Jeff Volek, PhD, RD | Exploring the Keto-Adapted Phenotype: Focus on Muscle | Ep.49

[@sebastianhoracioforondagon8813]

We need more scientists as him, great talk.

[@thelaststylebender1678]

dude. some of this guy's papers helped me tremendously in my low-carb lecture to my stroke department. wild. he's definitely a legend.

[@aarongarner5155]

I had a minor stroke and ketogenic diet really helped me.

[@ScienceAppliedForGood]

This lecture was very interesting and informative, unlike the in video ads.

[@aprilek6003]

I so enjoy listening to Volek talk about his research excellent information keep up the good work

[@ketolomics]

Nice to see the callouts on some of the open questions in FAO/ketogenic metabolism. Curious that he went back to Owen and Reichard's work but didn't touch on acetone, up to 70 or 80 percent of which is utilized throughout the body, not merely exhaled as so often taught. The question of compartmentalized NAD metabolism (AcAc from liver, conversion to BOHB in muscle) is fascinating and has been nagging ever since I first heard him talk about it after the FASTER study. And what about that 8-fold increase in Hmgcs2? Muscle and astrocytes pose a similar paradox: expression of both the rate limiting enzyme of ketogenesis (Hmgcs2) and the rate limiting enzyme for ketolysis (SCOT). Synthesizing ketones from acetyl-CoA and then turning around and breaking the ketones back down to acetyl-CoA? The export of BOHB would make some sense of this if the mechanism revolves around NAD homeostasis. Verrry interesting. Thanks for sharing the video. Ignore the complainers - yes there are ads, but yes also this content was shared FREE. ❤

[@MetabolicHealthSummit]

Thank you for your comment and for watching! We appreciate the support, our sponsors do help us make this kind of content possible :)

[@cazza993]

fantastic presentation.

[@MetabolicHealthSummit]

We're so glad you enjoyed it!

[@omarsbaih4999]

Awsome... I have got aprecious information,... Thank you .......❤

[@RobertBurg-o1z]

Thank you for this information. Very Low Carb and/or Nutritional Ketosis Diets (NKD) have been used since at least 1922 (and earlier) to control Type 2 diabetes, reduce insulin requirements for Type 1 diabetics, and reduce epileptic seizures. More recently, NKDs have been used to prevent, delay onset, and/or mitigate other pathologies. Presumably, some diabetics and/or epileptics have been in or close to nutritional ketosis for several years (10, 20, or more). Given this 100-year history, do you know of any longitudinal, multi-year population observational studies (or clinical studies) of diabetic and/or epileptic (or other) groups that document the positive and/or negative long-term health impacts of NKDs for 5, 10, or 15+ years? The longest study I have found so far is 24-weeks, not long enough to identify some situations. Thank you.

[@vitalijussivakovas334]

Very interesting ❤ thank you

[@MetabolicHealthSummit]

Thanks for watching!

[@aivkara]

Great Presentation! But seriously, too many adverts :(

[@MetabolicHealthSummit]

Glad you enjoyed the lecture. Thanks for the feedback. The sponsors who support our podcast allow us to make this type of content available for free.

[@keto-rebellion]

@@MetabolicHealthSummit I cut the ads out. Sound off, or scroll on, or make coffee. I have no idea what the ads were. But they DO give me time to put the kettle on.

[@stephenwhite5480]

If you are long term fat adapted eg 3 years would doing 4 or 5 hours cardio in the middle of a 48-hour weekly fast for a number of weeks upregulate glycogen re synthesis via gluconeogenesis or would it down regulate glycogen use during this exercise?

[@monjurulmridha3895]

❤❤

[@clevelandgirl3226]

I could definitely do without the annoying ad interruptions in the middle of the researcher’s speech. Very distracting. It’s a complex talk, and the interruptions are not helpful in understanding the topic.

[@MetabolicHealthSummit]

We appreciate your feedback. Our sponsors allow us to make this type of content available to watch for free on KZbin. If you'd like to watch this episode without the ads, we do have that version available on our medical education platform along with other exclusive content: membership.metabolicinitiative.com

[@OGPedXing]

​@MetabolicHealthSummit it is waaay too many add reads, it's ridiculous. One or two max.

[@kathya1956]

Gotta make money

[@rebeccapenders5050]

Pay for premium instead of complaining to the content creators. YT controls the ads. It's SO worth it if you use YT at all regularly.

[@OGPedXing]

@rebeccapenders5050 premium doesn't help on this video, if you watched it you would know. The creator themselves are doing the ads, it is not just youtube.

[@keto-rebellion]

I'm an OLD KETO LADY gradually turning 69 years of flab and brain fog into something better. 72 next birthday. Yay! I'm OLD but NEW to KZbin. I want to add my voice to the KETO community...before I die! Look, I KNOW it is JUST ANOTHER VOICE. N = 1. But we can all add up to something significant (to counterweight the bad science/vested interests out there). We should ALL subscribe to folk like Jeff Volek (it's free to subscribe, after all). Google takes note of the numbers. Perhaps governments will too? (this Metabolic Health Summit channel has ads and sells things, so I (probably) won't subscribe here - but maybe Jeff Volek has a channel with nothing on sale except know-how?) Let me know!

[@Appleblade]

35:50 ... man! I was paying for NAD+ supplementation awhile back. Didn't know keto diet was producing it endogenously the whole time. : /

[@rickgrayaz]

Good information, but way to many ads!

[@MetabolicHealthSummit]

Thanks for the feedback.

[@mrrpgswe8931]

Jeff Volek is such a solid resercher. Nice to see a the heir of Stephen Phinney. Keep up the good job.

[@MetabolicHealthSummit]

We agree!

[@stephenwhite5480]

How does the body know how much glycogen it has stored?

[@V-t3n]

Where are the research references?

[@psychologistWinje]

Please, metabolic health summit- this had too much commercials interrupting the talk! It was super annoying!

[@hetzer258]

Match 2 much advertising - especially when thinking that I have paid for KZbin Premium or something..

[@peterokeeffe7506]

Interesting stuff but the number of built in ads is frankly ridiculous. This caused me to stop viewing mid way through.

[@MetabolicHealthSummit]

Thanks for the feedback. Our sponsors allow us to make this type of content available to watch for free on KZbin. If you'd like to watch this episode without the ads, we do have that version available on our medical education platform along with other exclusive content: membership.metabolicinitiative.com

[@변창해-o2p]

Too many ads.

[@MetabolicHealthSummit]

You can always watch our videos without ads when you become a member of our medical education platform: membership.metabolicinitiative.com

[@keto-rebellion]

I agree! But it gives me time to put the kettle on. Ho ho!

[@mrrpgswe8931]

What the Heck. How on Gods green earth can The Metabolic Health Summit allow Puff to push in ads for her crap in their channel.

[@ElizabethAlexander-yz3nb]

Really sad to see Poff now doing commercials. She needs to be separate from sponsors to maintain her independence.

[@MetabolicHealthSummit]

Similar to other science-focused podcasts in the field, our sponsors help support The Metabolic Link and enable us to make this content available for free. If you'd like to enjoy ad-free episodes, please see our medical education platform: membership.metabolicinitiative.com

[@steladimi4785]

great lecture, but this large female head appearing on the screen to advertise is just disturbing. you gotta change that to something better. at the least, use a medium shot, not this large close up.