Inflammatory reactions (LIRs) to hyaluronic acid (HA) filler injections - Video abstract [ID 312198]

Video abstract of an original research "Immediate nor delayed type hypersensitivity plays a role in late inflammatory reactions after hyaluronic acid filler injections" published in the open access journal Clinical, Cosmetic and Investigational Dermatology by Tom Decates, Jonathan Kadouch, Peter Velthuis et al.
Purpose: The exact etiology of late inflammatory reactions (LIRs) to hyaluronic acid (HA) fillers is currently unknown. Some argue that these result from a hypersensitivity reaction, although evidence to support this is very scarce. Most reports on such reactions are not substantiated by positive skin tests. The purpose of our study was to determine whether immediate or delayed type hypersensitivity reaction follows hyaluronic acid (HA) filler injections.
Patients and Methods: Twelve patients were referred for general allergic screening (patch tests), as well as specific intradermal testing (injection of 0.1cc boluses) on the medial upper arm with a selection of several currently available hyaluronic acid (HA) fillers on the market. A positive allergic reaction was defined as erythema, firmness or swelling.
Results: During the 4 month follow-up, no reactions to any of the tested HA fillers were reported. No correlation was found between results from the general allergic screening and a history with LIRs to HA fillers.
Conclusion: The results suggest that neither type I nor type IV hypersensitivity plays a role in late inflammatory reactions (LIRs) to hyaluronic acid (HA) fillers.
Read the full paper here: www.dovepress....

[@shughy1]

I had hyaluronic acid injection in my ankle 3 days ago and it's been agony ever since, feels like a fresh sprain it's so bad , edit: now nearly 3 weeks since and it has been a terrible experience, but I hear it works good for most people, it left me in agony though so be careful who you use, I was at a hospital in Belfast, it took 2 weeks for the pain to subside and even now I can only walk for about half an hour

[@aprilcloyce7426]

It’s been 3 weeks and my body itches and stomach cramps. I got filler in my chin voluma and something else. I had filler before and no problem. A yr ago I had nerve injury from microneedling radio frequency

[@Shine_095]

How to treat this? Does it go away by itself? Do u take antibiotics, inflammatory meds? When do u know u have to dissolve it?

[@annipsy2185]

yeah this wasnt complete at all

[@deniztekin8317]

@@annipsy2185 did you find a way to treat it?

[@ketogenicvegan4970]

They would use Corticosteroids and or Lisinopril 5-10mg. Basically fillers start to break down within 3- 5 months. Delayed onset reaction is thought to occur because of catabolism of the filler which generates short chain, low molecular weight hyaluronic acid molecules which causes an immunological reaction attracting inflammatory cells, T lymphocytes & macrophages that cause these inflammatory changes. These environments have also been reported to contain high concentrations of angiotensin converting enzyme (ACE ) II molecules. The high levels of ACE II stimulate inflammation still further inciting an immunological reaction that results in the swelling,

[@akankshasingh4072]

​@khow does it go tell this etogenicvegan4970

[@RowOfMushyTiT]

I had HA in my PP. Got inflamed and then HA was degraded/gone within a week. It's supposed to last 12 months.

[@anytractorman]

I got a hyluronic acid shot in my knee it has been in pain and swelling ever since. 3 weeks now.

[@sanamb6502]

I had my collagen injection on my face 5 months ago and it was all good, now I have different structure like swallowing on my corner of my check like a long line has deviated my cheek down to my face and it has bring up the lines in the corner of my eyes wich I never had I think it’s over all kinda swollen underneath my skin and makes my lines more visible. I have to include that before the injection like a month before I had nose job and tooth implants May be that did effected I really want to put it all together or help the research 🔬 I don’t like what I fell and see it’s not much invisible but I see it.

[@pnevlud]

What do you do about migrated 8 year old filler Restyle to be exact. I do have hashimotos but controlled by synthroid Tried twice dissolving it. No luck 😢