Hate those guys...can't even listen to them.

My pressure device says ER when I put it ony yh ankle should I call ER? :v

Berberine as an Ozempic replacement?! Lmfao. No. I’ve used berberine and I noticed 0 impact on my appetite.

Thanks Nic, from my readings berberine can have a synergistic effect on some of the PCSK9 inhibitor drugs such as statins and beta-blockers decreasing the first pass effect and increasing blood serum levels of drugs. Consideration needs to be given before taking it but there are other supposed benefits, anti microbial and increased gut health. Cheers

I love 'Talking with docs'

Not 2 pounds per day! You missed that, he said 2 pounds per week! Which is my experience, math is everything

Where can I buy this stuff ?

Hi Nicolas, I would very much like to take creatine. However, I have a damaged pancreas due to a severe pancreatitis. Research on the effects of creatine on the pancreas or development of pancreatic cancer, seems to be conflicting regarding safety. Do you have any opinions on that?

Your camera is out of focus.

Thanks

I had sensitive teeth for many years. It hurt to brush, when I ate icecream, oe drank cold drinks. I started a ketogenic diet, it went away in a couple of days. So, because gum disease is correlated with stroke and other cardiovascular diseases, keto must reduce those. Cause Correlation Said!

Yep, this is one funny joker...love him!

Didn’t Nasa prove that red light improved healing, with studies before and after, with increased collagen production and advanced healing.

N-Acetyl Taurine is the DeFacto way to reduce weight, not by messing up gastro motility.

I take a stack of a dozen supps, and if I could have only one, it would be berberine.

I would like to see a ranking of popular medical KZbinrs by a) scientific rigor and b) quality of presentation. I count this site as the most reliable I know, so how you rate other sites would be of great interest (and utility). In some cases, the shortcomings are obvious to me, but I'm not sufficiently knowledgeable to judge many of them.

Nick ur amazing love the content

Just a note about placebo control: Lack of a placebo group does not mean that the study is bad, nor does it mean there is no control group. In many medical studies, that deal with disease / condition treatment, the control is not placebo -- it is the "standard of care" -- the current best practice. A placebo -- no treatment -- would be unethical. For instance, in testing a new drug, the control group receives the current drug, and the outcome tested is whether the new drug outperforms the current drug. (In some rather rare cases, there may not be a current treatment, or may not be some addition to current treatment. For instance, I was a subject in a study, quite some while back, that tested whether chemotherapy was useful in addition to surgery in young women with aggressive breast cancer. Both control and test groups had surgery -- the test group got chemo. That could not even be randomized -- we knew whether we were receiving chemo. Patients and their doctors were allowed to pick which group they would be in. The lack of randomization meant that a very large number of subjects was needed, IIRC, tens of thousands. Partway into the study period, it was so clear that chemo was useful, that the study was ended early, and chemo offered to the control group. But that was waaaay back. These days, it is more common that there is a current treatment to compare to the new treatment.)

Is an hour in a hot bath as healthy as an hour in a sauna?

In the world of the 'diabetes industrial complex', no major "stakeholder"one will be interested in proving the effectiveness of berberine, however the same "stakeholders" will fund flaud studies to do the opposite.

I am a 49yo 225lb male and the ONLY thing that has helped me lose weight long term is Adderall. I was prescribed that a couple years ago and lost 30 pounds and have kept it off. It also lowered my BP. I would probably lose more, but most of the eating I do now is caused by family members wanting to have meals and I just eat because it is there and everyone else is. I did notice that when I was younger and drank tons of soda it seemed to keep me full during the day.

Web site study on Google: "Prevention of anti - psychotic - induced hyperglycemia by vitamin D : a data mining prediction followed by exploration of the molecular mechanism" May 16, 2016. Nature. (The journal Nature that is). An excerpt from the study: "Focusing on the phosphotidylinositol 3 Kinase receptor (PI3K) signaling pathway, we found the reduced expression of PIK3r1 mRNA was reversed by cholecalciferol supplementation in skeletal muscle, and that insulin stimulated glucose uptake into C2C12TH myotube was inhibited in the presence of quetiapine, which was reversed by concomitant calcitrol in a PIK3 manner. Taken together results suggest that vitamin D co - administration prevents anti-psychotic induced hyperglycemia and insulin resistance by upregulation of PIK3 function." Above study that presents possible evidence that vitamin D supplementation can prevent diabetes in some cases, as in this case, anti - psychotic induced diabetes and glucose dysregulation. There has been some debate that vitamin D supplementation could prevent diabetes. But a Stanford study some years back concluded that this was not the case. Their study found that diabetes was not prevented by vitamin D supplementaion. However, with this above study, the issue could still be open. With the vitamin D prevention of diabetes in quetapine treated patients, there is the additional benefits that some cancers can be prevented by vitamin D supplementation, possibly. Since diabetes inclines some patients to develop some cancers. And quetapine treated patients with vitamin D co-administration could be prevented from having cancer development via their diabetes development by quetapine, treatment possibly. But anyway the main point, is, vitamin D supplementation could possibly prevent diabetes in quetapine treated patients.

My dad had aggressive diabetes and he used Metformin which was hard on the kidneys..so he switched to Berberine and worked very well better than Metformin and affected not his kidneys. As a side effect it reduced his cholesterol

When “drs” get up and proclaim “They say it’s nature’s Ozempic” ……. Who the hell are the nebulous “THEY”. It is such an academically lazy way of speaking. It drives me nuts.

Curious what your thoughts are on using berberine during perimenopause to reduce belly fat? With the decline of estrogen, women start to gain weight in the stomach vs other parts of the body like breasts, thighs, hips and buttocks. If it can reduce waist circumference, do you think this would help? This is all assuming you exercise regularly and eat a healthy diet.

theres a study that says it caused muscle atrophy in mice - squeek

Doc. I've had PVCs for years, every single day, hundreds of times a day for years on end. Cardiologist said that it wasn't out of range, ànd that it's normal. Ive veen taking taurine for about 14 weeks now... PVCs almost to zero a day for the last 12 weeks. I've also lost about 30lbs in the past 4 months too. So I don't know which is causing it, but i do think it's the taurine.

Heroin is a better weight loss drug than ozempic but the side effects are just a little worse

Sure glp 1 may be better at weight loses but cocaine is a better stimulant than caffeine. Better doesn't mean better for you.

Again we see the medical community supporting drug companies. The self reinforcing castle of money that big medicine lives in is rotten to the core.

The "Talking With Docs" pair are glib & yappy. I've heard them make glaring errors on subjects like collagen.

There may be ‘reasons’ for why the studies are small but that does not get away from the fact that the studies are small. Useful video.

On the contrary, I think this is far more important than folks realize. I think what's being demonstrated is a reflection of Katp channel activity. The potassium channels dependent on ATP production cycles to regulate the depolarization, repolarization, and hyperpolarization necessary for their activation. Id like to see longer studies of this. ld like to know the biomarkers and subsequent effects in the pancreas, heart, thyroid, and hypothalamus at the very least. Id like to see and know the differences in the hair that regrows; I don't doubt they came back with the same thickness but Id bet my bottom dollar the slower growth ones are also a lot more susceptible to damage that over time makes them appear thinner, to the extreme extent that it eventually appears not to grow past a certain length because the hair degrades to it's breaking point. I think, based on all the data we have, this mechanism is exactly what goes awry in most disorders, especially those considered age-related. I think it does apply to us despite the length those times equate to for humans because the majority of people aren't actually getting what they need on a daily basis, leading those deficits to add up and take a toll. I think this could be easily tested by supplementing things we know to activate, deactivate, and/or bypass those Katp channels and see how that alters the regrowth. Some you've previously discussed for other benefits even, like Taurine. If I recall correctly it either blocks or bypasses the Katp channels.

thank you for finally giving a seemingly unbiased perspective on this. Its been driving me a little nuts that every single thing i've found so far either praises carnivore like its jesus himself or acts like you will instantly die if you take a bite of steak. Hyperbole aside, I appreciate the fact finding effort.

Do a video on Nobiletin as a GLP-1 regulator.

Got to the DNA repair proteins- using these videos as body doubling while cleaning and physionic just called me a nerd 🤓🥰

What else has Keyes done that is shoddy?

I am a male who was born with a small frame body like Pee Wee Herman. I'm 5'6" tall with a 29" waist. I guess I'm doomed to die an early death because I have never been strong. 😢😢

Those 2 are hacks.

I wish it worked that way I take that and Metformin and have done so for years

You mean insulin sensitive the opposite of insulin resistance just a little typo we forgive you

You look different.. 🤔 and I mean that in the best way possible 😍 what have you been doing??! Please share your secrets and tips? 🥹🙏🏼

Allulose is a GLP1 agonist

About the blood pressure-dementia phenomenon, here's my guess: Chronic hypertension damages small blood vessels in the brain, leading to structural changes, impaired cerebral autoregulation, and reduced resilience to changes in blood pressure. A sudden drop in blood pressure after years of hypertension can cause cerebral hypoperfusion, particularly in vulnerable areas like watershed zones, exacerbating neuronal damage and cognitive decline. This may also impair the clearance of amyloid-beta proteins, contributing to Alzheimer’s pathology, or trigger inflammatory responses that promote neurodegeneration. The combination of vascular damage, reduced perfusion, and possible neurodegenerative processes creates a high risk for vascular dementia, especially when compounded by cardiac dysfunction or overly aggressive blood pressure treatment in older individuals.

As a Naturopath I wouldn't recomend taking berberine without supervision. Its a non selective antimicrobial, long term use can lead to dysbiosis. Makes we wonder if the reduction in waist circumference may be due to killing off microbes responsible for bloating and not actual fat loss. Body composition analysis would be a better way to measure outcomes here.

Great commentary ... those 2 docs work in a hospital just west of Toronto.

constipator5000

Nature's ozempic is such a silly term. Ozempic is a bandaid on a bad diet. People be eating Soylent green out there all day every day.

For anyone interested in Berberine, it''s useful to know that it seems to be the only known currently accessible somewhat potent oral PCSK9 inhibitor, the inhibition of which is highly desirable for lowering LDL and preventing atherosclerosis. Additionally, it's oral bioavailability is very low (around 0.37% iirc if not combined with bioavailability-enhancing molecules), so it doesn't really get past the liver. Thus, its action is located mostly on the liver (which I find to be good thing, as I'm only looking for pcsk9 inhibiton and the low bioavailability should reduce side effects). Btw, big fan of you Nic! Keep up the good work

Take a look at olive oil/extract? to see if it helps as well. That's what Bryan Johnson takes and says there is some evidence for a weight loss effect. (although distanced himself to not get sued).