Immune Thrombocytopenia (ITP) - Most COMPREHENSIVE Explanation - Hematology

Immune Thrombocytopenic Purpura (ITP) (aka Idiopathic Thrombocytopenic Purpura or immune thrombocytopenia)…autoimmune attack on platelet receptors leading to bleeding (petechiae, purpura,and ecchymosis)…Order bleeding time, platelet count, PT, and PTT. Most COMPREHENSIVE Explanation.
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Bernard-Soulier Syndrome (BSS) is an autosomal recessive (AR) disorder characterized by a defective GP1b platelet receptor leading to a problematic platelet adhesion process (primary hemostasis).
Glanzmann Thrombasthenia (GT) is an autosomal recessive defect in the GPIIb/IIIa (GP2b/3a) receptor on the platelet which leads to defective platelet aggregation.
Ristocetin Cofactor Assay (RIPA) is usually abnormal in cases of Bernard-Soulier Syndrome (BSS).
Bleeding time is prolonged, platelets are big in size, but few in number (Macrothrombocytopenia).
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Platelet count is one of the lab tests used by a doctor or a hematologist to assess whether your platelet number is normal, low (thrombocytopenia) or high (thrombocytosis).
Bleeding 🩸 time (BT) is another test for platelet function.
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[@adin200]

you know, I have to have this.....

[@withlessAsbestos]

Hey, I used to hear that low platelets could cause irritable skin and more pain; however I have been actively told by one out of 4 hematologists that I’m making that up entirely. Is it a real thing?

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[@MedicosisPerfectionalis]

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[@aremedyproject9569]

Love this guy. He gives me some confidence in, and compassion for, my doctors!

[@addisonfearing8694]

Having ITP really sucks. I’m 14 and was diagnosed at age 7, so I’ve had it about half my life. This was an amazing description, I couldn’t have done it better! I showed it to my friend when she just wouldn’t understand and it got to her. Thanks!

[@MedicosisPerfectionalis]

Thank you 🙏

[@kieranparte8966]

I understand when I was younger I got diagnosed but I'm still doing ok we got this

[@withlessAsbestos]

I just realized I’ve had it for 75% of my life now.

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Really..افضل وأروع شرح لهذا الموضوع ..افتخر انك دكتور مصرى فاهم فى الطب لهذه الدرجه

[@MedicosisPerfectionalis]

Thank you 😊

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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Like the "medicine make sense once you understand what the flip you're talking about." Busted out laughing. Making me more motivated to learn this for my class. :P

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

You're very welcome 😊 Good luck 🍀

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@ThexEpicxKi]

I was born with this but only understood it at a basic level like bruising easily having to see the hematology and needing platelets when I got surgery as a kid so now that I'm 26 this is very informative thanks

[@MedicosisPerfectionalis]

Thank you 🙏

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U dont have spleen now?

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Im doing JR in Haematology with my minimal medical knowledge. Nobody has time to teach me, not even my consultant. Im learning alot from your videos

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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Awesome! And just a couple of weeks before my hematology exam.

[@MedicosisPerfectionalis]

Thank you :)

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Excellent!!! Should I be ashamed of learning Heme on KZbin? Not when it’s explained this well and made so relevant for us oral learners!!!!

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Brilliant! Love your teaching methods!

[@MedicosisPerfectionalis]

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Amazing! Love your videos. Impressive mastery of the subject.

[@MedicosisPerfectionalis]

Thank you 😊

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First time laughing so hard while watching medical video XD You turned the boring lecture into interesting one! Thank you !

[@MedicosisPerfectionalis]

My pleasure 😇

[@boubountobouboune5529]

Like you said, tis was the best ITP explanation in the planet!!

[@MedicosisPerfectionalis]

Thank you 🙏

[@savvymedicine9350]

It really was the best ITP video !

[@alyssab9813]

Had ITP for the first at 4 years old. Didn’t have issues again till I was 19 and had to stay in the hospital with plate levels at a 2! Go in for blood testing about once a month now :)

[@dec35]

spent a week in the hospital in January cuz my platelets levels were

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[@MedicosisPerfectionalis]

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The relief I get seeing that medicosis has a video on a topic I find difficult ❤🥺. Keep saving dreams sir❤🥺

[@MedicosisPerfectionalis]

Thank you! I am honored!

[@ABC-fv7ow]

Excellent explanation.Keep it up medicosis

[@morelostonatiuhperezmendoz9950]

Dang! It really was the best video about ITP. Also, besides the autoinmune diseases and HIV or HCV infections, i was thaught that the children frequently have a lower airway respiratory viral infecction previous to developing mild ITP.

[@MedicosisPerfectionalis]

Thank you so much 😊 You're right, viral illness comes before ITP in children.

[@AppendixVermiformis]

Like post-infectous Henoch-Schonlein purpura?

[@lroman.3939]

OMG thank you so much, i love how you explained ITP ♥

[@MedicosisPerfectionalis]

Thank you 😊

[@rubymusqan3792]

as always, wonderful videos. i really like how u repeat information from ur previous videos in the playlist until it becomes permanently embedded into the seeds of my brain. is there a video coming up on DIC?

[@MedicosisPerfectionalis]

Yes, it’s coming up! Thank you so much 😊

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@@MedicosisPerfectionalis you are the best♥️

[@MedicosisPerfectionalis]

Thank you 🙏

[@vanderhell_ke]

Had ITP since I was 8. It's in remission now. Don't have to worry about until my 50s. Good to know that people go through the same thing I did.

[@johnvincentconde3412]

What do you mean by remission?

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@@johnvincentconde3412 it means that its all good for now

[@Draya1824]

OMG this is actually the best explanation i've ever heard and seen ! THANK YOU bro

[@MedicosisPerfectionalis]

My pleasure!

[@poornimachowdary1911]

Love the way u explain so detailed and so simple!!loving to study after cing ur video

[@MedicosisPerfectionalis]

Thank you 🙏

[@phantom-quran-relaxation.1069]

indeed it is the BEST explanation of ITP. thank you so much.

[@MedicosisPerfectionalis]

Thank you 🙏

[@aditi3586]

My sister has this problem and is having multiple bruises on her body. Please pray for her 🙏

[@PatriciaSantos-qy9dl]

omg ive been waiting for this

[@MedicosisPerfectionalis]

Thank you so much :)

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Literally the best explanation for ITP on the earth 😅

[@MedicosisPerfectionalis]

Thank you 🙏

[@medisum9]

Whyyyy youuu aree sooooooo gooooooodddd🥹🥹💗 indeed the best ever explanation on the surface of earth.... Why I dont get this channel in my early medical school.... After 5 years finally i got to understand ITP TTP and that stuff crystally clear....❤

[@MedicosisPerfectionalis]

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"Who else is gonna explain to you like this, your professor? Give me a break" EXACTLY!!!!! i came here precisely because they don't freaking explain!!!! You're awesome, thank you so much ❤

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I wish I found you during my med school.Thanks a bunch..

[@MedicosisPerfectionalis]

My pleasure 😇

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wow what an explanation, loved it ❤❤

[@MedicosisPerfectionalis]

Thank you so much 😊

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I'm going to share ur lectures in different medical clg groups of Pakistan coz u deserve it inshallah I are gonna reach 1 M soon

[@MedicosisPerfectionalis]

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I am super proud that you're Egyptian I am out of speech seriously One of my favourites that You're using your voice tone incredibly well that makes me feel like i am listening to rhythm of music and stuck to my head

[@MedicosisPerfectionalis]

Thank you!

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Wow am I the only resident who is impressed !! .excellent work thanks .

[@MedicosisPerfectionalis]

Thank you 😊

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No one else can explain it like this And my professor needs your lectures Too I guess 🤣🤣 Thank you 🙏 You are awesome 😍

[@MedicosisPerfectionalis]

Thank you 😊

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It’s really the best on the face of the planet , Really thank u 🙏🏻

[@MedicosisPerfectionalis]

My pleasure 😇

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You saved my future thank you very very much 🥺

[@MedicosisPerfectionalis]

My pleasure 😇

[@bitterguard5233]

This was the best ITP explanation on the face of the earth ✌

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@Mugshot214]

I have ITP. Was diagnosed 13 years ago. This was well done and I plan to just send this video to people when they ask me to explain it. 😂

[@MedicosisPerfectionalis]

Thank you 🙏 Good luck to you!

[@Mugshot214]

@@MedicosisPerfectionalis Thank you :)

[@MedicosisPerfectionalis]

My pleasure 😇

[@kazehayaluca7966]

I wals also diagnosed with ITP last august and it was great but now I tried to have bloodtest again and my platelet drop to 50 😭

[@mochamadchairulridjal1514]

lmao I'm here for the same reason

[@daniaizzah4335]

omG i really love it when you're implementing soft medical puns during the teaching.. the laughing wakes me up haha truly a passionate professor you are

[@MedicosisPerfectionalis]

Thank you so much, Dania! I appreciate you!

[@zayneb98]

U are my hero in medicine Thank u 🥺❤️

[@ExoticxSenpai]

Came across this video today I was diagnosed with itp today wanted to get more in depth my platelets were supposed to be at 150-400 per whatever and mine are at 5

[@ektanain7400]

“Idiopathic which means we are idiots and we cannot figure out the pathology.“ “Intellectuals and their verbal virtuosity.” “I think I should stop talking.” LOVE IT! 🤣

[@whatapainx5420]

you're humour really made learning fun thank you ❤❤

[@MedicosisPerfectionalis]

My pleasure!

[@alaasarieddine4227]

i also have another question. so you mentioned that ITP is caused by autoantibodies against Gp2b/23, but on the table you showed at6:46 ITP is also caused by autoantibodies attacking Gb1b. so it could be caused by both right? thank you

[@GabbyLouis]

oh my...why i just know your channel Sir. The best explanation ever. PERFECT Prof

[@MedicosisPerfectionalis]

Thank you so much 😊

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@@MedicosisPerfectionalis 😁😁

[@MedicosisPerfectionalis]

😊😊

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Man, you are very good and even funny in a nerdy way lol

[@MedicosisPerfectionalis]

Haha 🤣 Thank you so much ☺️

[@rathodnehal2869]

you are a hero of students man 💪💪😍😍

[@rahmahl5762]

ITP has a sensitive meaning in my life as I saw a long story of it with my best friend ever and she's still suffering from it" Thanks for your video

[@MedicosisPerfectionalis]

I am sorry to hear that

[@withlessAsbestos]

Rahma Mahmouudd And in my life it means I can’t play sports.

[@mochiibonbon6700]

@@withlessAsbestos i also have itp but somehow my doctor let me keep on doing ballet

[@withlessAsbestos]

@@mochiibonbon6700 your dr. Doesn’t play by nobody else’s rules.

[@halooja4708]

Thank you sooo much your explanation is fantastic😍

[@MedicosisPerfectionalis]

My pleasure!

[@shahabuddin6149]

Super super informative lecture thanks sir a lote

[@AyazKhan-ti8xw]

Are there only anti-GPIIb/IIIa antibodies in ITP or against Ib as well? Because you mentioned autoantibodies against 2b/3a but peripheral smear MACR-thrombocytes which are in 1b disease or Bernard diseas.

[@smp1446]

Thank you for the GOOOOOOOOOOOOD video!!!

[@MedicosisPerfectionalis]

My pleasure!

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This is crazy high yield. THANKS

[@MedicosisPerfectionalis]

My pleasure 😇 Thank you so much for watching!

[@aadyajha6751]

Literally no oneeeee ,can ever explain like this 🙌🙌🥰

[@MedicosisPerfectionalis]

Thank you so much!

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I cant stop loving ur videos sir you are just amazing

[@MedicosisPerfectionalis]

Thank you so much 😊

[@jeremiahbaker6396]

I could never thank you enough

[@MedicosisPerfectionalis]

You’re always welcome 🙏

[@ajmalnazir2120]

Excellent presentation please speak slowly so that we can understand in better way again I appreciate your presentation thanks

[@janecaroline1578]

THIS HELPS ME SO MUCH THABNKYOUU

[@MedicosisPerfectionalis]

My pleasure 😇

[@luffy101n2]

Professor kindly tell me what are your reference books for hematology?? Pls plsss

[@mdam1543]

PLEASE u're amazing 🥺💕

[@MedicosisPerfectionalis]

Thank you so much 😊

[@prakashn960]

Enjoyed ❤️. Enlightening

[@MedicosisPerfectionalis]

Thank you!

[@marear1979]

I have lived with Chronic iTP for almost 20 years. This is by far the best explanation I have seen out in the world. Does iTP cause other complications such as to the liver, heart, kidneys?

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Ehlers Danlos Does, which is supposedly a correlated disorder.

[@angelanambiro4788]

Thank you for this video.

[@MedicosisPerfectionalis]

My pleasure!

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Huuuuuuge thank you from Russia, your videos are very very helpful 🙌🏻

[@MedicosisPerfectionalis]

Thank you so much 😊, Alina! And thanks for supporting me on Patreon. It means the world to me!

[@alaasarieddine4227]

i have a question, whats the difference between cranial and intracranial bleeding, cz you mentioned that in the clinical 1ry hemostasis disorders we dont have cranial bleeding but we have severe intracranial bleeding. whats the difference thank you.

[@maithilypatel104]

Me before watching the video: YYYYEEEESSSS, so excitedddd!, Me after watching the video- woww, that was lot of information explained so amazingly and interestingly( AS ALWAYS). I thought I knew about the topic before hahaah!!!! Thank you :D

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BEST VIDEO EVER. LOVE IT SOOO MUUUCH

[@MedicosisPerfectionalis]

My pleasure!

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U are my hero thank u so much 💜💜

[@MedicosisPerfectionalis]

Thank you 🙏

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You are super .. really thank you 🙏🙏

[@MedicosisPerfectionalis]

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Medicosis is so fun and savage at the same time😂😂 Love you

[@MedicosisPerfectionalis]

Thank you!

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Thanks so much for the video, O2antibodies

[@MedicosisPerfectionalis]

:)

[@javierrodrigochavezaguirre2499]

Literalmente es el mejor maestro de hemato JAJAJA, muy bueno tu video

[@ProTroll69]

Thank you for this explanation. I’ve had this for about 3 years and the doctors at the VA check my platelet count every few weeks. No talk of a cure or effective treatment besides steroids or a transfusion if they drop below 10k. Is there any way to improve immune TARGETING? A way to get the macrophages to stop eating the platelets long term without compromising immunity?

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Jesus this literally was THEE best crash course on ITP

[@MedicosisPerfectionalis]

Thank you 🙏

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you are the best! thank you!......and hilarious!

[@MedicosisPerfectionalis]

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Thank you do much!

[@MedicosisPerfectionalis]

My pleasure 😇

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Thank you so much

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[@MedicosisPerfectionalis]

Thank you ☺️

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you are the best!!!!!!! thank you

[@MedicosisPerfectionalis]

My pleasure 😇

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you are good ! It's very understanding. really appreciate your effort ! but some stuff you say are distracting in the middle of teaching.

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[@MedicosisPerfectionalis]

Thank you!

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Medocosis I love you you are a life saver thanks a billiin times

[@MedicosisPerfectionalis]

My pleasure 😇

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[@MedicosisPerfectionalis]

You’re welcome 😊

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May Allah keep you happy. ❤😊

[@MedicosisPerfectionalis]

Thank you 🙏 You too!