Tom Rapoport (Harvard, HHMI) 1: Organelle Biosynthesis and Protein Sorting

[@lastchance8142]

Absolutely amazing. I love how he often says, "it's very simple", when describing a system that incorporates many tens of thousands of molecules performing a choreography of miraculous complexity!

[@medicinefuture]

your work is really great, I am fond of your work, I want to know about the molecular mechanics, how molecules move to the target, what makes them move,

[@r3g4rds]

i think it is just thermal dynamics no? they will probably sample lots of different positions in space due to diffusion, and be arrested/associate for longer periods of time with their target.

[@medicinefuture]

@@r3g4rds I do not think it is simple as that, I think it is an invisible matrix or lattice, that makes molecules move directed by this invisible matrix, or may a quantum mechanical phenomena take place

[@medicinefuture]

​@Λ I think it is not a space-time signal, it is a nonlocal signal, while generated it does its action remotely and instantaneously like quantum entanglement, and the chemicals we measure are the result from this effect, not the cause

[@timblackburn1593]

@@medicinefuture Wow - so that really turns it all upside down. How do we go about specifying/locating the non-local mechanism? I realise there may be motivational constraints.

[@medicinefuture]

​@@timblackburn1593 I think there is a field of some kind controlling the motion and interactions of molecules. The time we discover the nature of that field, we will be in so different era of science or medicine, I feel we are creeping so slowly now because we depend on describing things and look at how they work not really why they work like that or this. The right way is to think about the unseen forces, and how they affect the scene

[@merlin5by533]

This iBiology series is Brilliant. The complexity just defies creation-by-accident.

[@merlin5by533]

@Dev Rifter Inanimate stuff, doesn't evolve, and most of the archaea class, over 4 billion years old, are still here, and don't use DNA. They are RNA class users. Nothing is left to evolve.

[@scottnineteen]

The characterisation of the cell ....internally it's a 3D interwoven structure of two different entities the microtubules and the ER tubes. Seems amazing.

[@mistersir3020]

All the details of one eukaryotic cell make up a more complex system than the whole macroscopic biological world combined!

[@Sol-gq1pu]

Thanks so much Dr Rapoport!

[@changyongkang7651]

Thank you for good lecture :)

[@viesturssilins858]

Thank you so much for sharing this! It is wonderfull!

[@CarterColeisInfamous]

we need to come up with some way to have like "dry" organelles that we can mix all together to create the constituent cell... or like some way to "bootstrap" simple cells into complex cells with a series of viruses or like turn a prokaryote into a eukaryote by printing a nuclus inside of it

[@devinyoung5735]

looks like the signal sequence uses a hairpin to pick the lock of the SecY channel protein

[@chunglee6895]

Amazing human intellect

[@LAGoff]

How is the mRNA 'exported' to the ribosome? I mean, how does the tRNA (that which -- I assume -- transports the mRNA) know to go left or right or straight. And how does it execute whatever degree turn it needs to make at its final destination in order to fit its cargo into the slot at the ribosome,?

[@KuziKQwertY]

tRNA doesnt transport mRNA, it transports aminoacids to the rybozome-mRNA complex to build a protein.

[@o2807]

why cant we build the economy around science and scientisfs? instead of workers or capitalists.

[@jameschamberlain6700]

call him tom rapoport cayse he can rapup a report ya know what im sayin

[@Orenotter]

You lost me when you started talking about evolution. Math proves it didn't happen, yet you stand there talking about it s if you were there watching. Sorry, but I can't respect that.

[@truthbebold4009]

Agreed, de-evolution from perfect harmony should be the accepted understanding of our history. Sin destroys.

[@user-tk2jy8xr8b]

Math proves it happened, sorry

[@aldenfriend9625]

God you people are so fucking dumb lmfao