How to install Autodock and MGL tools in Windows 10 and prevent fatal errors in docking

[@GracielleFreitas]

aaah muito obrigada, o meu tinha dado tanto erro, alguns consegui resolver e outros não e fazendo dessa forma os erros nao apareceram mais. OBRIGADA

[@pymolbiomolecules]

Thank you for your comment. I understand only English so I translated your comment using google translate and read that.

[@petroaraujo6416]

Você ainda teria o instalador do autoDockTools para me enviar? Aqui o site esta fora do ar

[@robertaking6592]

MolecularModeling@University of Rhode Island The installation directory path (no spaces, only numbers and letters or "-" or "_"), making the path match in the Environment Variables, and copying the two AD4 files directly into the installation directory is critical to correct function. Also must have all files accessed during docking or analysis directly in the installation directory (not in a subfolder). Very clear description! I will use this video for my class I have been teaching for 10 years.

[@vanessaaitkensilva4279]

I've been trying to run Autodock Tools for hours, you've saved me, thank uuuu!!!

[@ExploreMalaya]

Sir what is the music name playing after 2:30

[@priyamurugan5014]

Many thanks, sir!! You literally saved me.

[@ninadiyana3774]

Hi. i followed your steps. when i run the autodock the dlg showed like this: FATAL ERROR: Sorry, I can't find or open AD4.1_bound.dat Unsuccessful Completion. How can i fix this? thank you.

[@eshwarb2489]

When I run the "autodock4", I get the following error autodock4: FATAL ERROR: ERROR: 4631 records read in, but only dimensioned for 2048. Change "MAX_RECORDS" in "constants.h". autodock4: Unsuccessful Completion. After changing records in constants.h, how to compile further ? thank you

[@hobamohamed2023]

I have a problem ... after opening the ligand file and try to detect the torsions, i got a message “ sorry, you need to read or choose a molecule at first”.. i ignored this message and completed the next steps but in “run” step, i got a message” warning: disabling accumulation buffers unable to share lists couldn’t configure togl widget”.... i do not understand the problem and what can i do to solve this problem..

[@pymolbiomolecules]

You should go to Ligand then input and open the ligand file, then only you will not get the error

[@rahulsharan213]

Thank you for making this video sir!!

[@ermihikmawanti7849]

I tried installing Mgltools-1.5.7 and autodock4.2.6 on Windows 11. However, the app doesn't open. Any suggestions for me?

[@pymolbiomolecules]

yes me too had same problem, sometimes Mgltools-1.5.7 has some bugs. Try Mgltools-1.5.6 version

[@lillianifeoma8490]

@@pymolbiomolecules your response saved me the frustration of downloading autodock for two days with no progress. thank you

[@kumudhadhamothrasamy4122]

very clear explaination, very useful thank you very much sir, please post a video on autodock

[@pymolbiomolecules]

as you wish, i have uploaded video on autodock please check out.

[@pom2978]

It doesn´t allow me to edit the system variables :/ only the user and it does not run idk if its because of that or not, please help

[@pymolbiomolecules]

Okay, edit user variables that will also work ... :)

[@PriyakshiPachanimusic]

Very well explained. Thanks a lot!!

[@natalieja8405]

You saved my day. Thanks!

[@pymolbiomolecules]

You are welcome!

[@adeniranyesirat5418]

my AD4. 1_bound and AD4_parameters is in video file

[@vypham2240]

finally, thank you so much

[@theborec1]

I can not find anything named „Edit the system environment variables“. What should i do now?

[@pymolbiomolecules]

what operating system u r using Michael

[@rushikeshgarade9390]

I tried to save my file as .pdbqt but it gets save as PyMol.pdbqt in extension in autodock.. can anybody help please🙏

[@karthi6990]

Just rename pymol.pdbqt to the name you want. Because that is also pdbqt file. While saving the file don't forget to give extension also.

[@rushikeshgarade9390]

@@karthi6990 i did give the extension but it is still not showing the result when i use command prompt for result

[@rushikeshgarade9390]

@@karthi6990 and in name it shows "protein.pdbqt" but in right side when i see the extension it shows "PyMol.pdbqt" please if you know the solution then tell me🙏

[@pymolbiomolecules]

Ok, share me all the screenshots i will see that [e-mail]

[@zaboubamal5149]

Thank you, very much

[@boukraanaima4824]

Thanks so much🙏🙏🙏

[@utpalendu8172]

Sir, thank you very much for making this video, its very much helpful for me. I have just one doubt, autodock vina should be installed in the same original folder, i.e. in "C:\adt" or a separate folder should be created?

[@pymolbiomolecules]

Yes, vina should be installed in same folder as mgl tools. So that it is easy to run the commands 👍

[@utpalendu8172]

@@pymolbiomolecules okay..thank you sir

[@sumaiyaqureshi3198]

When I am running auto dock....I am facing fatal eroor... Error: All atom and hetatom record must be given before any nested branches; see line 25 in pbqt file"ligand.pdbqt''. How can i fix?

[@pymolbiomolecules]

Okay, check line 25 in ligand.pdbqt.what is that line

[@sumaiyaqureshi3198]

@@pymolbiomolecules I am not able to understand

[@pymolbiomolecules]

I mean there may be problem in ligand.pdbqt file. Try to prepare ligand again

[@diva9852]

There are no errors when l compute but its still not showing results after docking

[@pymolbiomolecules]

You should analyse the dlg file after docking

[@neideleniobaltazarsoares3332]

Tank you!

[@manjunathbk1313]

Its showing python.exe has stopped working.. What might be the reason?

[@pymolbiomolecules]

Reinstall autodock tools, that may solve the problem

[@dianaolivera8132]

Hello!! Excellent video, thanks! I have one problem. After installing in the "adt" folder and then search for "AD4" files, I couldn't find any of those two files. Did anyone have the same problem? :(

[@pymolbiomolecules]

It will be present, pls search it✅

[@pathmavatiramanujam6623]

Can i download in windows 8...

[@pymolbiomolecules]

Yes you can do it

[@eshwarb2489]

Hi, I have a issue. I'm not able to get docking results as it show error like, FATAL ERROR: ERROR: 3778 records read in, but only dimensioned for 2048. Change "MAX_RECORDS" in "constants.h". Can u please suggest how to rectify this error ?

[@sujithragnanasekar9091]

so, we never launched mgl tools file ?

[@pymolbiomolecules]

Yes, we never launched mgl tools after installation. After installation you can launch mgl tools from desktop.

[@sujithragnanasekar9091]

ok thank you @@pymolbiomolecules

[@oseakhere6965]

Please help! I can't install it. It keeps saying error

[@pymolbiomolecules]

What error is comming

[@oseakhere6965]

Hi when I try to install mgl tools it keeps saying error

[@pymolbiomolecules]

May i know What error is showing

[@alpkaraman1116]

thank you very much

[@pymolbiomolecules]

Glad it helped

[@arianaoliveira5849]

Muito bom! Obrigada!

[@danilonascimento446]

Uma brasileira rs

[@bijayantasircar2829]

Following these steps, installed properly AutoDoc Vina in Windows 8 and it's working. But don't know why it is failed to open my Windows 10 laptop...In that laptop Chimera 1.15 also failed to open and show the error code 1073741819..........please help Sir

[@pymolbiomolecules]

I have no idea about that sorry buddy :(

[@bijayantasircar2829]

@@pymolbiomolecules It was a problem with graphics settings....already solved 2 weeks ago. 🤗

[@noura5631]

Thankyouu

[@dadasaheb12377]

Sir don't working in my computer 😔😔😔

[@pymolbiomolecules]

Ok, don't worry. Try again... :)

[@dadasaheb12377]

@@pymolbiomolecules sir i try again and again but don't working 😭😔

[@dadasaheb12377]

Sir, 2 day ago and still I try but don't working 😭😭 How to solve this problem

[@Nayanpatel99]

Systemvariable problm

[@pymolbiomolecules]

Try again, path should not have any spaces.

[@sanjaisrao484]

Thankyou very much