Hard and Soft Nucleophiles

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I also from india ,this video really helped

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Best video that has been ever released in Ochem, thank you for all your hard work Good luck

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[@magn8195]

I was struggling to find information on this until I saw your video!

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holy shit, im pretty happy i found this vid. like its so so so well produced in terms of the information !! tytyty

[@jOeCHEM]

holy shit, Vin, I'M pretty happy you found this video 🤓. Thank you for watching, and if you're looking for any other type of video for a topic/concept, check out my YT channel or my website joechem.io because I have videos that span OChem I and II. PLUS, if you go to my website, I have guided worksheets + solutions for each video 100% free.

[@talkmedia151]

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[@mdtauheedansari4391]

Great Explanation brother 👍

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[@jOeCHEM]

Glad you found jOeCHEM 🤓 so pumped you found the video helpful--thank you for watching, and thanks for being a jOeCHEMist.

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Amazing , good job 👍

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[@roshanpatil3078]

thank you 🙏🙏

[@mahaveerchoudhury1445]

Hello there good sir , it would be very good of you if ya can tell me why is the attack 1-3 in the case of soft nucleophile

[@giftsadique1806]

This was helpful😍😍Can you also do a video about the Wittig rxn and stabilized and non-stabilized ylides please, ? That would be appreciated 🙏

[@jOeCHEM]

Hey there! I was out of the country traveling & sorry this is late, but I have TWO Wittig videos: Intro to the Wittig reaction: kzbin.info/www/bejne/oH-uh3qZr7JqqK8 Wittig rxn more in depth (with stabilized & non-stabilized ylides): kzbin.info/www/bejne/hpqpoYdoj92qntk Thanks for watching!

[@giftsadique1806]

@@jOeCHEM thank you Bcz I managed to watch them and they really helped thanks😍also share the link about enolates: formation and alkylation🙏

[@jOeCHEM]

@@giftsadique1806 I'm not exactly sure which video you're referencing, but here is the video on my channel regarding Kinetic and Thermodynamic Enolate formation: kzbin.info/www/bejne/r6eqnJ6fqqt8g6c&ab_channel=jOeCHEM

[@isaac-chemist]

I'm glad you're not my tutor, otherwise I may develop feelings for you.

[@debdeep3533]

How to understand hard and soft electrophile? When ph oh reacts with ch3cocl lp of o will attack, but if we use acid anhydride then the attack will occur through benzene ring via resonance. Can you clear that out?

[@nikhilpundir1433]

Can u help me with hard and soft nature of reducing agents like nabh4 and lialh4. Everywhere I read I found that lialh4 is a hard nucleophile and only gives direct addition whereas nabh4 can also give 1,4 addition because it is more soft as compared to lialh4. But i cannot get why is nabh4 softer than lialh4 when Al is less electronegative than boron so H of aluminium hydride has greater partial negative charge and if it has greater negative charge then it is easily polarisable so it should be soft

[@jOeCHEM]

Hi, Nikhil! I think this video will hopefully clear things up for you: kzbin.info/www/bejne/sGrOnGSImbh-ibM

[@Sumit-j5z5j]

What is reason for Gilman reagent as soft nucleiophile

[@jOeCHEM]

The reasoning involves advanced molecular orbital theory (beyond my knowledge of organic chemistry), but check out Master Organic Chemistry if you want to go down that rabbit hole www.masterorganicchemistry.com/2016/02/05/gilman-reagents-organocuprates-what-theyre-used-for/

[@S4NGSTAR]

Would Aryl lithiums be hard or soft, I know alkyl lithiums are hard but would the size of a phenyl group attached to lithium make it soft?

[@JUUUANZ7]

Enamines are considered hard nucleophiles? They are strongly reactive but I just dont know for sure due to their size

[@jOeCHEM]

Hey Juan! Enamines are less nucleophilic than enolates, which are soft nucleophiles. Both nucleophiles have a charge delocalized via resonance, and enamines are net neutral versus enolates that have a net negative one charge. So enamines are "soft". Does that make sense?

[@JUUUANZ7]

@@jOeCHEM I see, thank you very much for your answer! Greetings from Spain :)

[@jOeCHEM]

@@JUUUANZ7 so glad it makes sense (sorry for the delayed response)! And wow, that’s awesome 😁

[@JUUUANZ7]

@@jOeCHEM No worries it means a lot that you took a moment to answer my question :D