How Psilocybin Can Rewire Our Brain, Its Therapeutic Benefits & Its Risks | Huberman Lab Podcast

In this episode, I discuss what psilocybin is (chemically) and how it works at the cellular and neural circuit level to trigger neuroplasticity, which is our brain’s ability to rewire itself in ways that lead to long-lasting shifts in our emotional, cognitive and behavioral patterns and abilities. I discuss the emerging clinical trial evidence for the use of psilocybin in the treatment of depression, addictions and other psychiatric challenges. I explain the typical duration and phases of a psilocybin journey, the different categories of dosages often used and I explain the importance of set, setting and support when using psychedelics. I explain which groups of people place themselves at great risk by taking psilocybin as well as groups that could benefit, and I highlight the rapidly changing legal and medical landscape around psilocybin. This episode is a thorough exploration of psilocybin from the scientific and clinical literature perspective and ought to be of interest to anyone curious about psilocybin, mental health, neuroplasticity and/or psychedelics more generally.
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Articles
The neural basis of psychedelic action: go.nature.com/3VInMlE
The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers: bit.ly/3VW8iL7
Increased low-frequency brain responses to music after psilocybin therapy for depression: bit.ly/3LKj6XK
Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression: bit.ly/42c7y6x
Brief structured respiration practices enhance mood and reduce physiological arousal: bit.ly/3wEvGRf
Therapeutic use of psilocybin: Practical considerations for dosing and administration: bit.ly/3HPHLZM
Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo: bit.ly/3HQ8J3z
Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics: bit.ly/44Gpwjx
Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression: bit.ly/3pjvu9N
Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: bit.ly/3sFSGMM
The costs and benefits of psychedelics on cognition and mood: bit.ly/3NNyEwI
Other Resources
The Physiological Sigh: • Reduce Anxiety & Stres...
Dr. Matthew Johnson: Psychedelic Medicine: hubermanlab.com/dr-matthew-jo...
Timestamps
00:00:00 Psilocybin, Legal Considerations
00:08:32 Sponsors: Eight Sleep, ROKA, HVMN
00:12:00 Psilocybin Becomes Psilocin in the Gut, Serotonin
00:17:00 The Serotonin 2A Receptor, Therapeutic Outcomes SSRIs vs. Psilocybin
00:21:40 Serotonin Receptor Expression; Visual Hallucinations & Eyes Closed
00:27:21 Safety & Cautions for Specific Patient Populations
00:29:13 Sponsor: AG1 (Athletic Greens)
00:30:28 Psilocybin, “Magic Mushrooms” Dosing, Micro-Dosing, “Heroic Doses”
00:36:21 Psychedelic Journey: Set, Setting & Support
00:43:43 Music & the Psilocybin Journey; Duration of Effects
00:48:58 Psilocybin & the Brain: Subjective Experiences, Perception
00:58:36 Sponsor: LMNT
00:59:48 Brain Networks & Therapeutic Outcomes
01:05:23 Creativity; Music, Emotionality & Psychedelic Journeys
01:12:39 Depression & Psychedelics as Neuroplasticity “Wedge”
01:16:53 Positive Psychedelic Journeys, Unity, “Oceanic Boundlessness”
01:25:23 “Bad Trips”, Anxiety & Physiological Sighs
01:32:57 Therapeutic Use of Psilocybin
01:36:11 Neuroplasticity, Structural Brain Changes & Psilocybin
01:48:08 Psychedelics: Therapeutic Breakthroughs & Depression
01:56:37 Combining Psilocybin Therapy & Talk Therapy, Antidepressant Effects
02:03:11 Psilocybin Experience & Mental Health
02:06:42 Zero-Cost Support, KZbin Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com
Disclaimer: hubermanlab.com/disclaimer

[@jopo7996]

Andrew's delivery of psilocybin information doesn't leave mushroom for improvement.

[@mipacem]

damn

[@leonlee8524]

What else would you expect from such a Fungi?

[@phlezktravels]

Dad joke approved

[@PlubusDomis]

Noice!!!

[@justanerd1138]

Alright. You win the internet for today. Well played.

[@AkilPalanisamy]

As a medical doctor practicing 20+ years I can say that psilocybin is the single biggest breakthrough in mental health transformation for many of my patients

[@warmaiden2438]

​@Andy griffin Nobody believes you man. Just stop.

[@bellelacroix5938]

How much did you get paid to say that says the mother of two who were lured into this so-called stressin by lawyers and therapists who were really sexual predators at the high-level?

[@joshuahunterwilkins4922]

@@bellelacroix5938 please stop mashing random keys on your keyboard

[@ThereISABootONYourTHROAT]

ZERO benefit from ANY drug to help in ANY WAY ones mental status/ability. 100% harm each and every time a drug or drugs are taken.

[@spearcat710]

@@ThereISABootONYourTHROAT that's a pretty strong stance to take. Fact is we pretty much all take drugs in some way and almost everyone tries to dissociate at certain points. People pretty regularly say its one of the most important experiences in their life and I think its pretty apathetic to be dismissive of that, to both the hurt and the healing that those people been through. But you keep your abstinence up, we're all proud of ya for not doing it, and we're all proud of people that did do it and saw real progress or benefits. What's 100℅ true for you, isn't for everyone. Good luck to you in you're endeavors!

[@ingridsara213]

I have been depressed for a long time, but after taking shrooms few months ago, l feel much happier and highly motivated and my ADHD gone , lost a ton of anxiousness and had a few epiphanies about how I should live my life. I decided to buy an ounce for backup, but haven’t yet felt the need to take any more since then.;;

[@harrybill1249]

I have autism, I was diagnosed with it when I was 15. I tried shrooms and it made me function so much better.;;

[@JessyLives]

Eek I’m autistic too and might wanna try mushroom. Anyone know how I can go about it??””

[@harrybill1249]

Yeah doc.brenttt is your guide. Man is exceptional with anything psychedelics.”

[@AndreaNicholls-pr2wd]

On instgrm??

[@harrybill1249]

Yes doc.Brenttt

[@wellfedlove]

I was a participant in the John Hopkins study. All i can say is that even years after, I am profoundly changed and I want desperately to shout to the world to allow this research and use! I received decades of healing in one session. The most profound experience of my life. Thank you for talking about this! Man, I want to go back to that mind space. Everything fell into place and was so clear to me. Death doesn't scare me at all! Life is joyful even on the hard days. I went back to school. And I'm now pursuing a masters degree in chaplaincy. I was over 50 years old during the study And i recommend it to anyone, as long as they don't have contraindications. It is shameful this is withheld and illegal. Keep talking about this!

[@maryannpainten2695]

How did you get chosen?

[@wellfedlove]

@maryannpainten2695 I applied to do this and was accepted. I had to do so much documenting but I was glad. It means this could actually become a reality for our country to help in healing so many people. I'm a retired paramedic and an avid believer in holistic health and natural medicine whenever possible. I jumped at this opportunity and was able to do this at my home with a safe person in a safe setting. It was one of the most profound experiences I've ever had. The effects continue to this day. If I could ever become a guide, I would jump at the chance. It's that healing. Life changing actually.

[@w3w3w3]

do you suggest using it for someone with bad depression most of my life bro? i am thinking of getting some magic mushrooms (not sure from where tbh atm) how much would you reccomend taking?

[@wellfedlove]

@w3w3w3 I do recommend using it for healing for profound depression but it must be with someone who knows how to guide. You also need to make sure you do not meet the criteria for who should not use it. Dosing will be dependant on many factors including body mass and size. I took between 2 and 3 grams and had a long and powerful session. I am 5'5" and weigh 125 pounds. I recognize that it is illegal however and you must be aware of that. I have been profoundly changed for the better and that has not changed. I love a joyful life and I'm thrilled to be alive! I plan to do another dose soon simply to wrap up what may be a couple loose ends related to my past. I am an abuse survivor. Both at the hands of a pedophile and an ex husband and then was excommunicated and shunned when I left that marriage. To this day, neither side of my family speaks to me. It's been over 25 years now. I had profound PTSD and had a date chosen to end my life. 09/27/2021. What mushrooms did for me is nothing short of miraculous. My number one recommendation is to be under the care of a guide who understands the process and will keep you safe and the environment as you need it. I never felt fear. The visual hallucinations were stunningly beautiful and I was in the presence of the Divine. I'm absolute in my belief of that. The experience was so incredibly profound and healing that I found my brain struggling with not wanting to leave that Presence. I finally felt part of everything and that my existence is not accidental and it matters that I'm here. I went back to school in my 50s. I'm now an ordained minister of chaplaincy and I'm going for my Masters. Iwas formerly a Paramedic. I'm also a HUGE advocate for psilocybin use in treating depression, PTSD, and abuse. No counseling ever came close to helping like this did. I wish you all the best!! Heidi

[@wellfedlove]

@maryannpainten2695 I applied to be part of the at home use study through John Hopkins and was selected. I was required to send lots of information and they required answers to many questions. I did two sessions, spaced apart. Both were truly beautiful. It's the fact that the results continue that truly blows my mind! I am a joyful, social, happy human where before, I was planning to end my life. Had everything set.. day, method, place. What a true pleasure to be alive every single day!

[@ericarice4588]

After my first time using shrooms, the very next day I was sick of my procrastinations. I put myself in school for massage therapy the very next day and have been an LMT for years, with my own business. It literally has shaped my life.

[@RitaLynn444]

❤

[@gerbertron3226]

It unlocked anxiety and not long after I started having panic attacks. Fast forward years nearly 2 decades later and I still struggle with my panic crap. Glad it worked out for tho

[@CrazyWhiteVanDriver]

Lmt ?

[@JRoze101]

@@CrazyWhiteVanDriver Licensed Massage Therapist

[@icecube8496]

@@gerbertron3226 what dose you took?

[@CNAPharmaceutics]

It’s been 4 months since I stated microdosing psilocybin (can never spell it right 😂😂) and it had cured my depression. Gone, poof 💨 like the wind. Imagine 7 years of trauma and depression and shackles around your and then in 10 minutes it’s gone. What a time to be alive. Thank you God ❤❤❤❤

[@onurkaya9163]

What was your daily dose?

[@CNAPharmaceutics]

@@onurkaya9163 I did not take psilocybin every day, I took it every other day. I took 8.5 mg every other day. It takes a lot of math to find what the actual dose of psilocybin is. If you have a gram of dried mushrooms, that does not mean you are taking a gram of psilocybin. Psilocybin content in a gram of dried mushrooms is roughly 10 mg.

[@kplay7705]

How can I get this

[@CNAPharmaceutics]

@@kplay7705 smokers alley

[@CNAPharmaceutics]

@@kplay7705 smokers alley in some cities and states, like Roseville Michigan and detroit Michigan.

[@sednasix6608]

I dabbled with microdosing (1g max) about 3 times in 2021 - last Sunday I finally pulled the trigger on 3.5g of p. envy... most profound, deeply emotional and introspective experience of my entire life. The lessons I took away from it are forever embedded in my psyche. What I've taken from it made more of a shift in my consciousness in a single session than a year of talk therapy. Although I think therapy was a huge element in exposing me to a lot of valuable information, but it was always difficult to implement. Old patterns die hard. With my trip - I cried for 3 hours about various things my mind was bringing up. It came in waves. It was so intense but as soon as I let out all the emotion and tears about whatever I was processing I would then calm down and then the next wave would hit. The cycle would repeat until I went through everything I needed to. Above all, the lesson I took away from my trip is any difficult emotion or challenge - I can handle. And I learned to truly ACCEPT. Accept that if I am the way that I am, to accept others as they are. And that is LOVE.

[@plamenconev3387]

❤🍄🌍

[@ICameToBringThePain]

❤🍄

[@janpijanica3980]

r we talking dry material or fresh mushrooms?? Andrew failed to mention 🤔

[@neondeon475]

Love this!

[@jenilpatel7048]

It's been two months, I'm curious if you still feel like a changed person. Or are you the same old person for most parts?? My experience is, changes are short term (1-2 weeks) and then you expose yourself to the same thing again and you become the same person.

[@SusanHoskins-df9kk]

Psychedelic mushrooms really healed me years back. Totally got rid of depression, anxiety and illicit pill addiction.

[@Greg.Olson2299]

That's great man, Can't wait to feel same. Trying to dispose of depression. I’ve been searching, but I can’t find anywhere to order.

[@JayGleason1556]

Yeah, dr.perryshrooms. Psychedelics should only be used with great care and respect

[@ry1255]

awesome to hear, I've struggled with intense anxiety and PTSD and nothing has worked, a bit afraid to try microdosing but from this video and many positive comments including yours, it might be something i need to try

[@TimTalley6388]

dr.perryshroom is your guy. Got all kinds of psychedelics stuff. Guided me through my first ever experience

[@RobPendy]

YES, dr.perryshroom. It would be great to hear in more detail about your mystical experiences during meditation.

[@mirabelwatson7863]

Psilocybin saved my life. I was addicted to heroin for 15 years and after Psilocybin treatment I will be 3 years clean in September. I have zero cravings. This is something that truly needs to be more broadly used in addiction treatment.

[@carsonelias4594]

Please does anyone know where I can get them? I put so much on my plate and it really affects my stress and anxiety levels, I would love to try shrooms

[@zarkos2313]

Psychedelics saved me from vears of uncontrollable depression, anxiety and illicit pill addiction. imagine carving heavy chains for over a decade and then all of a sudden that burden is gone. Believe it or not in a couple years they'll be all over for treatment of mental health related issues.

[@Armus187]

Shrooms was the best trip I had. It was an amazing experience.

[@patriaciasmith3499]

bergwilly11 is the best, he's been my go to for anything psychedelics.

[@salimictus]

Hi Mirabel! Do you do psilocybin often or you only needed a few intakes to stop using heroin? thank you so much!

[@manonthemoon8765]

Psilocybin helped me quit every addiction namely nicotine, alcohol, and cannabis. I am 19 and this substance helped me quit all my drug addictions before i even reached my 20s.

[@biogen1768]

My first psilo experience at 18 had me quitting nic, weed, hell, even the internet/my phone for nearly a month. The hard part is maintaining this lifestyle after the effects on neuroplastisity end. Stay strong!

[@shitimade97]

keeping the life changing effects of a good trip is sometimes as easy as microdosing, doesn't mean you should do it until you die, but it will help you integrate the experience into your daily life a lot better than macrodosing once every x time.

[@Hislittlelamb]

That alone saved your life. I’m curious, how long had you been addicted given your age?

[@Joopfyi]

Wow glad for you bro!!! It got me of my cannabis addiction too!! 😀😀🙌🏾🙌🏾

[@Joopfyi]

Im Dutch and live in Amsterdam so there was plenty of weed. Been smoking 1 gram a day for the past 6 years at least. Im now totally of cannabis and have no issue staying away from it. I can sit in the same room with my friends who still smoke it. I can role them a joint but no issue to not smoking it. It’s as if it’s really not made for me anymore. Literally something has changed in my head. Started microdosing at the beginning of this year. It’s been one month now and really this is the first time after alllll those years that Im clean with what felt like the least effort I ever had to make. I think the magic mushrooms helped me making my manifestation stronger which was not wanting to smoke it anymore and better myself and my life to become the man that I want to be in my life 🙏🏾👏🏾

[@richardward9582]

I did some, and it changed my life for the better .i did 15 years in prison and had horrible mental health problems , this fixed me and my brain from years of hell and drug abuse and then prison . This is Gods medicine .

[@SusanaGomez-mp8sk]

I could remember several years ago, I was diagnosed with cptsd. Also suffered severe depression and mental disorder. Not until my son recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 8 years totally clean. This is something that really need to be use globally to help people with related health challenges.

[@BrownGeorge-pw2xo]

Congrats on your recovery. Most persons never realizes psilocybin can be used as a miracle medication to save lives. Years back i wrote an entire essay about psychedelics. they saved you from death bud, lets be honest here.

[@Bastianbishops]

Can you help me with the reliable source 🙏. I'm 56 and have suffered for years with addiction, anxiety and severe ptsd, I got my panic attacks under control myself years ago and they have come back with a vengeance, I'm constantly trying to take full breaths but can't get the full satisfying breath out, it's absolutely crippling me, i live in Germany. I don't know much about these mushrooms. Really need a reliable source!! Can't wait to get them.

[@DonnHowes]

YES very sure of Dr.alishrooms. I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.

[@NicoleCtirad]

Ive done shrooms last month in my house. It taught me how severely traumatized I was from alcohol. I healed from many mental traumas from my past and was able to forgive, let go. Shrooms to me is a remedy not a vice. I even felt more refreshed the morning after. So no hangovers. No depression mood for days. No anxiety.I now have a more calm mind

[@Wimruther-hk4zn]

How do I reach out to him? Is he on insta

[@mr.lebeau2015]

I was in the pit of despair and was offered Adderall or antidepressants to "fix" me after a 5 minute conversation with a Dr. I went the mushroom route and I actually was able to learn how to sit in my emotions and face past trauma. I can't wait to watch this.

[@mathias5578]

Did you use it once?

[@mr.lebeau2015]

@@mathias5578 multiple times with bigger doses where now I prefer to microdose.

[@mathias5578]

@@mr.lebeau2015 nice

[@ThereISABootONYourTHROAT]

ZERO benefit from ANY drug to help in ANY WAY ones mental status/ability. 100% harm each and every time a drug or drugs are taken.

[@volfied992]

​@@ThereISABootONYourTHROAT you are doing more harm by commenting your BS than these substances do. Literally 😂

[@themadmusician5307]

As someone who has suffered with mental illness the majority of my adult life, and someone who has taken psilocybin on half a dozen occasions.. I can honestly say there have been times where I was suicidal and a complete hermit and one trip would, as I called it, 'reset' my depression and anxiety. Immediately I would begin to set goals and exercise daily. The suicidal thoughts went away.. I believe a lot of it had to do with serotonin and/or dopamine receptors getting kick started back into gear.. also, I wouldn't trade the trauma breakthroughs I've had on psilocybin for anything in the world. They have been the most life-changing, and self-changing experiences I have had in my near 30 years.

[@noonetalksaboutaaroncarter]

I went to bed as Dorothy in Kansas and woke up in Oz

[@joek292]

How much were you dosing?

[@themadmusician5307]

@@joek292 It varies based on the strain of mushroom. My first dose was about 2-2.5 grams and I'd recommend that as a perfect first time dose. After that it was anywhere from 3.5-6 grams.

[@codydagg2259]

I'm a veteran with a pretty severe PTSD/bipolar and if other people want to know if it works, I'll answer questions as much as anyone else here. I think it has so much value for treating PTSD.

[@kacyharris9325]

I actually have a few questions if you don't mind, tho don't think KZbin lets you message any more

[@flylikeafly0]

İ had same fear of death , awating to die in my sleep during duty. And now any small noise freaks me out , during sleep or awake.. how did that work on you?

[@codydagg2259]

So for me, my traumas compartmentalized themselves obviously due to the training and me doing that to keep my mind afloat during my time in. Problem is with compartmentalizing and the military is they don't ever teach you to unpack that stuff later for processing and etc. So you're mostly just left with the memories, feelings, emotions and so forth. PTSD to me was feeling like I was in a prison in my own mind. While I can interact, talk, have fun and be the life of the party, my brain actively was still in this mode of analyzing people as threats. Hyper vigilance though no one could tell I was being hyper vigilant. Psilocybin worked for me in this way. Upon microdosing for a month after meeting someone who grew their own and then put it into capsules, I went about my life taking it once a day like a vitamin. I would describe it as feeling like the world was just so much clearer to me than ever before. I was able to notice things within myself that I felt like just never entered my peripherals mentally speaking. I didn't believe that I had PTSD from the military. I blamed it all on my other more concrete mental disorder (bipolar). But at the end of my microdosing, I had one of those big moments that people talk about so often. I chalked that stuff up to basically being an overactive imagination. The military life style grinded up any sense I had to even consider such a thing being possible. I was very wrong I have to admit. I remember meeting my 19 year old self in only what I could describe as a meeting of the minds right outside my apartment underneath this set of trees. There I was, a young boy who just graduated high school. He was innocent in all the ways I was not. He was happier. He had a sense of wonder. He still held on that there was good in the world and sometimes it has to be you if you want that good to exist. I realized I had left my own innocence behind when I joined the military. I left it in the past. That young man asked me why I left him behind and I told him it was because he wasn't strong enough. Then they said "Well you didn't do much better without me". Sarcastic as ever apparently back then. Idk, the conversation with myself in my own head with visuals accompanying it all in what felt like an eternity but also the blink of an eye. PTSD locks up the mind in such a way that you are living in the past but also still here in the present. Microdosing felt like it gave me a sensation of feeling very safe and feeling cozy inside my own mind. That is not the usual for me. Usually I don't want to be in my head but with microdosing? I have been able to enjoy things again that I thought I would never be able experience without unpleasant thoughts, images and memories. The feeling of it can be described as being on a mini-vacation inside of your mind. I have also read studies that describe it as.. "One said he felt like his brain had been 'defragged' like a computer hard drive, and another said he felt 'rebooted'. "Psilocybin may be giving these individuals the temporary 'kick start' they need to break out of their depressive states and these imaging results do tentatively support a 'reset' analogy." I agree with this quote from Imperial College. I still do microdosing as 7 years of trauma can't be undone in a day but goddamn, it gave me a big jump in terms of my progress. I couldn't even conceptualize that I had PTSD even after I've had two therapists bring it up briefly, both of them I respected highly. If you decide to try it out, perhaps find someone you know that has experience with it AND trust them. Only reason I say this is because if you're not used to this sort of thing, it 'can' be overwhelming but a proper microdose shouldn't do anything crazy. I have never really 'hallucinated' while microdosing aside from the story but the whole time it occured I knew it was all just in my head, though no alarm. I typically get chocolate milk (funny I know) whenever I know I'm going to be starting another round of it because I feel like the sweetness of it is comforting for me, so if I ever felt anxious, take a little sip from the chocolate milk and suddenly back into happier thoughts. If you have anymore questions, I'll respond. @@flylikeafly0

[@flylikeafly0]

@@codydagg2259 wow man thank you so much for expressing all the personal info and experience such a detailed and brilliat way ! İ really appeciate 🙏🙏 u gave me a great vision of it. Sorry for your bad journey but seems like u going to make it the way u want like back in old good yourself once happiness was so much easy to access 🙏 i will read back it as English isnt my native tongue , i do really respect your effort and u being brave more than service in this REAL life. İ suggest you to look for EMDR therapy also, i got that one and its a miracle too , but mushroom seems like a very deep correction. Once again i really respect u for sharing your experience, so valuable 🙏🙏 i am not into nations and races but just wanted to mention that u made a great touch on someone from Turkey, thank you 🙏

[@chasethorn8986]

@@codydagg2259 Hey man, just finished reading your response. Thank you for your service. I'm happy you have found relief from your PTSD using psilocybin. I was reaching out to see if you've had any adverse effects while/after using psilocybin, due to your bipolar. I haven't been diagnosed with bipolar, but I think I suffer from it. I read a lot that if you have bipolar, schizophrenia, behavioral/personality disorders, you should stay away from psychedelics. Has it negatively or positively affected you in that aspect? Thank you in advance!

[@HarpaAI]

🎯 Key Takeaways for quick navigation: 00:00 🍄 Psilocybin is a psychedelic that modifies consciousness and can lead to long-term changes in perception, memories, and thoughts. 00:55 🔬 Psilocybin mimics serotonin and activates a subset of serotonin receptors, leading to neuroplasticity at the level of neural circuits. 03:13 🎶 Properly conducted psilocybin therapy can lead to lasting improvements in mood, insights, and creativity. 06:30 ⚠️ Psilocybin is still a Schedule I drug in the United States, but there are exceptions in some states like Oregon and Oakland. 08:51 🛌 Eight Sleep makes smart mattress covers for better sleep. 10:18 🕶️ ROKA offers high-quality eyeglasses and sunglasses designed for optimal clarity and performance. 11:16 💡 HVMN Ketone-IQ is a ketone supplement that can improve cognition and physical performance. 12:12 🧠 Psilocybin closely resembles serotonin, but its selectivity for serotonin 2A receptors leads to specific neural changes. 19:23 ⚖️ Psilocybin's selective serotonin 2A receptor binding differentiates it from SSRIs, leading to different outcomes and side effects. 21:17 💊 Understanding how psilocybin interacts with serotonin 2A receptors is crucial for proper dosing and therapeutic effects. 21:47 🧠 Psilocybin selectively binds to serotonin 2A receptors in the brain, particularly in the neocortex, leading to visual hallucinations. 25:06 🚫 Psilocybin is contraindicated for individuals with a predisposition to psychotic episodes or bipolar/schizophrenic conditions. Not recommended for individuals under 25 years old. 30:50 ⚖️ Psilocybin dosing: Microdosing ranges from 1-3 milligrams per day, while "heroic doses" are around 50 milligrams. Dosing should be carefully regulated for safety and effectiveness. 39:18 🌈 "Set and Setting" are crucial for a successful psilocybin journey. Set refers to the mindset, while Setting refers to the physical environment and presence of responsible individuals for safety and therapeutic outcomes. 44:06 🎵 The presence of music is a major driver of the cognitive and emotional experience during a psilocybin journey. 45:32 🍄 Psilocybin journeys typically last 4 to 6 hours and are influenced by factors like dose and gut contents. Fasting before ingestion is advised for optimal effects. 48:27 🎶 Music played during clinical studies using psilocybin for therapeutic purposes has a specific contour. 51:49 🧠 Psilocybin increases brain connectivity, reducing modularity, and promoting integration of brain circuits, which may explain perceptual blending and synesthesia experiences. 01:03:19 🔄 Psilocybin leads to adaptive rewiring of the brain, an exciting therapeutic option. 01:05:14 🍄 Psilocybin has potential benefits beyond treating depression, impacting creativity and the experience of life in some individuals. 01:06:43 🎵 Psilocybin therapy during depression treatment can change one's emotional response to music, restoring positive emotions. 01:10:02 🧠 Psilocybin can rewire connections between emotion centers and auditory perception networks in the brain, changing how music is experienced emotionally. 01:14:53 🌌 Psilocybin may rewire our relationship with life, breaking free from habitual negative thought patterns associated with conditions like depression. 01:17:14 🌊 The feeling of ego dissolution during the psilocybin journey is correlated with positive therapeutic outcomes and relief from depression. 01:19:09 🧠 Specific subjective experiences during the psilocybin journey are associated with positive therapeutic outcomes in treating depression. 01:26:41 🧠 Psilocybin journeys can be challenging, experiencing ego dissolution is important for therapeutic success. 01:27:37 😨 Extreme anxiety during the session may hinder positive neuronal rewiring and mood elevation. 01:30:25 🌬️ Real-time respiration tools can help reduce anxiety during psychedelic sessions and guide users to a calmer state. 01:32:48 🧩 The quality of the psychedelic experience is vital for therapeutic success. 01:33:17 📚 The paper "Therapeutic Use of Psilocybin: Practical Considerations for Dosing and Administration" provides valuable information on dosage and contraindications. 01:41:27 🧪 Psilocybin induces neuroplasticity by primarily promoting the growth of dendrites and dendritic spines. 01:45:47 💊 Animal studies show dramatic structural changes in response to psilocybin at doses higher than the typical therapeutic human dose. 01:47:42 🍄 Psilocybin's effects on the brain involve multiple mechanisms, including intracellular signaling and changes in neuron excitability patterns. 01:48:37 🧪 Clinical trials exploring psilocybin's therapeutic potential have shown promise for treating major depression and intractable depression. 01:49:34 🌐 Researchers like Robin Carhart-Harris and Matthew Johnson have pioneered research efforts to explore the clinical potential of psychedelics like psilocybin. 01:51:30 💊 Several clinical trials have demonstrated that one or two sessions of psilocybin can lead to substantial and long-lasting relief from treatment-resistant depression. 01:58:42 💡 Psilocybin, combined with supportive psychotherapy, has shown antidepressant effects greater than psychotherapy alone and psychopharmacologic treatments like SSRIs. 02:03:59 ⚠️ Caution is advised with psilocybin, especially for individuals with psychosis, bipolar disorder, or those under 25 years old. Work with a trained physician and be aware of safety precautions. Made with HARPA AI

[@adenascher]

How this isn’t one of the top comments is beyond me… thank you

[@HarpaAI]

@@adenascher Very fresh comment :) I discovered both psilocybin and Dr.Huberman last year, and not sure which one is better.

[@adenascher]

@@HarpaAI intuition always at the top of the food chain, for me personally

[@Michael-iw3ek]

omg this is lovely, thank you

[@jonmeisburg]

Here are some ways to take action on the key points from the podcast to improve your life: * **Learn more about psilocybin and psychedelic therapy.** The more you know, the better equipped you will be to make informed decisions about whether or not psychedelic therapy is right for you. There are many resources available online and in libraries that can teach you about the history, science, and culture of psychedelics and psychedelic therapy. * **Consider psychedelic therapy for mental health treatment.** Psychedelic therapy has been shown to be effective in treating a variety of mental health conditions, including depression, anxiety, PTSD, and addiction. If you are struggling with a mental health condition, psychedelic therapy may be a helpful option for you. * **Participate in well-designed clinical trials.** Clinical trials are the best way to ensure that psychedelic therapies are administered safely and ethically. If you are interested in psychedelic therapy, consider participating in a clinical trial. * **Create a supportive set and setting for psychedelic experiences.** If you do choose to use psychedelics, it is important to create a supportive set and setting for your experience. This means being in a safe and comfortable place with people who you trust and respect. It is also important to have a plan for how to handle any challenging experiences that may arise. * **Engage in integration work after psychedelic experiences.** Integration work is the process of processing and integrating the insights and experiences that you had during your psychedelic journey into your daily life. Integration work can involve therapy, journaling, and other contemplative practices. It is important to note that psychedelics are powerful substances and should be used with caution. They should only be taken under the supervision of a qualified healthcare professional. Here are some additional tips: * **Set realistic expectations.** Psychedelics are not magic bullets. They can be a powerful tool for personal growth and healing, but they are not a cure-all. It is important to set realistic expectations for what psychedelics can do for you. * **Be patient.** Change takes time. Don't expect to see results overnight. Be patient with yourself and the process. * **Talk to a therapist or counselor.** A therapist can help you to explore your thoughts and feelings about psychedelics, and to develop a plan for how to use them safely and responsibly. * **Join a psychedelic community.** There are many online and in-person psychedelic communities where you can connect with other people who are interested in psychedelics. These communities can be a great source of support and information. Please remember that psychedelics are powerful substances and should be used with caution. They should only be taken under the supervision of a qualified healthcare professional.

[@compostjohn]

Well that was excellent. I'm 57 and when I was 18 in 1984 I had a massive '100 Liberty Caps' trip, and it was by far the most profound and important thing I had ever done. Previously I'd been a geeky kid who studied nature - during the trip I experienced a deep connection with the Universe - probably some degree of ego death, as I felt my body's molecules to be at one with the earth under me, the grasses around my head (I couldn't stand up) and the insects flying over me, the trees in the periphery of my vision and the clouds overhead, and the moon and emerging stars - I felt part of this whole. I experienced a deep love for all of this, and was at peace. Also during this trip I found a horse in a field, and I'd never cuddled a horse's head and scratched behind it's ears or 'bonded' like that, and I could tell it was sentient and had thoughts and emotions. Many things changed after that - went vegetarian, dropped out of college, got into music and art, and started living a 'deep green' lifestyle which has since given me some degree of fame with one of the lowest carbon footprints in the UK and a very unusual 'freegan' lifestyle. I focus on quality of life, health and happiness, and try to spread joy wherever possible. I work as an entertainer and circus skills teacher, but educate about various ecological and climate-related subjects too. I put much of this down to my psychedelic epiphany. So I'm glad to learn some of the biochemical and neurological reasons that I had such a wonderful awakening, thank you.

[@scoutwithoutclout]

You are a righteous man. Many blessings are coming your way. Share them freely with love and abundance.

[@Diogenes_Lantern.]

So you became a hippy instead? 😜

[@FlapsMcGee-sn6oe]

@@Diogenes_Lantern. I knew he would be a circus skills teacher. 😝

[@plamenconev3387]

❤

[@EankiEtAl]

I’ve recently started micro dosing and it has been a very interesting experience. It awakened my sex drive that I had completely given up on. I didn’t realize how important having one is, it literally is the thing that drives us to build, accomplish and do. I’m so soooo happy to have it back. It also made me stop snacking and over eating. Junk food looks repulsive to me now and if I try to eat it I get nauseous. I can only eat real food now and it no longer takes much to satiate me. Bcuz of stopping that my skin is clear and I’ve dropped back down to a normal healthy weight. And last but certainly not least, I feel calm. Everything doesn’t seem so scary and require me to overthink it into the ground. I’m so so happy to have found this.

[@jazzyflorida3757]

Where are u getting this help from? And are u seeing a doctor for it?

[@EankiEtAl]

@@jazzyflorida3757 a local dispensary, no doctors required

[@chaddrusso8850]

Super curious on your dosages? I’ve been wanting to microdose but don’t have all the info I’d like on it

[@EankiEtAl]

@@chaddrusso8850 I grind mine up in my ninja then measure out 1/4 of a teaspoon. Sometimes less sometimes a tiny bit more depending on if it’s not great stuff or is getting old. It’s best to use a scale. You’ll have to trial and error it at first to see what works for you as everyone is different.

[@p.a.w.sthetravelinggamer6750]

​@EankiEtAl you have local dispensers??

[@13BD]

I believe I am at a crossroads in life. I can either give up on life or challenge my negative thoughts and insist on enjoying the rest of my days here on this planet. I hope psilocybin will help me in this journey.

[@13BD]

@@nicolejohnson-du4dk thank you!

[@MrSpaceace1999]

I’m same here, close to not caring anymore

[@ManifestingRealityAcadem-cq9et]

@13 You deserve the very best of life. Shrooms are amazing, start tapping using EFT. Lots of videos on KZbin for every issue thats holding you back, play your favourite tracks, clear and rearrange your house, try Qi Qong and meditation, gratitude, watch your favourite comedy.. Do any, part or all of these suggestions for 30 days, you'll feel much better.

[@ManifestingRealityAcadem-cq9et]

​@@MrSpaceace1999 You deserve the very best of life. Shrooms are amazing, start tapping using EFT. Lots of videos on KZbin for every issue thats holding you back, play your favourite tracks, clear and rearrange your house, try Qi Qong and meditation, gratitude, watch your favourite comedy.. Do any, part or all of these suggestions for 30 days, you'll feel much better.

[@BarrettMcGraw-ei5ew]

Psilocybin saved my life. 1-14-21 I ate an eighth and I quit heroin cold turkey. I began growing and it gave me a joy in life I thought was long gone. But I am now fighting a rather serious case. But after 15 years of hell, the 3 years of joy I received from growing were well worth what I'm dealing with now. When this is over, I will be back to my research and the life I love. I am greatful to still be sober through all of this.

[@brendatowey933]

A serious case of what?

[@boahnlangeres9872]

@@brendatowey933probably a grower, the federal government doesn’t f*ck around.

[@boahnlangeres9872]

@@brendatowey933it seems that mushrooms are in the same boat cannabis was in years back. It’s going to take some work but we will continue research so that we can spread the love that lives in this substance.

[@KillingItForYears]

Soon after I started experimenting with mushrooms in my late 20’s, I completely lost my need/want for alcohol. It also changed my diet. Candy started grossing me out. These changes appear permanent (it’s been about 10 years).

[@stefanallard3084]

Thanks for your comment, can relate

[@tomwolfe7782]

Can confirm that I started drinking at 17 or so, and spent at least a decade from low 20s to low 30s drinking what feels like an average of every 2-3 days; anything from a couple of talls to the better part of a 12-pack of I.P.A.s (higher percentage). I started delving into trips in my low 30s, and at one point went two years sober. Began drinking again, had an angry drunken conversation with my father, and was so embarrassed by my lack of control in that moment that I wanted to return to sobriety not long afterwards. I chose to quit on April 22nd (my addict brother's birthday), and just passed the anniversary recently. Seems at this point that my mind is in a place where I can take it or leave it with regard to alcohol. It'd be interesting if my deep trips were in some way responsible for not craving it the way I once did.

[@B3A5TxMODE]

Last summer i took shrooms or lsd weekly for like 2 months straight. Man my diet and workout routine really got in order during that time and still are. Psychedelics truly helped me realize what’s important and what’s distractions

[@jamesmorrow2594]

Since I started cultivating my own meds. I have gotten off of all meds .. like 20.. besides my thyroid meds.. no more ssri's. I have never felt happiness and love like I do today.. I actually have emotions. Which have been numbed for decades. I love now.. I love myself now. Never thought it was possible

[@aprilkitten]

Yep, I started doing psychedelics over 50 years ago and have receive benefits every single day since.

[@p2dar2daag90]

Mushrooms helped me with crippling PTSD and related mental issues (drug use, anxiety, etc). It’s not a cure, but a tool to improve and find a way out of unimaginable darkness. Without it, I don’t know if I’d still be here. Thanks for taking the time to educate the public on this! Hopefully for my children and grandchildren’s generation, this will be easily available and widely used to heal mental trauma.

[@lilyhempt1144]

Same for me and my brother ❤

[@miguelstevens3042]

How many journeys did you undertake?

[@jefayoung01]

Me too

[@Terri330]

I tried '😢 to take my life in November, im severely depressed, I have ptsd , anxiety, I hate it! I just ordered 3 gummies to try, ill take less then half of one first just to try, it they help ill order the capsule s

[@rickberglund2134]

How did you get it..??

[@chrissimon3790]

I noticed the greatest effects of psychedelics like Lsd when my eyes were closed. I was seeing visuals that looked like patterns until it eventually started clearing up and I saw what looked to be DNA repairing itself. I then remembered that I had a knee injury from a couple weeks back and It was healing faster than normally. I think because of the anti inflammatory properties of the drug and the fact that it kinda takes sensation away physically you can easily point out problems like injuries more pinpoint accurately. It was honestly huge to realize that visualization of my knee healing because of the fact that your thoughts can curate your reality to a degree and I knew that visualizing being healthy and healed would allow me to heal faster. It puts your ability to recognize your problems as not being so much as a real problem but a perception of what you believe these things to be. They can be good or bad and you always have the ability to choose how you feel especially the healthier you are physically. It's why diet and exercise is vital for optimal health as well as sleeping well.

[@adempc]

Great post, thanks.

[@crazybudyys]

How many grams?

[@crazybudyys]

How many grams u take

[@hannahmontana44]

I have been struggling with several large muscle tears in my abdomen for about a year. I recently tried mushrooms for the first time and the entire area felt like it was healing at an increased rate. That in addition to the boost in my mood/ clarity of thinking has me wanting to try it again.

[@poopyfartballs5363]

I have autism with psychosis like symptoms. Psylocibin has been a life saviour for me. It helped me 'cure' from my gender identity crisis I had back in the day. That may sound odd, but it happend and I'm very thankful for that. I've done trips & I've microdosed. Both are amazing tools to improve your life. ❤

[@carlosfajardo9998]

You're truly doing a huge service to society by sharing this information. I wish there were more science educators like you that can give clarity on these relatively little known subjects

[@dmcintyre4804]

Much room for improvement of the much needed information we shrew do need🗽🎯❤ thanks you e moved my mind🚀🏆☺️

[@ryanspivey8969]

@@andygriffin1543they’re talking about the knowledge surrounding the science. Getting mushrooms off an Instagram dealer doesn’t really seem like a controlled setting 😂

[@tykobrising5339]

Tremendous even 😉

[@vincentahmad]

i started taking a small dose psilocybin everyday this week. I can say that my performance increase in football (soccer) is absolutely unbelievebale. My teammates are like "what the fuck happened to you" everytime i play though I wasn´t even that good or popular before. My social and emotional intelligence improved so much I couldn´t even think of. It´s like I automatically understand other people and their emotions and act unintentially in an appropiate way. I have never experienced somthing like that. You have to know what you are doing but psilocybin absolutely changes my life right now and I recommend every one to inform about that

[@danielfcastro]

I had the same effect on my chess, The level just increased greatly The Day after my first trip.

[@TSE_WOODY]

Shrooms are PEDs confirmed lol

[@irinafiruti]

I'm new so ...any reliable int'l source available for the public?

[@megandonnelly1028]

Of all the content out there on psilocybin, this is by far the most informative and concise. The more people learn and understand, the better off human kind will be.

[@paulukjames7799]

If Big pharmer allows it

[@Tripsqueak]

Often when I've tried psychedelics, my trips were really scary and revolved around death and a loss of being. It's helped me understand better my life's transience and showed me just how much my friends and family mean to me, how much my mother has suffered for me even through my selfishness. My ability to use language was very diminished, and it was hard to richly describe what I was feeling. I've dealt with obsessive thoughts and rigid thinking all throughout my life and I'd say that mushrooms, though potentially horrifying in the moment, have served to benefit me greatly. I cannot however, say I am unbiased and may be a little too grandiose when describing these things. Either way, they're very interesting nonetheless.

[@AcidMan_303]

Very well wrote. And same here, it completely changes your perception. I use Ketamine for a bit, buts its non sustainable. Ive only tried lions mane, but looking into pysolcibin, but after real bad trips in the late 90s im very cautious

[@tyatwell35]

You got it

[@sarahhammond7185]

I did a therapeutic journey like the one you describe just a few months ago. All the boxes were checked -- laying down in a safe space, eye mask, facilitated journey with a very experienced Guide, curated music. I let the facilitator decide the dose and she gave me 4.5 gms.... I am grateful she believed I could handle such a dose, as I don't think I would have had the courage to take that much on my own. I experienced All THE THINGS -- My hearing became extremely sensitive, senses merging, I couldn't really speak or communicate during the peak hours, extreme fear/sense of anxiety that seemed to be induced by the music but lasted even after the music changed; intense grief - I cried a river of tears; complex geometric images that were indescribable; the sense of dissolving out of my body over and over again (almost like an elevator dropping)..... My point in giving this detail is that a good portion of my journey could be called a "bad" trip, though after the first few hours I felt sensation of incredible pleasure in my body, and even the fear/grief I was able to view from a witness place. It allowed me to see various ways in which I give my power away and create stories in my life that aren't serving me and that are really just fabricated by my mind. This truly was one of the most profound healing experiences I've ever had. Of course, I am still doing the work of integrating the insights. It takes courage to do this kind of work, but done properly, even when it's difficult, it can be healing and life-changing.

[@Scrapzula]

Hello and thank you for this. I am a clinical psychologist and a plant medicine practitioner and I have seen first hand the reduction of depressive symptoms in my patients. But I also have witnessed an associated phenomenon that I haven't heard discussed. Patients report a decrease in symptoms but they also report feeling unconditional love, feeling cared for's and about and feeling like they are part of something bigger themselves. Feelings of awe, while in a psychedelic state. They come out of the experience with an increased desire to cultivate these feeling in their waking life. I don't think its just less depression but I think it's a result of the ability to feel more and the mystical experience many participants have. It has been a very interesting, although anecdotal, observation. Thank for all you do!

[@biancadiblasio1331]

Hi, I would love to know more about how it helps people dealing with trauma depression ptsd etc.

[@Scrapzula]

@@biancadiblasio1331 Hi there. There is lots of info out there and it’s multi layered but basically it has to do with brain elasticity, changes in the limbic system both during and after the experience

[@Animal-Reaction-Clips]

Ya bot

[@Sutterjack]

Agreed - the consistently reported experience of feelings of unity and interconnectedness are part what fascinates me of this drug.

[@zenconservative2370]

you sound like someone that would know about situations that turn out bad for your patients as well. What are some of the negatives of the use of psilocibin. I believe I read tht it can cause paranoia, and high anxiety i.e. a bad trip. I am wondering how an individual would handle that if they are not in someones care at the time.

[@Stevemazzagati_TheToolBox]

As a guy who ruined my teens and 20’s because i had so much fear and anxiety it was insane..psychological distress alot of times and i absolutely tought that i would have to live that way for the rest of my life! And then i found psilocybin..started micro dosing at first and then 2 bigger journey’s of 4-5 grams each..it completely changed my life and perception..cleared all of my anxiety and fear.

[@thesilverone94]

Hi Steve, did you work with someone when dosing? I’m desperate to find out how we go about it. Thank you.

[@Stevemazzagati_TheToolBox]

@@thesilverone94 the way i would do it is alone on the couch with an eyemask..also put on a pscylocibin playlist for the journey..to be clear that is for a macro dose so 2.5 grams and up

[@kplay7705]

Where can I get this

[@boahnlangeres9872]

Been micro dosing/macrodosing for a few months now and it’s completely changed the way my mind absorbs information, I feel as if I’m learning so much more everyday and it’s truly a blessing, I have been fighting ADHD/Depression for years and I’m just glad I found something that works with me.

[@LouisOfficial22]

@👉Luna tripstores That's the mycologist's page name.

[@Bea54694]

Thank you for having the courage to approach this topic that can be so controversial. As someone living with PTSD, I hope this therapy will be available low cost everywhere soon.

[@Axiomatic75]

It's already available at low (or even no) cost, either pick them yourself when they're in season or get a grow kit and grow them yourself. We lose too much time if we wait for it to become widely officially) available. Big pharma hates it so they'll do what they can to slow the process.

[@solinvictus7582]

How is this controversial? You Americans are so backwards.

[@nena_stardomes]

That's exactly the main issue. Here in Brasil, we work with M.A.P.S. and Usona Institute, but to keep the research on phases 2 and 3, we need money, and there's too little (or non) support from government, companies, philanthropist

[@mikerausch3974]

They work for depression and anxiety. Been microdosing for a few years now and I’m a different positive person. I believe they saved me.

[@SupraSav]

@@mikerausch3974 I found it works for this as well. Should be noted that one should not be taking psychedelics while in a depressive episode or in your thoughts and feelings in a negative way, as it will greatly magnify (negative) feelings.

[@EpictetusAurelius]

7g golden teachers and I’ve never seen the world more clearly. Saved my life and drastically improved the lives of those around me.

[@i_am3629]

i took 4g golden teachers in 2019

[@gabrielegagliardi3956]

I just came back from Amsterdam and I followed all Huberman's suggestions, especially the one about using a bend to dive in instead of focusing on the environment. It was extremely beneficial, my music of choice was three album from the residents: Eskimo, not available, meet the residents. This podcast is gold, the amount of free information and quality is off the roof, thank you Mr Huberman'

[@zazeel1]

That music is wild!! Im not even sure it can be called music. I can only find 'Eskimo' but i'll keep searching. Not sure I could trip to it. I almost feel like im tripping just listening to it straight! Havent listend to whole album yet. I love the story that goes along with it. Thankyou!!

[@laurenb916]

creepiest music I have ever heard

[@laurenb916]

it's terrible! @@zazeel1

[@gabrielegagliardi3956]

@@laurenb916 Yep, but I'm pretty familiar with the music and I don't perceive it that way. The residents has an abstract quality I have never found anywhere else, common songs during trips are too verbose, instrumental classical and jazz are great in general but too "earthly", my cup of tea is electronic music like tangerine dream but the residents are still unmatched. I believe it's a personal preference.

[@dahlusion]

A fine combination: Shrooms and The Residents -- been listening to The Residents since 1980. Saw them live in San Francisco, 1986. Be well and enjoy, Dah

[@Bermudablue3]

Listening to this in preparation for a presentation I’m giving to other student counselors about psychedelic-assisted therapy. This field is so exciting at this time. Thank you Andrew and your team!!

[@TreasureHaines]

I started microdosing psylocybin 15 years ago to combat debilitating cluster migraines. All my research had led me there and I would try anything for relief. German studies at the time had indicated that it was effective. It was- I’ve been 15 years since even seeing an aura and I’ve had maybe three normal headaches. The other added bonus I found out was that it helped me extremely much with emotional regulation, anxiety, nightmares etc and continues to help keep me on an even keel. I take it and go to bed- the dosage is so small I experience almost no visual stuff and I do it once or twice a month to maintain.

[@imosdefinite]

how small is the dosage? I've found that I need to take mega doses to keep my migraines away! but I'd love something that doesn't actually make me "trip"

[@RitaLynn444]

❤

[@jacobroy89]

Cluster headaches are the worst. Shrooms helped me keep the beast away as well.

[@misukiylambertson2764]

You’re better off doing it in the morning. It can interrupt rem sleep :)

[@lovevalkinkpiernette4897]

Am curious, do you mind if we exchange emails?

[@FaughtyEmit]

It changed my life completely. Lifted me out of depression and gave me a renewed lust for my life. I now go a full trip once a year to 'reset'. Very exciting time for science.

[@cochisenahuh7939]

I knew i was missing out on something. Closing your eyes is critical in true therapy. Otherwise you are constantly reacting to other stimuli around you physically. Thanks Dr. Huberman.

[@phriedokra6158]

62 y o female lifetime sufferer of ptsd from early childhood molestation and neglect....seriously considering this for healing as the ssris ive taken since the 90s NEVER DID anything..

[@ryanfrank1309]

Yay! I tweeted Andrew if he had done a stand alone episode on psilocybin. He said no, then dropped this gem. I'm excited to listen. Thank you Andrew!

[@thomasgwynn1984]

Wow so cool... he pretty much did the podcast for you!

[@ryanfrank1309]

@@thomasgwynn1984 I can't tell if you're being facetious or not, but I'm not that special. Lots of people showed interest in him doing an episode on this. I'm one of many.

[@damienwilson6610]

Glad to see you right that. Shows you don't think the world revolves around you as I first though. 😅

[@asana_awakening]

Microdosing Psilocybin has changed my life as someone who struggled with PTSD, OCD, & autoimmune issues for years. I literally tell anyone who will listen about it. I started with 100mg (capsule of mushrooms) and took my first 300mg yesterday. I was worried because I’m very sensitive to substances but my experience has been life altering (in a good way). It’s like someone turned on the lights for me. Truly remarkable.

[@Ivanlc1993DC]

Im gonna to start mine, did you do It with intervals between days, like day in day out?? Pra every day?? Any tips?? God Bless

[@TheWalkingNomadTours]

how long did microdosing took to help you with ptsd?

[@tmurglaze704]

Where the he'll are you getting pills filled with mushies

[@JJ-zo5xw]

Oh I get mine from dr_alpha_courageous

[@florineiseli2621]

Psychedelic are just an amazing discovery. Is quite fascinating how effective they are for depression and stress disorder. Really saved my life.

[@zenfulliving555]

Psilocybin helped me repair my left brain after meningitis - I found this to rewire me back to amazing... I'm a huge fan of mirco-dosing. Both my partner (who is 75) and I consider microdosing psilocybin an evolutionary vitamin for everyday life... We share this with all our 60+ friends and family!

[@soniapalmisano8158]

You must be a happy bunch❤️🥰🥰

[@ItsTripTips]

Yes! The science on psilocybin has been shunned for decades props to Andrew for bringing it to light in the Huberman digestible format we all love ❤ Psychedelics changed my life, I managed to use them to cure ALL my addictions and anxiety amongst so many other benefits that I couldn't even not make it my career!

[@vipul_chauhan9384]

Can you please elaborate about anxiety?

[@botanicalbecca8443]

Amen! My husband, as well. 💖🍄 Continued healing and blessings to you.

[@caprisuns9477]

glad to see you here!!

[@ItsTripTips]

@Tru Win It took a lot of trial and error and I made a product on how exactly I did it that walks you through but very generally speaking: 1. Be extremely careful and responsible, I consider psychedelics incredibly dangerous if this principle is taken for granted 2. Intention, planning, preperation, goal setting, etc 3. Spending the trip journaling, contemplating, meditating, etc 3b. Using a variety of doses, sets and settings relative to the goals and intention you have, for example, low doses tend to have very different types of theraputic qualities to high doses, same with tripping alone vs with other people and tons of other variables. Aligning all of these in an ideal way helped me a lot. 4. Integration, using the increased neuroplasticity and momentum after trips to form an improved identity for yourself and solidifying that tangibly, and more 4b. Not just forgetting about your trips and getting sucked back into normal life but actively going back through your experiences so they remain emotionally significant to you and keep driving you forward in life indefinitely (especially the high dose powerful ones that felt like death/re-birth) Also it probably helped a lot that I've spent thousands of hours researching this topic and have tripped hundreds of times by now so I can bring all of that with me into my trips and really optimize them

[@rashneelwalla380]

So using a drug to cure a drug addiction good work druggie

[@SpaceCadet327]

I put this on to fall asleep to but I couldn’t. Way too informative for me to. I’d like to hear information like this about DMT. I was addicted to heroin most my life and I kept trying the 12 steps over and over again and I was always left feeling defective, like I just couldn’t grasp what those around me could. I finally decided to try mushrooms, lsd, and dmt and I’m now coming up on 2 years clean. The longest I’ve stayed clean in the past was 97 days. Psychedelics showed me how to love myself, love the world, and find spirituality. I never thought I’d be who I am and where I am today

[@rodneygreen2613]

God bless you

[@jayhughes3843]

Did you know that another name for psilocybin is 4-PO-DMT?

[@carolinemulliez8800]

Well done and what hope it is for others to hear these reports..

[@Max_Charb]

I am a fierce adherent of the twelve steps. It has saved and gave new directions to my life. I'm coming back from a five years relapse where I let sloth become me. I plan to microdose and I plan to love it, yet I can't imagine my life without NA members and the program itself. I recon I'll feel a bit of an hypocrite attending meetings. Do you have an advise or words of wisdom for me? ❤

[@joshuaelek]

I am in a clinical study evaluating the effectiveness of psylocibin in helping with treatment resistant depression - and three weeks after my first administration, I can say it has been incredibly helpful. I don't feel cured by any means, but I do feel dramatically better - things that used to send me down a dark pit of despair are far less impactful than they once were.

[@joshuaelek]

After my experience with what I assume was synthetic psylocibin (could have been a placebo, I don't know for sure) I'll 100% pass on doing this without a highly trained professionals to guide me through it. It would be physically impossible to have that experience safely on my own. I was quite literally out of my mind for hours. I thought the world didn't exist and I was escaping the plane of existence I have known my whole life. I tried exploring the physical world in ways that I would never have tried before - like when I attempted to squeeze my face through the chair my therapist was sitting in. I would never try it without a guide who was as highly trained as the therapist who sat with me for those eight hours, and the nurse and doctor who checked my vitals periodically throughout.

[@julius.2003]

​@@joshuaelek Wow! How are you feeling now, two months later?

[@joshuaelek]

@@julius.2003 I've had a second administration, and I feel measurably better than before. I feel like I'm more able to take things as they come... like I am moving more slowly and purposefully. When I walked to the grocery store the other day, I remember thinking how I was just focused on the sound of snow crunching under my feet, and not thinking about all the things in my life that I wasn't working on right then. It's strange, but that deliberate intentionality has really been noticable in new and very calming way.

[@ninomagla]

Dear Andrew, thank you so much for your tremendous work! I have read so many books that you recommended, learned so much, thanks for giving us the access to the latest research… it would be amazing if you could make a podcast about music and neuroscience in particular…

[@caro1942]

Looking forward to watching this one! I used LSD to help me quit drinking over the winter. That’s actually why I’m here, just wanted to say thank you to Andrew for doing what he does. The first show I listened to was the alcohol episode that randomly came across my Insta feed, and had the direct result that I was 98% dry from November to New Year’s and I’m currently over 130 days sober. I went from a vague sense of “I really shouldn’t drink so much” to having concrete numbers and data to compare myself against, and realized that my behaviour was far worse than I’d thought. So thank you Andrew, you may be personally responsible for adding years to my life and keeping me from following my grandfather into early dementia and incapacity ❤️

[@ThereISABootONYourTHROAT]

ZERO benefit from ANY drug to help in ANY WAY ones mental status/ability. 100% harm each and every time a drug or drugs are taken.

[@theworkethic]

Psychedelics like lsd and psilocybin are great and I’ve done my share of loads of large trips but they are not weening someone away from addiction. They are not reversing a heroin or crack brain that has those neural pathways firing off. You may have been drinking but you weren’t in despair of addiction.

[@BgAndrew100]

@@theworkethicwow thanks genius

[@fuzinonzlot]

​@@ThereISABootONYourTHROAT You people sure like to talk out your asses. There's already studies on MDMA therapy and how it's healed to people suffering from traumatic issues. I'm sure you prefer big pharma's treatment plan being a dependent customer of popping psychotropic pills daily.

[@razacosmicapilled]

@@ThereISABootONYourTHROAT this is my opinion when I cope and am retarded

[@andrewhazelwood698]

I just quit roughly 7 addictions all at once after one night of mushrooms.

[@botanicalbecca8443]

What was your dosage, if you don't mind sharing?

[@andrewhazelwood698]

@@alexgordon951 Severe nicotine addiction I've had since I was 16 where I would wake up in the middle of the night to use, now I'm 21 nicotine free. Quit roughly 2 months ago. Quit taking adderall daily. Many compulsive behaviors that I won't go into detail about. Stop using reels on KZbin my screen time has gone down 190% since my trip. My technique for quitting was quite different. I basically engaged in all my triggers (things that make me wanna use nicotine) the few days of quitting making it as difficult as possible. Things like taking adderall, drinking coffee, having sex, anything that made me crave it and would just sit there with the feeling. I personally believe people use drugs to avoid stress so I wanted to face my avoidance if that makes sense. I had a build up of stress that I had been blocking out with nicotine specifically and it all came rushing out at once aka withdrawals so the only way to deal with it was to face it head on. but for me it's not about quitting it's about being able to regulate/respect myself not to use chronically or on a daily basis. I still use my adderall but every other day at half my prescribed dose. I now do the same with caffeine. I've started working out more consistently, every day besides one since the trip. I've become more socially fluid trying to sharpen my people skills. I just basically stop abusing drugs I didn't stop their use completely. I plan to use nicotine gum for cognitive enhancement after 3 months of quitting because it's not nearly as addictive and is preventative against dementia.

[@andrewhazelwood698]

@@botanicalbecca8443 Dose is bullshit. All the batches are different and some people need less or more. I never exceed 2.7grams. On the trip where I quit everything I took 2.5grams. Also I saw aliens and they healed my body just for reference of how intense this experience felt.

[@tcggggg]

Na fr. I saw a vision of myself 10 years in the future as still being a pothead and I told myself I have to quit before it gets to that point. And I realized how often I waste food at home to eat outside- and how nasty those outside foods can be. This was off like 2.5 gs

[@jenilpatel7048]

Are you still addiction free? Hope you are ❤

[@Wadebrwright]

I tried shrooms for the first time a couple days ago and it changed my view on the world with just one experience. I sat outside staring at the sky from 8:00pm to 12:30 just taking in the absolute beauty of the world and realizing that it’s always been like this, it’s always been this beautiful. I also realized that I’m way too hard on myself and need to forgive, and appreciate myself. A few days later and my anxiety and depression is still at an all time low. I will definitely be doing it occasionally more and micro dosing.

[@LouisOfficial22]

@👉Luna tripstores That's the mycologist's page name.

[@KeishaKiger]

What mg to try the that experience?

[@seraphchaluer9763]

I love how you broke down the sience behind the saying of smell color and see sound i knew a lot of these things already but you have given such a true in depth explanation of this miraculous fungi chemical in a way that was very interesting to watch. Thank you

[@loririghteousness]

Thank you for your thorough yet digestible videos. Not only is your voice easy to listen to, but the content is always mind expanding. ❤

[@mindovermatterpodcast1973]

US Army vet over here and going to use all this incredible information to explain to my mother why I would like to explore psilocybin. She doesn't understand it at all and her first question was "Is it legal?" (I'm living in her home so I respect her views) I thank you for this beautiful piece of work you've given me. It's going to be used for a great cause.

[@damienwilson6610]

I pray it all goes well for you

[@mindovermatterpodcast1973]

thank you🤝@@damienwilson6610

[@krustysurfer]

Make sure there are people around to guarantee you safe passage, no weapons, no alcohol , safe setting..... Aloha let us all know how it goes

[@nathancandee1516]

Is it illegal should be the last question asked.

[@decksranred4183]

I am a Vietnam Era veteran (female) with four sons who all served. I was a contractor in Iraq and came home with PTSD (undiagnosed for years). If one of my sons needed this natural medicine, I would grow it myself. Studied mycology in college so I'm sure I could do it.

[@nicklyon618]

Currently watching while undergoing treatment and this has been transformative to say the least

[@diegoclement6678]

Thankyou ! I truly appreciate your content, thankyou for taking the time to make this video. I love your profeesional approach and format on this discussion. Well made!

[@jimmysoncookland5446]

Thank you Andrew. I am so happy you can talk about this topic now. It has enriched my life over a few times I've taken it when I feel ready for it and need it..which might be yearly or every few years but every time I've grown into being a better person through the direction it gives me.

[@matthewbrady9342]

And thank you so much for doing a video on this. Having a level-headed perspective on this subject is exactly the kind of commentary we need to do the work necessary to find out whats really going on here. молодцы!

[@perlitalaguna6622]

I had a very bad trip last week. I was feeling like crap about something in my life. It was my day off and I was out doing a lower-body HIIT routine at a quiet park. I workout hard whenever I feel like shit. Usually a 4 mile run makes me feel better. But I was feeling very self-destructive that day. And wasnt in the mood to run. I took my (stale bc I didnt store correctly for almost 9 months) mushrooms with me. I ate 2. And continued to workout. One hour later nothing. I got really angry and ate 2 more. I did a few more reps. Went home, showered, went to sleep. Woke up one hour later. It was the worst experience in my life. I thought I was going to die. But I glad for it. It ripped me apart....there is no bottom from here. Its all up moving forward.

[@declanallan885]

Awesome content Andrew, absolutely love the deep dive format of this episode and thoroughly appreciate all the effort/research you have put into this episode, also thank you so much for the links to the studies you referenced. 🙂

[@LiftYourHeartorg]

Psilocybin use and microdosing is profoundly impactful and life saving for so many...it's the integration though that's so important! So thankful that you're adding a voice to this space. Thank you for sharing your research.

[@athollhay3207]

I developed an intense interest in psilocybin-supported therapy after reading Michael Pollan's How to Change Your Mind 5 years ago and have since experienced 2 life-changing psilocybin journeys. Thank you so much for this accessible summary of the recent findings and developments. What an exciting time we are living in!

[@betterworld5358]

Atholl Hay, where can one have an access to a session on the east coast? I have also came across the Micheal pollan’s interview a while back and recently watched his documentary on psychedelics.

[@athollhay3207]

@@betterworld5358 I live in South Africa so I'm afraid I can't advise you regarding this. Wishing you all the best.

[@christianmrz]

Hi, South African here, where can I start the for journey, I'm new here.

[@athollhay3207]

As it is still illegal here I am reluctant to post information publicly. Google plant medicine practitioners or soma retreats in your area.

[@1coop01]

Debbie Downer here but I had felony pocs of psilocybin in Texas and it was under a gram in 1998. Only thing I’ve ever been in trouble for and still on my record; so ridiculous. That stuff is a miracle and not a drug unless you take as such

[@Unanythang]

We are all so grateful for you Andrew. Thank you for all of the work you do and knowledge you spread.

[@MrUnicornsinmycereal]

Just want to say thank you so much for making this and delivering the info in such an academic yet digestible way. Having a background in neuropsych, the talk of the seratonin 2a is making me excited. Ideally I think I’d like to go back to school in a few years time and help push psychedlics to a space where people are well educated and can have the option to expiriment safely for their own better self development.

[@rob7ygygybygyu]

Big love to you Andrew. Thank you for being a studious man and a great teacher. You have clarified so many questions I have tried to figure out myself. You're a saint and scholar ❤

[@chronicalcultivation]

I had tried to quit drinking many times. I was only successful during a time that I was eating small doses of psilocybe mushrooms. It's important to note that I was not microdosing, I was taking moderate macro doses. I wasn't trying to use them for alcoholism therapy, I was just growing some as a hobby and eating a couple here and there as they popped up.. In regards to the usefulness of neuroplasticity, unfortunately, I have noticed a lot of people "tripping" on their own seem to just reinforce negative ideas, or come up with total nonsense ideas. People who assume they will become enlightened, try the drug, but don't learn anything, and become increasingly ignorant..

[@KiyoAloto]

you are so correct about that

[@Mahkiaveli]

This is one of the most informative videos related to psilocybin and psilocin as a whole. Very easy to understand some very technical terms and concepts. Bravo sir! I look forward to viewing more of your content.

[@joy3472]

As you told Sam Harris “When you talk, I learn”. Your channel is such a gift to the world. This has been my favorite episode yet. I can hardly wait for the episode on Ayahuasca that you mentioned to air. Without psilocybin and ayahuasca, I wouldn’t be here. They are the closest things to miracles that I’ve experienced and I love that you are turning your spotlight on them and sharing your knowledge with us. Thank you so much 🙏 ☺️

[@jenniferkiraly7751]

Wonderful to hear this.

[@proffranco4229]

I am diagnosed with BPD and Bipolar 1. Hopped around hospitals for a while and took countless prescribed medicine. I felt out of options so I tried out micro-dosing with a few macro doses and I could feel myself healing from those mental disorders. I now feel like i don’t experience deep episodes of depression almost at all. I would consider myself pretty much healed from incurable, life long mental disorders. Do NOT take toxic pharmaceuticals that will have a grip on you for life! This is a means to an end. Study up. Change your life. Be smart. Stay safe.

[@thumperasasha2201]

Its helping ME, I'M on day 14. I use both sides of MY brain so this rather gives some significant comfort to how MY OWN mind works looking outside of myself. Its helped ME open up a floodgate in myself. And I mean, a flood gate. I have a TBI AND Severe PTSD which made things rather confusing for a while after a few near deaths. This gives ME balance In MY own separate self.

[@tstarr1776]

REALLY appreciate the information. I struggle with depression and have, in the distant past, had good experiences with some of these drugs, being used in controlled conditions. I have seen many shorter episodes of your discussions on The JRE and was intrigued. This was extremely informative and helpful in giving me information that will be critical as i move forward in choosing a safe method of working through this. I've already shared this with several other people and will be on the lookout for the other podcasts you mentioned. Thanks SO much

[@Max_Charb]

Hi! If you are willing, hearing from your experience (if you moved forward with it) would be of great use to me! ❤

[@firehawkfiresafety655]

Great presentation and I am currently micro dosing and have been on a regular basis for 4 yrs. I suffer from severe PTSD and 🍄 benefit my life. Thank you for getting this message/info out to others.

[@yourfuneral]

Thank you for taking the time and putting in the effort restructuring and compressing this valuable knowledge, as you always do, educating society and the young future. You're the man!

[@max-fj7np]

The happiest Ive ever felt in my life was a mushroom trip I took by myself in my room. Just sitting in my chair alone in the dark, headphones on blasting music, thinking about my life. I've felt super happy on MDMA before but it always feels like "artificial" euphoria. The mushroom euphoria I felt was even more intense and felt completely natural. Plus, that feeling of content lasted for weeks afterwards where MDMA has a nasty comedown immediately after coming down and I don't have that happiness afterglow afterwards

[@fridusfroetzl]

Such a brilliant and comprehensive overview over all aspects around psilocybin and its potential therapeutic effects. Just what I needed to feel more confident and prepared for making this step in due time and under the right circumstances. Thank you, Andrew Huberman!

[@mesken96]

I am going through a major depression. And I am microdosing psilocybin. 1mg in every 4 days. And it has a tremendous effect even with this low amount. I feel way more positive, way less anxiety and quite optimistic about life now.

[@Sophia-mn5mb]

I can recommend you where I get my stuff from an online store, he's got Shrooms, Gummies, Microdose, Dmt, Lsd, Vape Pens, Carts, Cannabis, alongside other dope Psychedelics stuffs well Refined ships discreetly to anywhere also guide you if you're a newbie;;;....

[@Sophia-mn5mb]

He's on in$t@gram,, also on Telegr®️m

[@Sophia-mn5mb]

Mycospread~~~~~~~

[@martinjanza34]

Do You feel the need of taking psilocibin every 4 days?

[@mesken96]

@@martinjanza34 it's not a "need". It's that I don't feel good, I feel depressive, I don't want to do the smallest things I used to do easily. And when I take it, I feel I am able to do those things without effort, my part of the brain that thinks excessively bad is inhibited. And the positive aftermath lasts for one day as well. And it's not the same every time ofc, it depends on my mood and everything.

[@hobojungle1]

Man you do such a good job breaking things down for us common folk. A natural born teacher 👌🏼.

[@patrickroche3366]

When on big trip I find when the anxiety goes up and you get bad feeling if you hum it stops.

[@5switch09]

Dr. Huberman, I can't say how glad I am to be able to listen to these podcasts. They are the holy grail of information for everybody. Thanks or doing this psilocybin episode in particular, it gave me assurance and relief in many ways.

[@sofiebjorklund7]

You can sour ce on line

[@sofiebjorklund7]

visit

[@sofiebjorklund7]

//mcclendontripz//

[@sofiebjorklund7]

on ig~

[@carleighmiller542]

Thank you Dr. Huberman for all the information you provide to the community. I have learned so much from listening to you. You make it so easily digestible for someone who isn’t a scientist. Thank you!

[@gerodnielsen805]

Thank you for your time. I truly do appreciate it.

[@hahahahaa1470]

this dude is the goat has everything i want to know even with time stamps in a singular video

[@stephanieopenshaw]

You’ve not only changed my mind on so many things, you’ve changed my life! Thank you!

[@alanwood3072]

Could you please cover an episode on histamine and/or allergens? Keep the content coming, loving it!

[@javi___]

that’s all about inflammation, change your diet removing inflammatory foods and you’ll reduce allergies a 95%.

[@ronnie-lynn]

I’m worried to do mushrooms in regards to histamines and allergens being someone who is allergic to A LOT of things it is the only reason I have not touched shrooms 🍄

[@PaliCanon250]

@@javi___ False. Don't play doctor on the internet. There are many issues involving histamines that can't be 95% handled by dietary change alone.

[@johannus777]

I remember the peak experience from a different psychedelic and it was a mixed experience, but i got lucky. My ego split, but then I was given a warning by a part of myself to follow his instructions to avoid having a bad experience. After about 15 minutes calmed down and had great time after.

[@jovansmilic564]

How is even possible that someone don't make one single mistake in his speech for that long period? Are you Superhuman, are you that genius? I am admiring this man...

[@carriepowles1544]

Thank you for this timely info. I've been doing cold showers for about 9 months and along with lots of other tools, have transformed my health. I no longer have cold induced urticaria which was so restrictive to living a fulfilled life. My immune system is stronger and RA symptoms resolved/in remission. Fasting/cold exposure/excerise/wim hoff breathing techniques and Gabor Mate's work has all been part of my own Nof1 study to restoring my health and reversing chronic illnesses. I did my first sauna/cold plunge exposure at newly opened sauna locally yesterday by our beautiful lake. I'm grateful to you for sharing this protocol as a guide to safely practice this hormetic stress therapy. Now part of my lifestyle kit to live and love life. I'm a nurse and am excited to share this knowledge in my personal and professional life. Thank you 😊

[@codystruck]

This is incredible and so important to future of psychedelics and mental health. Thank you Dr.

[@mr.theking2484]

My friend took 10g of psilocybin chocolate and watched this entire video. By the end of it, he turned to me, crying, and said "This is best video I have ever seen, it's so beautiful!"

[@jamesdavid7599]

Davidlushano got psychedelic, check on

[@jamesdavid7599]

Instagram

[@ROkkstar1687]

😂

[@SH-th4wy]

Thank you for this unbiased explanation of this topic. Accessible to a layman like me, but not dumbed down either. I appreciate it.

[@beauoneill312]

Amazing to have many of my personal preferences for therapeutic use of the mushroom confirmed by your scientific pals: darkness or completely eyes closed, music... this is a big thank you Mr Huberman .

[@excontini]

Another high-level presentation. I can't find words to describe some effects that occurred after the Journey with psilocybin. I hope that the scientific community will seek more ways to understand the effects and that the benefits can be available to all.

[@stevegonalien]

Thank you so much for putting all of that wonderful information together in a podcast. .Since the 80s when I tripping on an eighth of shrooms. I always knew that the next day and the following days were even better... Still today it continues to help me break out of tract thinking patterns..

[@stevegonalien]

Happily I am my own source of psyliocybin products for now..

[@macintoshimann9892]

I developed a movement disorder following a car accident. It wasnt supposed to have a cure but DMT didnt care. I thought i might get some pain relief but less than a year later its like i almost have a whole new brain! Once the pain stopped for a few minutes it never did come back. And within a month my brain was working on new paths to the muscles. Took a lot of work but wow I have a new pathway for movement!

[@EtukEsther]

I'll refer you to and online store where I got my own psychedelics and microdosing stuff very good reliable vendor

[@rosieg2833]

Thanks you Andrew this podcast is so precise and important it is impactful and is improving many lives. The use of Psilocybin will soon become mainstream in many clinic's . Now a certificate is offered: Psychedelic Assisted Therapy Certification Program. I am seriously considering adding this to my credentials. Thank you for sharing the way you do consistently, you are so generous.

[@janelouisewar3633]

Used to love that movie “altered states” which must’ve landed me here in the Huberman realm. They should cast you in a remake soon. Thanks for sharing about the oceanic expansiveness. I think Yogananda’s autobiography of a yogi really helped me dip my toes into consciousness. Really grateful for the experiences I’ve had with plant medicine. I’ve loved being sober fully, but there were a lot of aspects of myself that were very troublesome to reintegrate. Little did I know! Today, I feel many memories and things I like about myself have risen back. In my mind, I feel as fresh as I did graduating high school leaving for college, but with self knowledge it is more profound. Used to have a recovery mentor that said: hey, if the handsome ones keep you paying attention in meetings, then that’s God and I have no problems. Usually, a very strict aversion to gender mixing in that community for periods of time for good reasons. But anyways, thank you for these massive downloads. Love you much Doc. Have the best day. 😊❤

[@colorbugoriginals4457]

interested in this for ptsd (1 abuse by a medical professional + general anesthetic not working properly; 2 a man died literally at my feet bc of negligence of two airline crew). i have had similar "perspective changes" from rx cannabis plus a life-long practice of meditation so it sounds like the type of tool i might be able to work with. this was a great resource, thank you so much. be well ❤️

[@adempc]

Huberman does a great job with the topic, many thanks. That said, this is such a safe, clinical, careful, sanitized way of discussing mushrooms. If you aren't on medication and are mentally okay (great isn't necessary, okay will do it), just jump in, the water is fine. Don't over think it.. spend a few minutes figuring out when and where you will eat them, and have a few questions for the journey.. or not, but just eat the damn mushrooms.

[@mari0xDD]

Thank you Dr. Huberman for your relentless determination to provide your knowledge for your audience! It's always a pleasure to listen to your podcasts. Can we please have an episode on mescaline, too? :)