NEOPLASIA 6: WARBURG EFFECT: Hallmark of CANCER. What, Why & How?

[@saadzaheer3451]

I am a data scientist with no background in cancer or biology. I recently joined a lab that requires one to have some basic knowledge of cancer and biology. The team members were handed over a job of explaining the hallmarks of cancer by Weinberg, and I had to give a talk on the "Reprogramming energy metabolism" part. I had no idea much less a basic understanding of it. After watching your video, I feel like I knew it a long time ago. Knowledge can never go wasted. Your video helped A LOT. Thank You Sir. P.S. Also, I believe the 22 dislikes are from people who just looked at the ~13 minutes length of the video and skipped it because of that.

[@ilovepathologyVijayPatho]

Saad Zaheer thanks so much. Glad you liked it 😊😊

[@madwez]

Dr. Thomas Seyfried improved this therapy so magnificently with great results. Keto is also very effective against many of the cancers. tumeric and Green Tea both are very powerful against cancer. ofc no sugar intake is a rule!

[@brcarter1111]

interestingly, lactate is certainly not a metabolic "end-point" as taught in many medical schools, but is instead a potent signalling molecule and is often used as a source of energy itself. Lactate (lactic acid in solution) can also be transported to the liver and used in gluconeogenesis. Cancer cells can use numerous other biomolecules such as glutamine and under the new discovery of the "reverse Warburg effect", can manipulate cells of the stroma to package and deliver all the metabolic starting molecules they need

[@virgirma1328_PhD_scholar]

best tutorial on cell meatbolism and warburg effect i ve watched so far.Thank you sir for contributing to our education.

[@ilovepathologyVijayPatho]

thankss so much :-)

[@ChandraChandra-ko8uk]

Not just like sir we love the video.. I just wonder how underrated these videos r... Thanks a lot for these treasures and pls keep uploading more so that many can benefit from ur knowledge and understnding and clear crisp concepts and soothing explanations

[@indragesink]

I would be very happy with a transcript. Some parts of sentences are hard to catch

[@carstencarstensen4770]

articulation mens a lot

[@doc599]

I looveee ur videos...u put so much effort in collecting material,summarizing it,making slides....i hope other students may also get benefit from these lectures

[@ilovepathologyVijayPatho]

Thank you 😊

[@ilovepathologyVijayPatho]

Please do share 😊

[@cholponzhakshylykova4099]

one of the best educational videos so far! Thanks!

[@vaishnaviramakrishna265]

It was so helpful with such a detailed and toned answers for all questions. Thanks you so much! Keep doing more of pathology videos!❣

[@drnirmalraut]

i am an oncologist and never really understood why the hell are some antigens which are expressed during the embryogenesis expressed during the processs of malignancy (a.k.a oncofetal antigens -tetsis antigens ny-eso). today i had an epiphany kind of efffect after hearing your video .

[@brcarter1111]

careful. The warburg effect is seen in many other types of cell proliferations too. I had the same epiphany as you several years ago. There is some interesting research into oncofetoproteins though and it's hard to say if these proteins are being expressed coincidently, are acting as tumor suppressors, or are acting as oncogenes, or something else. Alpha-fetoprotein is reexpressed in most liver cancers (most of which are caused by EBV), but some new research has shown it has some interesting antiviral properties. Even the pregnancy associated protein HCG is often expressed as well. I believe the reexpression of fetal genes is a window into something of great importance, even the hox genes are repeatedly being seen expressed in human cancer. Perhaps it is not individual genes from fetal genesis that are being expressed, but gene programs...

[@gabrielafernandesdetoledo1526]

The best explanation ever. Who is the author of this wonderful class? Thank you!

[@rahmanimmr]

Very nicely explained, especially the mechanism behind this reprogramming of metabolism

[@j.p3318]

I bow to ur explanation..thank you so much..for making a smooth understanding

[@Ketocrittle]

A very understandable explanation. Thank you.

[@anusuktimondal9551]

Sir you were amazing and the tutorial was very enriching. learnt so many things..thank you.

[@drnaazneenmohammed1094]

now I have ACTUALLY started loving pathology ;)

[@pietromascialino1251]

You are better than my university professor

[@ramneekbindra2305]

Excellent video sir,crisp and made my concept crystal clear😊

[@mohammedishaq2616]

man you are really good. you first explain all background knowledge then coming to the main point. you can do more videos on 2nd year MBBS PATHOLOGY

[@sanjay3415]

You saved my life and explained this really well! We should get you to lecture at my medical school!

[@loloharb81]

Great explanation ..easy to understand thank you

[@prisca.a6795]

Very useful, sir. It'll be more helpful if you give your references in the end.

[@wafak9617]

Your cancer videos are amazing, thanks so much!

[@SandhyaRamachandran]

absolutely good one! cleared all doubts! thank you.

[@domm165]

If tumors are glucose hunger, is there any benefit to starving the body of glucose (i.e. putting the patient on a ketogenic diet or some other variation where the body uses fuel other than glucose?)

[@bigyin2794]

It would appear so, see The Metabolic approach to cancer, by Dr Nasha Winters, who is still surviving terminal grade 4 ovarian cancer 28 years later, KZbin and audible.

[@rahmanimmr]

In this case, autophagy takes place, which is triggered by low ATP. when ATP is low, the amount of AMP increases which is a used form of ATP. As the result, the ratio of AMP to ATP increases which turns on the process autophagy. cells try to use excess lipids and recycled materials from cellular compartments to produce energy.

[@victoriap2519]

@big Yin27 Thomas Seyfried is great to explain that. He has been treating cancer patients with great results following his protocol- ketosis , hyperbaric oxygen therapy and hyperthermia in combination

[@andrewboss2018]

Yes, but water fasting is best

[@vishalmuralidharan4515]

I think there's a TED talk about that yeah?

[@lisaschiller2392]

Thank you. You are a very good teacher. Thanks for breaking it down so it is easier to understand:)

[@ilovepathologyVijayPatho]

Thanks:-) glad you like it. Please do share if you feel it benefits others too :-)

[@mortgageloanoriginator5241]

Your explanation was excellent, as a lay person it was very clear..Thanks..

[@entadat]

such a concise and comprehensive explanation especially with the simplified picture. thanks!

[@honeyzbest564]

kzbin.info/www/bejne/qZaTqJ2FabNsbs0

[@sirichandana9794]

Best explanation I came across. Thank you very much.

[@alexataupin8052]

Cannot appreciate enough the help this has given me :)

[@saumyadhamanda3123]

Extremely helpful. Thanks to you, I guess I won't be tanking my cancer biology exam.

[@anbarasanpillai4338]

Greate information , we can consider anaerobic respiration reaction sulphor based and role of methyl donors

[@documents7840]

Thank you so much for explaining Warburg effect. I learned a lot from it.

[@jordanchildress2640]

Very enlightening!

[@mikecain6947]

A great video. Thank you.

[@DS-eq4si]

Such a beautiful video, we don't need to read the text after such a beautiful explanation. Please Sir, keep posting videos on important theory questions and practicals including slides which would be of greatl help for us PG students.

[@kawishabbas4521]

Thank you so much sir ❤it helped a lot

[@terryadams2652]

Excellent presentation. Thanks

[@chinmoydas1759]

Sir,great explanation. I was struggling to understand the concept qnd now it is much clear. Thank you very much.

[@108-salinis5]

Thank you so much sir easily understandable 😊

[@franklinpastranart]

Yes sir !, such a really good explanation and data recopilation !. It'll be awesome if you can also post the articules or your references, thank you so much. one more suscriptor.

[@Nick.5.9..175]

This is very good

[@che_mahii]

Seriously loved this.

[@honeyzbest564]

kzbin.info/www/bejne/qZaTqJ2FabNsbs0

[@dr.dharmilshah]

Wow sir. All are lectures are awesome. Up to the mark. 🙌

[@albertoratmiroff2265]

Good Video, nice explanation of possible causes for the Warburg Effect, in general. Cheers!

[@tatoverde9312]

Beautifuly explained. Thanks

[@rittenbrake1613]

Thank you bruh ! Thats so informative

[@honeyzbest564]

kzbin.info/www/bejne/qZaTqJ2FabNsbs0

[@shaiklathifmunnisha1426]

Tq sir for such good explanation

[@CarlosOrtiz-ht6rn]

Interesting information! Thank you for this video Sir.

[@harishguna4191]

Amazing 🎉❤🎉

[@leopardduck4490]

Thank you for the video! It’s interesting how cancer cells are able to use HIF-1 to stop the normal aerobic respiration processes in the presence of oxygen. But how does the cancer prevent the HIF-1 from degrading under normal oxygen-rich conditions like it is supposed to do?

[@syedmedicose7477]

Excellent

[@iagocorreia2458]

Thank you for the video. But why is 2-aminomuconic acid on the cover?

[@rakshithm1257]

brilliant! I like your way of explaining.

[@ilovepathologyVijayPatho]

Glad you liked it!

[@icedespresso]

Very well explained, thank you!

[@kannankamal5446]

Man upload more videos , really appreciated 👌👌👌👌

[@IjazKhan-yv9qk]

Good work

[@jamesselby796]

I really didn't need this talks to fast can't understand but then I learned sometime ago about cancer and fermentation CC WOULD BE NICE BUT THEN I WOULD HAVE TO STOP AND START TO MUCH. I am glad for those below I am not a speed listener

[@gykg3202]

Thanks for sharing information!

[@tanaymishra6372]

Plz make video on disease of infancy and childhood

[@sumitmandal3901]

so clearly explained. thanks. if you are going to upload more such videos about topics where students get confused, I am ready to subscribe. otherwise, since I liked the video I have "liked" it. but assure me and others reading this post about possibilities of future videos to get more subscriptions. thanks again for such clear illustration.

[@Bengalipoetry29]

Awesome explanation ❣️

[@shepherdw2781]

Well illustrated 👌

[@ahmetcan122jJIQJW]

Thanks for your all videos.Can u add subtitles pls.

[@1024DS]

Please make a vedio on feroptosis

[@subhikshapandyan2918]

Great video 👍🏻

[@radhakrishnanscience3339]

How nicely you explained this 🥹

[@dr.nehataneja4577]

Excellent Explanation....Bravo!

[@yuegao2016]

super great clear explanation！thanks!

[@frankbrancato3997]

Could you do a video on prostate cancer? Thanks. here is some info I found... Prostate cancer starts with OXPHOS not glycolysis or Warburg effect : Metformin is an OXPHOS Inhibitors 🙂 Seems like Glycolysis or Warburg effect starts with epithelial-mesenchymal transition (EMT) when the cancer starts to move. ..."(Fig. 1). However, during carcinogenesis, ZIP1 levels decrease and OXPHOS is promoted.8 Nevertheless, this only occurs during the first steps of carcinogenesis. One study shows that the mitochon-drial content does not change during carcinogenesis, but OXPHOS decreases with invasiveness. 22..." "The prostate is metabolically unique since the differentiated tissue is glycolytic instead ofoxidative. Prostate cancer (PCa) transformation involves ametabolic switch to oxidative phosphorylation (OXPHOS),which later, in the advanced castration-resistant prostate can-cer (CRPC) phenotype, turns again to glycolytic" "WNT/b-catenin and theinsulin-like growth factor (IGF) 1 pathways seem to play amajor role in the most aggressive phenotype of CRPC.18" "PCa cells use interleukin-6 secretion toactivate glycolysis in cancer-associated fibroblasts, which inturn, increase lactate secretion.25Lactate is consumed byOXPHOS-dependent PCa cells, having a role in redoxhomeostasis and angiogenesis.26" "GLUT1is related to recurrence after radical prostatectomy.62" "fructose uptake might have a rolein PCa progression, particularly, at early stages." onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.31165?fbclid=IwAR1eFkozn7LV8yOBd1L_kAmgq32NR23nIV5R7AG8qRETjasJahQPb7GnKDg

[@mind_flare7867]

Thanks sir 👍 Stay blessed 🌹

[@prashanthreddy927]

Superb videos sir ,can u please make videos on other topics as well

[@honeyzbest564]

kzbin.info/www/bejne/qZaTqJ2FabNsbs0

[@leptoquark6278]

It is very useful..........and thank uuuuu

[@farukyldztekin7848]

ı have questioned if it is using glucose to lactate why we are saying it is aerobic, it is anaerobic, isn't it. and thank you for your good presentation

[@rgh2164]

Cancer cells do produce much less ATPs and therefore much less energy. All the energy produced in a normal cell is not entirely used up. Some percentage of it is converted into heat. This heat is essential for sustaining normal functioning of the cell. Cancer cells are heat starved and this factor promotes their growth and proliferation. In other words, they maintain low heat profile which results in total disorganisation within the cell. This theory is supported by the fact that they do not produce conversion heat when exposed to high energy radiation.

[@Interestingworld4567]

Thank you this helps a TON.

[@4ran173]

Thank you, amazing video.

[@viviana5325]

Great explanation!

[@sharanyahemanth921]

Fantastic 😊

[@elakiyaelango8852]

Superb explanation👏👏👏

[@shrenjal9268]

Amazing!❤️

[@irmareyes3398]

DR. OTTO WARBURG WAS A TWO-TIME NOBEL PRIZE WINNER. 😎 🌹🌹🌹🌹🌹🌹👏👏👏👏👏👏👏👏👏👏👏

[@aimensaeed7210]

Make a video on invasion and metastasis(neoplasm chapter) in 2 to 3 days.. Plzzzzzzzzzz.. I need it

[@karenbeard7040]

Excellent video thank you :)

[@shivamgoyal4563]

Can u put more topics related to systemic pathology

[@safwanbanoon]

First thank you for the great video, Can you tell me what is the reference?

[@SimplyMeVanessa]

👏👏👏 thank you very much

[@albertoratmiroff2265]

good video, thanks

[@omyelia]

very useful, thank you!

[@wellnesspathforme6236]

Glycolytic inhibitors? Really? Just don't eat unnecessary carbs (get your energy from animal and other quality fats, like nutrient dense organic nuts, avocado, unheated Udo's Oil, organic cold pressed extra virgin olive oil (both vacuumed sealed in fridge when stored) and minimally or non-processed organic coconut oil. Only using ghee for frying will minimize intake of toxic damaged fats. Only eat non-toxin laden, nutrient dense, low glycemic vegetables for carbs, preferably cooked if you want maximum access to the minerals, you know, like copper to support cytochrome c oxidase. Retinol loads those coppers into ceruloplasm for safe copper transport, so some animal protein will be required unless your body is really good at converting 12 beta-carotenes into retinol via a copper dependent enzyme (and you want to be sure!).

[@bigyin2794]

Thank you!

[@maadyk]

That was great!

[@mohd.saleembhat5658]

Keep uploading more vedios

[@rajusen5715]

Hello sir, can you kindly help me to know about "pentalenolactone inhibits glycolysis by inhibiting specifically glyceraldehyde-3-phosphate dehydrogenase" how?? and how its resistant towards glyceraldehyde-3-phosphate dehydrogenase? Pentalenolactone has an epoxi lactone,this epoxi group has an towords resistant bacterial cell wall formation.can i get the answer ,i am looking for it?

[@satyajitpal1911]

nicely explained....

[@Matiwe]

what sources did you take this information from? thanks for the video!!

[@otiliaperales3433]

Donde puedo conseguir este libro ?

[@NARANGI113]

Very helpful👍

[@spek2554]

What happens if you eat food containing cancer cells or tumor?

[@VivekSingh-mv5zf]

thank you sir