How to Incorporate apoB into clinical care (mg/dl) (whiteboard video)

[@scottl8469]

My father in law had been on statins for 35 years, ldl supposedly under control. He had a quintiple bypass last year. It would have been interesting to see what his apoB would have been.

[@barasra8847]

Brought to you by big pharma! Thanks

[@chrispurvis9466]

Suprising that the Canadian Guidelines, at least as seen here, do not also take into account the Trigylceride to HDL ratio, which has been shown in observational studies to predict Major Adverse Cardiovascular Events (MACE) and generally should fall below 2.5. To achieve that usually requires some combo of a significant reduction in dietary carbohydrates (sugars, flours, pasta, rice, white potato, etc), an anti-inflammatory diet in general, elimination of omega-6 rich seed oils, possibly certain supplements (nicotinic acid, Rx fish oils) not to mention regular exercise and substantial weight loss. Yea, that's a tall order isn't it. Maybe that's why it's left out?

[@paulelkins425]

Excellent review on the importance of measuring ApoB for assessing CVD risk. I see that you mentioned the importance of Lp(a) and that you'd cover it in the next video. However, it's been almost a year and i still don't see a video on Lp(a). Any plans to discuss this contributory risk factor and how to include it when assessing CVD risk?

[@ExaltusCa]

Hi Paul, thank you very much. We have not yet produced that video but stay tuned. There’s another video coming soon.

[@OnyxOnyx-r7w]

@@ExaltusCa We will hopefully wait for the Lp(a), video! Thanks!

[@sergiomiranda5495]

​@@ExaltusCaSigo esperando el vídeo.

[@misterbaleize]

Dave Feldman's research into this precise subject is being released during the first week of December 2023 - it is going to be interesting to see whether the advice given in this video is correct. NOTE: I am not saying that the advice is incorrect but am waiting for the Feldman point-of-view.

[@danielmccarthyy]

What about root cause analysis and the role of insulin resistance?

[@Michael-4]

Fix both. Mediterranean ketogenic diet. High monos, unprocessed polys and low sats. It's important to know your apoB if on a high fat diet. You may find like me, you can eat eggs cheese, butter etc and still have a low apoB within the reference range.

[@Mike-du1dc]

Thank you for a informative video on ApoB I am curious though you only list three pharmaceuticals as treatment options ...nothing about possibly better nutrition & exercise. Why is that?

[@Dr.vip08055]

To sell more statins. There are no long-term studies yet on what it says about ApoB

[@HendrikRitsema]

Best treatment for atherosclerosis: Vitamin C Why do only coronary arteries clog with cholesterol and not veins or small capillaries? Scurvy = No vitamin C in your diet. Symptom: Your blood vessels break and you bleed to death. Think of the sailor of the past. Scurvy of the heart = Just enough vitamin C from food. Symptom: Arteries around the heart are not strong enough to resist high blood pressure. Damage is repaired with cholesterol LP(a) to prevent worse. After years of repair, your arteries become clogged. Enough vitamin C supplement of at least 3000 mg. per day gives strong and flexible arteries. Cholesterol is not needed as a repair agent. Cholesterol in your coronary arteries is broken down and burned in your liver. Source KZbin: - Cardiovascular disease and vitamin C (Dr. Rath Foundation) - Ending the Cardiovascular Epidemic by Natural Means - Dr. Matthias Rath

[@MsElke11]

mmol/L ....isn't this the CANADIAN unit of measuring lipids? Can you please have both, perhaps in your description?

[@ExaltusCa]

Hi there, could you please tell us at what time you see the mmol/L measurement? Thank you!

[@powderhound1234]

@@ExaltusCa I think what we are looking for here is that the measurements should be in mmol/L not mg/dl .

[@ExaltusCa]

@@powderhound1234 and @MsElke11: We have both versions, and they will both be published to a new website soon. Here is the second version, in the meantime. kzbin.info/www/bejne/oZLccpyHpNydic0

[@Steve-nb9kg]

Statins reduce ApoB, but do they reduce event risk?

[@garyjackson4054]

This is okay where the diet is high in carbohydrates but for for someone in Ketosis? Probably not. Elevated HDL and LDL have been shown to extend longevity for those on low to no carb diet so in this case the ApoB would also be elevated however ApoB/ApoA1 would be very low indicating low risk. So understanding the patient as well as the science is important.

[@ladinoan]

Needs to have ct plaque score before any medication

[@Marc_de_Car]

Merci

[@stanleyyu2079]

"Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms" Harumi Okuyama et al. Expert Rev Clin Pharmacol. 2015 Mar.

[@ladinoan]

You have to check other markers.

[@hillviewmews]

But, but, but, what about dietary interventions that drive Triglycerides through the floor and raise HDL and dramatically lower the ApoB/ApoA1 ratio a more inclusive maker than ApoB itself that of course is better targeted by drugs while no drug can lower Triglycerides or raise HDL effectively and why these excellent markers and their ratio are being surreptitiously sidelined as they present no financial incentives.

[@BallyverganFarm]

Injecting ApoB/ApoA1 ratio into the discussion in no way devalues ApoB taken by itself. Unless we want to keep the carnivores kryptonite hidden?

[@videofaery]

You had my attention until you recommended statins and super statins.

[@Dr.vip08055]

To sell more statins. There are no long-term studies yet on what it says about ApoB

[@AdamS789]

When in doubt, medicate. No hesitation. You can see who is finding this.

[@user_375a82]

Its electronegative LDL and VLDL that is the real risk and these tests do not address that. Where is the research on electronegative LDL, there ARE papers but they are ignored.?

[@ladinoan]

Is she a medical student. Or work. For pharm