Human Metabolism Map I - Glycolysis

[@armandohasudungan]

📌MAKE THIS LECTURE STICK: FREE PRACTICE QUESTIONS HERE! 🎓 youmakr.ai/test-playground/questionnaire/673d5701859b9c170836f39f

[@triantafyllosgames6732]

I want you to know that this is one of the first videos i saw from you back in around 2012-13 when I was a second year student in medical school in a foreign country where i was struggling a bit with the language barrier. You saved me countless times and im sure than many others....As a rezident i still search up your videos when i struggle to remember something or just dont know it and for this I THANK YOU FROM THE BOTTOM OF MY HEART!

[@armandohasudungan]

Im pretty sure, remember I am not drawing double bonds or anything, I am only doing a simplified diagram to compare between reactions.

[@haileywang3434]

THIS CHANNEL DESERVES MORE VIEWS!!! THIS IS LITERALLY HOW I GOT THROUGH HALF OF MY UNI COURSES

[@armandohasudungan]

Insulin has an effect between fructose 6 phosphate and fructose 1,6bisphophate, as well as stimulating the effect of phosphokinase or glucokinase, the conversion of Glucose to glucose 6 phosphate. I have a video of regulation between Fructose 6 phosphate and fructose 1,6 bisphosphate which you can watch, just go to my biochem playlist..should be there.

[@nataliacalvoncovarrubias3510]

I had this class for almost a year and I didn´t get it from any of my teachers but with your tutorials i got it SO QUICKLY you are the best !

[@phulkitrode4824]

Man your videos are the one thing that keeps me on top of my class even though I don't attend the boring lectures!! 😁

[@armandohasudungan]

No, Sucrose gives fructose and glucose. Then the Fructose can convert to Fructose 6 phosphate, which can then be feed in glycolysis for energy. Armando

[@NatilaTekila]

You're the greatest. I personally don't think you're going fast at all. Just the right speed for me. Thank you!

[@dezziedesmond]

I owe you dinner, your tutorials helped me a lot with my biochemestry oral exam! Thanks Armando, keep it up

[@emiliaarif]

dezziedesmond i owe him breakfast lunch and dinner HAHAH

[@raghadalomari4058]

i owe him all three meals with snacks XD

[@googleone9209]

Thanks a ton for the playlist! So good to follow while away from the desk!

[@MazuinHanissa]

I have a quiz tomorrow and this video is incredibly helpful! Thanks Armando.

[@NutritiousNews]

NO you are not talking too fast. We can always rewind and listen again.

[@qqshgg]

Life-saving video...I have such a poor understanding about energy metabolism ..Thank you so so much especially the ending part with showing or mitochondrial membranes!

[@emilierenard8342]

If you make me want to learn metabolism, you just have to make me listen The devils tears from Angus and Julia Stone. He just did. The conclusion that I can say is that I love you for make me like metabolism.

[@helyu891]

U r amazing!! I really love your video!!! it helps me pass my exam!! Keep uploading! I will always support u!!

[@armandohasudungan]

Sorry man, im not to familiar with that, but I may later on.

[@geraldinequinones5359]

Thank you for this videos!!!!! You are amazing.

[@HeavenKeller]

Our teacher has played 2 of your videos in class Today, which were very helpful. Thank you.

[@GatorAidMedical]

MCAT studiers - go back and focus more on PFK1 as the rate limiting enzyme, and also how G6P is a "universal substrate" because it will feed into the PPP and eventually make its way back as G3P

[@chitsayar7870]

Very nice Clear concept Plz continue upload videos Thanks in millions

[@LovetheLoveliness]

LOVE LOVE LOVE you videos! you make it so easy for me to understand! Amazing visul aids!!!!

[@MarkHakim]

I was wondering if you would have a video on the pentose phosphate pathway.

[@PSJish]

How could a human even remember stuffs like this?!? OMG!

[@PSJish]

+PSJish But great vids though

[@mustafatalib6130]

+PSJish if they have the midterm in 2 days like me they have to remember ;)

[@bonbonpony]

The same way a pony can :) By using a system. Notice that those names of enzymes have certain parts in them that repeat. For example, kinases usually transfer phosphates from ATP to some other molecule or the other way around. Dehydrogenases remove hydrogen atoms by shifting them to NAD+ or NADP+ to make NADH or NADPH. Decarboxylases remove the carboxy group producing gaseous CO2 (so they're irreversible, because you can't collect the gas back - it spreads). Isomerases just shuffle atoms without losing or gaining any of them, in order to change the shape of a molecule. The one with "-lase" in their names decompose molecules into pieces. Mutases shift the phosphate gropu to somewhere else. And each of the enzyme is named after the molecule it modifies, so as long as you know what molecule it is, and what is it gonna do with it, you can deduce the name of the enzyme. So now you just need to remeber the names of the molecules somehow. And there's a system in it too. The one with phosphates is easy: just note the position of the phosphate group, to which carbon it is attached to, to get the number. Then you only need the name of the sugar involved. There are two types of them: aldoses and ketoses. The former always start with the aldehyde group -CHO. The latter are ketones - that is, they have a bridge made of the carbonyl group >C=O that connects two carbon chains. Then you can order them by the length of the carbon chain: hexoses have 6 carbons, pentoses 5 carbons, tetroses 4 carbons, trioses 3 carbons. And since the first and last carbon are always involved into these groups, only the carbons in the middle can change their orientation to make different kinds of sugars. So they are like bits that can be either 0 or 1, each of the sugar having its own "bit code" associated with its name, depending on the orientation of the H-C-OH part in the carbon chain at this "bit" position. So there is only 1 triose, 2, tetroses, 4 pentoses and 8 hexoses in each group. Just remember their names in order (e.g. by making them into a poem, or a song, or some other mnemonic technique) and you're done :) The name of the sugar is the only part you have to remember. Everything else is just mixing and matching different "building blocks" and their names, like the carboxy groups (they end with "-ate"), etc. It's all just "LEGO bricks" ;)

[@imded4014]

@@bonbonpony holy shit that helps alot

[@OliviaW7]

These are great. It is helping me make my own metabolism chart. These videos exactly match my learning style! :) Thank you so much!

[@naomisaldanha9813]

Thank you so much. Really helped!

[@siddharthteotia5125]

u made all these complex cycles so easy......u r awesome....thanx for uploading them..:)

[@dohaabdullahtef1523]

you saved my life.. rreally thanks 💙

[@emmajanefrost8825]

Your videos are the best :) keep uploading :) prefer to watch your videos than khan academy now :) diagrams are so helpful

[@AbdulrazzaqAlRashed]

That’s an astonishing work. Thanks for your efforts. Just one question: how to get a copy of the overall map you have drawn?

[@maya05101986]

can you make a video regarding the mechanism affecting body pH regulation...thank you..

[@emdadulhaque8343]

Awesome demonstration man!!!! 😍😍

[@nabilharcha5322]

thanks you are my new hero

[@StrahOfTheSundjer]

I want to know if this knowledge has any use outside of biochemistry exams?

[@felixmichael2904]

Pyruvat Dehydrogenase Coenzymes are Tyraminpyrophosphat, Liponamid, CoA, FAD and NAD

[@Piptrader]

Great video, I like your teaching style and I understand Glycolysis better. Thanks keep making video's.

[@chaitanyakirti2335]

Thank you. 😊

[@verbalbatein2426]

Best learning videos keep uploading, thanks

[@saabiiine]

Soo helpful and makes the subject interesting!

[@sandranovoselovic4822]

Thank you, thank you, thank you! :))

[@SaAMo0]

FAD, lipoic acid, and TPP are not the three enzymes in pyruvate dehydrogenase complex. They are coenzymes, and there are other 2 coenzymes NAD and CaA. The three enzymes are pyruvate dehydrogenase, dihydrolipoyl trasacetylase, and dihydrolypoyl dehydrogenase.

[@swattie42]

thanks for this! i love the pens you use. what brand if you don't mind?

[@muamedejuniorburaimo4708]

You videos are Excellent

[@August2012melike]

Did you forget the carbon dioxide during lactate production as byproduct?

[@chandjinabade7196]

Thank you👉

[@xuzhaobin1]

谢谢armando老师！~

[@solmazorunova702]

So good 😊

[@BalaBiologyWorld]

im highly impressed for ur videos sir,,,,,,,

[@facortez]

Excellent

[@nivemind]

I didn't take much notice of the sound, it's fine:)

[@skydrake3]

r u sure about the formula of the P enolate???

[@Hopeswilldie]

Great videos. Would welcome subtitles or at least text of what youre saying in the description - it would make things easier for us, not lucky enough to be born english native speakes

[@justinblack9661]

Throughout the process of Glycolysis do the reactions ever actually reverse or is it more theoretical. For example does fructose reverse back into glucose on a daily basis? in what situations do chemical reactions actually reverse during glycolysis?

[@bonbonpony]

Usually when a reaction is reversible, it produces whatever is less of at the moment, to keep the balance. But in case of enzymes there might be other factors involved, because enzymes can be switched on and off by the presence of other substances that control the reaction.

[@therealconniefrancis]

Watch his "Fasted state" video

[@oyamatoayei4497]

Keep going man, open your patreon or whatever, i'll repay you someday.... or better we'll make your effort worth someday after we get out of college, for now thank you, it means a lot to us meds related student

[@adagbapsamuel7743]

Downloaded for personal use

[@majoodb9253]

You are awaaay too awesome

[@tehreemyaseen1237]

please explain calvin cycle deeply

[@TheSanlon]

you never mentioned glyceraldehyde dehygronenase to reduce NAD ->NADH before the 1,3 biphosphoglyceric acid

[@therealconniefrancis]

Glyceraldehyde 3-phosphate dehydrogenase is the same thing

[@TheMichaelJordanofGambling]

I don't know if I misheard you, but it sounds like you said the fructose 6-phosphate's conversion to fructose 1-6 bisphosphate is reversible. It is my understanding that this is one of three control points, and is decidedly irreversible. I also noticed the single direction arrow on this particular step, so perhaps I didn't hear correctly. Just wanted to make sure I am not misinterpreting this process.

[@therealconniefrancis]

You're right, he did say reversible. It's irreversible.

[@volethanhha]

can u add the sub for ur video ?

[@azariobeeh]

could you please upload that paper in pdf?

[@binigirmachew91]

Thank you

[@yourworstnightmare1488]

Armando , by the way you pronounce your last name and judging by your drawing skills , are you in any way into anime???

[@dranbin]

why cant u start a online biochemistry class online think abt it contact coursera.org or open2study.com v

[@mohamednour45]

man your are so good

[@freedomeminexnkubrah3291]

yeah u a bit fast....but i could follow till the end cuase the diagram are way too clear....thank you

[@tolentinod2]

the closed captioning is funny to read

[@local5ab]

gud one.thanx

[@MsDibyaRay]

Amazing :)

[@simpl6775]

fate of glucose. it helped a lot :)

[@ShubhamKumarPramanik]

2024 ❤

[@MunkesGamingDenmark]

I think you will remember it better if you write it down you self. :))

[@gordonledwidge2557]

yes you do speak way to fast thanks for what ever I have gained karen

[@rathorgaurav3312]

Ur awasome :)

[@MrThespecialOne7]

you are greating but you are fast ! thanks a lot :D

[@derekdurrett1905]

Where is your nitrogen metabolism videos? Haha

[@ndcmt1609]

TALKING WAY TOO FAST. Thank you, though!

[@gotofinancial]

maybe you are the one that think too slow.

[@OmerNaseem245]

i hate biochem..

[@danaabdulz2334]

U r talking soooo faaaaast .. Plz slow down :/