How to calculate inbreeding from a pedigree -2

[@imaneouadi67]

Thank you so much , I have been struggling with this for the past hours and now I totally get it , shifting my pedigree to the ones you have up is so much easier and makes me see things more clearly , a thousand thanks you saved me a lot of frustration !

[@GeneticsLessons]

You are welcome! Thanks for watching.

[@imaneouadi67]

Just subbed ! =)

[@GeneticsLessons]

Here is one more analogous video: kzbin.info/www/bejne/Z3mbnpuJfaiKrtk&lc=z13tufjh5q3ieluce231svwovkuqchcha04

[@jessicat3951]

Thank you for providing real examples and stepping through it!

[@GeneticsLessons]

My pleasure!

[@miekevdl2583]

Thank you so much for this video! I finally understand what I have been doing wrong all this time (4 years..)

[@Stephan131992]

Thank you Nikolay! This helped me a lot for my study!

[@Alextrim92]

Thank you so much Nikolay! I’m really enjoying your videos and they are helping me to learn how to calculate inbreeding coefficient in horse breeding.

[@GeneticsLessons]

You're so welcome!

[@emilyconley4967]

I like the pace at which you work through the examples--everything is clear and easy to understand. Thanks, sir! Question: What happens with successive generations of self-pollination?

[@GeneticsLessons]

+Emily Conley With each generation 50% of heterozygosity would be lost and eventually after about 10 generations organisms would be nearly 100% homozygous at all loci .

[@emilyconley4967]

+Nikolay's Genetics Lessons So if F2 is the base population, with inbreeding coefficient F=0, then in the F3 F=1/2, in the F4 F=3/4, in F5 F=7/8, etc., and F is equivalent to the proportion of homozygous loci? Is this correct, sir?

[@GeneticsLessons]

The filial generation is marked with the symbol, F. The filial generations are organized in a sequence of matings such that the successive generations after a parental generation is attributed by the symbols F1 (for the first filial generation), F2 (for the second filial generation), etc. F2 would have 50% less heterozygous loci then F1, and F3 would have 50% of F2... So F would represent Homozygous loci. But you can call it increase of homozygosity or loss of heterozygosity both would be correct..

[@eldettevanderwalt2117]

Thank you so much for this. It has helped so much! Thank you for your clean explanation.

[@dalalwhite5940]

Thank u Nikolay , helped me a lot

[@danielkwakuowiredu]

Thank you very much.

[@GeneticsLessons]

You are welcome! Thanks for watching.

[@anushkaathukorala_vonserendib]

Very useful video❤. By the way these calculations are done according to Hardimans rule or Weights?

[@GeneticsLessons]

Hardiman's Rule is not applicable here - Hardiman's rule is a concept associated with the genetics of sex determination in humans. It states that in mammals with XY sex-determination systems (like humans), in the early stages of development, there is a greater mortality rate among male embryos compared to female embryos.

[@МаргаритаЯшная]

Спасибо огромное, только теперь я наконец-то поняла, как решать такие задачи

[@GeneticsLessons]

Пожалуйста.

[@amelradiabounoua6973]

Please, how to calculate the inbreding coefficient when the half siblings' child marry the grand father?

[@GeneticsLessons]

Please check my channel - I have many more examples of inbreeding coefficient calculations.

[@sarahwood3076]

I'm confused for the first cousin and double first cousins, you said there were 5 nodes but there is 6 isn't there? You also calculated the answer as if it was 6 for the first cousin, I got the same answer using 6 nodes

[@GeneticsLessons]

Do not confuse nodes and pass ways.

[@GeneticsLessons]

5 nodes and 6 pass ways.

[@kookiemarta5442]

Thank you very much this was supe helpful and I could do my homework.

[@GeneticsLessons]

Glad it helped!

[@iskojc3574]

thank you for this video~

[@GeneticsLessons]

You're welcome 😊

[@Alextrim92]

Can I ask you how you would calculate a particular pedigree I’m having some trouble with? Im trying to calculate the inbreeding coefficient of a specific horse who is the result of two full siblings. However these two full siblings are the result of a half aunt and nephew union. Don’t know if that makes sense 😅 I would have to share the image of the pedegree

[@GeneticsLessons]

I recommend you to use special software.

[@Alextrim92]

@@GeneticsLessons do you have recommendations?

[@kristjanafrangaj9103]

Thanks a lot! This is very helpful! I was wondering, in the first pedigree if the siblings would mate and produce another son and daughter who mate again and produce offspring would they be more inbred? By the nature of genetics it makes sense to me but using the same way to calculate coefficient of inbreeding doesn't show that. Is there a different method in that case?

[@GeneticsLessons]

Yes with each round of such mating there would be reduction of hetrozygocity by 50% or homiozygocity would increase by 50% which we call inbreeding.

[@kristjanafrangaj9103]

Thank you so much!

[@arijitroy3799]

What is n called in the equation? Pls let me know. Thank you

[@GeneticsLessons]

I did say that in the video, number of passes.

[@GeneticsLessons]

Watch my new short: What happened to the siblings of Adolf Hitler? kzbin.infow1bvnQwWjw8

[@PavanKumar-ef1yy]

Thanks Sir Excellent

[@GeneticsLessons]

Most welcome

[@clockwork161]

Say the top two individuals in the full siblings pedigree have Fxy = 1/8?

[@GeneticsLessons]

Then we have to include initial inbreeding in our calculations.

[@clockwork161]

Thanks for the reply, can you please let me know how to include it in the calculations, it will be immensely helpful.

[@GeneticsLessons]

Here is example with one inbreed parent: kzbin.info/www/bejne/kHXRoZeOe9Spebs

[@shaboatrad4066]

What if it's like 2 parents and two children which we want to calculate inbreeding coefficient between( the mother's and son's child) and (The mother) I'll Upload the pic 4 ya but if a person is twice there will we delete him or calcukate each way snd then sum them up

[@GeneticsLessons]

Here is example with one inbreed parent: kzbin.info/www/bejne/kHXRoZeOe9Spebs

[@akemumoren4133]

why dont you just multiply it?

[@GeneticsLessons]

I gave explanation, probably you need to watch couple more videos on the topic in a play list - "inbreeding".

[@kamaranmustafa1304]

That is very nice vedio

[@GeneticsLessons]

Thanks a lot

[@jesymarbravo2394]

Thank you so much for this video. I still don’t understand in my case I am questioning whether I can breed 2 dogs that are only related by one dog. One dogs grandfather is the other ones great grandfather with different unrelated females. Can anyone help me with the percentage please

[@GeneticsLessons]

Please check my playlist "inbreeding" I have many more examples including yours.

[@clockwork161]

what if the two common ancestors share alleles identical by descent

[@GeneticsLessons]

These calculations take in to account that common ancestors are not relatives otherwise we have to adjust calculations.

[@GeneticsLessons]

Here is example with one inbreed parent: kzbin.info/www/bejne/kHXRoZeOe9Spebs

[@jaredleicht1656]

Absolutely none of this is true.

[@GeneticsLessons]

What do you mean?

[@jaredleicht1656]

@GeneticsLessons Because breeding doesn't work that way. The most inbred individual in a 3 generations pedigree will provide the highest percentage of traits found in the offspring the majority of the time. Ofcourse there is always an exception to every rule especially when considering the mystery of breeding. But it's not in equal percentages. None of it is. Mother nature is more complex. So this entire mathematical equation is nonsense.

[@GeneticsLessons]

What do you mean "highest percentage of traits"?

[@jaredleicht1656]

@@GeneticsLessons By that question, im going to guess you studied the mathematical equation in school and haven't bred many generations of successful animals in the yard. I'm sure your math is perfect. I'm saying the entire idea of knowing the percentage of inbreeding with a mathematical equation is totally wrong because nature doesn't work in equal amounts. I'll give you another example of how it's bullshit. I can send you a 5 generation pedigree of a dog and you can calculate it and tell me the amount it's inbred. You won't see the same name appear twice and you will tell me the dog isn't inbred. Then I can pull out a longer pedigree of 12 - 15 generations and show you how every male and female in the entire pedigree go back to the same sire, and your whole equation is nonsense.

[@GeneticsLessons]

1. I have Master of Science degree in Plant physiology and Genetics. 2. My specialization is Breeding and Selection. 3. These formulas are correct and is based not on single individual calculations but on statistical data obtained from the thousands of animals. 3. Individuals may have some fluctuations in genetic information they get from each parent and what they pass to their progeny. 3. There are sophisticated programs that estimate such fluctuations - for example in Genealogy in order to estimate degree of relationship. 4. Contemporary genetic analyses are based not on the pedigree charts but on genetic markers, which will estimate COI and IBD for each locus in order to estimate inbreeding. P.S. This video shows how theoretically genetic information is passed from generation to generation and it is correct and it is a generalization.

[@blowuplikeafrog3700]

So what would a 40% inbreeding coefficient diagram look like? Can you please make a video of this. Thank you

[@GeneticsLessons]

Watch my new video: Why mixed race people are so beautiful? kzbin.infoCqbF-liA4lQ