How the SARS-COV-2 Virus Promotes Pain Relief

Rajesh Khanna, PhD, a professor in the Department of Pharmacology, at the University of Arizona College of Medicine, and his research team found that the SARS-CoV-2 spike protein binds to neuropilin in the same location as VEGF-A, and when it does, the VEGF-induced pain is completely reversed. The paper, “SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia,” was published in PAIN, the journal of the International Association for the Study of Pain.
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