Vasculitis...Explained by a Dermatopathologist

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
More vasculitis entities and examples in this video: kikoxp.com/posts/3443
Entities discussed in this video:
- Leukocytoclastic vasculitis (cutaneous LCV): 0:00
- Henoch-Schonlein purpura (HSP): 6:08
- Direct immunoflorescence in LCV: 6:22
- Signs of systemic involvement in vasculitis: 6:30, 15:55
- Bullous leukocytoclastic vasculitis: 8:50
- Biopsy techniques for suspected vasculitis: 11:40
- How to recognize ischemia/infarct in skin: 14:20, 16:55
- How to tell blood from fibrin: 28:04
- How to tell eosinophils from neutrophils: 33:20
- Levamisole-induced vasculitis (from cocaine use): 16:55
- Mixed-type cryoglobulinemia: 22:00
- Direct immunoflorescence in mixed cryoglobulinemia: 25:30
- Polyarteritis nodosa (PAN): 27:39
- Eosinophilic granulomatosis with polyangiitis (EGPA) (Churg-Strauss syndrome): 32:04
- Granuloma faciale: 36:45
- Erythema elevatum diutinum (EED): 42:00
This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.
Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.
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Facebook: / jmgardnermd

[@JMGardnerMD]

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

[@missknowall]

Beautiful video. I have seen it over and over again and every time I learn something new out of it.

[@hellboy1710]

Thank you for your video. Could you do a presentation on panniculitis? Those diseases really challenge me whenever encouterd on clinical practice and that's when I think of dermatopathology.

[@tonydemarco9315]

For a non pathologist like myself, just someone who really enjoys morphology, I'll like to thank you for the hours of teaching you have given me. You are both a scholar and teacher a rare combination .....Thank you!!

[@JMGardnerMD]

Thank you for such a kind compliment! I’m so happy you have enjoyed them.

[@imrangorur3417]

Thank you ! Another fabulous informative insights into vasculitis .Very useful for daily practitioners.

[@ferhatozden]

Such a great video again. Love it! Many thanks Jerad.

[@DrSurfia]

Thank you for the excellent overview. This was perfect!

[@loudefeo2510]

This was another great presentation. Thank you

[@rafreitas]

Awesome, as always! Thank you!

[@randaamin1100]

Thank you for your perfect teaching material.

[@grigonius]

Ty for all the informative videos!

[@mvernez]

Excellent. Thank you!

[@ATHLETE.X]

It’d be interesting to see info on Behçet’s, seeing as it has dermatological aspects and is a type of vasculitis.

[@nataliabrandellizandona8290]

Thank you from Brazil - Porto Alegre

[@rykestr]

thank you very much from berlin, dear dr. gardner!

[@JMGardnerMD]

My pleasure. I have been to Bavaria and loved it but never made it to Berlin. I hope to visit one day in future. If any meetings there need a speaker, please keep me in mind!

[@AWISHCLINIC]

Excellent. Thank you sir

[@dr.prasanthipalla2793]

very nice and usefull;thank you so much sir.

[@wallendegen1]

Excellent as always, could you do one on skin adnexal tumours.

[@JMGardnerMD]

I have several adnexal tumor videos, and have more planned soon. I'm publishing a review paper about skin adnexal tumors for the general pathologist. It will be out sometime this year in Archives of Pathology & Laboratory Medicine. Here is a page where I have links to all my adnexal videos: pathinfo.wikia.com/wiki/Skin_Adnexal_Tumors. I'll post link to paper on that page too once it's published.

[@sultanalmogairin6284]

Outstanding lecture

[@minetteking7]

Thank you. Warm greetings form South Africa.

[@dbinod]

Thank you sir for the video. For a a pathology resident like me your videos are very informative. I expect more videos sir. If possible not only of dermatopathology but also of soft tissue slides.

[@teresinaamaro2206]

Excellent. Thanks.

[@Gatatheringg]

Gracias, saludos desde Perú :)

[@ularahim9348]

Thanks a lot

[@azgonz56]

Leukocytoclastic Vasculitis (LCV) seems like an autoimmune Aetiology without an environmental causation as in " narcotic" induced Leukopathy. The Diagnosis is rather complex as the Clinical Presentation with dermal Signs and Symptoms of Plaques and Nudules with Thrombi in and around Medium Vessels which can mirror other Eosinophilias (Even though a most involved Infiltration [Neutrophils, Lymphocytes, Eosinophils, Histiocytes and Plasma Cells] is probably diagnostic even on Hematoxylin and Eosin Stain (H&E Stain) if not a myriad of hematopathies as in Anemias or Malignancies. At any rate, the Differential Diagnosis is really simple with Different Immuno Fluorescence (DIF), a rather innaccesible Staining Technique for less fortunate patients. Immunohistchemistry is nevertheless an all telltale or a "Jack of All Trades " Workup that nips this entity on the bud....lol

[@neelambuttt7423]

I am having leuckocytoclastic desease for last 3 year.i am very upset. I haven't cured.

[@annasutton8078]

It is diffucult to treat, my friend has had it for several years. She has responded well to some drugs however more recently not much seems to work. Her damage is in her feet and legs with daily pain and skin breaking down.

[@sujatasood9991]

Aso give your advice is LVS ON TRUNK portion is more dangerous can I send you the pics and reports?Is it curable if with celiac disease ? I had pfizer vaccine after 12th day I had this LVS Is it die to after effect of first dose of vaccine?

[@redaelhawary8815]

Thanks

[@woloabel]

Vasculitis seems to be unmissible as an easy diagnosis with the patient's presentation much more with an Hematoxylin and Eosin Stain (H&E Staion). It is rather assuring that the immunostaining (immunofloresence) is plain and simple flawless as a Leukocytoclastic Vaculitis LCV diagnosis....Cheerz Fellow Gardner.

[@ericaayomo]

Thank you for all the videos!!

[@malinigoswami8526]

Apart from the location,how to differentiate between EED and GF if both have fibrosing vasculitis?are these secondary vasculitis?

[@JMGardnerMD]

Fibrosis is much more abundant in EED. Very little in GF. But they may exist on a spectrum. I will have a GF video coming out soon.

[@franciscosimental4930]

Dr. Jerad, I have a very probable case of Henoch purpura, I am a dermatologist and I want to know where I can get Michell's medium for IFD? thanks.

[@JMGardnerMD]

Whatever lab you send your direct immunofluorescence biopsies to should have bottles of Michel media. You can also send in saline as long as it goes to the lab same day and gets processed right away. Talk to your lab first to find out what they need you to do.

[@JMGardnerMD]

Great review of vasculitis! "The histological assessment of cutaneous vasculitis." Author: J Andrew Carlson. onlinelibrary.wiley.com/doi/10.1111/j.1365-2559.2009.03443.x/abstract

[@ramadevivalaparla9086]

Sir plz .... Save me