Thrombotic Thrombocytopenic Purpura (TTP)

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Medicosis Perfectionalis

Medicosis Perfectionalis

Күн бұрын

Пікірлер
@medic-9
@medic-9 Жыл бұрын
Love the Gordon Ramsay monologue at the end 🤣
@dayo.s2512
@dayo.s2512 3 жыл бұрын
Wow loved how you explain everything in details and you repeat the important things more than 1 time.
@Sammy.a1287
@Sammy.a1287 3 жыл бұрын
Coombs test is negative because although the IgG antibodies are present, they are not against RBC's or platelets, they are against the enzyme which breaks down vWF.
@siddharthtrivedi320
@siddharthtrivedi320 3 жыл бұрын
You made medicine super fun whilst givin proper info. Thanks . Subbed!
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Thank you 🙏
@msdreirae6401
@msdreirae6401 Жыл бұрын
OMG I love this so much! thank you. i just started working in hematology after working for years in onco and ITU. I was having a hard time making patterns and organizing my studies. this extremely helps! thank you!!!!!
@MedicosisPerfectionalis
@MedicosisPerfectionalis Жыл бұрын
You're so welcome! Would you please help me by sharing?
@jameslazib4989
@jameslazib4989 3 жыл бұрын
love the energy you're bringing hahah
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Thank you ☺️
@cjodyssey
@cjodyssey 4 жыл бұрын
9:59 "i dont care nerd" will now be my response when the attending trys to pimp me
@princevegeta5968
@princevegeta5968 3 жыл бұрын
The unique and funny way of explaining stuff and the way tough topics are broken down into easy and digestible bits are a boon to have, before exams. Keep up God's work good sir!! Left you a like❤
@oldghostbilly
@oldghostbilly Жыл бұрын
Plasmapharesis BABY!!!
@ifrahakbar2878
@ifrahakbar2878 4 жыл бұрын
the gordon ramsay bit: excellent!!
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Hehe
@PedramV
@PedramV 3 жыл бұрын
I was diagnosed with TTP a couple of weeks ago. Still in the hospital, but PEX got things in order (the last one was three days ago). This video was extremely helpful and helped me understand what's happening to me. Thank you! Btw, they suspect I might actually be one of those extremely rare cases of inherited TTP. Gotta start buying lottery tickets 😂
@PedramV
@PedramV 3 жыл бұрын
Update: ADAMTS13 Inhibitor test came back positive so at least I was getting the right treatment. And it has been working. ADAMTS13 activity is in the normal range (0.41) and platelet count has stabilized in the lower end of the normal range. So far so good!
@salamsthoughts5842
@salamsthoughts5842 2 жыл бұрын
What are ur symptoms?
@PedramV
@PedramV 2 жыл бұрын
@@salamsthoughts5842 couple of bruises on the legs, a bit of confusion, and petechiae (both legs). I was feeling unwell for a few days before all of these symptoms appeared.
@PedramV
@PedramV 2 жыл бұрын
@@salamsthoughts5842 everything has been normal after the treatment. Platelets normalized around 160 (even though they dropped to 130 for a couple of weeks) and ADAMTS13 activity has been between 0.48 and 0.79 (doing the test every month).
@sefagoktepe7090
@sefagoktepe7090 2 жыл бұрын
@@PedramV get well bro❤
@cheffinitupwithmrpossibili5623
@cheffinitupwithmrpossibili5623 Жыл бұрын
currently an img studying for my step 1 and this video gave me a much clearer understanding of TTP!
@MedicosisPerfectionalis
@MedicosisPerfectionalis Жыл бұрын
I am glad it helped! Please help me by sharing my videos with others.
@shreyaray5500
@shreyaray5500 2 жыл бұрын
Ahh this was so much fun. Where was this channel all my life!,
@timiahgallishaw1405
@timiahgallishaw1405 2 жыл бұрын
I currently have ttp but I’m fighting I will get through this !!
@MedicosisPerfectionalis
@MedicosisPerfectionalis 2 жыл бұрын
Stay strong!
@amarbhagat5798
@amarbhagat5798 2 жыл бұрын
Data - information- knowledge- wisdom great bro💥💥💥💯💯❤️
@MedicosisPerfectionalis
@MedicosisPerfectionalis 2 жыл бұрын
Thank you ☺️
@mbimbi6157
@mbimbi6157 3 жыл бұрын
The Rolls-Royce of medicine indeed. 🩸
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Thank you, Sir!
@nninnne1432
@nninnne1432 3 ай бұрын
I love you man u literally saving my life .
@drbonfire
@drbonfire 4 жыл бұрын
"you need to know what the flip you are talking about" hahaha fortunately that is the reason I am here good sir
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Thank you so much for watching 😊
@drbonfire
@drbonfire 4 жыл бұрын
@@MedicosisPerfectionalis Thank you for making the video! We have our heme/onc/cardio/renal/pulm exam coming up (yes, our deans did that 🤪) and I am about to be the biggest fan of the heme/onc playlist!!
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Good luck 🍀 to you, dear :)
@shahabuddin6149
@shahabuddin6149 3 жыл бұрын
Wow really you're all material is very conceptual,thanks sir keep it up,be happy and healthy forever
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Thank you so much 😊
@nightstar8504
@nightstar8504 4 жыл бұрын
Hello, doctor I have one question. In TTP , vWf is overly active,platelets are adhered to form a thrombosis and the number of circulated free platelets decrease. In Bernard Soulier disease vWf is normal but receptor is inactive. It doesn't adhere to form thrombosis. So,they should be circulated freely through the bloodstream .But why ,platelet number decrease instead of increasing ?
@McMedLife
@McMedLife Жыл бұрын
Great question! From my understanding, lack of GP1b also leads to the platelets being abnormally shaped in Bernard-Soulier syndrome (i.e. "Giant platelet cells") and, as you mentioned, since they are freely circulating in the bloodstream due to lack the ability for adhesion, they are also subject to shearing forces, leading to further shape irregularities. This, combined with their increased freely circulating quantity leads to detection by the immune system and hence the their destruction and clearance by the immune system.
@hello-un8gh
@hello-un8gh 11 ай бұрын
Great video! Unlike many professors you explain in a clear and simple way! In this regard, I was told that in TTP, unlike DIC, there is no hemorrhagic risk and the purpura is due to blood extravasation following endothelial damage due to ischemia caused by the formation of microthrombi. But i was wondering...Isn't poropra a result of thrombocytopenia? Furthermore, shouldn't thrombocytopenia (
@MedicosisPerfectionalis
@MedicosisPerfectionalis 11 ай бұрын
Great question! There might be a hemorrhagic risk, but it really depends on how low the platelet count. A person with a platelet count of 4,000 is a completely different story than a patient with a platelet count of 48,000. Also, we have to take the coagulation factors into consideration. Platelets usually protect us from superficial bleeding, whereas the coagulation factors protect us from deep tissue bleeding (e.g. internal bleeding). Hope that helps!
@aakankshapatel2192
@aakankshapatel2192 4 жыл бұрын
Genius Simplifying Work ✅✅✅✅
@pinkrose9594
@pinkrose9594 3 жыл бұрын
Mo Salah of medicine 🔝🔝
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Thank you ☺️
@mohamedelhadi4477
@mohamedelhadi4477 4 жыл бұрын
my new fav channel ;)
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Thank you so much 😊
@s.u.k.k.u8765
@s.u.k.k.u8765 3 жыл бұрын
I thought i will watch the pathology of TTP only and skip the rest video…but crap i got Stuck 😂😂😂 Your videos are extremely helpful n fun to watch. 🙂
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Thank you 🙏
@marzena888888
@marzena888888 3 жыл бұрын
Where do the neurologic symptoms and fever come from? I have watched the video carefully and loved it, but I don't really get the reasons for these additional symptoms
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
It’s a systemic pathophysiological process that can affect anything. Statistically, some symptoms are more common than others, but I don’t know why.
@bitterguard5233
@bitterguard5233 3 жыл бұрын
Neurological symptoms due to microembolic occlusion probably
@driffat100
@driffat100 10 ай бұрын
Very well explain which helps to memorise clear concepts for exam preparation ❤keep it up bro💯👍🙏
@nimrafaraz2549
@nimrafaraz2549 Жыл бұрын
Wow, I wish to be amazing like this medicosis guy superb🎉
@MedicosisPerfectionalis
@MedicosisPerfectionalis Жыл бұрын
Thank you so much!
@ABC-fv7ow
@ABC-fv7ow 4 жыл бұрын
Nicely explained.Since TTP is intravascular hemolysis,then why splenomegaly in it?Pls answer
@SixthKiller
@SixthKiller 4 жыл бұрын
To increase the plt count. This is no longer applicable.
@DucTapeDino
@DucTapeDino 3 жыл бұрын
Im pretty sure its because you are getting Schistocytes from the platelet microthrombi that is being formed in TTP. Its shearing the rbcs as they come along and so now that they are effected/damaged, the spleen filters them out which causes the spleen to overwork leading to work induced hyperplasia. i.e. splenomegaly.
@DucTapeDino
@DucTapeDino 3 жыл бұрын
Or it could be what SixthKiller is saying and just extramedullary hematopoesis occurring due to the loss of platelets but i dont rlly believe that since there is no hepatomegaly.
@colormekubrick2757
@colormekubrick2757 3 жыл бұрын
Hello, I just got out of the hospital after a bought with TTP. Luckily I caught it in time before it took me. I’m 44 years old. My blood counts are normal. I had about 6 sessions of plasmapheresis. Its now my second night back at home after discharge, and at night I tend to shake a little bit when lying down. Is this just my body slowly accommodating to the plasmapheresis process? I’m also on prednisone. Thank you so much.
@codrut913
@codrut913 4 жыл бұрын
This guy is funny and very good !!!
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Thank you so much 😊
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
☺️☺️
@deepakb6517
@deepakb6517 4 жыл бұрын
Fever and neurological symptoms(AMS)
@1rrrrrrrrrrr544f
@1rrrrrrrrrrr544f 2 ай бұрын
Keep it up ❤❤ But why is the quality so bad 😢
@Kamalesh_77
@Kamalesh_77 4 ай бұрын
5:25 Ribozyme is not a protien I guess
@sydalg95
@sydalg95 Жыл бұрын
9:56 😂 I had this aquired ttp as a kid about 20 yr ago just wanted to understand it a bit better for some reason this morning. It went dormant without treatment if i am recalling correctly? The doctors back then thought it was lukemia for a short period before figuring out it was TTP. Scary stuff thanks for the laugh!
@AliHamza-bz2oo
@AliHamza-bz2oo Жыл бұрын
Why fever occurs in ttp plz explain
@sathakamara1324
@sathakamara1324 2 жыл бұрын
What's with the purple cat at the end?
@stanleyigbinosa1952
@stanleyigbinosa1952 9 ай бұрын
This is medicosis, the Rolls Royce of medicine 😂❤
@Moosemoose1
@Moosemoose1 3 жыл бұрын
I have a question: if the inhibitor of the ADAMST13 gene is IgG, why isn't TTP considered an immune disorder?
@ahmedrashwan7250
@ahmedrashwan7250 3 жыл бұрын
It is actually considered immune disorder and ttt is prednisone for that cause
@Moosemoose1
@Moosemoose1 3 жыл бұрын
@@ahmedrashwan7250 ah, then what would differentiate it from ITP in that case?
@ahmedrashwan7250
@ahmedrashwan7250 3 жыл бұрын
@@Moosemoose1 I asked myself the same question and the answer is that ITP is a no platelet thing but TTP is crazy platelets the forms thrombosis every where causeing micro angiopathic hemolysis of r.b.cs and stuff like that
@Tumi_2000
@Tumi_2000 3 жыл бұрын
OMG I was so going "its 76 to 100" on the MCV😂😂
@kennedychisenga4001
@kennedychisenga4001 3 жыл бұрын
Glad I've come to know you
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Thank you! I am honored!
@AliKhan-sr1cm
@AliKhan-sr1cm 3 жыл бұрын
Keep up the great work
@DinaAwd
@DinaAwd 3 жыл бұрын
Loved it thank u so much 💖
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
My pleasure 😇
@sarayaraddad23
@sarayaraddad23 2 жыл бұрын
Amazing video 🙏🏻
@MedicosisPerfectionalis
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 🙏
@زهراءسعدمحمدصالح
@زهراءسعدمحمدصالح 3 жыл бұрын
You are amazing thank you so much ☘️🙏🏻
@afridi3dart17
@afridi3dart17 2 жыл бұрын
Hhhh as you educating others as well as you bringing smile 🙂🙂😁 also the way you are teaching wooooww and you also making question from yourself and answering too
@MedicosisPerfectionalis
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 😊
@afridi3dart17
@afridi3dart17 2 жыл бұрын
@@MedicosisPerfectionalis i was my assignment and watching many videos but at least I found it at your channel and hence completed my assignment 🙂🙂☺️ love you
@andreacanepa2560
@andreacanepa2560 3 жыл бұрын
Loved it, thanks!
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
My pleasure 😇
@dranamika3
@dranamika3 4 жыл бұрын
Fantastic man!
@hammerradiology1470
@hammerradiology1470 3 жыл бұрын
Just yesterday I saw a case of TTP from a dog bite. It escalated to sepsis and internal bleeding...the lab results and images all indicate an aquired TTP. Really interesting.
@fidelia5937
@fidelia5937 2 жыл бұрын
I have 2 boys and now my baby girl husband and I are carriers..... But no matter what science says nothing is impossible for God Doctors are always surprise how my boy body react prayers are so powerful never stop believing God is amazing and always can do miracle's TTP🔗chain breakers Philippians 4:13🙏❤ thank you Dr beautiful explained
@kitydr86
@kitydr86 8 ай бұрын
Amin
@PremiumUserUltra
@PremiumUserUltra 28 күн бұрын
Watch sugars
@FatimaBaloch-n6z
@FatimaBaloch-n6z Жыл бұрын
Amazing 😍😍
@marciadorsey3974
@marciadorsey3974 3 жыл бұрын
he cracks me up
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Thank you 😊
@mekdadhassan4282
@mekdadhassan4282 3 жыл бұрын
Amazing vedio 🌹
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Thank you 🙏
@motomoto898
@motomoto898 4 жыл бұрын
Excellent. Thank you.
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
My pleasure 😇
@roshnyjacob5493
@roshnyjacob5493 4 жыл бұрын
amazing videos. Do you talk on histopathology topics?
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Unfortunately, not yet!
@psychewadud
@psychewadud Жыл бұрын
Why there is hemolysis i could not get it. Plz help
@123456789suarez
@123456789suarez Жыл бұрын
Due to the deposition of microthrombi in the small vessels, the lumen becomes narrower. RBCs try to squeeze through the narrowed lumen....and it goes boom
@nagatsatti8426
@nagatsatti8426 3 жыл бұрын
Wonderful and excellent thank you doctor
@aytakchichak7456
@aytakchichak7456 4 жыл бұрын
marvellous...thank you
@srinivasaraosirasapalli5104
@srinivasaraosirasapalli5104 2 жыл бұрын
Excellent
@MedicosisPerfectionalis
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 🙏
@drsamkitshah6177
@drsamkitshah6177 4 жыл бұрын
Excellent!!!!!!
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Thanks 🙏
@ShilpaSharma-tf4of
@ShilpaSharma-tf4of 2 ай бұрын
Brahmi Chyawanprash for planet Ayurveda It supports almost all systems of the body. It is a purely natural product and does not contain binders, preservatives, additives, yeast, and fillers in it.
@HarteTed
@HarteTed 2 ай бұрын
178 O'Keefe Prairie
@kpot9357
@kpot9357 4 жыл бұрын
thank u, helpful video BTW in university, we were taught that schistocytes could never be an artifacts
@bellenaval784
@bellenaval784 3 жыл бұрын
hi do you have document for these?
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Hey 👋 Belle, How are you? What do you mean by “document”?
@msbzamalek
@msbzamalek Жыл бұрын
Great 👍
@MedicosisPerfectionalis
@MedicosisPerfectionalis Жыл бұрын
Thank you! Would you please help me by sharing?
@mahdi6832
@mahdi6832 Ай бұрын
nice information
@ياسمينالشام-ف3ل7ر
@ياسمينالشام-ف3ل7ر 4 жыл бұрын
amazing! thank you.. I loved it .. but if you could please speak much more slowly.. I'm getting lost sometimes 🥺
@heatherrotz3388
@heatherrotz3388 4 жыл бұрын
change the playback speed to 0.75!
@DucTapeDino
@DucTapeDino 3 жыл бұрын
Awkward Im over here wishing 3x speed was as option 😂😂😂.
@dimana1004
@dimana1004 Ай бұрын
The FFP joke is elite 😂😂😂😂😂😂omg
@mhuraic
@mhuraic 4 жыл бұрын
Why is there a fever in TTP?
@billybarker3064
@billybarker3064 4 жыл бұрын
I have TTP. 7 episodes. Not a single fever.
@sofacitysounds947
@sofacitysounds947 4 жыл бұрын
Never had a fever either. 1 episode...super severe though
@SixthKiller
@SixthKiller 4 жыл бұрын
I am with ttp and I had a massive sweating all the time. Today was my second plasmapheresis.
@rahmahl5762
@rahmahl5762 3 жыл бұрын
I don’t get the answer ☹️☹️
@rahmahl5762
@rahmahl5762 3 жыл бұрын
AKI + Thrombocytopenia? 😕
@rahmahl5762
@rahmahl5762 3 жыл бұрын
Yuppp I’ve already watched the next video It’s MAHA + thrombocytopenia 🤭
@LeeMinhoNepal
@LeeMinhoNepal 4 жыл бұрын
I want to know how you make such videos. Writing and making pictures too. always explained best.
@al-qira8596
@al-qira8596 4 жыл бұрын
Amazing Keep up journey
@roop502
@roop502 4 жыл бұрын
Wonderful!!!!!
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Thank you 🙏
@eltonfredy8558
@eltonfredy8558 4 жыл бұрын
I'm waiting for your explanation about DIC 😁😁
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Coming soon
@abdou.b3259
@abdou.b3259 6 ай бұрын
There is no fever
@mandisangema2568
@mandisangema2568 3 жыл бұрын
LOL! The Rolls Royce of Medicine
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
😂😂 It’s true 😊😊
@stellarose4854
@stellarose4854 3 жыл бұрын
My brother is in hospital with this he is only 12 please give me hope
@sydalg95
@sydalg95 Жыл бұрын
I'm 29 I had it when I was younger than your brother
@sydalg95
@sydalg95 Жыл бұрын
It rarely even crosses my mind this many years later
@SassoonCheryl-y6p
@SassoonCheryl-y6p 2 ай бұрын
Ernestina Groves
@brewedmeditation2886
@brewedmeditation2886 10 ай бұрын
Upshaw Schulman syndrome. Very difficult name for Bengali
@deepakg4623
@deepakg4623 2 жыл бұрын
My baby 5 manth old TTP
@VogtDaphne
@VogtDaphne 2 ай бұрын
2563 Krystel Mount
@kingstonfreeman9309
@kingstonfreeman9309 2 жыл бұрын
it was very scary this is sierous
@chrisa.8032
@chrisa.8032 Ай бұрын
Medicosis - The Rolls-Royce of Medicine
@GretchenTurbyfill-f5w
@GretchenTurbyfill-f5w 2 ай бұрын
Vandervort Summit
@sonysanaka6056
@sonysanaka6056 2 жыл бұрын
Hello telugu lo explain chIagalaru
@udithaudumulla1139
@udithaudumulla1139 3 жыл бұрын
So funny ..thank you ❤️
@shamisomushayi1486
@shamisomushayi1486 3 жыл бұрын
Rolce Roy's medicine
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
😊😊😊
@mohammedimam2412
@mohammedimam2412 4 жыл бұрын
Can u make an Arabic translate for your videos?
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
I would love to, but it will take so much time. Sorry!
@doc1780
@doc1780 4 жыл бұрын
Fever and no bloody diarrhea !
@abdirahmangulled8128
@abdirahmangulled8128 2 жыл бұрын
You're goated 😂
@MedicosisPerfectionalis
@MedicosisPerfectionalis 2 жыл бұрын
What does that mean?! 😅
@drvivekpratap
@drvivekpratap Жыл бұрын
Gr8
@MedicosisPerfectionalis
@MedicosisPerfectionalis Жыл бұрын
Thank you!
@IvethFonsecaop-x5z
@IvethFonsecaop-x5z 3 ай бұрын
Perez Patricia Lee Sandra Lee Barbara
@Yottifferent
@Yottifferent 3 жыл бұрын
Here bc J Dilla died from this
@jamalimurtaza6527
@jamalimurtaza6527 4 жыл бұрын
@WalkerVirgil-i6q
@WalkerVirgil-i6q 3 ай бұрын
Young Patricia Harris Frank Lewis Matthew
@douglasthescottishtwin3989
@douglasthescottishtwin3989 2 жыл бұрын
Tehrik-i-Taliban Pakistan is TTP
@grmnsmith145
@grmnsmith145 2 жыл бұрын
My mom died from this
@MedicosisPerfectionalis
@MedicosisPerfectionalis 2 жыл бұрын
I am so sorry!
@denniswebster3519
@denniswebster3519 3 ай бұрын
Young Susan Robinson George Perez Kenneth
@ЮлияШеина-с4д
@ЮлияШеина-с4д 4 жыл бұрын
AKI & MAHA?🙈
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Nope
@ЮлияШеина-с4д
@ЮлияШеина-с4д 4 жыл бұрын
😁How come?!
@ЮлияШеина-с4д
@ЮлияШеина-с4д 4 жыл бұрын
Thrombocytopenia is too nonspecific, it is present in HELLP and DIC. The last two criteria (fever & mental status changes) do not work for HUS, only for TTP...
@toufytaylorsversion8700
@toufytaylorsversion8700 4 жыл бұрын
you are so fast slow down a bit
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Got it...Thanks!
@ebisinecarlmaristobi8842
@ebisinecarlmaristobi8842 Жыл бұрын
Hello, your teaching is really nice but you talk really fast it would be nice to tone down your pace. Thank you
@PhoenixRising-21
@PhoenixRising-21 Жыл бұрын
Slow down with explanation
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