Ramanujan Hegde (MRC) 3: Recognition of Protein Localization Signals

[@christiandiwo3591]

Thank you, for this really well structured and easy to follow crash course! The whole process is beautifully visualised. Great job!

[@michaelmacdonald2907]

In my 'paint-buy-number' opinion -- That's Brilliant Work !! What a great age to be alive. The technological tools and techniques for you to investigate this fascinating and pertinent field and also your willingness to describe your efforts to my crayon mentality. Oh yeah, and great presentation.

[@woloabel]

I like Doctoress Voorhees Contribution Really Nice....64 kDa of Pure Enchantment......

[@rogerparker3422]

Thanks - this has been a brilliant series of three presentations. I hope you do more in the future.

[@nanotech_republika]

awesome presentation!

[@woloabel]

(On Tuesday of April 18, 2023). ON the Matter of PhD Ramanujan Hegde (MRC) on the Idea of Recognition of Protein Localization Signals in the Overall Matter of Proteomics and Protein Biosynthesis or Biochemistry Therein: 1) Amphipathic Peptide Residues of a somewhat Cognizant Rationale is my understanding of the SRP Protein, SRP-R -Sec61 Protein Translocon as the Prevailing Nature of all the Proteins aside from the Hydrophobicity on the Transmembrane Polymerization but Hydrophilicity Specificity is almost Unaffected or Highly Insensitive there to. At any rate, what about Isolation of the Protein of Interest and Amplification/Purification along with the Sequencing Analysis. I reckon by now Proteomics is almost as straightforward as Complementarity in Nucleic Acid (RNA/DNA). 2) I also do see the Protein Biosynthesis of the Pancreas a Highly relevant in a Medical Approach as is as a Pure Protein Translation-Translocation Exercise of Pure Science, for the Pathology of GMOs is straight Pancreatic Cell (Beta Mostly) Exhaustion sometimes to the Point of rendering the Translational Fidelity as the Primary Mechanism of Pathology and less so a Matter of Investigation of Medical Therapeutics. Maybe some form of High-Fidelity Reprogramming via some Enzymatic Correctional Gene Therapy is likely to garnish Pharmaceutical Interest but Not here. I rather Correct the Psychosis therein. 3) Ribosomal Consistency of a Ration of 50-50 Protein to Ribonucleic Acid has to also Permit this Intelligent Biochemistry as the Structural Part of the Ribosome can be Attributed exclusively to the Protein Side of the Organelle while the Ribonucleic Acid merely to Mediate Translation-Complementarity. Or this Dynamics also reminds me of the Protein Function in the Nucleus as Basically Carriers or Holders (Chromatin Stability of DNA being Primary in Such Design) of Deoxyribonucleic Acid (DNA) and Epigenetics Therein where the Methylome (Totality of DNA Nucleotide Methylation) or the 5' Cytosine-Phosphate-Guanosine-3' (CpG) serving to Repress of Upstream Genes, an Epigenetic Mechanism in Proliferation Pathology. Or Even the Understanding of Post Translational Modifications (PTMs) within the Histone, Histone Variants, or the Remodeling of the Nucleosome Entirely as a Function of Environmental Factors often Reflecting as Pathological Features. 4) Transmembrane Helices 5 and 6 are the most Amphiphilic and therein the Surfactant-lIke Flow of Proteins. I have read a 3.4 Angstrom Resolution yields a Vantage Point where SEC61-Gamma Endoplasmic Reticulum Side allows Translocation therein while all other Helices simply serve to various amphipathic Extents depending on the Ribosome-SEC61 Complex Orientation (Secretory versus Translocation Positions) and the Voorhees-Hedge Submission of 3.6 Angstroem Resolutions yields Another Sequence and Molecular Weight maybe there is Variation if Not Mutation. Anyway, nice to know pathology herein can be visualized for Possible Mechanism if any (Alzheimer's Disease but Certainly Huntington's Disease are herein Correctable if not Associated with Protein Translocation Deficits or Defects. I would reckon Variation in this Gene is not yet even Understood or Locus Localization for that Matter. Praises and Salutations. PhD Ramanujan Hegde, es geht sehr gut zu verheilen und wiedersehen Proteomiks der Gesundheit gegen Die Kranktierenstoff heran. Es immer soll die Naturalische Type Heilig Sein. Heil!

[@scottnineteen]

Nah mate, even now, the ER is an interwoven 3D web which dynamically interacts with both a similar web of microtubules and perhaps all of the other organelles, that is the explanatory description of the cell.

[@lastchance8142]

It's always incomprehensible to me how so many thousands of highly complex macromolecule pathways and atomic-level interactions are accomplished by highly specific products presumably evolved by random mutations. Nobody can explain this.

[@rishaalsharma]

So does the first part of the protein chain always have to be hydrophobic?

[@Thomaaasooo]

no, but most of them are but it doesnt have to be the very end of the chain. you can have a signal sequence a few amino acids in and it still works. transmembrane proteins type II and III for example have their hydrophobic sequence close to the n terminus but not at the very end. and of course proteins which are released in the cytoplasm have no signal sequence at all.

[@CarterColeisInfamous]

17:28 thats sick AF

[@hdhddhdb2894]

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