Genetic Engineering and Diseases - Gene Drive & Malaria

[@kurzgesagt]

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[@dldez8590]

Can you please fix your atom in the intro?! Its supposed to have two electrons on its first orbital not four

[@xwater1361]

👍

[@turkuas23626]

@@dldez8590 thanks Einstein

[@Nugcon]

only 42 likes wow

[@rejjaq7627]

What if plasmodium develops resistance against the antibodies?

[@YMS]

I'm okay with eradicating mosquitoes.

[@Stalast.]

Sup

[@dylanbreheny4359]

Don't mind me, just another commenter with no Subscribers passing through--- Wait, what are YOU doing here?! At the bottom of the comment section, no less!

[@mahatmaghabdu7592]

i should have assumed a educated man like you watches kurzegesagt

[@Petrico94]

It'll be next to impossible and besides not all mosquitoes even suck blood. Plus other animals eat them so we'd need to get more flies to replace them or everything is fucked

[@DeineLieblingsvideos]

Seeing this comment excited me more than the fact that Brad Pitt and Angelina Jolie broke up.

[@CdeCiencia]

Since the biggest problem with modified mosquitoes could be the parasite adapting to become stronger, couldn't we test its interaction in the lab on a reduced scale and then proceed if there was no adaptation?

[@imveryangryitsnotbutter]

Sure, but we'd have to make abso-fucking-lutely certain that the test population is completely sealed in.

[@DrawCuriosity]

One of my friends is starting cutting edge research on Wolbachia very soon, hopefully in December we will have a video on this :) they have done tests with very positive results

[@architrungta120]

*reduced scale*. That's the problem.

[@danilooliveira6580]

they know the parasite can adapt. the problem is how fast the imune population will spread and how fast the parasite will adapt. its like a roulette, you can make a estimation, but there is no way to be sure. maybe the numbers will say that the estimate time of the imune population become dominant is higher than the probability of the parasite mutate, but then the improbable happen and one single parasite end up adapting just before the old population is eradicated and suddenly all effort is in vain

[@DrawCuriosity]

I commented before watching to the end, I automatically assumed this was about Wolbachia which is going to be a groundbreaking bacteria which lives in many insects and can be engineered to stop the spread of zika and malaria :)

[@70jcarbon]

Malaria too OP for game, must be nerfed/banned. - Immune System

[@erikjohnson315]

But the admin(human) are too busy

[@DavidAllen-px7gr]

Fortunately, one of the players has found the console. (Dropping the joke, at least humans found C.R.I.S.P.R. & CAS9) [Edit removed ambiguity]

[@zaoralj]

70jcarbon thats called overwatch nerfing XD

[@catrinasmith5366]

David Allen said he is only provide any service or the trash container itself it was her first day on the phone fighting with Westgate shopping mall and the best part he wearing it like Now Wal-Mart shut down for the other families such a tragedy for me the pic of the other illusion that was given but most illusion of course you have to show it to the next level and I know it but you continue loving it up tonight or tomorrow night with the correct names and stuff like the orange 58 chairs for you have become 8th and chairs sometime.

[@katraena5225]

God: -Buffed Immune System

[@swiftycortex]

"Imagine that, killing someone from their inside, and then using their skin as camouflage. Brutal!" Imagine that, sharing scientific information with love, and highlighting the horrific. Contagious! Thank you Kurgesagt, every video I have watched has been a concise, informative, and joyous piece of art, which I have loved watching equally as much as it's made with love.

[@arvt_]

they stole my tatics bro

[@NguyenMinh792]

a wolf in a sheep’s clothing

[@magicman8166]

I love this channel, i wish school was like this...

[@magicman8166]

Really good visuals and brief but acknowledging facts!

[@aphoticlight]

Yep

[@Kollynator]

Tell me how they change the DNA then....

[@pvic6959]

mainly i _LOVE_ the visuals. they can even make a boring lecture fun

[@astodone9022]

If school was like this I'm pretty sure everyone would become an Einstein but the government doesn't give a shit.

[@sahilbaxi]

Coming here after the news of genetically modified mosquitoes being released in Florida, and it suddenly makes more sense

[@muratakpinar9094]

For real? Great news

[@ayasya.]

what happened sorry ive been hiding in cave im confused

[@kornelfarkas6224]

@@ayasya. same, never heard about it , but i'm happy about it

[@yoavboaz1078]

wait really?

[@Lumberjack_king]

What I haven't heard about this. I hope this is a good thing and it doesn't back fire final last words sorry I had to

[@puggumpus]

Living in Africa, as a young kid, I've heard of malaria once, and every single time I've gotten a mosquito bite, I was getting ready for death...luckily those preparations were never used

[@Jensenrobinb]

Phew

[@puggumpus]

@@Jensenrobinb ikr

[@bluejacket4429]

Funny enough, I lived in Africa when I was a kid due to my parents being missionaries. I got Malaria once, and that was probably the most miserable week of my life as I felt terrible just standing up, and vomiting was frequent. Though as you can see, I'm not dead, so I suppose that's good. Though a missionary lady that I knew passed away because of Malaria. Personally I wouldn't use the Gene modification for mosquitos though.

[@fernandorobinson8272]

@@bluejacket4429 why not? You don't want others to avoid the terrible experience you had?

[@bluejacket4429]

@@fernandorobinson8272 It's terrible, yes. But it's avoidable and survivable. It's hard to do either of those in a 3rd world country, but it isn't the only solution. Gene modification is the easy way out, and one of the biggest impacts it'll have is on the food chain. A lot of animals need mosquitoes for food, and I don't know how well they'd do without them.

[@lunawazhere]

It's now 2023, and I am very pleased to inform this video that genetic mosquito engineering has been a success in many countries, and I have visited one called "Singapore". This country uses Project Wolbachia, a name they came up with for a project, in which they released thousands of genetically modified male mosquitoes into the surroundings to mate with female mosquitoes and produce harmless offspring. Some versions of the modified mosquitoes completely block off the birth of female mosquitoes by killing them even before they turn into adults. As a result, more male mosquitoes are hatching than female mosquitoes and dengue cases in Singapore are going down rapidly. I am proud of this country and every country in the world that has tried this genetic mosquito project. This might just be what we all need to overcome malaria, dengue, zika and many other diseases mosquitoes have brought horror upon in this world.

[@stressed_vivi]

You've given me a cause to believe in humanity thank you.

[@onlyms4693]

Sheeshh... W Singapore, let's hope Malaysia and Indonesia do the same

[@doggommm6963]

​@@onlyms4693Malaysia actually did this too, though not the whole Malaysia, mostly KL

[@y_fam_goeglyd]

Fantastic news! Thank you 😊

[@Destragond]

I don't understand the "the modified mosquitos die before turning into adults" part. If the modified mosquitos are more likely to die, aren't they just gonna die out and be replaced by normal ones? Like the video says, you don't really want them to die, you want them to spread as much as possible and dominate the species.

[@kurzgesagt]

You can get the MUSIC of this video (and of all the other ones) here: soundcloud: bit.ly/2cJQIsk bandcamp: bit.ly/2dj4np0 www.epic-mountain.com

[@RadioRin]

oi

[@mabeI]

Mm love ya kurzgesagt

[@stealth_pool8780]

as always grate video

[@aparnapandey6537]

newww videoooo thanks

[@sashataylor6171]

Hope you hit three million soon ;)

[@leinadlink]

I think it should be tested first in an enclosed enviroment to see how the mosquitoes develop and evaluate it's effectiveness. We want to help those affected by that terrible virus, but we don't want to make a mistake that could create a bigger problem.

[@rockets-dont-makegood-toas7728]

true true

[@djr5995]

Good point. By doing so they could get a clearer idea about how fast the trait gets passed on and how long it will take to change the whole population

[@bigbluebuttonman1137]

Yes, I had the same exact idea in mind.

[@rancidmarshmallow4468]

the problem is that an "enclosed environment" large enough to properly model it would be huge, costly, take years, and possibly not be accurate because of the lack of other factors like actual humans to bite (and use to spread the disease) among other things. (you can't put humans in there because they would die. putting this here because inevitably somebody will say "well then just put those other factors in")

[@sasuke2910]

I've sure that's been done countless times by now. What we don't know is how this stuff works when it's released into the open environment.

[@aidanrozema8522]

I did my health fair project on malaria, inspired by this. I got an A+ so thank you.

[@PsychonautTV]

Congratulations! Nice work!

[@erek]

Congratulations!

[@PhoebeJaneway]

Good job! Bet your teachers didn't know that this is already researched! I didn't have a clue and I'm a biology teacher. But I'm definitely going to teach my kids about that. Sooooo interesting!

[@erek]

@@PhoebeJaneway Yes, you should definitely teach students these things. I hate teachers because they are just teaching boring things. I learn more from youtube than books/teachers.

[@PhoebeJaneway]

@@erek But on the other hand: some things are boring and STILL have to be learned like maths, history and politics, a foreign language and some basics in chemistry. Life isn't (oh what's the English term) a "Wunschkonzert" .....ah, there's no English idiom like that....So: Life in our modern world isn't always about what you want. And that's a lesson teachers should teach their students and thus make them strong for this world, don't you think?

[@natileroxs5226]

As someone with beta thalassemia, I'm not too worried about contracting malaria. but the rest of the symptoms aren't exactly a great trade-off even with a mild version

[@smiley5836]

what that

[@AlOqab_]

@@smiley5836 cuz thalassemia/ sickle cell anemia gives u somehow an Immunity to malaria

[@di_bortz]

@@AlOqab_ bc of the shape of the blood cells the malaria cant hide itself

[@PoaTB87]

@@AlOqab_ Not complete immunity, but it does help prevent the parasite from mass replicating. People with sickle cells of any type still have healthy red blood cells circulating in their bodies (those organs still need oxygen to function), but finding a healthy red blood cell that can host it long enough to replicate is the challenge the parasite faces. But OP is right. The trade off isn't worth it. Especially if they live in an environment where malaria isn't prevalent.

[@rorocash1376]

I think people tend to forget that Kurzgesagt makes a simplified explanation of the issue. Which is awesome but also it means that before we completely agree or disagree, we should be educating ourselves more. Kurzgesagt is awesome because it makes you interested in the topic but it's just a beginner's conversation. You should research more into it and think critically about the situation, pros and cons of both sides before joining an agenda.

[@ienigmaz8495]

agreed

[@Banoffeenyx]

Yah

[@marclikesmoths]

That CRISPR sword was highkey aesthetic

[@namelessguy199]

Need a skin of that in csgo

[@WAZZA1235]

I guess gene editing is a....double edged sw- ok i'm out.

[@silvertheelf]

AlliedExplore, kill all misquotes, effect all organisms, all organisms die because no misquotes, barley any organisms die because of misquotes, they are so popular they are a prime food source for many organisms, but it’s malaria we need to wipe out.

[@growaplant]

How do i give all my money to the investigations so they will kill Malaria ;-; I'm sure that they van kill it but they don't have money :(

[@notaweeb4177]

Did you say, *A E S T H E T I C*

[@grande1899]

So I guess my hatred for mosquitoes is justified.

[@ServrHax]

Weird finding you here xD

[@yanjia1777]

hi grande!

[@angeloanan]

Why are you here lol.

[@mattstorm360]

it's not there fault.

[@occult14]

yup same here

[@oslopaper5538]

Our recent lesson in biology was genetic engineering and the timing of this video popping out couldn't be more perfect. Great video as always!

[@theCodyReeder]

If I could post links I would post one to the Shia Lebuff motivational speach.

[@cowbones6864]

"Just Do It!"

[@danhatman3538]

How about precious metal refining #15. Mosquitoes to dust

[@jholotanbest2688]

Damm you are real :O

[@axel_d]

JUST DO IT! Happened in my head when I saw this so yeah same here.

[@Creationsofmyown]

youtube. com/ watch?v=ZXsQAXx_ao0

[@-hitman-9103]

The immune system really needs a buff in the next update

[@adorablecheetah2930]

You are from that animal channel right

[@KalleVonEi]

Tierzoo knows how this engine works

[@badgerous8320]

the update is under development the video just said that

[@anunayy]

The game is supposed to be challenging tho, else there will be no fun, and in any case the "Modern Medicine" exploit is too OP anyway.

[@neonicplays]

Anunay ikr humans are becoming too end game

[@James33498]

Everytime I watch Kurzgesagt's video, it feels as if I'm watching a movie.

[@joshuapeters567]

I feel that way too

[@ScibbieGames]

James Lupei the production is high quality indeed

[@jeanicehoffing8935]

Every time I watch a Kurzgesagt video, I feel like I have to rethink a lot of my views and ethics

[@jum8082]

@Paddy Lawn that is like the opposite of school

[@nooneofconsequence5847]

These videos help to remind that the professionals and experts do really consider all the possibilities along with consequences in science.

[@dorian1370]

Yes the consequence was a laboratory made virus in 2020 made with gene altering technologies witch are promoted in many videos of Kurzgesagt. It is called : GAIN OF FUNCTION RESEARCH.

[@fish6550]

“Imagine that! Killing someone from the inside and using their skin for camouflage!” *Laughs in leather jacket*

[@haztetv7226]

@Mohammad Al Arab You can do it for military purpous, like colour it for camo in military. So yea you're just a sand dumbass

[@paryudisaditya8845]

@ i wish you know

[@frog8878]

@ dumbass

[@Syphrilyn]

Well at least you dont use it as camflouge, also you can say the same thing for fur coats except some don't kill the animal and only try to get the fur of the animal.

[@BB-uo1qy]

Are you calling yourself a cow?

[@williamsledge3151]

Now that I think of it, using CRISPR to change the genes of a creature is the biological equivalent of making a mod for a game.

[@alessandroceloria]

Mosquito v2.13.45 + Added 3 different sizes + Mosquito can now be coloured + 30% more annoying - Removed malaria

[@squishy_boi2524]

XD

[@TakingThisWay]

And it can always come with unwanted glitches.

[@williamsledge3151]

@@TakingThisWay very true

[@cadunkus]

And you can never uninstall the mod.

[@yes4612]

Kurzgesagt: about 5 kids have died since this video started Murderer: *watches video multiple times*

[@user-zg4dx2sw3y]

Makes sense to me 👍

[@Monarch_Prime]

Makes sense

[@xxmarblesodaxx9798]

-_________-

[@aidanhays8348]

100% plausible

[@goldensupmanz]

[sad dead meme noises]

[@masupalami33]

I contracted malaria in utero (thanks mum), it was obviously untreatable at the time. The doctors in Papua New Guinea treated mum with tetracycline which gave me grey teeth. Throughout my life I’ve suffered relapsing malaria symptoms and liver problems. Luckily, as an Australian, I’ve access to excellent free public health care. There are so many who don’t. I wouldn’t wish this disease on anyone.

[@bertbuschbertbusch]

Hey Kurzgesagt, almost 5 years passed, could you do an update video on this please? Dankeschön :)

[@yukinaproductions5647]

Fun fact: Biontech, the company which invented the covid vaccine Cominarty in cooperation with Pfizer, announced that they will try to develope a Malaria Vaccine with the help of MRNA Technology.

[@blazingfish8486]

I think they are being released in some places

[@amberblyledge7859]

I did not know that was how that was spelled. German is so confusing sometimes.

[@almostcertainlynotapotato6528]

Dankeschön: Thank you very much, Thank you. Translated from German

[@cejuonline]

@@yukinaproductions5647 the zombie apocalypse is upon us my friend

[@triciaf61]

can we get a video on why your voice is so amazing?

[@natanaelkristian1342]

Daniel A Freeman I just came here like 5 minute ago and already have orgasm.

[@rohanagrawal6132]

ikr

[@rickmcbigbolt808]

IKR he kinda sounds like Morgan Freeman

[@nathanfrench1551]

Daniel A Freeman yay

[@ebolapie]

+Rick McBigbolt I don't think he sounds like Morgan Freeman, but he does sound amazing in his own way. For one, MF has an American accent :D

[@bananaraptor7747]

5:15 Damn, those fleas are *menacing*

[@R9000]

If this sort of thing becomes common, are we going to get video game-like patches for planet earth? "X species is becoming endangered because it doesn't readily produce enough offspring." "Oh don't worry, that'll be fixed in patch 2.6.7 beta. I heard they're nerfing mosquitoes too, people have been complaining their 'disease attack' was a bit too OP."

[@BamseTheBear]

you are terrible

[@SUPERSamuraiGaming]

come the fuck on

[@R9000]

What's up man?

[@SUPERSamuraiGaming]

ceiling man.

[@metcas]

Would make sense if we're destined for Type-1 civilization.

[@ArcKlight]

I am still laughing by reading that bloodlust and cuteness of a mosquito is unharmed

[@futuregmchess1561]

Cuteness lol it looks hideous

[@Anonymouse0538]

Lol same hahahahaha

[@micaelgarcia8532]

Well, their bloodlust is pretty important for the survival of the species, and cuteness may affect how they distinguish between species, so although it is funny, they are two important factors that shouldn't be messed with!

[@saileshnaidu8102]

@@micaelgarcia8532 cuteness LOL, they are HIDIOUS no matter which angle you see them with

[@micaelgarcia8532]

@@saileshnaidu8102 Well, who said their cuteness levels were positive? they just remain unchanged :P

[@Bibky]

Mario says: This technology could be used for dangerous purposes, if used unethically or in a incorrect matter it could present many new problems to our ecosystem, it might turn out worse for the people we’re trying to protect. Luigi says: If he can fly he can die!

[@thebigpew]

Oh boy! It was nice of the princess to invite us to have spaghetti!

[@arpithasr128]

thats why we have biosafety commitee to look after it..and to select which is good for all of us and nature

[@bernardogouvea]

Hello, even if used for this purpose has some danger. This has to be applied together with the education of the population, especially those living in tropical forests. For the planet's population is increasing even with fatal diseases. Without them people have to know how to use contraceptive methods. Otherwise the population will grow at a faster rate.

[@bernardogouvea]

and poorventry will raise among the world

[@big_joe_8478]

sont you mean malario lmao

[@ShannonBlasick]

These videos always make me feel smart 😊

[@jackozbloke5079]

Only the scientists that understand this can truly debate the topic as they know 1000 time more than the average person on this subject and all possibilities.

[@Jan-vw5cg]

Where's the fun in that tho?

[@davidknight3920]

EXACTLY! I've read up about CRISPR, but my input should never have any real weight on the debate to use or not use it. Only qualified (let me repeat that, QUALIFIED) scientists should decide. I say that because there's a lot of bad science going on out there (check John Oliver's report on scientific research).

[@Squidward558]

I have to disagree. Scientists used to universally agree on some very stupid and harmful things, and many still do. I think that anyone should be able to debate these topics as long as they bring valid criticism to the table. This technology is going to effect everybody on the planet at some point or another.

[@seriouslywittygaming6471]

agreed with Yewtub, Scientists will think like scientists, if they are going to fuck up the world, let everyone get involved in a debate, because earth belongs to us all and whatever results occur, it will effect everyone

[@crimsoncount8215]

I feel like it will go the same way as antibiotics if we use it where we are met with a threat of a constantly changing threat so we try to stop but it just keeps changing to survive the changes

[@kmuturi238]

Malaria almost took me as a when I was 9, the symptoms developed so fast in a matter of hours I moved from having a mild fever and headache to hallucinating and having convulsions 🤢

[@KanyeTheGayFish69]

@Raedits I can think of a lot of diseases far worse than malaria

[@marykapodistria7204]

As someone who almost died from malaria and just caught it at the comma stage , I think we should use these genetic engineered mosquitoes

[@e-deternaldatabase4721]

Congratulations you are safe from coronavirus now

[@Drealmers]

They fear if the gene go wrong and it can't not be reverse back again

[@busicals9015]

it the gene goes wrong, let us sing a song. we will dieeee from zombies. and then everything WILL be screwed up.

[@nattybird1146]

F, and its been so long since this video was made, its most likely been tested for bad side affects, they should use it, if karen doesnt make a facebook blog so bad that it stops it, FUCK KARENS, and i havent had any bad disease or virus before, but i know its really bad because even common diseases are horrid, so i hope you have recovered well

[@ahall9839]

As someone who has died from malaria, I second this

[@Coreykoon]

I literally have malaria as I’m watching this. Release. The. Mosquitoes.

[@xannax2050]

This video ACTUALLY made me smarter. Actually, this whole CHANNEL makes me smarter.

[@drxgium2340]

watch crash course.

[@dcs3395]

You should have known all of this

[@xannax2050]

yeah, I just started today!

[@dcs3395]

Fuckin' know right

[@patrickgrey7894]

I agree, me too

[@aj7092]

I’ve done lab research at the University of Arizona on this exact subject area. It looks to be very very promising, but it’s a tool that people are extremely afraid of unfortunately.

[@15243james]

Aj Aguilar For good reason, Id say. Never before has the wheel of progress spun so fast, its unknown territory, and the unknown is frightening.

[@norhamimiyusof9546]

Paronoid people.....😧

[@vishwaeshu9566]

Zelo Avarosa Humans have artificially select Ed species for millennia nothing happened. There is a very good system in place with multi staged trail programs.

[@disposabledishsoap6520]

Also we can fuck this up by accident which can unintentionally kill thousands.

[@lucaskelley3418]

HAS ANYONE WATCHED MARVEL AGENTS OF SHIELD... If you did than you can see what happens when you mess with the genetic code of shit (BOOM DEAD)

[@orphans3089]

not only does these videos get me intrigued but they also teach me stuff that my school doesnt even know and that all of this is free is just so cool

[@nithen8179]

Can we just appreciate how their animation has improved over the years

[@adamzhafri6677]

That genetic sword be looking hella dope

[@HelloTher1313]

In Spanish, the suffix -ito means small, so a genetically modified mosquito that grew to a gigantic size would be called... EL MOSCO

[@arcangelonmagus4239]

Emmm. Noup. Mexican here. El mosco exist. Is a regular fly. You mean "El Moscote"

[@arcangelonmagus4239]

"ito" "o" "ote"

[@HelloTher1313]

@@arcangelonmagus4239 oh OK, well then, I guess my Spanish is getting a little rusty lol

[@nomellameshomerollamamehomer]

@@HelloTher1313 don't worry, he said mexican spanish, than it's so different from Spanish, "mosco" it's a good joke for a person from Spain, because we don't have that word, there's one so similar "mosca" in English "fly(insect)"

[@HelloTher1313]

@@nomellameshomerollamamehomer oh, I guess my Spanish isn't that bad then 😀 thanks for telling me, I forgot how much the different versions of Spanish vary lol, I learned the version most common in Spain

[@Violeta.zake8323]

Who on earth dislikes a free, entertaining and educationcal video? That's like giving a restaraunt where you don't have to pay for food 1 star.

[@GESTOPTKANAALDJARO]

my minecraft parody with 770 views has more dislikes (this video 21 my video has 23)

[@BuildMineSurvive]

yea there's a reason for that. this channel has a team of pros.

[@SmashupPvper]

Their finger slipped. KZbin should really leave some space between rating buttons.

[@MrAntieMatter]

Actually I did accidentally dislike the video, good thing I came back an hour to look at the comments, right?

[@mpw4c]

Its like giving a free restaraunt 1 star despite the food being good. Haters gonna hate. Potatoes gonna potate

[@Kam5]

Just leaving a comment here to say that I'm re-watching your videos all these years later because we're doing topics that you've covered in my senior biology class and without your videos I would be failing this class. tysm!

[@Mishcaferraz]

*mosquito bites me* Me: *searches in google* how can I bite a mosquito back

[@vrv3088]

Good idea

[@guramritpalsingh6778]

Hahaha

[@fz_de]

This man ate a mosquito to “retrieve” his blood

[@bobsempletank1222]

**No try search in English**

[@EquatorialPike]

Uno reverse card

[@drcrow5767]

We can make every other animal extinct, but we can’t do it to the mosquitoes? COME ON HUMANS, THIS IS OUR SPECIALTY!

[@colin-kun3611]

Ikr

[@agentc7020]

Well but what if we create a super mosquitoe by mistake, would you want that?

[@warbirdgaming8091]

@@agentc7020t would be easier to kill.

[@oatmeal7818]

I think the same. Lot of ethics for mosquitos but we have killeds billion of other inocents animals

[@m.j.v.4463]

Well, in fact we can.

[@cosmiccrab]

Imagine whoever owned the bird that got eaten from the inside and was used as camouflage

[@clementdef]

you can decide that your bird gets killed horribly in a video, most expensive stuff on the patreon

[@orange993]

@@clementdef lol

[@asola5811]

Insane

[@jonny_codphilo7809]

what?

[@AllmightyGigachad]

It was probably John Bird Gacy

[@Davisnacho]

Use it. It is simple risk vs reward. The potential to save millions versus the potential of the virus adapting and edit not working is a no brained.

[@sebastianpoppenborg6850]

I always get goosebumps when you say 5 People died of Malaria since the video started.

[@geilerhengst6892]

pussy

[@pilzening2810]

Goosebumps of happyness?

[@geilerhengst6892]

Mitglied der Pilzarmee oh yeah maybe

[@antonioetv]

Its sexually arousing

[@moddy252]

?

[@vrmpyr]

"Cuteness- unharmed" Oh thank god! I tought we were gonna get ugly mosquitos up in here

[@chennancy8822]

catvee lol

[@tdub6542]

right

[@rollypolly1557]

Wait, they count as cute?

[@andreww5]

but they r cute

[@bakedgoldfish45]

catvee Mosquitoes. Check the spelling

[@raivinbarker]

I’m sitting here, staring at my mosquito bites, very worried.

[@SDLocke]

Same lol

[@rosietano8810]

Rest In Peace XD

[@cooperfreeman9102]

Checking in a month later, did you die? XD

[@JONAHcrBL4CKDR4GON]

o3o snake? Q3Q SNNNNAAAAAKKKKKEEEEE!!!

[@ghxst5595]

Bro u ok?

[@Lowkeykindabi]

Bro!!! I am living in Africa and lets say I get malaria like every two months since when I was six I would get really sick😪.......now I am 12 and my immune systems are stronger to malaria and still living!!!! Thanks immune systems😊

[@Lowkeykindabi]

Don't forget vaccines

[@dorian1370]

No need for gene altering technologies.

[@Anonymous-gu4te]

Imagine that, killing someone from the inside and using their skin for camouflage, brutal! Laughs in animal skin camouflage

[@maguyonseanlewis7696]

Mr. Jellyfish *laughs in leather boots*

[@cristianolaboureur5999]

@@maguyonseanlewis7696 lmao😆😆🤣

[@tannermurphy2444]

Mr. Jellyfish mate i do that all the time but the main point of it is to not waste eat the meat use the skin and waste as little as possible.

[@russophile9874]

You don't kill animals from the inside.

[@lancer7447]

Laughs in FnAF 5 language

[@thatdragondrawer6572]

I love this channel. They don’t try to scare you, they just give you the facts and the tell you why it is or is not a problem.

[@guhanathreya981]

ok

[@victoryaaron5264]

Ikr

[@QUBIQUBED]

They scare you and then say “nah it won’t happen lol”

[@thatdragondrawer6572]

@@QUBIQUBED Exactly😂

[@Mr.Armada]

@@QUBIQUBED True😂😂

[@PsychonautTV]

Me: *smiles in class* Teacher: what's so funny? Me: nothing. Brain: *_ELON MUSKEETO_*

[@eve_avery]

They're electric. The wings are solar panels.

[@tempest031]

🤣

[@rubellite4480]

wow

[@akasakasvault7597]

Omg

[@tohrubo]

Does this mean elon musk's dream come true?

[@ElTwOJaY]

As an employee of the Umbrella corporation I can say that genetic engineering of viruses is the future 😀

[@lenvos]

Just do it!

[@dailydose8172]

baguette

[@cheekysteak5238]

Moldy baguette

[@Name-ul8es]

'let your dream come true.'

[@papervalley_9918]

what if we did it wrong and made something far worse??

[@ivopopov6661]

yesterday you said tomorrow

[@seansaldevia721]

You are really an Adobe Illustrator God

[@Hunterrion]

After Effects*

[@soup3583]

Overkill Rengar they're 12 but ok

[@lidulkadut]

what?

[@Ida-xe8pg]

this technology is 6 years old why haven`t we still used it yet

[@roanbone1810]

because of the plasmodials that malaria uses other helpful bacteria use plasmodials and the mosquitos today transmit the plasmodials to other animals that have bacteria cultures in them that use them in ways we dont understand, making a mosquito that cant transmit them could impact the environment in ways we cant discern yet

[@ahmadbintahir1562]

3 people died while watching this video... I hope none dies when I watch this the next time.

[@Whydoineedahandlepissoff]

I hope more do

[@ahmadbintahir1562]

-.-

[@memedruglord472]

I hope both of you do next time you watch a video from malaria

[@Deathmachine513]

I hope I do.

[@ahmadbintahir1562]

Hhhh. Negativity.

[@Tyron-yy9yy]

aftermath: malaria evolve:"stupid humans we can evolve" phages:"remember us?'

[@user-by7gk4nn7v]

How can people dislike a Kurzgesagt video?? how can you find fault in their videos? who are these people?!?! mosquitos?

[@hawkecrail5186]

Although I don't, I see why. TheY have different opinions than the kurzgesagt team

[@MegaMGstudios]

people who hate genetic modification

[@awesomeman3750]

Parents/Religious people who believe that vaccines cause autism.

[@arjunmodi1729]

People who held their phones upside down

[@1footflash]

mosquitoes hated this vid.

[@Nico-nt4id]

Only those who can understand gene editing like scientists and other intellectual people should have a say, for if we're going to trust this into the hands of politicians, they'll probably make the wrong decision

[@Tachizuu]

Nicolo John B. David well said!

[@vassalofthenight9945]

Nicolo John B. David indeed. Politicians do things that give them recognition and popularity, not things that are wise and right. The decision should be made by non-sided commission of the best scientists who know the topic, messing with nature is risky.

[@karinwestscott7822]

Nicolo John B. David No shit sherlock

[@peacefulinvasion]

Agreed. What the fuck does trump know about genetic modification?

[@htoodoh5770]

Terezi Pyrope Agreed.

[@Derpsider]

so the mosquito is one of Our Deadliest Enemies? well then, I just killed one of them on the wall and will call myself from now on a *WAR HERO*

[@ImperiaGin]

If you get malaria would you have ptsd also ?

[@nonenothingnull]

I wonder if we could differ the genetic modified from regular

[@bassiroucamara5711]

Thank you for your service!

[@PacoCotero1221]

TRIGGERED

[@stefanilserbo2]

In the second world war, they didnt call you a hero if you killed one nazi because there were millions of them... when your kill counter goes over 1 billion, then we'll call you a hero ;)

[@CRAZYBOT9371]

In 2021 there was 617,000 deaths from malaria which is 1717.8 deaths a day or 71.5 deaths an hour which also equals over 1 death a minute and this possibly could have been prevented

[@thewatchingchurch8687]

I want that sword.

[@TexelGuy]

It could be a great kurzgesagt mascot. Like the master sword.

[@K.azanti]

It's a DNA sword or something

[@diebananaface]

it's the legendary gene slicer. You need a logic skill of 90 or over and level 50 or over to even equip it!

[@kitsuko810]

It's not an ordinary sword it's excalibur. Only the king can wields it.

[@argenteus8314]

It looks like Fierce Deity's sword.

[@c.b.7153]

it’s a me *_malario_*

[@elias7858]

Facking hell good one

[@doggoslayer5679]

Country roads itsa meeeeeeee MARIOOOOO

[@silvertheelf]

Lol

[@starly3846]

Best pun I’ve ever seen

[@10ksubswithnovidschallenge78]

Lol

[@mo5h3rman]

Just build a wall and make the mosquitoes pay for it.

[@greaterspirit4033]

the rate of sarcasm is too high..😂

[@LordyNateur]

Mosquitoes don't have jobs. How are they supposed to pay for a wall?

[@TheRisingDzn]

its sarcasm u know?

[@Eddy-nn7wj]

They have jobs! We work to get money --> to make a living, buy food, home.. They work to get the living literally, by gaining life essence as their custom.

[@user-vp6cn4kb2t]

They evolve to steal wallets!!!

[@thvariableyt]

First Ever Animation Channel I Have Seen That Upload Their Vids In 60 FPS :)

[@oliverholm3973]

I say we test it in an isolated, manmade system first. That should reveal the majority of any unforseen consequences.

[@rhyzvanic3660]

Huh... Building an underground ecosystem does seem not like a terrible idea... But it would be silly expensive and there would be a slight chance of unintended escape if people are not careful.

[@jaskbi]

finally a smart comment, but in this case i think it should run for 3-5 years, and introduce a multitude of different viruses to see how the new genetically mosquitos react. Also i think you would need all types of live stock to see what happens to them when bitten.

[@minimash2485]

Oh no, a hundred mosquitos have a 1% chance to escape into a world full of billions of them.

[@rattrap1985]

Actually... They have already tested it. That's where he got his numbers from. I remember the papers from a while back that they were really surprised when 95% of the mosquitoes took the gene when it should have not been possible.

[@divyhsingh6385]

That is a very good comment, but then again they will have to spend an extraordinary amount of money to make this happen. And, I'm pretty sure politics will get in the way.

[@EMPBossHacks]

this needs to be a TV show

[@thorr18BEM]

It is a TV show.

[@squid_cake]

EMP Boss Really? What channel?

[@jacksonheaberlin6051]

EMP Boss I agree

[@stargirlgamer1315]

EMP Boss this helps me learn while TV is just a distraction to me.

[@zepwafels]

Who watches TV now that we have internet?

[@blumer9615]

Honestly, if my teachers showed kurzgesagt in class I'd be way more excited to go to school.

[@KyleAnderson-gh9rp]

Then ask them to

[@UnframedAnimation]

tbh

[@zacharymagnuson2147]

Frixon same

[@Jarnt8]

Mine did, it makes no difference...

[@intelbentium1204]

mine showed the measles video.

[@Krunchier]

5:52 "oh god a muto?" MAN THAT GODZILLA REFFERECE JUST HIT. PERFECT

[@rainbowalbinohyena6804]

I thought I was the only one who noticed, lol!

[@brendanb4361]

We should use CRISPR to save the bees so we don't all fucking die

[@ricksanchez8081]

how do you think we should do that?

[@aviinthepast]

Same reason of how we are eradicating mosquitos well eradicating the diseases Mosquitos spread. But I don't know if when someone is given CRISPR it's genetic. That's my only question

[@ricksanchez8081]

not why,what could we alter to help the bees?

[@Deathmachine513]

Make the bees more resistant to pesticides that are currently killing them?

[@ricksanchez8081]

i don't think you can just flip a switch in their DNA or add something like that the only i see them building a resistance to that stuff is by evolving by themselves but im not a scientist im a student that's training to be a doctor behind a screen with a keyboard and im not too caught up on the subject of DNA

[@Florian_TB]

"Is malaria bad enough to risk it" Everyone: *YES*

[@akshaysodhi_1044]

@@freelanserns187 so when are you getting your family infected? for humanity.

[@freelanserns187]

@@akshaysodhi_1044 un called for

[@freelanserns187]

@@akshaysodhi_1044 I'm just saying that without disease the population will go out of control

[@olska9498]

@@freelanserns187 so let's close hospitals, I guess? Maybe additionally let's ban soap and disinfectants so that our population won't go out of control. What about some famines now and then? Great idea!

[@freelanserns187]

@@olska9498 I'm not saying any of that and for your information i fully support vaccination ether by law or other means we need to keep the population under control because if we don't malaria or not we will all die

[@igoral3035]

CRISPR is like mods, if you install it it might glitch or get corrupted, tho you can't unistall or patch it.

[@illegal.argument]

you can patch it but still there are people who refuse to update, in this case mosquitoes

[@barrylyndon5552]

Yeah but if the game is Malaria: A mosquito story then who cares if we screw up the game no one wants to play

[@welcometothestream8860]

You can delete mods,they just leave lag in the game.

[@gustafstrom9091]

@@barrylyndon5552 I suppose the fear is something worse will happen, or at least bad but uneccessary because it was avoidable.

[@newworldmusic9008]

Yall are taking crispr tech too lightly. Theres a reason why they are taking long. Editing genes can have unintended consequences, so much so that instead of malaria, we get a whole new disease which is not curable. A little thing such as this can wipe out humanity. Hence why, it is not used readily. There are lots of amazing thing u can do with it. For ex, making babies who are resistant to hiv virus. But again, every action has a reaction. And till we learn that, its sensible to not use it.

[@enderking_13]

I like how slowly, we are figuring out how to bend the world around us. Instead of adapting to new conditions, we make those conditions into what we are used to, since adapting takes longer. If we keep at a pace of advancing like we currently have(and we probably won’t it should get faster) then probably in the next 10,000 years we can bend reality itself.

[@joanagomes9272]

That DNA sword is just the cutest thing!

[@Masterwolfman001]

"The public discussion is way behind the technology in this case." So leave the public out of the decision. The people who know what they are doing should be the ones who have a say in if it's done or not, not people who don't understand a word of what's being talked about and just have an opinion for the sake of having an opinion.

[@AndDiracisHisProphet]

While this is elitist af, i am tempted to agree with you on this one.

[@Masterwolfman001]

Under normal circumstances I would not have said something like this. I do believe that the public has a right to voice their opinions but when it's a stupid opinion based on no facts and only speculation then they shouldn't be aloud to hinder progress by complaining about something they know nothing about.

[@FoxiestDuck]

Only have to take the vaccine public discussion as evidence, that normal people will believe incorrect facts given by a celebrity. The poor scientists that work hard to make a difference and they just get shit on, because their studies don't seem important to the general populace.

[@ryanlewis4953]

While a part of me is inclined to agree that the people who know the most should be in charge. We are talking about modification of a species on a global scale. This has ethical concerns beyond wiping out malaria as the question also arises, where is the line where we stop?. Which is why a public discussion needs to happen. You don't need to know the technical details of how CRISPER works to have an opinion on the ethics. A small section of society that works in labs should not be able to make decisions that have ramifications that affect not just us, but the planet itself.

[@windwaker0rules]

Masterwolfman i guess you like Nazi policy then, go Hitler, plus for all we know malaria is a huge part of the ecosystem, and killing them off would cause something catastrophic to happen.

[@NCONestor]

The first minute was so much epic! Science is cool! :D

[@sceerane8662]

what?

[@onose10000]

He said the first minute was so much epic! science is cool! smiley face.

[@NoReplyAsset]

Jeez Crispy-an....why you got a be such a killjoy? It's not a crime to be enthusiastic about something.

[@passerby4507]

6:10 That's not how heads are supposed to turn.

[@peterhuwe8709]

lol

[@TheKrensada]

Speak for yourself.

[@coldsobanoodle7407]

Crispr the master sword of the genetic warfare against mosquitos

[@coldsobanoodle7407]

and other insect transmitted disease

[@rekouanehichem9653]

against parasites :'( those poor mosquitos didn't ask for it :c

[@StochomackTheEbonyEagle]

Name of a new Call of Duty lol

[@wanderingrandomer]

More like the Fierce Deity's sword.

[@themoagoddess1820]

+WanderingRandomer you've put it best(even if you were just joking about the shape), Crispr is not the/a sword of evil's bane, but rather a dramatically powerful tool however it might be used.

[@Bluezerg]

We YEETO THOSE SKEETOS

[@-AGGRESIVEPEANUT-]

yeetus mosquitus

[@wishfulwoomy9159]

The best comment.

[@gallex9571]

Mosquito Mosqyeeto

[@proballyuselessacc1966]

YEETO DEM MOSYEETOS

[@proballyuselessacc1966]

Yeetos mosyeetos

[@CT--gs1wj]

Mosquitoes don't kill humans, viruses do. Mosquito is insect of peace. #MosquitoLivesMatter #MosquitoesAreMisunderstood

[@sylviaxx3574]

Exactly. This video represents the changing of mosquitoes but not actually harming them.

[@johnmotherfuckincoltrane1242]

#Mosquitoesisareligionofpeace

[@TaraZaraChara]

#mosquitosarefuckingannoyingandicanthaveamomentspeaceoutsidewithoutthembitingmeforcingmetogobackinside

[@DavidAllen-px7gr]

Exactly, mosquitoes don't kill anyone, only their pathogenic payload does. The only kind of person this would hurt would be someone who can't make additional blood, which would always result in a miscarriage anyway.

[@Tylernal]

All religons are "religons of peace." No religions are peaceful. If there are super insane followers of any religon, they will do harm. (Islam just has the most insane people)

[@Inosuke_HashibiraYTT]

He made it sound so majestic and scary “THE MIGHTY..mosquito :>”

[@Qureas]

I want a DNA sword in a RPG!

[@squartron2473]

why not Terraria? It would fit perfectly

[@hennyzoel7062]

Jørn Haugum well screw it i want it in real life of curse

[@shaisai6798]

You'd know what would be cool if that happens? What if it has a chance to change (insert enemy monster here) in some way? ex. giving it the ability to inflict you with some sort of fire-damage, or another ex: making its attack lower

[@shivaprakash4717]

lol

[@brandonvelde5774]

The sword will work like this, whenever you hit an enemy you would gain +5 points of health back. And if you'd got 5 kills with it you would be able to heal you and your friends to full hp.

[@jasonshen7600]

Something: goes after humans Humans: uno reverse

[@Bennahr_Fett]

Mosquitos: Draw x12,345,353,500 bitch

[@jasonshen7600]

@@Bennahr_Fett lol

[@bluehouse2093]

Mom, get the CRISPR! WE'RE GONNA SAVE THE WORLD!!

[@L5940]

You know that virusses will always adapt to us right? They've been on the earth far longer.

[@robertrosenthal7264]

Sorry, but incorrect. This video isn't about viruses, so that's a different subject. Also, the vast majority of viruses are not adapted for humans, thus we don't get infected by them, and unless you're a veterinarian, or someone other profession that works a lot with animals, especially sick ones, you won't notice it much. There are entire families of viruses that only attack bacteria. Then it is true that some viruses are very quick to mutate, one obvious example is the influenza virus, but even then, we are slowly figuring out how to target the parts of them that don't and can't mutate like that. If a parasites reservoir species can be made immune before it can find a way around the immunity, it becomes extinct as it no longer has a viable environment to reproduce in.

[@Josephine.T.Rogers]

XD

[@margaritakouzi5630]

Robert Rosenthal I think I'm da only one who read that whole reply

[@rebirthedo5]

Gaming ninjaxxx693 I read it too -_-

[@blue_ice4]

trust me, if you ever got a fever, your body did a great job on noticing it

[@kevin135683]

To be honest, I think that having the anti-malaria mosquitoes would be one of the greatest things humans have ever done, since malaria can only be harmful to us. So if it's only harmful to us, why not get rid off it? It'd be better for us, and possibly other species as well.

[@Berek71182]

We are already "modding" other creatures. Look what we have done to the dogs! Zynical speaking: Genetic Engieniereng is just the next step.

[@jackg.3060]

yay!! space.................. wait what are we talking about?

[@serpentsword_3689]

I blame religion - "god says we can't tamper with nature" fuck that! SAVE THE CHILDREN

[@nivozee]

Who doesn't

[@juveriasaba3418]

LETS DO IT!!!!

[@anotherbencultmember9125]

why would anyone dislike this?

[@lostsoul0417]

A Wild One Punch Man fan has appeared! Because people are strange creatures.

[@copernicusepoch]

Sjws that know nothing about the subject "UUUUUUU PLAYING GOD IS WRONG!!!1!1!" "UAAAAAA YOU SHOULDN'T MESS WITH STUFF LIKE THIS! I NEED A GLUTEN-FREE VANILLA BEAN LATTE TO HELP ME FORGET THIS!" the type of people that, if there was a vaccine for cancer, proved by scientists to be 100% safe, they wouldn't let their children get it because they're so fucking sure that it will give their special little snowflake autism. That type of person.

[@jannaweber3257]

Conservative God-botherers are way more likely to oppose it. Because it's interfering with God's plan, don'tcha know?

[@MsKimchheng]

so a big scale mosquito killing is right??

[@Harisgok]

the same reason anyone subscribes to jp

[@ebinmemes2298]

i think screw it, we set off the first nuke expecting it to crack the crust of the earth, as long as this stuff is used carefully it can be the greatest tool ever invented.

[@duskyracer8800]

just because one thing didnt kill us all doesnt mean something else we dont understand wont

[@Potentialiser]

that's why Mitchell noted "as long as this stuff is used carefully"

[@ebinmemes2298]

i think if we don't try we'll never know. we don't stop using hammers because they can be used to bash someone's head in, and we don't stop using scissors because you can stab someone with them. with great reward comes great risk, of course, and no corners should be cut, but this could be to genetic engineering as the combustion engine was to transportation

[@theporcupine9993]

+Mitchell Anthony the question is not wether we should try it or not. the question is when shoukd we use it and is it ready to use, is more research needed ? the fact that we already set off a nuke is a bad argument and false reasoning. its nog because bad things happened we should continue doing things recklessly.

[@miklosgergelymorandini2340]

Your parallel examples fall short in the nature that using a hammer or a nuke is a one time event. Whereas if we introduce this new genome to the genepool it will be self-replicating, and expanding. And we cannot know for sure WHAT will happen exactly.

[@aryanasmith4426]

I extremely like the video, man. Very helpful and informative. Thank you very much. It is presented so well too. Great, positive work.

[@lopan1698]

Human K/D ratio not high enough on leaderboards *DOWNLODE KRIZPER H4X* !! Nature: WTF Man. Man: _LOL GETGOOD NUB_

[@devilhunterdante9197]

LMAO 🤣 🤣

[@darkphoenixgaming8253]

Bruh

[@thegodzillafandomsrookie5514]

Kaiser Ghidorah

[@jakoblindh4932]

There are two recent lectures on how to design gene-drives and their respective traits, they are phenotypically reversable, the exact sequence is not. The lectures are labeled "Kevin Esvelt (MIT) 1: Gene Drive" and "Kevin Esvelt (MIT) 2: Gene Drive and Local Drive" here on KZbin

[@jesuscastillo6951]

Mosquito: used 200 millions of years of experience Humans: use command block for banned

[@noodboy4633]

human: /kill @e [Type=malaria]

[@tausiftaha12]

@@noodboy4633 /kill @a (if we nuke stuff)

[@noodboy4633]

why

[@andrewe2875]

Old video but still relevant, thankyou! Is the sword in the animation a reference to Excalibur? If so, I find it very appropriate.

[@aliciabaumgartner1406]

This needs to become an international discussion, and fast. This kind of technology could have disastrous consequences if used carelessly. Who has the right to modify nature in this way? We all need to agree on the rules of the game before this technology is used. (Edit, since people are mistaking my question for an argument: "Who SHOULD have the right to alter global ecosystems")

[@davidwebb4755]

An international board of zoology that's completely transparent should be the ones who should wield this power.

[@BrightOut]

I want to end malaria as much as the next guy, but we need to get hyper-vigilant about possible great-filter technologies that might wipe us out or destroy our will to live.

[@sheltonburnadeski5946]

If you don't support the extinction of mosquitoes, then fuck you.

[@invernomuto7550]

the next president of the US will be born when TV wasn't yet of common use and can hardly use a computer... I wouldn't count on them to understand the issue

[@jackwallace7091]

World super powers already be growing mega soldiers in jars. HEIL PEPE MEMES YOLO SWAG

[@NAME494]

CRISPR is the future, and you can't stop the future

[@NoveskeYT]

You know little about the consequences, you should really look at the pros and cons. Plus, I'm sure you the only source of knowledge you have about it is from the channel's videos.

[@NAME494]

space travel, electricity, nuclear bombs, someone will invent it, you can't do nothing

[@person800]

+NAME494 Nukes are the future too. Should we be working to increase nuclear proliferation?

[@NAME494]

Sean Lang You don't understand... I don't talk to nuclear bombs number, I talk about nuclear bomb as invention

[@Thekilleroftanks]

and if we die so do you...

[@burritotorpedo7772]

This is what I say say when I see a mosquito M’laria * tips hat *

[@Mr-ji2im]

Don't tip the hat too far... a man once did so and it wasnt pretty. A black hole erupted, the 2nd purge began and the pilgrims were resurrected. Lets just say that the tipping of hats is a risk not worth taking.

[@toneblocc]

*_oh_*

[@Mr-ji2im]

@@toneblocc abraham lincoln the CEO of microsoft was the first victim...

[@msdiomara]

XDD

[@Connorly800]

totally will support on patreon just to have a birb