I MEGADOSED Melatonin for a Week - Here's What Happened

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[@SiimLand]

Order my new book: www.amazon.com/dp/B0CW1B2XM1 How I Increased My Sleep Score from 75 to 100%: kzbin.info/www/bejne/qZSbm5aNjr5-Y6c Top 15 Supplements: kzbin.info/www/bejne/oKPSq31spLJ4oNE&pp=ygUQc2lpbSBsYW5kIDE1IHN1cA%3D%3D

[@projimbo]

Ive gradually upped my dose for 20 years. 10mg the past 2 years and sleep well. Added 8g glycine and 6g taurine a year ago and seems positive results.

[@DavidSkalsky]

Do you take the 8g glycine and 6g taurine before bed as well, or spread throughout the day?

[@maschoff69]

​@@DavidSkalskyDoes your liver take a break? I do 2g taurine and 6 grams of glycine 5x a day.

[@projimbo]

@DavidSkalsky I just put it in a shake at about 10am after a fasting workout. Works for me but everyone is different.

[@whoknows8223]

Like your own pineal gland not producing own melatonin anymore?

[@projimbo]

@whoknows8223 I sleep fine without it but I prefer my sleep with it, more dreams etc. Also as others noted its a powerful supplement for a range of metabolic functions.

[@imikewillrockyou]

I'm now 61, I tried this and had the same experience, groggy in the morning, difficult time waking up.

[@marcogemma616]

nocebo effect, only in your mind

[@orion9k]

After I stopped taking 3mg melatonin per day, I feel groggy and tired every morning now

[@Deej99999]

@@imikewillrockyou Try at least 100mg. You most likely won’t be groggy

[@miloradmilutinovic7691]

I amtaking 10mg since 2 years. 0 issue

[@jonhadley-zx2iu]

@@orion9k With drawall?

[@shubhamvibhuti]

Bioavailability of oral melatonin is very low. You are discounting this fact. 10-12 is standard for a lot of people.

[@DCGreenZone]

Dr. Russell Reiter 180 mg per day for well over 20 years

[@crossfitguy]

And the guy seems sharp as ever in the interviews I've listened to.

[@diamond_s]

And already past average male lifespan too iirc.

[@user-mr2lv2fq8g]

Again , same question, how's yours eyesight and eyes health?

[@DCGreenZone]

@user-mr2lv2fq8g Not too bad for an elder.

[@crossfitguy]

@@user-mr2lv2fq8g is your question in regards to Dr. Jack Kruse's recommendations against melatonin usage? Just curious.

[@servethesongs]

NO thanks.. I smoke a joint

[@johnfontana7256]

I noticed a slight hangover when supplementing melatonin some time ago, I will try again to see .Thanks for your content and results!

[@williamdias3456]

less than 50mg can cause headaches and grogginess for some people , that used to happen to me too , i am currently taking much higher doses and feeling great from it

[@Zoet50]

I’m 68 and just started taking 10mg each night. Really helped my sleeping . I’m sold

[@j.woodgard]

Mega dose," you say? Well, if we're talking SI units, a mega-dose of melatonin would be 10^6 mg-which, unless you're trying to time-travel to the next calendar year in one nap, seems a bit extreme. But if we're getting technical, a "mega dose" isn't just about sheer quantity-it’s about potential of action. Like midi-chlorians for the pineal gland, a smaller dose might still pack a Jedi-level punch depending on receptor sensitivity. That said, if you’re Finnish, I trust your sleep science as much as I trust your memes and Star Wars takes. Just don’t start calling 40 mg a “giga dose,” or I’ll have to pull out my TI-84 and settle this like a true mathematical Sith Lord.

[@Domn879]

In my experience, any medication or supplementation that makes you groggy in the morning, even for an hour, is not worth it other for occasional use for acute insomnia. Starting off feeling like you’re dragging yourself about has a crappy effect on your entire day.

[@harputian]

Thx for your Video! Siim, make a Video on how to increase or fix REM Sleep since a study suggests that if you get the REM Phase after 98 minutes of sleep, you are at a higher risk for developing Alzheimer's.

[@cryptodeath854]

That’s not a mega dose, bro. 100-200 would be a standard mega dose. You haven’t watched/listened to the experts on this topic.

[@zbridgjpxupzm]

My mega dose is 20-40 mg. down side is I have a very hard time falling sleep without supplementation.

[@SiimLand]

12 mg is 40x what your body would make naturally

[@alanwakeup3344]

You haven't read the literature and are just parroting what other youtubers have said bro

[@pasi-wm4hb]

@@SiimLandonly 16% is absorbed orally dummy

[@marcogemma616]

@@SiimLand you're wrong! When you eat you assume also melatonin from food! fruits etc!

[@AIandComputerUse-nw6lc]

Thank you for experimenting on yourself 😁

[@Bb94MC]

hi siim, I wanted to ask if doses of 4/6 mg of melatonin taken chronically can negatively influence testosterone and lh and fsh. Is there a maximum dosage without having negative hormonal effects? thanks

[@davenockels5028]

It depends why you are taking melatonin…… there are many different reasons. And do recall that most (about 95% ) of Melatonin is created in the mitochondria and NOT in the pineal gland at all. You are missing a BIG piece of mela tonin

[@Swivelsonwheels]

Yes by sunlight exposure

[@blugato22]

What time of the day did you take it? Timing is a critical factor with melatonin.

[@_bodyconnect_]

In what age range does the body produce 0.3mg per day? Because as you showed it varies a lot from childhood to old age.

[@fyrerayne8882]

I've been taking 40 mg per night, for the past 7 months

[@DRourk]

Gonna hurt yourself if you don't stop....

[@fyrerayne8882]

@@DRourk There are people who've been taking 3 grams or more per day for years with no bad side effects

[@DRourk]

@ I'm well aware that people do this. They're wrong about the zero side effects however.

[@As_Ss]

@@DRourk nope, studies show its safe even in much higher doses

[@fyrerayne8882]

@ However, they seem to be doing just fine after years of this regimen. And I haven't experienced any bad side effects going on 7 months now.

[@SMASH_REVIEWS]

AT 2mg i start getting blurry vision in the day.

[@Deej99999]

This is NOT a megadose. I am taking 4,000mg of Mel a day (yes you read that correctly). Look into Doris Loh and Russell Reiter’s work.

[@TheKamraten]

Where does one even buy that high doses

[@Deej99999]

@ Bulk powder. I dose day and night. It’s been hugely supportive for my health. Theres no better way of supporting mitochondria IMO.

[@riffs9504]

Sounds expensive

[@emosag]

What differences have you noticed in your health since taking this high dose?

[@JonathanOvnat]

Is it helping you, and how so? Thank you.

[@dove72]

You got incredible results! Do you really think they are attributable to the melatonin? What were the other changes you said you made that might have been responsible for great results? Can you tell us, or make a video on it?

[@Seanonyoutube]

Which supplements confer the strongest benefits for overall health assuming someone is already relatively healthy and eating well etc?

[@miles-levoit]

What about impact on testosterone levels?

[@bigguy130]

There's a guy here on youtube that says he takes 1000mg of melatonin per day(not a typo). Seems crazy to take that much. Personally I have taken 20mg per night and noticed no negative side effects, but I cycle one month on, one month off.

[@williamdias3456]

i have taken much more than that and felt great

[@thomasmuller1850]

I take 0.5mg. I don't like dabbling with hormones.

[@Jsarson1976]

It people take vitamin d and that’s a hormone???

[@thomasmuller1850]

@@Jsarson1976 I am fine with taking them as long as I reach the optimal range as I could have achieved naturally or during my prime. Beyond that, not so much.

[@Swivelsonwheels]

I agree,be very careful supplementing with stuff your body already produces,also get your sun exposure right and you get plenty of Melatonin combined with less synthetic light exposure.

[@emosag]

I take 10mg a day, but my sleep was ruined since taking ssris so I need it. I do feel a bit groggy in the AM but that’s quickly sorted out with a cup of Yerba mate tea.

[@jozefwoo8079]

How did ssri affect your sleep?

[@adriansrfr]

What hardware do you use for your sleep scores?

[@MountainMitchYT]

Do you recommend herbatonin?

[@ChessMasterNate]

I thought you typed hibernation.

[@KoenDeJaeger]

My experience with 10 mg of sustained release melatonin is like 10% of users: actually waking up earlier than without. I did some digging and it has to do something with the quick drop in levels during the night which makes for a quicker stronger cortisol Spike. So basically I wake up after 6 hours and unable to fall asleep again. Think the industry needs to Make triple layer tablets haha. If anyone has a hack to sustain it longer, please tell me. Maybe mixing it with some oil?

[@shubhamvibhuti]

Don't use sustained release ones. I tried with the same effect; woke up after 6 hrs. Then I switched to regular melatonin.

[@KoenDeJaeger]

@shubhamvibhuti but don't you then get an even bigger Spike and an even bigger cortisol reaction around 6:00?

[@shubhamvibhuti]

@@KoenDeJaeger Nope. I sleep well. I realised lately that it's about maintaining a low heart rate before sleep time and regular sleep schedule. A small dinner 2-3 hours before bed helps in that. Besides, I do long distance running. That helps a little only. My sleep is not perfect but it is getting better. I tried everything under the sun to improve my sleep quality.

[@douglascutler1037]

When I first started taking melatonin I would get that grogginess in the morning. But after about 20 minutes of daylight, even indoors, it would dissipate and then I would feel a normal morning refreshed feeling like after a good night's sleep.

[@brock8332]

i took once like only 2mg and was so groggy and eyes were very sensitive to light

[@With_Mandy]

Hi Siim, can you talk about Anti aging drug for dogs ?

[@franshartman4378]

Almost every night taking 10 - 11 mg, for a year now. Luckily, I don’t need more. Not feeling tired at morning.

[@steveking4878]

I've been taking 10mg daily for the past 3 years at least, along with 1.5g GABA and 1.5G magnesium bisglycinate, about 30 mins before bed. That's the minimum dosage of melatonin that is even useable for me, I never had any effect whatsoever from anything under 3mg, and even that was barely noticeable. 🤷‍♂

[@orion9k]

where can i get these high doses from? What brand? Is it powder form?

[@ilevitatecs2]

GABA supplementation is 100% useless. It doesn’t absorb and it doesn’t signal either. Do not waste your money. Research is unambiguous

[@steveking4878]

@@orion9k I get the 10mg melatonin from the grocery store, Jamieson brand - common in Canada. The GABA is from Naka and Magnesium is from Jadin, both Canadian brands evidently. I get both from Amazon. Capsules (3x ea), no powder.

[@deuss001]

Do you have to cycle through it?

[@BlackSeedOil20]

I used to take 30 mg but was scared the first time of 9mg after a doctor put me on. The doctor told me I he uses 60 mg (he was old)

[@Forever_Laura]

I've been taking between 40 and 50mg every night for the past 3 years 👍 But as of just a few weeks ago I'm experimenting with around 16 mg per night

[@Spe1k]

talk about your calorie restriction and how affects muscle mass and testosterone levels 🏆

[@instars2027]

1mg daily - no problems

[@ziggy1019]

what happened to your rem ?

[@nico2000ad]

If you have felt lethargic is because the dosage is to small.. You may need 50mg to 100mg. You may consider reading DORIS LOH

[@acs66562]

Not even close to a mega dose. Try the 400 mg suppositories

[@jozefwoo8079]

I take 1kg and the results are amazing

[@williamdias3456]

@ bot account trying to dismiss important information , one kg is stupid but 1 or 2 grams are actually amazing and there is plenty of research proving this

[@cajampa]

@@williamdias3456 Yeah this strange dude is running around all over this comment section trying to argue a bunch of BS. I have no idea why he is so afraid or clueless about melatonin. Or why he is trying so hard to steer people wrong. It is a very very useful substance that can give a lot of people more health and he keep trying to muddying the waters for no good reason.

[@jozefwoo8079]

@@williamdias3456 can you point to the evidence then please?

[@jozefwoo8079]

@@cajampa strange because I don't just accept a health claim from someone in the comments under a KZbin video? I would be strange to just accept those. Point me to the evidence and if it is there I will be the first to take a gram of melatonin. I'm constantly looking for ways to improve.

[@AceKinG2024]

I think 5mg is the sweet spot. 10mg or more should be used to target specific issue like you mentioned. Someone should play with the doses and see how it feels for every dose and find the sweet spot. In the end, better sleep is the end goal

[@henrikmadsen2176]

But also: Feeling alert, and not groggy, when you wake up, is nice too

[@AceKinG2024]

​@henrikmadsen2176 yes sure

[@jasononblast]

I used 320mg last night and I slept great and feel good this morning. The groggy feeling for me went away after a few days.

[@AceKinG2024]

U mean 32mg

[@jasononblast]

@@AceKinG2024 320mg.

[@brians1793]

@@jasononblast I'd believe it, when I was going through kratom withdrawal from 2 ounces a day I was taking up to 100mg. It's probably not a good idea long-term though. Apparently getting sun raises melatonin, but not the kind that makes you sleep your pineal gland produces, but it's more the whole body anti-oxidant. It's the same melatonin, it just works differently, so sun isn't just for vitamin D. That explains why it feels better to get sun versus supplementing vitamin D.

[@Forever_Laura]

@@brians1793 The sun does actually help in the production of the sleepy type of melatonin. First sunshine helps the body produce serotonin which is then later converted into melatonin 💪

[@brians1793]

@@Forever_Laura Makes sense, also in the sense that the sun is crucial for circadian rhythm, but that's more to do with the eyes than the skin, but it's important for that throughout the day and not just later. That's why people should minimize wearing sunglasses. I don't recall ever knowing serotonin converts to melatonin, but I did know l-tryptophan does and also converts into 5-htp, which raises serotonin when you supplement that iirc. So the relation makes sense. The sun is so important though for so many things, it's sad that the government has people afraid of it, and dermatologists blatantly fear monger about skin cancer when most of it is harmless and they don't want you to know that. Most sun screen is toxic, as if blocking vitamin D raising risk of worse types of cancer wasn't bad enough, but then recently realizing it does the same for melatonin and probably more than even that.

[@shimondoodkin]

Did you try or want to try melatonin with nmn

[@chriskoort5717]

The f**k is it with that thumbnail picture?

[@Adam-rf5xp]

That's what happens to you after you snort a line of 120 mg melatonin

[@tomasbeniusis9236]

Nothing, taking 10mg for a year

[@GuidoDePalma]

I take 25mg daily and nothing happened :)

[@marktapley7571]

You failed to mention wether the melatonin was synthetic or natural. Synthetic likely does nothing so is probably psychogenic.

[@KoenDeJaeger]

Oh, maybe a week might have been a bit too short to draw a conclusions.

[@CCmagee3]

I took 80mg for a year. I slowly dropped down to 30mg, it works with all the other stuff I take to sleep.

[@starflower999]

The time release melatonin made me feel the worst, i would awake with a headache even from a 3mg dose

[@Adam-rf5xp]

What do u mean "even from 3 mg"? 3 mg is a huge dose, 300-500 mcg is optimal...

[@williamdias3456]

@@Adam-rf5xp headaches and grogginess can happen on doses lower than 50 MG , 300-500mcg is extremely tiny and very far from optimal . For anti cancer and longevity benefits much higher doses are needed, i have taken over 2g per night in the past and had amazing results from it . 25 years ago when i first started taking melatonin similarly to like Siim land i was under the impression that melatonin had awful side effects but after looking at research i found out i was just not taking a high enough dose. He is really making a big disservice to his followers by recommending the useless big pharma approved doses . Melatonin is a extremely powerful and beneficial substance but also cheap , no wonder there is a big push from Big pharma to get the people to not use it in the right way.

[@michaelayalaathotmai]

12mg is a fraction of the dust left over on the spoon. Use it as a signaling molecule. Everything else is extra. Differentiate between what the body produces and what the pineal gland produces.

[@GloriaCote-o1c]

I am immediately taking 20 mg tonight a d will go from there.

[@keithrogers9741]

I assume the amount of Melatonin (a Hormone) a person needs has to do with how much a person produces and its feed back loops, degradation ect since its produced mostly in your cells. I am 75 yrs and .3 to .5 is sufficient for me and studies done so far so this is optimal , anything more knocks me out like a drug with the groggy side effects unable to get going in the AM. the body can be shocked into short term positive effects but I am not ready for the the long term side effects. Just common sense until more studies done

[@maschoff69]

Wrong again Siim. The groggyness eventually goes away. I take 12 mg every night and it's amazing.

[@cajampa]

True. I take 100mg it works great

[@jozefwoo8079]

Why is he wrong? If he doesn't see improvement in markers then there is no need for him. He's already in top shape

[@cajampa]

@@jozefwoo8079 He is wrong because 12mg is not a mega dose. He can make up his own terms. But it would be wrong if other have been in this field for a very long time talking and researching this stuff. And defined what a mega dose is already. And 12mg is not a mega dose of melatonin. = he is wrong. A mega dose start a 50-100mg and goes up to several grams. He is beginner at this and by calling 12mg a mega dose, exposes him as clearly not knowing what he is talking about. Also on OP point the groggyness goes away. And the proper protocol is to raise the dosage slowly to lessen any side effects.

[@jonhadley-zx2iu]

For me melationin is the only supplement that seems help with my sleep However, I think that you arent meant to take melatonin long term for sleep & you should take the precursor of L-Trytophan

[@BitZapple]

Tryptophane is great valerian glycine magnesium chamomile lavender

[@geoff_onYT]

melatonin completely ruined my sleep. Then I went to reddit, and discovered this is very common. I found hundreds of commenters saying how melatonin completely destroys & annihilates their sleep quality.

[@jozefwoo8079]

How so?

[@__NikolaTesla__]

same. First with 3mg and years later 1mg + valerian + other stuff. You wake up after maybe one or two sleep cycles and that's it. Falling asleep faster but waking up after 2 or 3 hours is pointless.

[@geoff_onYT]

@@__NikolaTesla__ yep. 100%. I also wake up after 1-2 sleep cycles, and feel awful in the morning & throughout the next day

[@truthseeker8502]

Try 220mg!

[@scentedgamer8676]

12mg is a Mega dose?I have taken 50mg without any effect,only headache.

[@AceKinG2024]

Maybe headaches are because of upregulation of Detoxification using such high dose. Did u try lower doses?

[@alanwakeup3344]

He literally adressed this countergument in the 4 minute video 🤦

[@scentedgamer8676]

@@alanwakeup3344 i know,but what he thinks is Mega dose and what really is Mega dose is day and night!

[@scentedgamer8676]

@ 🤷🏼‍♂️🤷🏼‍♂️🤷🏼‍♂️….yes,i take only 2mg-5mg now.

[@scentedgamer8676]

@ i will do 10mg now…build up to 100mg slowly….will order bulk powder now.

[@scottk1525]

why tf would you do this?

[@jozefwoo8079]

Why tf would you need tf here?

[@scottk1525]

@@jozefwoo8079 For emphasis. "Why do this is" a casual question asked about a normal behavior. Whereas "why tf would you do this" is a perplexed reaction to an absurd behavior. See the difference?

[@jozefwoo8079]

@ yeah sure, thanks. I'm perplexed that you are perplexed. What are you perplexed about, that he's taking melatonin?

[@scottk1525]

@@jozefwoo8079 Are you acting clueless on purpose, or what?

[@jozefwoo8079]

@@scottk1525 not at all, truly don't know what you are perplexed about

[@ilevitatecs2]

12mg is not a megadose at all. Comparing to natural production is not the appropriate benchmark.

[@jozefwoo8079]

Says who?

[@cs-cr2sx]

sounds like you just suck at sleeping

[@EtienneLeBoeuf]

You missed the most important point here. Taking a high dose of melatonin for 30 days would leave you having difficulty getting to sleep when you stopped using it. This would remain until your body re adjusted itself back to normal

[@williamdias3456]

That is not true , there is no negative feedback loop for melatonin , taking high doses actually improve mitochondrial function and will help correct a melatonin metabolism even after stopping supplementation

[@EtienneLeBoeuf]

@williamdias3456 The secretion of melatonin is regulated by a negative feedback loop. It may have benefits but as correctly stated by the sleep foundation, an organisation comprising the worlds sleep experts, long term use of melatonin, at any dose, may lead to decreased effectiveness and impact your natural melatonin production. Many longevity gurus state how they have improved their sleep scores yes they have by using a sleep aid. They have used artificial means to improve their sleep scores and have become reliant on these artificial means to maintain improvement. Creating imbalances

[@cajampa]

Haha you are clueless 10mg is standard dose. Mega dose is in the ranges of 100-200mg to grams of the stuff. I take 100mg to sleep it works great.

[@jozefwoo8079]

Who defines what a megadose is? His definition makes sense, he clarified it so why argue about it? Just share your believe, opinion or experience. Don't argue over arbitrary definitions.

[@cajampa]

@jozefwoo8079 He can make up and define his own terms. But it would be wrong if other have been in this field for a very long time talking and researching this stuff. And defined what a mega dose is already. And 12mg is not a mega dose of melatonin. = he is wrong. A mega dose start at 50-100mg and goes up to several grams. He is beginner at this and by calling 12mg a mega dose, exposes him as clearly not knowing what he is talking about. I am not sharing any beliefs. This is well threaded topic. He just don't know it. So he makes up his own terms and to click bait people who knows even less than him. He didn't take 40x dose. He took 1x dose. Not very special is it? He didn't want to explore the actual mega dose ranges so he made up that 12mg is a mega dose. But actual mega dosea have actual real life applications. So he is steering people wrong when he mixes up the concepts. For people who actually can benefit from actual mega doses of this stuff.

[@cajampa]

@@jozefwoo8079 Just to be extra clear what I don't like is that he is mixing up the concepts when mega doses of this have real important clinical applications. So if someone have heard they can benefit from a mega dose and then see this video they can wrongly assume that taking 12 mg will give them those benefits. Mega dosing this is its own topic. What he did was taking a very standard dose. He is confused and he is confusing people, when he mixes up the concepts of a very standard and common dose of around 10-12mg. And the actual mega doses people are using that have their own extended benefits. And yes like he said higher doses have their own possible side effects. But for some people those possible side effects are more than worth it, for the benefits they get in the actual mega dose ranges.

[@jozefwoo8079]

@@cajampa YOU cannot define the terms for others because YOU believe a megadose is more than 12mg. There aren't even recommended daily intakes established for melatonin. The dictionary AND the scientific community define a megadose as follows: "Megadoses are described as the consumption or administration of nutrients in supraphysiological doses that exceed the recommended dietary ration ten or more times.". Depending on the recommendation and the target of treatment (jetlag, insomnia, etc) doses as low as 0.3mg are suggested by experts. As Siim specified VERY clearly (even in the thumbnail), he is taking 40x the dose that the body produces (which is the supraphysiological part of the definition). Now if you want to say that higher doses are better, then by all means please do share (with evidence preferably). Just don't make unnecessary drama over your interpretation of a megadose not aligning with his equally valid interpretation. This is all pretty new science and there is no hard evidence or well defined standards. Just recommendations by certain experts based on general research which might still be debunked later.

[@jozefwoo8079]

@@cajampa you are defining your own terms. Check the dictionary for the meaning of megadose and then check what is generally recommended for sleep. Usually that is between 0.3 and 1mg in many countries. Feel free to share your experience with higher doses but chill about the definitions and it's certainly no reason to laugh at him. There is no one correct interpretation and it's certainly not yours.

[@DRourk]

You generally only needs .5 mg to have a good effect. Dosing more than this is generally not wise. In no small part to what you correctly brought up. We don't make or need that much.

[@terminator3728]

lol I do 40 a night

[@jozefwoo8079]

Lol!

[@marcogemma616]

i take 10/20 mg every night, minimum dose in commercial products is 1 mg not 0,3! Your 40x is clickbait.

[@SiimLand]

40x of what natural production is

[@KingdomOfDimensions]

Nootropics Depot makes a .3mg dose

[@maestroharmony343]

There are products on the market with 0.3 mg or even 0.1 mg of melatonin.

[@jozefwoo8079]

@@maestroharmony343exactly

[@jozefwoo8079]

Did you watch the video?