How Does Ozempic Work?

How Do Ozempic and Wegovy Work?
Ozempic and Wegovy are synthetic GLP-1 molecules named Semaglutide. Ozempic is approved for type II diabetes mellitus and protection against cardiac events in type II DM patients. Wegovy is approved for weight loss in obese and overweight individuals and for protection against cardiac events in obese and overweight individuals. Let's review the mechanism of action and the side effects of these drugs.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Why Ozempic Causes Diarrhea and How to Manage Your Symptoms - GoodRx
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[@nbrown5907]

Haven't we learned yet that taking a pill to lose weight never turns out well. I have gone from 235 to 175 in about 9 months by not eating highly/ultra processed foods, limiting added sugar to no more than 25 grams a day though I usually do 2-6 on average a day. I switched to healthy breads one is Rustik sourdough and has no added sugar and used extra virgin olive oil and Ezekiel's 4-9 bread, all sprouts no flour or oil and is fantastic! Just switched to avocado based salad dressing too. I walk lightly, I have stay stay low impact so I know the food is the bigger factor!

[@reeldeelz2940]

Never turns out well? My buddy has lost 60 lbs and stopped alcohol on Zepbound so far.. turning out pretty fine from what I see

[@nuggiesma]

Glad to hear that worked for you but it's not that easy and straight forward for everyone. These class of drugs help with people who struggle with food noise and bingeing which are the mental component of weight issues. Prior to semaglutide, I was on a yoyo variety of diets for 30 years with zero successes only frustration and misery. This has been a life saver on so many levels especially mentally.

[@fsinjin60]

@@reeldeelz2940there is definitely an aversion to alcohol built into drugs. I don’t know what causes it but alcohol becomes unappealing

[@marianneb.7112]

Good job! I am happy for you.

[@peacepoet1947]

I'm not a health care provider, but became very interested in medical evidence during COVID 19 days. Being informed about the latest medical breakthroughs should be of interest to everyone and I thank you for sharing your knowledge with all of us.

[@VahanNisanian]

I wouldn't touch Ozempic with a 10-foot pole. I think it should be avoided like the plague.

[@reeldeelz2940]

why

[@cherylbovee1296]

​@@reeldeelz2940because it is permanently injuring people and I am one of them. Legally blind from this drug (low vision optic neuropathy)

[@petejames9366]

Why

[@cherylbovee1296]

Because it is killing people, permanently harming people making them disabled and ruining lives

[@XeonProductions]

I don't trust any of these GLP-1 drugs. I'll lose weight the old fashioned way, or I'll die trying.

[@ArifKhan-vh2gx]

Getting old and fat is natural and I love it. Never felt better

[@thereishope3867]

just cut the carbs, or go carnivore, you will achieve the same result as GLP-1 drugs

[@reeldeelz2940]

@@ArifKhan-vh2gx old is natural, fat isn't .. eat less and less processed food and the fat part goes away

[@jellybeanvinkler4878]

​@@reeldeelz2940 IDK.... I manage to get fat on healthy natural foods very easily.

[@susanbeever5708]

Dr Been, The glp-1RA lasts for ~hours~ as opposed to natural glp-1 that only lasts for ~minutes~. This is why hyperinsulinemia and hypoglycemia occur with this drug. It will start out not being as obvious in a highly insulin resistant individual but if an individual has little or no insulin resistance they will get hyperinsulinemia and hypoglycemia. The hyperinsulinemia will then ~cause~ insulin resistance! Do 6 hour oral glucose tolerance test plus insulin and c-peptide to actually see what this drug does before, during and after treatment with this drug.

[@snowmcsnow4732]

Everyone taking that medication should give your video a watch at least once. Thank you very much for all of your work!

[@tinysmith1834]

No long term studies...yet fda approved. We need to change the way fda gets paid by pharma (80 percent). How is that NOT a conflict of interest? There are more drug commercials on tv than processed food now. But lets advertize all that crap so it keeps people buying their pathetic drugs. Drugs are the answer....give me a break!

[@anjijack5392]

Yep. They do everything bass akwards nowadays. 😒

[@horsn9]

If you comply...you are easier to control.

[@oldschool8292]

Thank you Dr Been. I watched it all and shared it. Excellent presentation.

[@jfltech]

What about the Eli Lilly version ? Mounjaro/Zepbound..the active ingredient in that case is tirzepatide .. does it work exactly the same as semaglutide ?

[@jperksification]

Such a great explanation making complicated processes simple. Thank you!

[@susanbeever5708]

UC Berkeley found that the effectors of glp-1/glp-1R is TRPA1 and TRPV1 on the sensory neurons of the lymphatic system. This is the neurolymphocrine system. The signal travels from the lymphatic system to peripheral and central nervous systems where it stimulates insulin secretion and satiety it also inhibits GnRH inhibition -> excess LH and FSH from the pituitary. FSH is the main stimulant of SHBG production that binds estrogen inactivating estrogen. This leads to not enough estrogen control of osteoclast maturation and this leads to bone loss. A preprint study in The Lancet shows a double blind study where semaglutide leads to bone loss in susceptible adults. Glp-1/TRPV1 in the peripheral neuron stimulates sodium excretion in the kidney and this leads to hyponatremia/hypoosmolality and bone break down.

[@carlagellerman914]

Would this warrant extra caution for menopausal women who ALREADY have low estrogen levels and increased risk of osteoporosis?

[@susanbeever5708]

@@carlagellerman914 absolutely.

[@WeBeGood06]

Thanks for the great discussion on GLP-1 and this drug. A Rare Sugar call Allulose, which is very similar to Fructose but also works thru the GLP-1 pathway in a more natural way. I found the discussion of the half-life going from minutes GLP-1 to a week for Semaglutide interesting. Allulose stimulating GLP-1 would keep the control system more intact when added at meal time, instead of completely obliterating the Control System for weeks at a time.

[@jperksification]

My wife completely stopped alcohol on semiglutide. What is the mechanism for that result?

[@scoutdixie4412]

I stopped biting my nails.

[@reeldeelz2940]

yea my friend (an avid liquor drinker) stopped alcohol cold turkey on Zepbound.. he says "He lost the taste for it"

[@dianemendoza9531]

Yep. Seeing lots of addictive behaviors stopped. I'm thinking it may have more to do with the GIP component.

[@HeavyDutyfx]

Here to the end! Thanks!

[@NoTrashInHeaven]

Love your teaching Dr Been! Thanks 💗

[@bobchannell3553]

Thank you for the informative lecture Dr Bean. I watched this because my doctor has mentioned having me take Ozempic for my diabetes, but I've been reluctant to take it due to possible side affects.

[@amreshyadav2758]

Great stuff Very well explained Thank you..

[@VegasGuy89183]

Seriously. I love your illustrations. Some are a hoot!

[@westfield90]

So beautifully explained Dr Been. I was always confused why not just give GLP-1 and why a need for Ozempic but you’ve now explained it so well.

[@redmond1913]

Thank you so much for these videos. I am definitely sharing this one. Please don’t underestimate the value of what you do especially how understandable you make this tough medical jargon make sense.

[@tinysmith1834]

Great video...watched every minute! Thank u!

[@fsinjin60]

I watched every other minute. Made it more challenging

[@deirdramchugh917]

Fabulous explanation. Thank you

[@ShadowMan66]

*From Google* In total, the FDA's system has recorded 117 fatalities among people taking blockbuster weight loss drugs since 2018. Of these, 81 were linked to patients using semaglutide - the active ingredient in Ozempic.Serious side effects, including allergic reactions, hypoglycemia (low blood sugar), increased thyroid cancer risk, gallstones, and swelling of the pancreas. Regaining weight when no longer taking the medication if lifestyle changes haven't been made. *I think it is a dangerous untested option*

[@9111logic]

A very interesting mechanism, as usual, it's a pleasure to watch your lectures. 🙏

[@carlagellerman914]

Excellent!!

[@techadsr]

Finally watching/listening to this lecture. Hearing that hypothalamus knowing the insulin level and thus knows glucose is present. Maybe our glucose testing should learn from hypothalamus and measure insulin too.

[@paulhastert1518]

Thank you Doc.

[@gerryaddley6200]

Thank you

[@youbetcha108]

Hi drbeen ! Terrific explanation for how these drugs work. This is a must listen to for all people who use these drugs whether for its intended or off label (Ozempic) use. Thank you😊 again!

[@cherylbovee1296]

I am not a dr but I do have a FB page on Ozempic side effects. I shared this video there for the others. I would be interested in asking you some questions. I was on Ozempic for 5 months and it dropped my A1C from 12.7 to 6.8 in that short time. It also caused inflammation in my eyes which caused me to have optic neuropathy in both eyes so I am legally blind now. The makers of this drug acknowledge retinopathy and blurry vision but not optic neuropathy. I often wonder if it was because my blood sugars plummeted so low. I would love to hear your feedback. The next question is why a large percent of the people who stop taking Ozempic get extremely hard to control blood sugars. I have been on a strict carnivore diet and my blood sugars still are around 150 and if I cheat they skyrocket even up into the 500's. Why is this happening it is as if all my liver wants to do is crank out glucagon and keep my sugar high. My Drs don't listen they are too busy protecting Ozempic so I am left to try and figure this out on my own. That is what led me to your video. And as a side note I would have kept listening even if it were longer ☺️ thank you for posting it.

[@arleneblackwood835]

Thank you always Dr Mobin for all your wisdom and insight and tremendous work on helping the world and I appreciate you so much. You help me through Covid. I binge watched you for about 4 to 5 hours a night during those first couple of years and I still watch you and learn and I thank you so very very much for all your doing and all you taught us and all you’re going to teach us thank you so very much for caring so much.👏👏👏👏👏👏❤️❤️❤️❤️❤️

[@nickyrivernene5921]

Hello Dr Bean, so after prolonged use of the synthetic semiglutide, would the l cells work less effectively leading to weight gain? Not interested in taking it myself, just saying : )

[@ArunRamakrishnan]

Wonderful explanation as always. It is such an important topic as folks are popping such drugs as if they were candy

[@mariaekman13]

Thank you for a great lecture. Have to watch it again, to better understand. I know about Ozempic, but in my case there were things you explained that I found useful for Gastroparesis. My daughter got diabetes type 1, and know suffers severe G. Even if she's not fat, maybe Ozempic , or anything related, could ease it.. Only a hasty thought. Gastroparesis is most common in diabetics, but seems like its an increasing problem also among others..

[@nuggiesma]

It's only for Diabetes Type 2

[@TJP-tq4np]

What about Trulicity (dualities)?

[@planegoodmusic]

Mounjaro work the same? Risks same?

[@edmeyer1691]

Does the drug reduce serotonin in the gut-so this is why the the action of the colon is slowed.

[@SiegfriedEmme]

great video. I knew there was a great reason for me to not prescribe ozempic

[@pepperprovasnik]

It inadvertently helps women get pregnant as well which is interesting.

[@fsinjin60]

Well, she is losing weight and becoming more appealing if not more self confident

[@dianemendoza9531]

Metformin does the same thing. It's especially in women with PCOS and it's related infertility. If you can help the insulin resistance, you can help the hormones issues at play...thus helping regulate cycles and ovulation and increase chance of pregnancy. There is also the caution of taking oral contraceptives with the slowed gastric emptying that might interfere with absorption.

[@HeavyDutyfx]

Statins 2.0

[@tradermunky1998]

Just go keto.

[@nickyrivernene5921]

Just eat a whole foods plant based diet 🌱

[@tradermunky1998]

@@nickyrivernene5921 I tried vegetarian for like 9 months. Ended it after episodes of narcolepsy. Then was a healthy clean eater for 10 years. Became pre diabetic, hypertension stage two, near clinical tachycardia, autoimmune issues, near IBS. Keto fixed everything and tons of other issues. Not to mention energy through the roof, no more old man gut fat, looking hotter than I did in my 20s. Now getting down plant eating to zero. No way am I going back 😉

[@nickyrivernene5921]

​@@tradermunky1998starting with your premise, vegetarian is nothing like vegan in terms of diet because it includes animal products, eggs, milk and cheese which are inflammatory as well as exploitative on other beings. So if you don't have that right the rest is anecdotally incorrect : ) 🌱

[@petejames9366]

@@nickyrivernene5921no that’s a very bad idea

[@Gam3rLove]

Ozempic is a GLP-1 agonist, saved u all an hour

[@reeldeelz2940]

Umm your phrase doesn't explain anything ..

[@fsinjin60]

I pushed speed up to 2.0x. Saved myself a half hour and made Dr.Been’s drone bearable

[@Maddie-lv5sg]

This does not sound like a good idea.

[@FreddieFreeloaderxxx]

You know what else increases GLP-1? A ketogenic way of eating, which is much safer and cheaper to say the least.