Is THIS the NEXT BIG THING in Skincare?

[@mrmvianna]

Congratulations! I am a 48-year-old perimenopausal woman, a scientist, and a cell biology professor. You did an amazing job analyzing data, scientific bias, and commenting on important and limiting aspects of topic treatments (passing through the skin layers and basal membrane and stability)! I subscribe to your channel and have not seen your videos for a while, but today this one showed up (after I watched the one about retirement). Please keep doing this! This was truly great and I am sure it took a lot of time and dedication, so thank you!

[@tracymiddleton8580]

This video also showed up on my feed after I watched the retirement video.

[@pola.3068]

Same for me!

[@paulachristie7807]

I am sticking with Tretinoin, an antioxidant serum, and a moisturizer with peptides. At 73 I’m going to embrace my wrinkles as proving I’ve had a life well lived.

[@joycebenvenuti4782]

Me too … just turned 70 ,I’m beyond fine lines and I’m happy with the Tretinoin and all my serums .

[@beth8678]

Me too at 63 😊

[@elizabethmyers1328]

Same. 66 here. Loving my skin and happy with it. Retinol, antioxidant serum, peptide moisturizer, sunscreen. Weekly AHA peel. That's it.

[@melissavidic2895]

@@joycebenvenuti4782 Same at 59 I’ll stick with my retinaldehyde, Peptide night cream and my serums.

[@evabothwell454]

​@@elizabethmyers1328what antioxidant do you use? & moisturizer w/ peptides thank you 😊

[@aprilwichman98]

I tried both Skin Medica and Neocutis and they didn’t do a thing to improve my skin. Do not waste your hard earned money. I’m 58 and am constantly getting compliments. I use products from Neutrogena, Cosrx, the Ordinary, and Timeless. They do a better job to keep my skin balanced and healthy and they don’t break the bank!

[@danielmusca9930]

What do you use from timeless. Wa Ted to try vitamin c

[@helenorgarycrevonis2022]

Thank you

[@kam0406]

CosRX is the real deal! Korean skin care and sunscreens have improved my sensitive skin. It’s too bad the useless FDA won’t approve the Korean filters here. I really think Korean sunscreens might put the American brands out of business.

[@karenfarrell6158]

Ingredients are too toxic

[@phyllisaugustyn7963]

TNS essential serum and neo cutis eye serum worked miracles for my skin, be your own judge.

[@lorainemcgillivray77]

Hi Angie I was a Registered Nurse for many years and won’t buy growth factors either. The possibility of proliferation of skin cancer cells in the human bioengineered stuff is a big no and plant based - well I am not a plant 😂. I have rosacea and eczema so my skin barrier is chronically impaired therefore I use a lot of caution when choosing skin care. My rosacea hates retinoids during true menopause (I could use them carefully prior to becoming fully menopausal), but I believe in their efficacy as a topical treatment. My active of choice is azelaic acid- it has made the biggest difference in how my skin looks. Obviously I use spf and as I live in the UK use ultrasun or Evy with their more longwear modern filters (ultrasun is available on prescription for skin cancer patients btw). Niacinamide is nice, my skin absolutely hates vitamin C and peptides are hydrating😂. There is no miracle cure for aging and I personally am happy to have lived long enough to even worry about it. I was involved in cancer nursing for many of the years spent in that profession and trust me not everyone lives long enough to worry about aging/wrinkling. I want calm, hydrated and moisturised skin but just embrace the signs of aging as a life lived. My smile lines are far more prominent than frown lines so it is a reflection of that life on my face. I am not however on camera on social media with all the pressure about how I look that entails, so no judgement etc. I do think procedures will have a far more obvious impact than anything topical, so for those buying 300$ serums saving that money towards a procedure may get you better results. Best wishes x

[@Cinnamon349]

Have you tried over the counter butt paste for rosacea? Like desitine? Works!

[@halfamo2422]

Yes, here for the azelaic acid - makes huge difference to pigmentation (the only thing I really want to get rid of) - and niacinamide (my 66 y o skin was parched, nothing worked, until I discovered it, funnily enough in Cerave) Retinal works well, but so does a 1x week fruit enzyme peel. And why IS vitamin c so problematic - I sweat that was what wrecked my skin barrier and started off kp! Growth factors are such a half-understood science - def not going there.

[@user-xc7iq4cm8t]

@@halfamo2422- what tyoe of enzyme peel?

[@reesesha2289]

Agreed 100 %, past oncology nurse here too!

[@paulgillespie8813]

Totally agree about vit c! Rosacea is such a pain. I'll try the A acid you mention.

[@Lil-Be]

I am an esthetician and I wish we had teachers like you at school. They knew nothing compared to you. Great video Angie! 💕

[@heidifisk2830]

Angie - this is the perfect example of the type of video I enjoy. I love it when you go full on nerd and give the absolute truth of skin care products. This is saving your viewers a lot of time and money. Well done. 👍

[@catharinecowan4514]

Frantically waving nerd flag - excellent job!! You basically did a PhD thesis literature review in this video! Scientific research isn’t perfect but you consistently provide excellent summaries of ALL the data, good and bad, with enough nuance for folks to make their own choices. Nuance is sorely lacking in media these days, and I deeply appreciate your work and contribution. I’m sure these videos don’t perform as well as others, but please don’t stop making them!!!

[@adria89]

These are my favorite type of video that Angie makes.

[@KJB0001]

Yes!! Most of her OG videos were QUITE technical

[@Fiesty-1]

Blue is your color! It softens your blonde and makes your eyes pop. You look beautiful.

[@marilynshapiro516]

So glad or did this video, I did try the skinmedica advanced my skin felt smooth but when it Ran out I used Kiel’s hyraulonic serum which also felt smooth for much less money, will not buy growth factor serums again. Thanks again for this video

[@nancymccormick7567]

Agree!! Angie looks especially beautiful today!

[@mam564]

I'm guessing that Angie used blue or purple shampoo to soften her hair color. It really works!

[@skyeblu1722]

She looks good in anything she wears!

[@margieryne6220]

Hi, Angie, you are starting to sound like a scientist, you really dug in deep! Thank you for all your hard work, I appreciate all you do for us! Have a great weekend!❤️

[@AngieHotandFlashy]

I didn't know if I'd find my way back from that rabbit hole!! lol 😆 It was fascinating!

[@margieryne6220]

@@AngieHotandFlashy 😂❤️

[@guadelot]

Her dad is a scientist ❤❤❤

[@jann3443]

Angie is her father's daughter for sure!! I love that.

[@CherylBerryl]

Well, her Dad IS an actual Scientist, so, as they say, "little apples don't fall far from the trees!" Lol.

[@axisgirlvaughn7446]

As others have requested, I am eagerly awaiting your in depth review of estrogen cream for your face (estriol or estradiol?).

[@AngieHotandFlashy]

That video will come out in December.

[@jeanlrollins5901]

I hope you will address whether HRT might affect the efficacy of topical hormonal therapy…. Thanks for all you do Angie! Love your content.

[@axisgirlvaughn7446]

Thank you. I am sure I am not alone in looking forward to this

[@KingKikikoi]

@@AngieHotandFlashyhave you checked out dr Abs video of testosterone cream? For women too. He’s brought out compelling research and doing it himself, also he said oestrogen isn’t that great for anti aging compared to testosterone.

[@user-xc7iq4cm8t]

Yes !! I’m wondering if HRT is worth it at 61.

[@kam0406]

I just went to a funeral for a friend who was only 52. She was a nurse practitioner, in the Air Force, a wonderful wife, mother , daughter, sister and friend to all. She leaves behind two beautiful boys who are college age. All I can think of right now is that aging is a blessing. Looking good is great, but what Heather would not have traded to still be here with her boys and husbands, family and friends!

[@baharscorner8842]

May your friend rest in peace. I totally agree with you on what you say.

[@Canuckbelgo]

I'm very sorry for the loss of your friend. Ugh, 52. My younger sister is 53. May I ask what was the cause of her passing ?

[@CarrieAnn72]

I lost my best friend too she was just 50! So sorry for ur loss. When major things like that happen it puts things in a different perspective. ❤😢

[@rd7726]

Aging meaning getting older is a blessing but some of us don't enjoy the outer signs and wants to slow down the outer effects of aging.

[@User-2cents]

My brother has away at 55. Pancreatic cancer.

[@deborahbinnie5652]

Thank you for the scientific deep dive. You really did your homework. I'll stick to retinol, sun screen and peptides.

[@AngieHotandFlashy]

Me too!

[@amielynn2657]

What is a good peptide?

[@janekraft1359]

I'm 71 an have used tretinoin since early 40s. I'm workout, take supplements I don't look 20, but I look good for my age. Stem cells creep me out. Used for growing other body parts.

[@lindagoldman2351]

Angie, I have been watching you ever since you practiced your make up techniques on your then husband (funny video). Speaking as a person with a medical background, I am very impressed with the depth of your “deep dive” into this study. You are without a doubt, one of the most trusted and respected influencers on KZbin. Thank you for that.

[@deniseavt]

Yay now your videos are showing up after watching the retirement one. Do NOT retire please 🙏🏻

[@svetlanaanthony2675]

Neither Skin Medica nor Neocutis, used for at least a year, did anything for my skin. I also tried it with microneedling. Not worth the money in my opinion. Tretinoin, occasional microneedling, and Omnilux mask worked and continue to work. People ask me what do I do to get a glass-like skin at 52. Don't need expensive skincare, need consistency and appropriate for the age ingredients. Great video, Angie!

[@LisaNix2]

Thanks so much Angie! I asked for this video from you months ago, so I appreciate all your research to help me understand this. My dermatologist told me not to use Growth Factors because I’ve had melanoma skin cancer in the past. I think this is important for people to understand.

[@lightseeker108]

Thanks, Angie. This is a great example of why you have so many fans for your channel. You could just tell us buy this and get a little commission, but you’re basically giving us the information to determine which things are effective and which things are a waste of money and we appreciate you for that. I too come back to your basic recommendations of agency tretinoin, timeless vitamin C (Effective and affordable ), Omnilux red light skin mask, and your common sense when it comes to saving money on things like moisturizers if you’re getting your active ingredients elsewhere.

[@sherylbeamer7189]

~THANK YOU ANGIE!~ I tried the TNS $280 gf serum a few years ago, took before and after pics and NOTHING! No improvement whatsoever, it was throwing hard earned money down the drain. I so appreciate your analysis of the statistics and data. It’s interesting how very small the study sample sizes are🤓🧐. As always excellent video!💕👏🏻🙏🏼🌷

[@MischiefManaged-c5k]

Not what I expected! I’m glad I watched to the end bc I almost skipped straight to the links you shared to buy something you were sharing in the description box 😱 NO WAY will I be adding a pre-existing-skin-cancer-developer into my skincare routine 😳 (Maybe adjust the title to this one?) Love you AHF!! And thank you for your research! You’re my hero ❤

[@mermaid4122]

Thank you for the scientific study. Angie, your brilliant and gorgeous! I have missed seeing your uploads for a long while. I just thought you went to another platform until your last upload. Thrilled your videos are in my feed again :)

[@anniezion]

I've been using "Bioeffect" Egf serum (a brand from Iceland, using a patented egf ingredient) for some years now during winter time. (live in Scandinavia with dry cold air) I haven't notice any revolutionary results in terms of younger skin more than from the tretinoin I use. I will say though, the capacity to keep moisture in skin and keep dryness at bay, then the Egf is outstanding. I can have the most dry flaky skin, and if I put it on at night, I wake up with soft, moisturized skin that arent dry anymore. And it only requires a tiny drop from the serum, it's potent in that way.

[@mariannezehler1760]

I totally agree - I love Bioeffect EGF Serum!

[@tracymiddleton8580]

Growth Factors …..and Stem Cells are the rage now! Excellent relevant subject matter! (Appears to me KZbin wants to keep you active!). This is my second pop up of one of your videos today. I am so happy I saw this one!

[@user-ij5ek4qw9i]

Thanks Angie, we so needed that debunking, because at 78, it is tempting to try the next miracle cream. I have also been using Tretinoin for a few years with positive results, but I find my skin has gotten super dry no matter how emollient the creams are. I have chosen to reduce my use to no more than 3 times a week and it has really helped. My skin is looking a lot healthier and plumper. Thanks again

[@denisemishkel7473]

You just saved me tons of money .. I had used the TNS as well and was always questioning the results . We appreciate you so much !!❤

[@NowIknow-c3c]

I used Neogenesis Recovery for over a year and saw no changes at all.

[@platinum11110]

Thank you, it's so difficult to find opinions!

[@Alykat736]

I was recommended that product over the skin medica TNS . Thank you for sharing your experience. I’m sticking with the TNS for now . I’ve seen ppl who use it religiously and there skin looks younger than there age . Bc of its cost (with even its crummy pump dispenser) I just don’t spend money on other products, it covers all my skins needs -except for sunblock and retin a which I still Purchase , but both those are very affordable lol

[@user-xc7iq4cm8t]

@@Alykat736 - so you use Retin A and the other product?

[@maureenturk8578]

Same thing for me with TNS. My dermatologist recommended it - I used it - didn’t see a difference.

[@rambotheragdoll8940]

I stopped using growth factors after using it for 5 years. The skin cancer experts are concerned that the skin growth factor’s will grow both the healthy and the cancerous cells.

[@SugarPuffAndFluff]

Hi sis, great video. I have been looking into EGF for a while and have been using EGF serum(from human stem cells) for over a month now and I can't see any significant difference, maybe if you looked under a microscope lol. I have heard that using it with microneedling might be more effective. I am giving up on finding a miracle cure we are all going to get old and wrinkly eventually 🤣🤣Love ya xoxo Nisha

[@dvanhottie]

I’ve been to scared to try after reading somewhere it could accelerate skin cancer.

[@ldelre7439]

So basically growth factors don’t work and they are mainly just humectants? WOW so good to know. I’m going to start saving some $$ ❤

[@christinemangan7642]

Right? I have one on subscription and am canceling now!

[@renejohnson37]

Thank you. I appreciate your critical eye when reviewing research.

[@janicelphillips]

Hey there! I’m over here flying my ‘nerd flag’! Thanks for the deep, deep dive into the research of these claims! I’ve been following you since just after you started your journey and have taken it ALL in to develop my skin care routine. At 72 years old now, it’s never too late to be our best selves! Thank you and thank you again for your efforts on our behalf. ❤️😘

[@jennicrow2946]

So comprehensive! Was hoping you would do a video on this. I agree, the bottom line is if it could potentially make a skin cancer cell grow then it may not be worth it.

[@Tsili-Walela]

I saw a Huberman Lab podcast on skin and when the dermatologist said that, I knew I was out. I already had a stage 0 melanoma. Not taking that chance.

[@kellyfleming251]

Hi Angie! Might you have the time to look into the OS-1 peptide, and OneSkin products?

[@tcm3097]

Oh my goodness. While science advancements are very much appreciated, let’s face it, nothing will turn back the clock. Being and accepting your best self in every stage of life is the healthiest approach. The cosmetic industry is well aware of the “taboo” of aging in our society, especially for women, and they seek to financially capitalize on it. None of us are getting out of this life, “alive”. We are all going to age. Just do the tried and proven: limit sun exposure, wear sunscreen, use a retinoid or tretinoin, moisturize face and body, eat healthily, do both cardio and strength training min of 5 days per week. You are all set.

[@anniezion]

Amen to that!

[@courtneyjackson4843]

I got convinced I needed Growth factors, so I purchased the Neocutis one...and nothing absolutely nothing changed.

[@christinemangan7642]

This!

[@latherandlace]

I can't use growth factors because I had skin cancer. 😢 But, thank you for such a great presentation of growth factors! I've never heard anyone explain it so well. Have a great weekend ❤~lori

[@karimenlee]

absolutely love your looking at the science behind. you do hard work for us. thank you so much. I had followed you since pretty much the beginning of you on youtube. other's come and go, but I always have you in my corner.

[@juliebacon3027]

Thank you for doing a deep dive on this subject. Very informative. As someone who has had melanoma twice, I will be steering clear of these products! ❤

[@AngieHotandFlashy]

I think that's a smart decision!

[@practicebalance]

I’ve done sunscreen, vitC and rx retinoid for 15+ years. I added Skinmedica TNS serum a few years ago, and I noticed a significant improvement in my skin’s texture. It’s so soft! So I’ve continued to use it.

[@marcyjackson7577]

I am trying Calecim PTT-6 professional serum, almost done with vile #2 and just ordered #3. I am noticing the elasticity and overall plumpness of my skin especially my neck skin is better (not like in my 30’s or anything but it is improved) and my overall skin texture is improving, which was what I was hoping for. I blend three drops of the serum with Vichy Mineral 89 for better slip AM & PM. I have large pores due to sun damage and am post menopausal 56yr old using transdermal HRT. I have been using retin-a for 6yrs thanks to you, and vitamin-c serum as well. This brand is also approved for use with micro needling (I did a series of 4 treatments 3yrs ago and it works well for me with collagen stimulation and pores) so just had one of four in office MN treatment and used this after and my healing time was faster and I was not as red or puffy the next day. I plan to give this a good six months and decide from there, but as of right now I’m liking this addition to my skin care routine and it doesn’t interfere with the other goodies I’m using. Love your channel, Angie! Xxx

[@AnD-bu4xs]

yes, I also have very nice results with calecim serum.. I am on my second bottle and will give a try with third also

[@d.a.5982]

One more vote for Calecim!

[@KingKikikoi]

So sorry I doubted you Angie! Going into this video I wasn’t sure if you were going to do the right thing. But you sure came fully prepared and I am so impressed with the time you took on the research and the variations of papers you sited plus your own experiences! You are the goat!

[@reneklein6049]

Hi Angie. You are a scientific genius. I love all of your research and how well you delve into these studies. I think I personally will skip the growth factors, and continue my experimentation with the vaginal estradiol used topically on my face in combination with the Tretinoin. So far, it's only been 3 weeks of using estradiol twice a week. I most likely need to bump it up. By the way, for anyone interested, if you use a Good RX coupon for Tretinoin, for some reason the brand name, Retin-A is cheaper! It's also much creamier and therefore you need less than the generic. Timeless Skincare is definitely the way to go for other products. I use all that you have recommended. I would never be without the Vitamin C, nor their Coq-10 serum. You are the best! Have a great weekend. Stay dry. We're finally getting much needed rain!❤🌧🌧🌂🌫

[@kimberlyf4888]

Same here, but I apply the estradiol cream about 5x/week, Tretinoin a couple days a week, and OneSkin daily.

[@KarenGaylor4712]

I would love to know how your vaginal estradiol on the face works out. It's an interesting concept. I know several menopausal women using it vaginally, but no one using it on the face.

[@reneklein6049]

​@kimberlyf4888 I'm going to up the estradiol dosage, but so far it's been fine in combination with the Tretinoin. A bit drying, but I always seal everything in with a moisturizer. 😊

[@KarenGaylor4712]

@@kimberlyf4888 do you find the OneSkin to be worth it? I'm looking at the eye cream because that's where most of my wrinkles and fine lines are. I basically have a smooth face and very very fine lines. Biggest issue for my face and neck is sagging from 100+ lbs loss 3 yrs ago and surgery is the only way to fix that.

[@marianne-8979]

Be careful that you’re not taking too much estrogen if you use it both on your face and vag. Estradiol is much stronger than estriol

[@wendywittmann]

I'm grinning from ear to ear. You totally KILLED IT, Angie! As someone who has spent way too much money on these products, I'm so happy to see the research. You've found your calling!

[@manonsinclairladyofblairad9675]

Hi Angie, once again you did a comprehensive research to save us some big money. Thank you!!!

[@AngieHotandFlashy]

You're so welcome!

[@sandee5980]

Angie, I have been following you for years. I always trust your intellectual and informative videos. My favorite medical aestheticism and friend told me that no creams promising firmness, collagen boosting, etc, can get in your dermis. BTW, have you tried Cerave Vitamin Cserum in a tube? It has lascorbic acid that is stable.

[@lynnecarr5791]

Thanks Angie! I have avoided growth factors. I am hearing a lot about DNA repair enzymes. Would you consider doing a video on this?

[@AngieHotandFlashy]

Absolutely!

[@JonEllis-o1q]

I’m on my first bottle and also would love more info!

[@LisaNix2]

@@lynnecarr5791 I’m using DNA repair in my sunscreen (Isdin) and I’m loving it!

[@tamikops]

I just started the DNA repair enzymes as well. Wondering if it’s worth my money and time

[@user-xc7iq4cm8t]

Everything changing so rapidly with technology. I planned on a f/l around this time but hoping I don’t have to. I haven’t tried OmniLux mask/red light therapy yet. Hv been told tox will no longer mk my 11’s disappear bcuz they’re static. Might just try the Omnilux b4 I plan on surgery!!

[@carriepetersen2377]

I’m 62 and noticed a big difference when using Necutics BioFirm on my neck so I will be sticking with it. Thank you for the review though.

[@lisas7516]

i can't believe you just posted this video... i just asked myself this morning, "I wonder what Angie thinks of growth factors?". TY

[@DanaWaid]

Thank you, Angie. I just want to know the truth - not the hype - about products, so videos like this are exactly what I'm looking for.

[@lauriemcclelland9845]

Good morning Angie! Thank you for all the thorough research you do for us. I have been following you and have been using your skin regimen as closely as a I can for a few years. I get so many complements on my skin. I am in my early 60s. 😊Could you please review at some point the products from OneSkin and Adipeau ?

[@AngieHotandFlashy]

Hi Laurie! That's awesome to hear! I'll put them on the list! 💜

[@bhall9874]

I've actually been using Adipeau for the last two years and a bit. While it may also do some nice things for the skin, it's primarily a fat cream. That is, it's designed to help with loss of facial fat. I don't think Angie has any significant fat loss at this point, so I don't think Adipeau would do anything for her. Based only on my own experience, I think it does work to some extent. It didn't give me filler-type results, but it did restore some fat to the right hand side of my face. Benefits to the left hand side are less noticeable but extant. It's probably worth noting that my left side lost facial fat first. Adipeau also helps with the small hollows on the inside tops of my eyebrows. Alas, it did not help noticeably with my undereye hollows, but I've been happy enough with what it's done that I keep up a maintenance level. Also, it can take time that differs from person to person. For example, a You Tube journalist had some results with it within three months and not much more after that. It took six months for me to see anything (except lip plumping), but in the 7th month I got fast results for a bitand then incremental improvement for about another year. I'm now 72, by the way.

[@kathleenthiel4973]

Great job on the products Angie! I bought some of the same cream you showed, the drunk elephant. I am very leary about products. Do you think this one is safe??? Thanks again for another very informative video. 🎉🎉🎉🎉

[@vickierotell4995]

Thanksnfor confirming what I thought tried Skin Medica back in 2013, and didn't see any amazing results. The COST IS OUTRAGEOUS. Have you deep dived Cosrx? Just turned 60 with very dry skin. Looking for fine lines and deep wrinkle help. Finally broke down and got the Snail 96 Mucin and eye cream. Was impressed with the hydration. Then I saw a utube video on Cosrx The 6 Peptide Skin Booster so I purchased the peptide along with their Spa Mask and All in one cream. 1st use of the peptide serum I saw immediate plumping of my deep forehead wrinkles. I've only been using less then a week but I'm impressed. Plays well with my Ordinary Retinol. Help with large pores that I've developed post menopause. All products purchased on Amazon at reasonable prices. Would love to know your thoughts. Thanks for your deep dives and time. ❤❤❤

[@doreenmaggio3624]

I used tns for years . Since 1998 . I stoped because of the high cost . I use Agency now for a year . Its affordable and my 66yr old skin has improved quite well . Thanks Angie .

[@margot9647]

When are you covering the estrogen cream. I got my compounded Estriol cream about 9 days ago. Also putting on my hands and forearms. They are in rough sun damaged shape after 59 years.

[@AngieHotandFlashy]

I'm doing a 6-month trial on it (that's how long they say it takes to see a difference) so I'll do a video on it in early December.

[@margot9647]

@@AngieHotandFlashy perfect! I'm having a delayed midlife crisis getting so close to 60. I've got my large menopause tool kit, walking daily, trying to get enough protein, weighted vest+++🤣

[@thedesigndaily]

Love the deep dives! Had same ? re the estrogen cream (using Alloy) and now wonder is it “small enough” to penetrate skin? Since it’s a hormone, don’t know if that works differently? Thank you!

[@elsagrace3893]

Estriol is too weak to do anything. Estriol is the estrogen that is left after menopause because it is produced in body fat. What waste your time and money?

[@margot9647]

@elsagrace3893 fat cells make estrone. Estriol is made when you're pregnant . They actually have pub med articles comparing Estradiol and Estriol on skin and aging with similar results improving collagen and elastin. It's froma compoundingpharmacynot Amazon. Pharmaceuticalgrade.

[@Sweetnessjuju13]

Thanks again for doing the hard work! Had several bad sunburns as a child, so not worth the risk to awaken any cancer cells, will keep using Trentinoin and sunscreen ❤❤❤

[@easyfrenchdiet]

Hello Angie, great video, your blue top suits you very well. May I suggest a deep dive into sculptra, radiesse, etc. if you have the time. Have a nice day.

[@patriciastark7292]

Thank you for an excellent unbiased review of human growth factors. My anti-aging MD takes expensive human growth hormone injections, and the skin on her face and body look absolutely beautiful. I personally would not use human or plant based growth factors because I had breast cancer several years ago, and I don’t want to activate any cancer stem cells that may remain in my body. Excellent video Angie! Thank you for the research deep dive! I certainly appreciate your research! I always learn so much from your posts! 💜

[@smitasingh6462]

Love that blue color on you Angie.

[@strawberry1025]

As always l bow to thee O Skin Oracle.🎉 Not only for your wonderful deep dive research but also your flawless presentation and communication of all you've found. No one has more clarity. Thank you! 😊

[@robinaltman8151]

Hi Angie! I'm a 61 year old doctor who's super interested in skincare and I've been following you for years. I use all the products you recommend (including the lasers) and get compliments on my skin all the time. This was the best video - so well explained and intelligent. You are wonderful and thanks for all you do! 😍

[@ja-ma-bo]

Hi Angie. I am Jan , a 71 year old who loves makeup and have been watching your videos for many years. I watch a lot of KZbin but rarely comment on any so you may not be familiar with me. I have truly enjoyed and benefitted from your videos, both makeup tutorials, product testing, fashion, and skin care. For some reason I really really want peptides in my skin care. I use vitamin C, tretinoin, among other things. I would be very interested to learn which peptides are best for skin so I make sure that if I buy a peptide product I am spending my money on ones that actually make a difference. Would you consider doing a video on peptides? Or would I find the information I want in the video you mentioned in this video? Thank you so much for great content through the years, I always feel I can trust you and your information. One other thing, I have been interested in growth factors for years but the price kept me from purchasing. Now that I have seen this video I am glad to know I haven't missed anything and can quit thinking about them:)

[@kellyfleming251]

I second the above :) including any comments about OneSkin's OS-1peptide and products? Thanks Angie!

[@mgromz]

$295 for one bottle?? When there’s people who can’t afford to buy food and are homeless, I would rather donate money to them than spend $295 on a single bottle of skincare.

[@MBT372]

I feel the same way!❤

[@Tracylyn42]

I’m so happy other people feel that way too. I can’t imagine spending that to maybe look a little younger. At 65 I love the way I look. And like you I want to spend it on my grandbabies, or to a favorite charity. These prey on the people who want to look younger. Embrace your beautiful faces ladies and gents.

[@sailingsoulmate7551]

THANK YOU! Good grief!

[@lillygordon9121]

1 oz, it is 1 oz for $295 plus taxes and fees.

[@bodyjewels]

300.00 bucks. Bs, ejal 40 is 30 bucks in uk. I use this to induce collagen. It works fantastic.

[@stephanieflechter6978]

I respect your research and information that is provided in your videos. I know anytime I watch I can trust the information provided. I’m 52 and have followed your skincare regime for 5 plus years and I’m often told I look like I’m 40!! Thank you for your hard work!!

[@jdnicholas8194]

Really informative and useful (and your hair looks great today!)

[@AngieHotandFlashy]

Thank you so much!

[@margot9647]

I hadn't seen your 2017 trial of TMS, and before your video started my first thought was that I did try a full bottle and saw zero results. Glad I'm not alone. Instead of buying it, I can save that money and get another Halo laser where I actually did get amazing results. And of course Tret and sunscreen

[@margot9647]

TNS

[@AngieHotandFlashy]

A laser treatment is definitely a better use of that money than a bottle of TNS (IMHO) 💜

[@patkern185]

Great video, Angie! I'm here for all the nerdy, science-y stuff that you do so well! Thanks for providing information that debunks outrageous claims and noting that growth factors can't discern healthy cells from diseased cells... something that has stopped me from ever using them. At 75, I don't expect miracles from skincare products, just healthy improvement and a slowing down of the signs of aging. You always do a thorough dive into facts and science, and it shows in how young and healthy you look. I'm so happy I found your channel so many years ago. I'm a disciple. Have a fantastic weekend, gorgeous! XXOO ❤️ ❤️

[@sherry1647]

Please make a video with solutions for back of hands thinning skin and veins. Thanks

[@gategirl66]

Not sure there's a ton we can do about veins, but I've been having good results with estriol cream. I get mine through Alloy and ParlourGames. The one from Parlour Games has worked wonders on my hoo-ha, too. No more UTI's, itching or dryness 😁

[@SheilaSchwertz]

Yes, please!!

[@TXforever]

Yes please!!!!

[@bonitamoore7679]

I know Angie uses red light “mitts” made by same company as her mask. Strivectin makes a hand volumizer cream that makes a noticeable difference to me when used consistently. They don’t really advertise it - not sure why.

[@amy9864]

Why not try micro needling?

[@amyswygert4532]

Thank you so much for this deep dive. So good to know. I hadn’t seen much around growth factor skin care yet, but when I do, I’ll know not to fall for the hype.

[@JonEllis-o1q]

Hi Angie! What are your thoughts on DNA recovery serums like Photozyme?

[@alexander_no350]

Yes i want deep review on those to. So many high end youtubers talk about them. But no one give us research and trial testing and delivery system.

[@acetheshe8700]

Thank you Angie for this extensive research. You're awesome❤

[@sueanderson9860]

I tried the TNS about 10 years ago for 6 months ago and also saw no difference. Massive waste of money!

[@susanjacobs9784]

Thank you, Angie! Your sharing of research and data from clinical studies is so helpful and appreciated! And just explaining what the heck growth factors are! I love you how you keep reminding your viewers of what actually has been proven to work and inform about what would be a huge waste of $$. Thank you again!!

[@patticarnevale2360]

Thank you for taking the time to research this.

[@Yogawithyoda]

Thank you for taking the time to look so thoroughly into these ingredients- this is why you are the queen of woman at midlife- you are detailed and thorough… I am grateful for your work Angie! You have an amazing ability to be tenacious and wise! Thank you for the details and it really sets you apart! ❤

[@AngieHotandFlashy]

Thank you so much! 💜

[@christinatruchon1924]

Thank you for your research and honesty.

[@inquisitive9248]

Thank you, Angie! I love your scientific reviews of different cosmetic ingredients or procedures. The corporations are here to make big money on our insecurities, so we all really appreciate your help navigating this complex marketing bs!

[@amandamcadam114]

Im a scientist with study design and statistics training. An absolute bare minimum should be 30 patients treated with product and with another 30 controls, and with patients at those low numbers, should have the same age, gender and skin types and skin damage. Measures should be be objective and not "patient felt skin was younger looking" means nada. Drives me crazy...

[@shannonbellamy5186]

Love this content! And Thankyou for diving deep!!😊 I’m a nerdy RN and I really appreciate this type of information! Would love your next deep dive to inform us on DNA repair enzymes!❤

[@kelleycranny3972]

Please do a deep dive into the ingredient "volufiline". Curious🤔

[@nn7397]

Yeah me too!!

[@moongoddess5858]

I use Dr. Rajani’s cream and see no difference. Big disappointment because it’s really expensive!

[@kelleycranny3972]

@@moongoddess5858 yeah, I watch him and have followed his advice on some things but his products are way out of my price range! Have a feeling that volufiline is really hyped up.

[@anniekj6421]

@@moongoddess5858hi I follow him too which cream do you use? I was thinking of ordering from him TIA

[@smallnwise1]

thanks Angie! Glad to see the 500 dalton rule & (all) peptides addressed. I remember learning at some point that one particular company solved this (Alastin) but, unless and until I see the people I trust address this, I won't spring for it. Really appreciate you taking a deep dive.

[@lghealthyover6074]

What a ripoff! I’m glad that I haven’t been tempted enough to buy those uber expensive face creams. 😅 Lots of manufacturers making easy money on this “anti-aging” industry. Good video!

[@jgoldfarb3]

Angie, you do so much investigating into everything you recommend to us, I believe you100% and always try if it’s something I’ve been wanting to truly!🌹🙌

[@sonjaforrester9255]

Inwould live to hear your thoughts about DNA repair products! Fir now I agree I will stick with my usual!

[@DangerZone-w6y]

I use Vitamin C serum, then Copper Peptide serum, then I apply Trentinoin .05%. I think it does a great job!

[@danaprahl9748]

Angie, Can you suggest or have a video on jowls and wrinkles around the chin area. I am trying so much and nothing seems to do it. Can you help. Please!!!!!!

[@elsagrace3893]

Sorry hun, a face lift or just accept it. We all change. The beautiful young models that you are comparing your face with are also going to age and change just as you are.

[@CherylBerryl]

Look into the Nua RF home device. Dr. Rajani recommends it, & this is the 1st time that he has Ever recommended Any RF at home device. And I trust him! Go to how channel & watch his very recent video all about it

[@HautePinkFluff]

Check out the videos on using a Gua Sha tool or the channel Face Yoga Expert. It will really help to naturally tighten that area around the chin. You don’t have to just live with it and accept it as it is (as someone else said). ☺️

[@meldavis2563]

​​@@elsagrace3893That's rude. Why even comment if you do not have any suggestions?

[@anniezion]

​@@meldavis2563Rude? She's just telling how it is, in reality. Also, she did have a suggestion..

[@johnnysgirl]

I really appreciate you doing all the research you do to keep us informed.Thank you,Angie

[@mabimorgan4316]

Hi Angie! Love your channel! Please try TIZO Primer/Sunscreen mineral tinted SPF 40 please. I know you tried another TIZO mineral sunscreen but the one I reference is AMAZING!!

[@AngieHotandFlashy]

I'm pretty sure I tried that one 7-8 years ago & it wasn't my cup of tea, but I'm so happy you love it! 💜

[@renuk3493]

Love it too!

[@eloisehellyer6857]

Thanks for this. I have been using Stratia peptide cream and I must say I like it. Reasonably priced and you do not need much. Great pump bottle too.

[@alonaburman5245]

You missed Calecim in your review for growth factors …

[@rambotheragdoll8940]

@@alonaburman5245 It sounds like you are also listening to Brianna😄. I just finished my Calecim and won’t be buying it again.

[@corinnecourchaine4416]

This was the perfect video to pair with my morning coffee. Your sciencey talks help me forget about my problems, much appreciated!

[@AngieHotandFlashy]

So happy it helped! & hope you have a better day! 💜

[@cherylt5818]

Thanks Angie, so good to know and it was way to high of a price point anyhow. I would love a video on how to make our body skin look its best, currently I alternate between the Alpha Hydroxy lotion and the Goldbond Retinol but is there anything else that is helpful and effective?

[@karlaharvey2623]

Hi, I also use Alpha 12%Glycolic lotion as well as Goldbond Retinol lotion. I also do a body scrub once a week, then I shave, the I apply the GoldBond and or Alpha glycolic lotion. But Body Scrubs have really made a huge difference in making my skin soft, no more alligator skin etc.

[@cherylt5818]

@@karlaharvey2623 thank you, I have used body scrubs what is your favorite?

[@karelappel4131]

I am using EGF gel for several years now. I only noticed a significant difference after six months. On my face it’s amazing. Everyone is complimenting me for my age. I also was using it on my neck and décolleté, but noticed it created “skintags”. So I now only use it on my face. It’s working great!!!

[@muiawat]

Considering this information , what is your opinion on topical estradiol/estrogen products . In my mind , the benefits and risks of growth hormone seem similar to estrogen products . I need more education . Is there a good review or expert of topical estrogen for beauty and health ?

[@meganbritt22]

She's testing this right now. Stay tuned!

[@elsagrace3893]

Forget estriol. Estradiol is the only effective estrogen. We have plenty of estriol after menopause especially women who are packing extra pounds because it is produced in body fat. It has a very weak effect.

[@suemahoney7330]

Such an amazing scientific deep dive. This is exactly why I take Angie's advice. If you listen to anyone else, (but why would you), it would be interesting to see what they say about these products. And how may they link for you to purchase. So many KZbinrs are all about the hype so you purchase and they get the kickback. Everything that Angie recommends has helped me immensely! Thank you for all you do!

[@abcdef156393]

LOVE the deep dives!!!!

[@r.k.9648]

Dear Angie, I am always interested in knowing more about Castor oil for the skin. Please share your review with us if possible. Thank you for all your hard work. By the way, you look fabulous.

[@TruthRobinson411]

Use in combination with micro needling for optimal results!

[@phyld6491]

Please explain because I just had micro needling

[@creditreporthelp]

Excellent. Long-time fan, Angie. Thanks for your candor and honesty.

[@cathyproctor1693]

Have you looked into the anteage line. I have been using it for the last 3 to 4 months. Hard to tell if it's working. I feel like my skin looks better

[@lifeandhomewithmeredith9050]

thank you so much for talking about how cancer cells could replicate and divide! i will always have skin cancer on my face so i cant use the growth factors. I would not have known that if you had not said anything about it. Much love.

[@sameold1212]

Thank you for saving us a lot of money! 😊

[@debbiepayne903]

Thanks for your research. Always helpful! I fell for a SkinMedica and a Neocutis product once. They did nothing! I can spend the $200 dollars towards a nice vacation. You’re the best!

[@SpecialK711]

When I worked in wound care as a nurse, we never used glycerin bc it is a humectant that will draw moisture & beneficial nutrients from deep layers of the skin that eventually leads to dryness and delayed healing. Although glycerin is marketed as a sought-after ingredient, I personally avoid it for that reason.

[@Calmerthanyouare17]

Good to know!!