just kinda gets back all the crap that's taken out? Does that make autophagy useless? Also does only pure fasting cause AP or does restrictive diets or keto etc also create it to some degree?

[@bobcocampo]

Root cause is AMPK. What upregulate AMPK?

[@bobcocampo]

If Insulin is low does it upregulate AMPK? is low insulin below 2 a sign of autophagy?

[@winstonchow3694]

the best to date

[@Physionic]

Thanks so much, Winston!

[@SinkingPoint]

I believe you posted a video at some point recommending John Campbell as a source on COVID info. Maybe I'm wrong because I can no longer find the video but I'll assume either it's just not coming up in the search results or you've taken it down. Has your opinion changed on Campbell? If so would you consider making a video on your updated position on him and why it's changed? There might be other people like me who started watching him because of you and are now being mislead by him.

[@Physionic]

Sure, Billy. I can definitely do that. I'd planned on addressing that on my next podcast - I hope to record that this weekend. For the record, I did take the video down, because my opinion has changed. I had watched about 20-30 of his videos and appreciated his open, correct interpretations of the data. However, of late, I saw several videos where I felt he was not representing the data correctly and seemed to float more sensationalist interpretations without presenting clear data to the contrary. I'll try to find the one example I thought was especially egregious and expound on it in the podcast. As a result, I felt it right to remove the video.

[@SinkingPoint]

@@Physionic thanks. I'll keep an eye out for your podcast episode. I think Campbell's beginnings as a genuinely good communicator of the scientific consensus make him a particularly insidious source of misinformation. I'm sure lots of people have been led down the pseudoscience conspiracy rabbit hole after placing their trust in him as an initially reputable source. I always enjoy your videos btw and find them informative and balanced. Thank you.

[@littlevoice_11]

This is so interesting. Have you seen the research on fasting before chemotherapy? it improves outcomes by "protecting" healthy cells and making cancerous cells more vulnerable to the chemotherapy (Please excuse my basic explanation of a far more complex process that is likely beyond my comprehension). I wonder if research exists on autophagy for infection from virus? How does it effect immunity? Some recommend fasting.

[@Physionic]

I’ll need to look into it, LV!

[@terrancephillips5798]

Thank you for this video. And I’m still wondering what the length of time is in the entire process, Autophagy takes place on a singular cellular level correct? So I wonder in any individual cell how long the process takes from the time it’s signaled to start to the time that it leaves the cell changed. Enzymatic processes are super super fast, no? if Ataage has been observed, somebody has to know the answer to this stuff. Anyways, lots of new info fir me, great video thank you.

[@Physionic]

Great question - people don't always consider timing. So, on a cellular level, many of these reactions are occurring extremely quickly - seconds, even. However, if you're talking about the movement of large components like the autophagosome, it can take minutes to hours.

[@terrancephillips5798]

@@Physionic thank you so much for that info. That would be an awesome topic for a video. So I guess “wake me up song called how long might you say the process would be paused if a person took in, say, 10g protein or maybe 10 carbs? Would it just be a matter of those calories being worked through or would other factors be at play that might take longer, like signaling chemicals or hormones?

[@Mario-forall]

Autophagy gets all the spotlights when talking about Fasting, but I fast in hope of preventing cancer, then I am more interested in Apoptosis. Are you planning on covering this topic?

[@Physionic]

Sure, I will, but I can only work so fast. One day, if I ever generate any real money with Physionic, I'd love to hire other people to research and release information so we can get through topics more quickly, but until then, we're all limited to what I can do alone, so I have to make the best of the situation and move within my means. One day I'll cover fasting and cancer, and apoptosis.

[@mildredd1805]

Hi love the video , I was wondering as I am starting a 21 day water fast. Would my maintenance calories be lower after the fast ?

[@Physionic]

Yes, Alisha.

[@denisarackal]

So in short, it is good for my health to go on a two days fast at least once in a month, right?

[@Physionic]

I think it depends on your health and your weight. If you're overweight, then sure. If you're normal weight, and you want to restrict yourself for religious reasons, motivation reasons, whatever - it's probably fine. If you struggle with hypoglycemia, then no. The point being - your starting situation determines the answer to the question. But, to give you a plain answer - for 98% of the population, it's fine.

[@savagestation7153]

Hi Physionic, do you think prolonged fasting is a good weightloss tool?

[@Physionic]

Context matters a lot. If you're trying to lose body fat and add some muscle, then absolutely not. If you're quite overweight and just want to focus on weight loss, then it can be done effectively.

[@savagestation7153]

@@Physionic Lets say I would like to add some muscle and lose body fat, what fasting regime would you recommend? currently doing 20:4

[@martijncrowe3901]

I am amazed by the complexity, like the crep cycle and cellulair respiration. It is not only the order in which things happen, everything seems to be available and ready to work. But the backline is.... i did get all that, makes me that a scienist?

[@Physionic]

Absolutely - here's your doctorate. :) And yes, it is amazing.

[@martijncrowe3901]

@@Physionic I already hold a professorate and doctorate, but thanks anyway. It took me 2000 hours of reading in biochemistry, and of course watching your videos. Todat I said to a doctor: "we as anthropologist see you as an old medium, a totem". You are wearing different cloths and talking a language that make people feel small, well I do better than that, in your case I would say; in your reificicated context, actors feel the imparitive to act without thinking. Shall we change out cloths?

[@erich8057]

Can you do a vid on epitalon?

[@TheMesquiteCreek]

awww, this took me back to A&P one in college (

[@Physionic]

Hopefully not too much trauma. :)

[@drumunism3781]

OMG that was the simplified version? 😭

[@Physionic]

Haha, yes.

[@hofimastah]

Does autophagy really helps battle cancer? Heard about that but it would be too easy if the cure for cancer was just fasting.

[@N330AA]

That's not a Lysosome, that's Pac Man!

[@zoopi451]

I've heard people say autophagy increases and reaches it's peak in 48 hours. If that was true what would it even mean? Does it mean that the cell is constantly producing autophagosomes and it has reached the maximum amount it can hold?

[@Physionic]

Great question, Zoopi - good to see you again, btw. Typically, yes, you'd see more autophagosomes, you'd see more LC3 processing, you'd see more ULK and AMPK activity - there are a lot of measures, but the most direct would be LC3-2 and autophagosomes (which would both be far more plentiful).

[@CoryLaframbo]

Good on ya m8

[@Physionic]

Thanks, Cory.

[@Honeypepper.]

Once I see your face in the video it gets a like, I can always listen to what you said after😄😄

[@Physionic]

Haha! Thanks, WH. I appreciate it.

[@homesignup]

Hey this is an awesome detailed cartoonized version - you could turn this into a computer game - Autolysopacman (ALP)

[@Physionic]

I love the idea!=, Talia!

[@sabincioflec8413]

"Autolysosome, transform and roll out!" 😄

[@Physionic]

HAHAHA! That's hilarious, Sabin. Yes!

[@UberHummus]

“AUTOLYSOSOME” yes

[@FleetwoodMacadamia]

quick spoiler: it does not

[@Physionic]

Why do you say that?

[@FleetwoodMacadamia]

because, for the vast majority of americans, what is in their cells, are toxic breakdown products from the SAD, in the exact place where autophagy happens; the lysosomes. if lipofuscin is already is present, again, the vast majority.. it clogs the proteasomes and lysosomes! protein production declines, dna is damaged, stem cells divide, nuclear envelopes deteriorate, telomeres erode, redox potential changes... oxidation, cross-linking, glycation skyrockets! a starvation protocol/carb re$triction (primary fuel of the cell) makes it worse! then you start to tell overweight people to fast... and what did we just describe is in that back-up fuel!?!?!! this is also why no one should want to burn fat!

[@Physionic]

Can you point me to a DOI number that mentions any of that? First I've heard of it. All the literature I've read doesn't indicate any of that.

[@FleetwoodMacadamia]

@@Physionic having looked at both sides of the coin, the fasting, keto, dave asprey, gimmick dieters, AND the pro metabolic community, ray peat forums, dinkov, a slew of other indipendent experimental researchers, extreme health radio, atom bergstrom.. and if you begin to investigate lipofuscin, how it works, crotonaldehydes, yellow fatty liver disease, 4hh-n.. these mechanisms of the breakdown, etc, you begin to remember key bits of info regarding that, fasting, increases stress. this dissolves the thyroid, now some key elements in the metabolic function, metabolism, slow down, and in my experience, tested by checking pulse and body temp, did an aggressive approach to fasting.. and it seemed to be putting me in hibernation mode. now my brain works, i pump sugar into it, and vitamins/minerals, never fast, high metabolism, utilizing the primary fuel.. keep throwing coal into the fire, targeted supplementation, proteolytics, senolytics, specific herbs, root veg, and grass fed nose to tail, fasting when i sleep only

[@Physionic]

So, there's no scientific evidence of this. Unfortunately, I need some study or studies to investigate; I can't take it based on experience considering Physionic is based on breaking down the science.

[@creepychris420]

bro are you making all these words up lol. when i was younger i was poor and i only ate 1 meal a day, now im not but i still only eat 1 meal a day. i am small but i am awesome i can do backflips and wheelie my motorbike and look 5 years younger than i am. i feel like fasting is good, like food is fuel. like maybe when ur cells grow and store fat and unstore it and shit that is how your dna starts to get fucked and ur cells replicate bad and you get old person features. i tried to understand the video and what it means but idk wtf ur saying lol 😂

[@Physionic]

Yep - I made the whole thing up. ;-)

[@scottyd980]

Roger That.

[@Physionic]

10-4, copy, copy.

[@pramasauskas]

Begins beyond 20h, at least ?....