NEOPLASIA 4: p53 gene: The Guardian of the genome. functions, regulation and inactivation

[@haripriyar8291]

You're the reason I'm passing exams with a clear concept instead of just writing what's in the book. Thankyou so much :)

[@nathaamruth9751]

😂🙌me too

[@dariofilipovic893]

Harsh truth

[@tharunkumar5587]

so cutee haripriya

[@Arcanescrunchies99]

me too

[@naomiirhontumhan1544]

And 7 year later your videos are still saving lives👏 Thank you 🙏

[@ilovepathologyVijayPatho]

Thank you😊 glad it still helps😊

[@janefrancesladyf]

5 years ago and still very helpful. I can now go into the exam hall in a few hours with more confidence. Thank you.

[@ilovepathologyVijayPatho]

Thank you 😊 best wishes 😊

[@janefrancesladyf]

@@ilovepathologyVijayPatho Thank you

[@ilovepathologyVijayPatho]

Thank you 😊 am glad it helps😊

[@MDISLAM-qw7ic]

P53 is guardian of the genome / old man of the genome/ police man of the genome / care taker / gate keeper of the genome . The information which did not get from dr.sparsh gupta & dr.najeeb but i have found amazing & very effective information from your channel. It is why i have subscribed and followed your you tube channel. Thank you sir and i really love " i love pathology " channel..😊

[@umairhabib4618]

Just 10 minutes lecture give alot of information is a miracle Thanks sir Our prayer always with your dedication and hardwork.

[@ilovepathologyVijayPatho]

Thank you 😊

[@zcameron_]

I’m a week out from a huge pathology exam and I really wish I’d just studied from your videos from the beginning. I read all this info in a textbook and never retained it, and now it makes so much more sense to me. You break concepts up really well and you also keep it focused on the important stuff. Thank you!

[@cindysababa0204]

I was reading my book, but it makes no sense to me. You made it clearer! thank you so much!

[@ayokcomfort]

I can relate

[@84-pavithradevi2]

yass!!!

[@asmitajain7201]

U are a really wonderful teacher, making the basics so understandable in a simple way, thanks for taking all the efforts in making such wonderful presentations

[@ilovepathologyVijayPatho]

Thank you very much 😊.glad the video was of help 😊 Best wishes.

[@marioaraprotopapa1503]

You are a really good teacher , thank you for all the time and energy put in to make these videos extremely clear and concise ♡♡ .

[@ilovepathologyVijayPatho]

Marioara Protopapa thanks so much 😊

[@shaileshrao8694]

Neoplasia was one of the hardest topics i've ever studied and thanks to your videos my concepts are very clear!! please keep uploading more videos on pathology it is indeed very very helpful!!❤❤❤

[@ilovepathologyVijayPatho]

Thanks so much..glad these videos are helping 😊 do share with your friends

[@Josef2820]

Man i really have to thank you so much for your Video. Somehow we dont have anything that easy to understand in germany related to p53 Thanks a lot !!!!!

[@irem0090]

Josef Boy Björn same hab nix gefunden

[@andreapella4234]

I love you. This is so well explained i'm in tears.

[@drabdul86]

Thank you Sir , I am from Pakistan , u made this tough topic much easy to understand , love you

[@pinrani98794]

i already have subscribed to this channel and gave thumbs up to this channel/video. He will be fool who will not do this ... great work and proper guidance provided .... bravo....

[@kniiknoi6197]

Wow ... Great video. Excellent, detailed yet simplified tuition. Thanks a lot

[@parthjobanputra3742]

I have my exam tomorrow n this video helped me to drill the concept really quick... ty ... great explanation...😎🤘

[@chinmayeechhotaray7116]

Thanks dude...i was searching for p53 explanation and ended up in your video with perfect explanation.....you helped me a lot.

[@songbaolin5479]

Thanks to the author，I will finish my paper easily.

[@Artsylove4]

I'm super thankful that I found ur channel sir..

[@vaishnavik7367]

You're a gem sir. Pls upload some more videos. I have my uni exams in 10 days and your videos on neoplasia are a saviour. Keep it up, good luck :)

[@ChukimeRMarak]

One of the besttttt explanations I've come across. So systematic and made easy to grasp the concept. So grateful to have found this.

[@ilovepathologyVijayPatho]

Thank you 😊

[@mahfuzajebun5968]

Best pathology tutorials site I have ever seen.. Really grateful to u .

[@ilovepathologyVijayPatho]

Thank you.

[@080mirdhulak9]

Just an amazing clear cut concept I have ever seen🤩

[@20imke]

Thanks for helping me understand it so easily. Textbooks are just overcomplicating everything.

[@lucelence6312]

Thank you so much for making the concept clear and easy to understand

[@priyachakraborty2260]

It was great.... 2moro is my exam nd this video worked for me a lot....

[@sanaakbar3663]

Well explained sir. Neoplasia is one chapter that scares me but you have made it more interesting. Your videos have made it more easy for me to go through the text and understand it in a clear way. No amount of paid online classes have made me understand neoplasia as well as these videos . Please keep posting regularly sir!! 🙂

[@samina9199]

Thank you so much sir for making Neoplasia too much easy and understandable😊🎉

[@OvErShadOweDaZn]

Keep up the good work! I love this video and it was very helpful in understanding. You are a great instructor.

[@debigdogk9563]

Great teaching and illustrations thank you for teaching and sharing ❤❤❤❤❤

[@VijayKumar-ee2si]

Me studying in PG . really u r explained very well and it's very helpfull to understand easily without confusing tq so much sir❤️

[@yashkumarprajapati9648]

Beautifully explained!! Thank you sir 😊

[@ahmedkhan1560]

Excellent presentation. You made this complex topic so simple that I should recommend that it should be used as a template by the Authors of Molecular pathology Books. Thanks a million, Amjad Ali Khan MD USA

[@krishnamanikalita1612]

You are doing great work sir... thank you so much ❤

[@Pluripotent1234]

Thank u so much sir saw this video before going into exam.. got this question today

[@roohullahaminsafi351]

Thanks sir, really appreciate your hard work and hope to keep loving pathology. Lots of love from Afg🇦🇫

[@shubhamkushwaha8513]

Thank you for the amazing video sir! You explain things so simply!

[@pavansharma8966]

Nicely illustrated about p53 gene regulation in tumor suppression

[@CytochromeC]

I m actually dealing a while with p53 but the Video is Great

[@Artsylove4]

U make all the concepts really easy to understand ... thank you so much sir!!

[@ilovepathologyVijayPatho]

Thanks 😊 Glad you liked them

[@cossav2560]

Thank you from London. Great work.

[@zoyawin]

Thank you so much you made this concept so easy to understand. I was really struggling with this concept. Really helped with studying for my exam!

[@svartmetall48]

I realise this is a very brief look at p53, so I'll leave out some of the simplifications, but I would say one thing needs to be corrected regarding the molecular weight. p53 was named because it ran on an SDS-PAGE gel at 53 kDa, not because its molecular weight is 53 kDa. Due to the fact that p53 is quite proline rich it is a more rigid structure with annoying "kinks" in it, and thus it migrates differently on SDS-PAGE. As I am sure you know, proteins don't necessarily migrate at their actual mass (and there are a plethora of reasons for this). p53 is around 44 kDa.

[@svartmetall48]

@johnny torres Probably a good thing if you attend KI. I should know, I taught some of the undergraduate labs that med students took! ;)

[@karishmadeegan8297]

Thank you so much Sir for such a beautiful explanation. I wish you all the best, may you continue to educate lots of students like me. I study at Imperial College London and will tell my friends about your channel. Thank you!!!

[@ilovepathologyVijayPatho]

Thank you 😊

[@kishori4621]

You have made us love Pathology ❤️

[@cutyteeshu8068]

Loving this series of neoplasia... ❤❤ But I'm too late to reach hence regretting 😢

[@munkhbilegenkhbat4492]

very goodjob that explaining p53 also known as guardian of genome. But don't forget some virus can disable cell's p53 protein which means p53 can also protect cell from oncogen viruses like HPV.

[@shahmaf1768]

Thank you so much for the video because I was very tired with p53

[@dartanveer2046]

really a good art of teaching...Amazing...

[@divyamachevar9156]

You are doing a great job. Please continue doing it, your videos are of great help. Thank you ❤️

[@animeloverXinuyasha]

Very good job at outlining this topic - this is a perfect and easy to understand introduction to p53, so now I can go and delve deeper! I do wish you had explained a bit more as to what causes p53 inactivation and how, but all in all great video!

[@elizabethmendes5935]

great explanation and intro to the background of p53!

[@ilovepathologyVijayPatho]

Thank you 😊

[@rakshanas3960]

Pls do more videos ,its very helpful 🥺

[@alienatedaliens]

This was so helpful and clear, thank you!

[@shahidulhchowdhury6411]

wonderful illustration of role of p53 gene

[@riyaan1089]

Tqs so much for this very easy explanation

[@beesmooth6060]

Sir, what book do you recommend for exam point of view for second year mbbs?

[@MA-zo5jl]

Wow so amazing and very clear ty so much ❤

[@oviya7715]

The concept is clear and easy to understand thanks to the author

[@j3v167]

Hi. I have read an article where the P53 gene was mentioned. Could you please explain what is meant by mitochondrial translocation of the p53 gene?

[@afraahmad-g2u]

SIR YOUR VIDEOS REALLY VERY HELPFUL

[@haroldkumar4766]

Good stuff and explanation! However I wish p53 videos also mention that it's part of the BAX/BAK pathway and Bcl2 as that can be a point of confusion.

[@RuchiKumari-lu7cg]

Thanku sir a lot i really get concept from ur video thn i can make concept

[@varshilpatel2122]

Now I got it completely 🕺

[@shalynwheeler2126]

Do you have a video about neuroblastoma?

[@maryamaslam1612]

These are so helpful and easy to understand :) THANK YOU!!!!

[@keshavgupta5297]

i love your channel ......all videos are just amazing.......please upload some more videos of pathology #Medico

[@ilovepathologyVijayPatho]

Thanks:-)

[@health-and-beaut-secrets]

Best teacher

[@sanmeetkour8777]

Thank you sir ..god bless ..you made it so easy to understand 😊

[@mananvaid2304]

Lovely video! Thanks man! Keep uploading more videos. Greetings from Gujarat.

[@nandugopan5973]

Thank you so much sir❣️

[@shivanagpal1163]

Sir this video helps to learn a lot in short🙏🏆

[@solangecontreras8325]

Thank you!!!! The information helped me a lot with my classes

[@ilovepathologyVijayPatho]

I'm so glad that it helped

[@clarksims3776]

Thanks for posting this. It was very informative.

[@surajmishra1125]

Sir D-CDK4/6 perform Hypophosphorylation or hyperphosphorylation becoz my book mentions E-CDK2 complex for hyperphosphorylating pRb proteins ?

[@satadruray9787]

Hyperphosphorylation of pRB, thereby releasing the transcription factor E2F,.and the latter will then bind to the DNA and initiate the sequence leading to generation of proteins necessary for the cell cycle to progress

[@euge6994]

Thank you so much! This was really helpfull and clear.

[@yaqeenyousef8094]

thank youu sooo much you arethe best in pathology :)

[@ilovepathologyVijayPatho]

Yaqeen Yousef Thank you very much 😊

[@rikkigupta9546]

Thank u so much sir 🙏very clear explanation may god bless u 😇

[@ilovepathologyVijayPatho]

You are most welcome

[@tejasgadekar6153]

Great video

[@ThuriaElhassan]

it's really really helpful .thank you

[@rusulkeshwan9297]

Many thanks for you, you make it very easy

[@ramyatatte5408]

Sir kindly make more videos on general path so that our basic concepts will be clear

[@GjokGjelaj]

P53!!!!! Yes!! Thats so cool! I am going to name my child Ilirian P53!

[@manavkavathiya3078]

Exellent videos regarding neoplasia ,injury etc . But we require more videos regarding other pathological conceptual topics basis Thank you

[@drbiologyarun]

Amazing explanation.. Thank you 😊

[@Aman-hk4ov]

Such a great video!

[@pradyumnakumar6988]

Really helpful. I'm impressed sir. Thank you so much🙂

[@lauramojica8929]

Helloo! Do you have any article to read more about this? Also I want to know what happens when the oncogenes E6 is present? What does M2DM do?

[@gargichakraborty1083]

Great explanation !

[@madhusmitamall5069]

Sir ,if question will be discuss the p53 tumor suppressor gene ... Will it be the answer for that question tooo

[@intigutierrez5557]

Thanks for ur videos! I loved them, now i can do my essay easily hehe

[@farihahamid7580]

amazing video! you kept it simple and not too complicated ! :)

[@disloyaltyovercovid8350]

Thank you! The video is very clear!

[@rohit_roars]

Thank you for your explanation sir...

[@sameeramehmood4766]

sir what is mechanism of p53 inhibition through viral oncoprotein

[@Humanity12_34]

I just have found your channel recently and I have subscribed bcz my friend talked any this channel. Can you sir tell me what's full form of WAF 1 ?

[@Rotzfresh89]

Thank you so much for your efforts. Much appreciated!

[@NoorKhan-pv3ex]

your lecture is just👌

[@HobosRockEmTrashCans]

i learned that the p21 actually stops the CDK2 and cyclin E and therefore stops the cell from entering into the S phase.

[@danzlebronr9807]

Very helpful sir! Thank You :)