How Good Is Kesimpta Actually?

[@Jerusalem_Warrior]

Boy, you are going to make doctors out of us!! Thanks for the education: Made me like my bi-yearly Ocravus treatment better. Wonder how I would have gotten along with injecting myself. 💉 🤔 Best wishes from Jerusalem to you and everyone in our Village for a good and sweet New Year!! ⚖️🍎 🍯

[@AaronBosterMD]

Howdy! TY for sharing your perspective, I suspect many feel the way you do. Apples and Honey and a sweet new year to you and yours!

[@tbonegddss]

Team Ocrevus for the win!

[@676dancer]

Best wishes for your New Year 💕

[@2listening1]

not only doctors, but we are all going to be researchers too, haha! Apples&Honey to everyone! :)

[@kelleyolenick6003]

I’ve had MS for 20 years and using a wheelchair for 6 years. I’ve tried many different therapies . Avonex, copaxone, tysabri, ocrevus. After giving myself intermuscular shots, one sub Q a month is a breeze. Just started kesimpta yesterday. No problem! Thx for the info!

[@jjwatchin06]

Diagnosed with rrms in December 2015, Dr Boster I just started on Kesimpta this week. 1.11. Was very surprised no initial reaction at all felt quite normal for the first 4-6 hours then started with a headache then went to sleep after taking 2 paracetamol. Not the best of nights woke up several times feeling a bit warm had to go to the bathroom surprisingly steady on my feet. Then in the morning I felt much better was walking around the flat steadily without support of any kind almost with a spring in my step for the first time without my scooter or cane. This morning 2 days Later still feel great and 💪

[@user-ig3kn2ly2x]

Thanks posting. Was diagnosed in April, 2016. This year, two relapses, so I'm right behind you. I'm on Medicaid and don't if I can get Kesimptra, but Ithink I'll try this or Lemtrada. Thanks!

[@nwad76]

22 years diagnosed here and so glad I found you! So informative and clear. Just took my first injection of Kesimpta literally 20 minutes ago :-) Looking forward to more of your videos! Also, not bothered by shots only once a month. compared to the specter of losing my ability to walk? Bring em on!

[@slee8600]

How’s it going since?

[@kritikasupreum1923]

Please tell..how it's now?

[@za3315]

Loved seeing the phase II results. I knew this was a great drug going into the phase III open trial because my doctor and another neurologist explained that it was going to be up there with Ocrevus. I tolerated the drug very well and didn’t have any reactions or side effects. I wouldn’t mind getting a shot once a month. Another thing to note is that Ofatumumab has been around for a long time treating leukemia in much higher doses. I felt it had to be safe being that it’s only given at 1/100th the dose for MS. I feel that this is going to be a great therapy which is why I was so bummed that I had a relapse in the extended trial. Maybe I would have had the minor relapse no matter what I was on. The only inconvenient part of the trial was driving all the way to my doctors office so often. It was a lot of MRIs and lab work. Nevertheless I was glad to be part of research.

[@whoosh_angel]

Thank you for taking part in the trial! ♥️

[@troimckinnon5458]

I have just been diagnosed with RRMS. I started with Kesimpta today. I am a nurse so I’m not squeamish at all about giving myself a subq injection. It’s so easy especially with the pen. I’d much rather do this once a month than take a pill daily. Even if it were a weekly shot, I’d be ok with it. I’m glad my doctor and I made this medication choice. I’ve gotten past the tears and look forward to better days. Thank you for putting out the information for Kesimpta.

[@colleenstack210]

I'm recently dx Nurse as well I went with Kesimpta as well, can self inject subq make life easier. I pray it works.

[@tiffanybernier4586]

I will be starting this med next week. Curious how you are doing on it? I know everyone is different.

[@aTom-aka-de_baby]

@@tiffanybernier4586 diagnosed and started on this a week ago, hope you all are doing well

[@harmansinghdhillon4589]

Im a 31 year old male doctor from Cali. Got diagnosed with RRMS in march. Started kesimpta in june. So far so good. My doc said to give it about 5 months for full affect. Stay strong comrads 💪🏽

[@j.m.p8051]

How are you doing now?

[@emmadickson65000]

Very interesting video. Thank you. I've been taking Kesimpta for a year. The monthly injections are very easy and I am very happy to continue with them. The initial injection gave me a headache, but I've had more significant side effects from 'flu/Covid vaccinations. Since then, no side effects at all. One injection a month is nothing compared with the 3-4 injections a day, plus finger prick tests that some diabetics have to cope with. If Kesimpta can hold back the progression of my MS, I consider myself lucky to be taking it.

[@carla8651]

I just did my 3rd Kesimpta injection and so far so good. No side effects and no pain at injection sites. I prefer everything about it over Betaseron, which I tried over 10 hrs ago and had terrible side effects and several relapses while on it. Keeping fingers crossed I’ve found my new favourite medication! 🤞🏻😊

[@HunnyBunny215-n4o]

Is the medication working for you? Can we get a update on how it’s going for you so far? Please and thank you 😊

[@harmansinghdhillon4589]

@@HunnyBunny215-n4o Im a 31 year old male going on month 5 of kesimpta. So far so good. Slight injection site discoloration. Minor nasal congestion. I go out and about. I always carry a mask if deemed necessary.

[@Jason-Pez]

This was a good video that backed up everything I knew about ofatumamab and what my neurologist has told me. I've been taking that drug for years. Started in a study testing the autoinjector for ofatumamab and it's effectiveness compared to a regular shot. By now that has been approved as KESIMPTA and I'm still on the drug and continue to see my dr every 3 months. My bloodwork helps them with their study on neurofilament light chains so I was glad to see that reference in the video. I have not had any events in more than 3 years on the drug.

[@chrystadwyerhammon9169]

Thank you so much for making this video. I feel doctors are so busy they don’t have time to explain the process or MS journey (which differs with each patient). I am 55 and was recently diagnosed with RRMS; just took my second dose of Kesimpta- so far so good 🤞🏻. Thank you again!!!!

[@vivip2273]

Hi Chrysta! I just got diagnosed last month. I'm a 51 y/o RN and I'll be starting the kesimpta soon. If you don't mind, would you update me on any side effects you might have and what your thoughts are regarding this medication? I would be very appreciative. Thank you!

[@RealtyByHart]

I was diagnosed with RRMS one year ago and all these DMT drugs scared the heck out of me. I have extreme needle phobia, especially with getting IV’s placed in my arms. The sound of the Kesimpta self-injection once a month sounds the least traumatic to me and I am finally considering having my Neurologist prescribe it for me later this week. So far I have only been on Low Dose Naltrexone (3mg daily) for the past 4 months. I’m happy with the LDN but my Neurologist thinks I really need to be on a DMT. I’m scared of all the DMT’s. My1st Neurologist wanted me on Gilenya but I wasn’t willing to risk possible heart damage to take that scary pill.

[@sonsofanarchy5316]

Ofatumumab is a human antibody monoclonal for CD 20,with clorambucil is treatment for leukemia, Ofatumumab is very good for MS, i, m nurse🤣and i know IT, thank for this video, is very interesting for me(i, m nurse with MS)♥️♥️♥️♥️♥️

[@senull56]

As a mom to 3 young kids and a husband that travels a lot for work, I really love that I can Kesimpta shots at home on my own and I don’t have to figure out how I’m going to schedule an infusion and figure out childcare. This is the best of both worlds to me - effective and convenient

[@SmallTimeTrees]

I decided on Kesimpta because I felt that a simple shot once a month was less intrusive than having to book a day off work for an infusion. As well I was led to believe Ocrevus and others have more side effects especially in the following days after infusion. I have had zero side effects from Kesimpta and the single shot a month is no big deal at all. I think if it’ll keep working for me and there isn’t anything convincingly better I’ll stay on Kesimpta as long as I can. Thanks for making these videos doc!

[@ParisV]

I have no issue with shots. It may help that I’m also a Type 1 Diabetic for nearly 20 years though. I’m recently diagnosed with MS and excited about this new drug. I have not been placed on any DMT yet, but expect to be when I meet with my Dr the week after next. So this info is helping me get educated on treatment options. Thank you.

[@EvenSoItIsWell]

Thanks Dr. B! I love these videos! I am a numbers lover and totally geek out on data. I also love learning more about the technical side of MS treatments and trails. Keep up the excellence!

[@cinlou5804]

Diagnosed Oct. 2020, been on Copaxone 40mg for 9mo. Injections don’t bother me. I’m more concerned about efficacy and side effects. I’m currently trying to decide between Kesimpta and ocrevus. This video is helpful. Thanks as always!🤗

[@AA-ex5nq]

What did you decide to take of you don’t mind me asking ? and why ?

[@saras2302]

I was on Copaxone and was ok with giving myself injection and if this drug will help MS more I am all for it !!!!

[@NeuroNerdyX]

After 2 years on Ocrevus and having experienced the crap gap at month 3 every time, I'm now looking at this. Thanks for the Ectrims slides. These help tremendously with the decision.

[@TheAceofhearts84]

I've never seen it phrased as the crap gap, but it fits so well.😁

[@AcidRetroArtiboe]

The first month after an Ocrevus infusion is very hard on me as my body adjusts to it. How’s the Kesimpta working out?

[@LivingLifeSlower]

The Crap Gap was terrible but I've just started Ofatumumab. 4 weeks on and it's tremendous!

[@bebravemswarrior3243]

I'm on Kesimpta, just finished my Third Injection for the First Month 💪🧡😎

[@AaronBosterMD]

Nice!!

[@jakubvarini]

I´ll probably be on Kesimpta next month...how are you feeling Patricia, do you have some insights, anything?

[@brendakerber7923]

I started on Kesimpta in the middle of May. I two my first monthly shot two weeks ago. The pen that it comes in is very easy to administer. I seem to be having no reactions to it after feeling quite sick after the first shot. i am happy that I am able to do this on my own and that it's been made to easy - with the pen and the excellent instructions, I have no worries. I would much rather do this than take a pill every day.

[@starlight1234321]

I'm currently on Ocrevus but have to travel twice a year to get my infusion and miss a day of work, in addition to the two days a year I miss for my MRI and 6 month check up (small town, no neurologist here). I didn't mind injections but failed out of Avonex and then Rebif because I built up an immune response. Once a month injection doesn't sound so bad and would save me a lot of money and time because I wouldn't need to travel so much. P.S. I appreciate getting the actual science and data, thank you for sharing this!

[@rhondawilson1141]

Thanks so much for this information. I would much rather inject myself monthly than spend hours driving to and from monthly infusions in often bad weather with a wheelchair. Great news to discuss with my neuro!

[@TheAleqzi]

Going to shortly start Kesimpta (most likely option). Your question about how I would feel to take a shot once a month was interesting to think about. Right now I would feel more than happy in order to slow down any relapses. I'm curious how I feel in some years...

[@AaronBosterMD]

I’m excited to share some brand new clinical trial results from #ECTRIMS2019 with you!

[@mattz5275]

Fantastic video as always Dr B! If I had to give myself a shot once a month I'd be happy with that. Presentation was 💯🔥👌🏼 very easy to understand and follow. Safe travels back to the states.

[@zacharykelway5797]

Any idea when we can expect this drug will be FDA approved for MS?

[@nursecatorn3449]

Interesting! As a African American female -mayzent darn near killed me. I suspect (btw, I’m no doc, just a RN of 42 yrs) because I’m in neuro/oncology-I didn’t want infusions of any type (call it PTSD from infusing others via ports & piccs at a cancer & research institute for 22 yrs) yet I’m doing well with Kesimpta (no side effects, more energy less spasticity) it is imperative that we try to increase the diversity of those in clinical research studies. My rarity is that I acquired MS after age 50 after a gastric surgery that interfered with b12-intrinsic factor, boy did I become lab rat. I ❤️ research & statistics, your presentation had me mesmerized My neuro in Tampa, FL is a MS specialist Dr Carrie Downey; we share a love for clinical trials & studies. 😢😢

[@nursecatorn3449]

@@mattz5275 the injection is painless & when time rolls around monthly I’m never bothered by the 4-5 minutes entire process takes & im still a working nurse, wife, granny; etc. praying that a cure is found in our lifetime.

[@richardfrankenberg4268]

I was diagnosed in April 2021. I was started on Kesimpta.

[@safaeelh8045]

Hi doc! Thanks for making this video! I took part in the original Asclepios trial, so I love being able to see what went on. I was in the Ofatumumab group, so great results till now.

[@julieannmoore8740]

Very interesting trial! I just started Aubagio in May, 2019 so far I like it. I was a Copaxone patient for about 15 months and I agree with you on the “fatigue” issue. I simply could not stick myself with a needle any longer. Taking a pill is easier and fits into my life much better. Have a safe trip back to the US.

[@megd7593]

Thanks for sneaking out those slides! There’s some exciting data there for sure. I suffered needle fatigue (mostly because it REALLY hurt and I felt flu-like symptoms constantly) on copaxone and Rebif. If those side effects were absent with the new drug, I might be more inclined to be compliant. However, if there ARE the aforementioned side effects, I’d want to stay with Tysabri. I really don’t think I’ve had any ill effects besides “slump week” before my infusion.

[@mikebrewer1346]

Diagnosed in 2022 and started on Kesimpta. Many thanks for the information - reflects my (limited) experience with the drug well!

[@TheRabbitopia]

Once a month self injection would be more tolerable than once a week or once a day, but I’d be less likely to go with it over an infusion like Ocrevus or Lemtrada if the CDI isn’t there. I really liked this, thank you!

[@wendymcclatchey1651]

I injected Copaxone for over five years daily, not using the pen just injected directly. Needles do not bother me but laziness took over in the last few years in that I only used my belly injection sites and I injected through my clothes (it didn't ever sting that way). So while I continued to inject I did fall into bad habits with time. I think a monthly injection, for me, would be very doable. Thank you for a very informative and exciting video.

[@JustChrissytheCrone]

I am going to answer about shots....I am currently on copaxone and will 110% state once a month injections vs three a week sounds so much better! I am feeling defeated every “shot night”. For me is M, W, F. I do them before bedtime but the lumps and bumps have never been welcomed! I am debating discussing med change but my nuero seems of the mindset “if it’s working don’t switch” and I should note I’m new to her practice sooo there’s that! I’ve only seen her once and honestly wasn’t impressed..well blown away. I dunno what my plans ahead are but this video was awesome! As always, thank you Dr. B!

[@AndiPandiBee]

Always good to see the results of clinical trials looking good. Anne Rowling clinic in Edinburgh are currently doing a study on progression and wether or not they may be able to track progression with data from the first year of diagnosis. When I was doing my last past of it research, I was told by the nurse they are only a few patients away from being able to start colating all the data to see what they can find. I believe there's also a trial on a remylination (forgive my spelling) medication in Edinburgh currently also. Sadly I couldn't go for it because it was age 30 and above. Clinical research is soo needed though. Fingers crossed for more and more high efficiency drugs with less side effects.

[@AaronBosterMD]

Ellie Smithy Amen! #WeHaveMS

[@msmartian]

Ayeee it's Dr. Boster! I met you at this MS Conference in Columbus last year with my aunt from the MS Views & News thing. I had lost 100% arm and hand function and it wasn't the first time but it took Plasmaparesis to bring me out of it I had been considering HSCT it was so bad. Plasmaparesis finally worked thankfully. You gave me advice on things I could try to regain hand function like the Ampyra and my current Dr. in Columbus, Dr. Eubank over at OhioHealth has been using your medication recommendations since then that have actually worked. Had not for your suggestions I'd have been screwed. I'm on Kesimpta and the Ampyra and doing well now (although the nurse Practioner for the doctor had some minor dyslexia with my walking speed for Ampyra for if you catch my drift.) Not much going for hand function in the study department on Ampyra but I'm so happy I was able to try this stuff. I'm in process of switching over to see you once I fax the paperwork to the office. :)

[@oreo7062]

I wouldn’t mind Kesimpta monthly! I did Avonex for 19 years weekly🤣

[@traceywhiting7093]

I wouldn’t mind a once a month Kesimpta (sp?)-subcutaneous self administered injection. I did Avoven inter muscular, for 2 1/2 years and Copaxone daily for 8 years. I think it would be more convenient and less time consuming than the Ocrevus and Tysabri I did. Btw, I went downhill on Ocrevus....I know everyone is different and we know MRI’s with Ocrevus can look clean, yet, my left leg drag/foot drop seemed to really progress on Ocrevus and now on Tysabri, 3 new lesions. So, My Neurologist said we want you to try, Ocrevus!?? I said, I was already on that for at least two years. I think charts can get lost in the businesses and the overwhelming number of patients, that Neurologists have to see. So, you get to see their PA’s, and it’s probably hard to know what is going on in a patient. Sometimes, unfortunately, we become a number....in a sea of patients. So we really have to advocate and keep good records of all of our treatments for the years/decades w/MS. Side note, when your left leg is a daily challenge, self injection is so much easier, than trying to get in for infusions. I hope my neurologist puts me on Kesimpta(sp?) and that I do well with it!! 🙏🏼

[@keelyml]

Considering the fact I’m still self-injecting (just finished Monday’s stick), I can do it. Going on 5 years of this, it does get old. Each neurologist appointment renders the same questions, “how are the shots going? Are you consistent? Have you missed any shots?” Once a month injections would be very welcome to the patients still on an injectable MS medication.

[@ope4r540]

Hi Dr. B. Greetings from North Texas! I’ve been doing well with my Ocrevus treatment, knock wood. 😊

[@tracif8637]

I drive about 4 hrs to see my neurologist and receive an Ocrevus infusion. I would much rather do that once every 6 months than have to inject myself once a month. Ocrevus has worked wonders for my MS. Yes I do like your scientific explanations regarding MS and possible treatments.

[@cindya12]

I’m a fan of this type of video! Thank you for the content and clear presentation.

[@petronamclean8413]

Hi Stephanie I hope you're okay I like your style keep up the good work same way

[@jessdash5261]

This was incredible! Thank you for taking the time to make this!

[@mikeecko]

🤔🤔🤔🤔 Hello Dr B , that was a pretty interesting video that I just watched . As you know that I am newly diagnosed with Ms as of April of this year. I'm currently on tysabri, which I just had my third infusion on Friday. And I've already noticed that my balance and my walking is getting better. Thank you for another informative video. It seems like your knowledge is endless on multiple sclerosis which I will try to retain everything you talk about .

[@2listening1]

I am SO pumped by this! YES I absolutely love this type of presentation! This may be my favorite one of all of your non-chicken/dragon/Grigio-including videos of all time ever! ;) And I would TOTALLY not mind giving myself a shot even every day like insulin patients (not myself) do. I donate platelets twice a month and I used to be hypoglycemic so I didn't mind giving myself the needle stick / pinprick. Once a month? That's no problem at all. Your the best Boc Boster. Apples and Honey to you & to all your neighbors, family, and patients, and to all the research subjects from these two trials.

[@danielleniez96]

To answer your question: I feel like it it was only once a month, it would be manageable. Doing a self administrated shot three times a week I think would get mentally and emotionally exhausting., and would have a large impact on not only my life, but those close to me. once a month seems far easier to manage.

[@christinasitto5601]

I use the kesimpta pen! It’s really annoying having to call and order it each month with the copay assistance but the actual injection isn’t too bad! My first reaction was horrible and I truly thought I was going to die, but after Benadryl I was back to normal. Each week after I had no symptoms except injection site soreness. The actual injection isn’t too long, it’s usually done when I finish praying a Hail Mary!

[@colleensmith3374]

Hi Christina- newly diagnosed and starting Kesempta this evening! Excited & hope it's effective in slowing this beast down:) I will also be saying a few Hail Mary's:) Would love to keep in touch- Colleen from CO

[@j.m.p8051]

Hi! I am currently on Tysabri and looking into switching. How are you doing now with it? Do you live in the US? Do you go through a specialty pharmacy like Accredo to order it?

[@chrisc757]

Another excellent presentation of a very complex subject, your methodical approach in explaining a difficult subject makes me wish you were my Physical Chemistry professor when I was at the OSU getting my degree in Chemical Engineering. I have been on Copaxone for 9 years, starting with daily injections and now down to injecting 3 times a week so a monthly injection schedule would be great.

[@t1gerangel]

I am a bit concerned about injection fatigue . I took Rebif for a year and my legs were so bruised I could not do it any more. I hope that one injection a month will be tolerable for my body. And I liked the presentation!

[@anthonypetit7984]

The format was excellent! The study information and high level analysis is much appreciated. It confirmed my choice of aubagio, which adds to your question about “injection reluctance.”I hate shots and will always take the non-shot alternative.

[@mikeecko]

And to answer your question I wouldn't be afraid of doing an injection myself once a month. I will do anything to not feel like I have MS. but like I said I'm on my third month of tysabri & my fatigue has got less and less , my walking and my balance has gotten better too

[@celiaa2006]

This was AMAZING Dr. Boster, I just soaked up every word you said! Thank you!!! Please do more videos like these! Re: injections. I started with Betaseron, so I have a negative association with self injections BUT once a month I could handle. I do monthly labs now and have for a few years (Lemtrada!) and have done well at keeping up with those, so the self injection 1x/mo would probably be fine. I doubt you’d see the same compliance issues as you would with the interferons and Copaxone, but I completely understand your dislike for self injections.

[@socallynn6735]

Hey Dr.B!You asked for opinions on patient administered injections. As a type 2 diabetic, who’s been injecting daily for 10 years, I would relish the thought of once a month shots! Now when I started I was a mess. I still remember the first time doing it on my own. TRAUMATIC! I almost passed out, my hands were dripping wet AND I was shaking like a maraca. I just knew I was going to die because there was no way I could do this everyday. Well, I was wrong. I still don’t like giving myself injections but, with time, I’ve become pretty proficient. What I’m saying is, that other patients might consider the injections if the potential payoff is significant enough. I think you call that the risk benefit. Thanks for sharing this. Although this new drug wasn’t tested for my particular “brand” of MS, I still found the information very interesting.

[@heatherdeskin8080]

Hey Dr. Boster! To answer your question, I would HATE to have to do shots on myself. I feel like there would be a good chance I would have skin irritations with the subcutaneous injections. Luckily I’m holding strong two years after Lemtrada! 💪 Hope all is well! Thank you for all you do. Can’t imagine having a different doctor. 😊

[@garryhopkins]

You asked about patients’ attitudes to monthly subcutaneously injections. I have absolutely no problems with taking a shot each month. This is especially so using the ofatumumab autoinjector which is totally painless and so easy to do at home.

[@t1gerangel]

Thank you Dr. Boster! I think I may switch to this drug.

[@hm1389]

I loved this information. As someone who has injected Betaseron, Avonex, Rebif, and Copaxone over 13 years, I have mixed feelings about a once a month self administered injection. If I was switching to this after years of doing either daily or a couple of times a week, I would be overjoyed to only need to do this once a month. But if I were new to self injections, I would probably struggle to do it regularly and do it right. Less time doing it would lead to hesitation and not doing it as prescribed. But if i works, it worth trying. DMT's have come along way in the last ten years.

[@tbonegddss]

I used Copaxone for five years. For the first two, I used the auto-injector. The "click" it made, combined with the pain from the forceful injection gave me anxiety and caused me to skip injections. A nurse came out and taught me how to do it manually, and that combined with a much slower injection speed significantly helped. However, five years of self-injections he times a week became very exhausting. I recently switched to a grievous, and I'm set to do the second half of my first infusion this coming Friday. The freedom of the infusion compared to the self-injections is wonderful!

[@tracyfromwv9374]

Good morning, Dr. B! Great news, and thanks for being sneaky! Not a fan of injections, but once a month seems do-able if the outcome is really effective disease management.

[@AaronBosterMD]

tracy fromWV if you had to pick between a twice annual infusion or a monthly self injection which would you pick?

[@tracyfromwv9374]

@@AaronBosterMD I'm good so far with Ocrevus twice a year . . . But it's good to know there are other highly effective options! (You ok?)

[@christinehedrick922]

I am a MonSter Slayer OG (only 4 dmd available @ dx). Once a month injection not so bad compared to Avonex fake flu once a week or the daily wasp stings of copaxone. If they could just inject a fatigue blocker in the shots, I'm down. Thanks Doc for the updates.

[@sherrilyncaron]

Thanks for another awesome video! I loved the Q&A that you did in Amsterdam. I’m currently on Tecfidera which I chose because it wasn’t an injectable. I wouldn’t do a self-injectable though the infusions are appealing.

[@LH-zx7bz]

Thank you for being our guide!Extremely helpful. Liked this presentation. Actually feel like I accomplished something cognitively. More mention of the nFl lab test. Would like to learn more. Personally I am tired of being poked/prodded, however if the drug works it does not matter how it is received.

[@amyfoster4694]

I've been self-injecting for almost 21 years, (daily for a long time) currently 3xs a week...once a month would be GREAT!

[@jessicabrusuelas2]

This is really helpful I just got diagnosed with MS April of this year . And Im in RRMS I start my first trial tomorrow of keisempta. Still looking more into it . I'm the first person out of my family that have it .I'm 24

[@BradMikes]

In the beginning of my journey I was on Rebif, injecting myself three times a week. That lasted about 18 months. Injection fatigue? Yes! So once per month injections don't sound bad to me in comparison. On Tecfidera for the last five years. But about to start on Ocrevus and excited about it.

[@helenadomenico892]

Btw I love your videos, you are helping us all so much when our current neurologists don’t have the time or ability to relay the information (dumb it down, with all due respect) the same way.

[@sacredweeds]

I’m actually watching this on behalf of my client. I’m the one who would have to inject her unless we could go to the Dr.. She used to take alemtuzumab but as you said though I trust she did better than the majority you can tell on her voice and the rolling of her eyes, injection fatigue set in during that series.

[@ayeshakelly6945]

That was absolutely amazing!!!!! It just reassured me so much more I choose a good choice . Newly diagnosed MS

[@flybyadebiwood5789]

Fantastic video, great info. I’m on Aubagio for 3 months and feel better but my ALT keeps climbing so might have to switch. I’m 59. “Preserving the reserve” is of high importance. I’ve never given myself a shot, but it’s worth a try I suppose. I believe I’d be more comfortable with an infusion.

[@jeanlagasse1001]

Thanks Aaron for another informative video. Saves me from after hours reading : )

[@beverlybelanger2814]

Aaron, thanks for another great video. It’s me your super fan from the Seattle conference. Still hoping you visit us in Concord, NH.

[@willieb2146]

I appreciate your presentation. As for me, I would prefer the subcutaneous monthly Kesimpta over bi-annual transfusions.

[@smr697]

I do not have MS, but my daughter does. Her monthly infusions of Tysabri take 3 hours making her miss work. She'd prefer doing self injections. Personally, I'd love for her dr to use the blood marker you discussed. Hopefully, it will be approved soon.

[@chez9831]

Thank you, I am on Kesimpta for my MS, after having some loading doses side effects, I am ok now and happy to inject once a month (btw it doesn’t really hurt at all, maybe only for a second or two but not that painful) I find the Kesimpta pen very easy to use and very convenient.

[@rafiklazid4289]

Hello from Québec 😊 going to start kesimpta soon i had a realapce last mars and i was on aubagio my doc suggest to change traitement because my MS is active..spot on the MRI i hope this New drug can help. Thank you i love your videos the contents is very rich and helpful.

[@paulasmith5928]

@ dr. Boster I actually just started kesimpta last month.

[@kerryhowes2161]

Fantastic video, especially as I was part of this trial. I also have no problem self injecting, I was very nervous at first but quickly got over it.

[@doctorken2k]

Good video Aaron! Looks promising. One step to a cure!

[@s51ta]

Hi Aaron, Great Video. Would you be so kind and maybe dedicate one full video and share latest insights on the Pediatric MS. Thanks

[@amys.3373]

Thank you for this! I have been on Tecfidera for 1.5 years with horrible side effects and severe lymphopenia. Next was Aubagio for about 3 years. I liked it after I adjusted, but eventually my liver did not. I also had significant hair loss. I had new lesions while on both medicines at the same rate as unmedicated. I've been on a drug holiday for 2 years now, and am looking for my next drug. I do not like needles AT ALL. I fact, I couldn't even look at my kids getting vaccinated. I think I could do a once a month shot, but not a daily or weekly one. I suppose you get used to it though. Kesimpta & Mavenclad are the two drugs I am considering. I am 57. I have been diagnosed for 9 years, but am estimated to have had MS for nearly 40 years.

[@reneeenglish9550]

I freaked when my nuero switched me to these monthly injections as used to faint at the thought of a needle. 3 months in and 2 self administered shots has me loving the convenience. Ocrevus infusion used to take nearly all day at the hospital followed by 2 weeks feeling flu like. Now it's a 2 min procedure and a couple of yuk days. Looking forward to hopefully a good MRI 👍

[@heatherpeterson1473]

If the shot isn’t painful and doesn’t effect me, I would do it once a month. It’s not that bad

[@freethinkeralways]

Thank you Dr. Boster! Once a month is definetely better than Rebif 3 x wk or daily Copaxon. I love your presentations! ... But since you asked for the feedback: I really appreciate when data is presented in absolute terms, not in relative terms as pharma tends to advertise. For example, the difference between 10% and 15% is 5% rather than , for example, "30% improvement". I'm still researching the data afterwards to calculate how many of 400+ investigational drug participants had relapses, AEs, SAEs etc. I'm not that much interested in comparator - SOC drug used in the trial. Again, your videos are awesome! That's just my opinion. Thank you for all you do!

[@luisguerra1975]

Thank you for creating this presentation - so helpful as some of us try to figure out a treatment for MS.

[@annettecail343]

You asked for comments on taking shots, when I was diagnosed in 2004 I began betaseron shots, then in about 2014 I changed to copaxone, then a couple years later I changed to the 3 times a week copaxone. Then October 2021 I began Kesimpta. I've never had any significant issues with giving myself shots, tho I also have never had issues with needles as some experience.

[@maia8962]

So helpful and informative as always, thank you. I’ve been doing so well since my first relapse / diagnosis in May 2019, following the OMS program and taking Brabio (3 x injections per week) but then I got covid, no symptoms from that but brought on a massive relapse which I’m fighting to get out of now. It’s effected my walking quite badly and am now about to go on to Kesimpta, so this video has helped me make my mind up to go on it. I’ve been swimming 5 hours a week since this relapse, trying to swim my way back to walking 😂 So my big question is will I be able to carry on swimming when I start taking Kesimpta? I’ve found swimming to be the best thing ever for MS exercise as I feel almost normal in the water, so I really don’t want to have to give that up. Any advice on swimming and taking Kesimpta would be hugely appreciated.

[@MSVlogSupport]

Thanks for the info! For your question, I was on Copaxone for years and became a pro at the shots. I still have lumps and bumps from injection site reaction. You can rotate but after so long it just doesn't matter. I was on Avonex for 18 months and it was horrible, intermuscular is painful and I was sick and never stable. No more shots for me.

[@llauram3650]

I'm going from copaxone 3 times a week to kesimpta once a month, and it's much much better. the injection itself is a lot easier too.

[@oreo7062]

Great info Dr . I was able to inject Avonex for 19 years weekly ! I’m looking forward to Kesimpta monthly , Avonex stopped working for me last year.

[@AaronBosterMD]

Wonderful!

[@mccorn75]

I think I would be okay with once a month injections. Previously, I have taken Copaxone (3x a week) and Avonex (1x a week) and I did become fatigued after 7 years.

[@thaishelena110]

Thank you for the video, Dr! Answering your question... I used to get a shot everyday (copaxone)for almost 2 years. So i wouldn't mind to do it once a month. Actually, i think if a medicine could help me to feel better and effectivelly slow my MS i could even have a shot everyday again.

[@KarenLaw-kl6uj]

Thanks so much for this. I chose to start Kesimpta based on the high level studies I could find. You have significantly increased my confidence with my choice. To answer your question, I chose monthly subQ injections over infusions because they are less invasive and I have more control over administration times etc. I start next week and I’m feeling positive about it. I’ve been working hard at changing my diet and lifestyle naturally (OMS) and I feel this will be a good partnership. Thanks so much. I love your videos. I subscribed 😊

[@helenadomenico892]

How do you feel about Kesimpta now Aaron? Btw I was on Copaxone for the first5 yrs of my ms journey and Gilenya for 9 years now. I’m not a huge fan of injection but once a month is far better than daily in my view. I’m on week two doing a plant based diet. I find in the last five years my physical ability has declined , I’m hoping to help the DMT

[@andrewkaldas3337]

Very great presentation, thank you so much Dr. Boster :)!

[@GraphxDesigner]

An injection once a month instead of 3x a week is very tolerable Thanks for another awesome video.

[@ctjmaughs]

Was allegic to the inteeferon shots pretty early on

[@blessedmamaD24]

Dr B- i’ve been a patient of yours for 11 years, since 2008. I followed you from OSU and trust you implicitly . I just called to make an appointment to see you. I don’t want to see another neurologist there. Please please update us and let us know if you are still seeing patients in the future. 😕😢

[@hahakittymsms1183]

charity davies He is leaving? I am in FLORIDA too broke to move or fly to Ohio.... This channel has saved my life!!!!!

[@ingridoneal466]

I started out on Rebif. As long as I have an injector, I can do it.

[@geoffreyfuller6221]

Thanks, Dr. Boster, for the video. Helpful, as always. And no, I'm not a big fan of monthly shots, whether self-administered or not. I'll do them, but could see injection fatigue setting in eventually.

[@molleereece5173]

Ive bee on mostly injections for my 20 years with ms. Most of the years on Copaxone. Yes, I was not doing the shots as I should have been doing for years. Skipped way too many. I had to face the fact that I had ran into mental wall of some sorts. Changed to a pill. However, I think that a once a month injection would be very doable especially compared to the three per week.

[@brendab5063]

Did you ever switch your medication?

[@ibuprofenBAN]

Teach us about neural filement light change