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A Teenage Girl's Incurable Cancer is Cured
A teenage girl Alyssa with an incurable leukemia was given a 3 base edited CAR-T cell intervention. Six months after she has no signs of cancer any more. Let's look at the technology and its application.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Thursday, Dec. 15 2022
Base editing: Revolutionary therapy clears girl's incurable cancer - BBC News
www.bbc.com/news/health-63859184
'Living drug' offers hope to terminal blood cancer patients - BBC News
www.bbc.com/news/health-48706822
CAR T cell - Wikipedia
en.wikipedia.org/wiki/CAR_T_cell
Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma | NEJM
www.nejm.org/doi/10.1056/NEJM...
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage | Nature
www.nature.com/articles/natur...
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage | Nature
www.nature.com/articles/natur...
GOSH delivers world-first treatment for Leukaemia | Base editing and CAR T-cell Therapy | Great Ormond Street Hospital | Great Ormond Street Hospital
www.gosh.nhs.uk/news/gosh-pat...
David R. Liu on Twitter: "Alyssa, a 13-year old T-cell leukemia (ALL) patient in the UK, was the first person to receive a base editing therapeutic-T cells with three base edits-and the first patient reported to benefit from base editing: complete remission, 6 months later. 1/3 t.co/CgL6mD6U7B" / Twitter
/ 1601770994070597632
CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets - PubMed
pubmed.ncbi.nlm.nih.gov/12594...
CD19 - Wikipedia
en.wikipedia.org/wiki/CD19
Pathogenesis and prognostication in acute lymphoblastic leukemia - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
CAR T Cells: Engineering Immune Cells to Treat Cancer - NCI
www.cancer.gov/about-cancer/t...
Causes of Death in Childhood Acute Lymphoblastic Leukemia at Hue Central Hospital for 10 Years (2008-2018) - PMC
www.ncbi.nlm.nih.gov/pmc/arti....
Chimeric antigen receptor CAR Technique - Creative Biolabs (Updated Version) - KZbin
• Chimeric antigen recep...
Costimulation in unmodified T cells and within chimeric antigen... | Download Scientific Diagram
www.researchgate.net/figure/C...
Cytotoxic T cell - Wikipedia
en.wikipedia.org/wiki/Cytotox...