Iron Absorption, Transport, Metabolism and Regulation - Biochemistry Lesson

[@eghonghonomonbude4643]

Ferrous iron is converted into ferric iron by haephaestin or ceruloplasmin, to bind to transferrin. Transferrin can only carry ferric iron (Fe3+).

[@rafaellabaia168]

I was just about to say that!! Other than that, this video is great!

[@rtpursuit4624]

I'm studying Iron overload diseases and this really simplified the ferroportin/hepcidin pathway for me. Very much appreciated!

[@marishacichon7572]

Just made 3 days of class make sense in less than 10 minutes. Thank you.

[@MessiEl5obar]

This is GOLD!! I'm super grateful that you take the time to make this video. THANK YOU SOOOOO MUCH

[@jjmedicine]

Hi everyone! My apologies for the error with regards to Transferrin binding. I will be re-uploading this video with the corrections ASAP. Thanks :)

[@emilysouther4614]

What does it mean when you have low soluble transferrin receptor?

[@yacout2661]

you never did :(

[@MisbahAfridi-r9h]

😂 ​@@yacout2661

[@jiaqiwong5017]

You helped me a lot!! My lecturer don't teach about this but exam come out with this.. I very speechless to that lecturer bruhhhh

[@nastarannazari5062]

I love your Chanel. It makes everything in STEN easier to understand. ❤❤❤❤

[@simondavis1270]

Transferrin comes from the liver.

[@daffodil_tram]

Thanks

[@AmitKumar-em3vz]

JJ you are Leading..... Keep it up. Great...... performance.

[@iikryun]

You really made it so easy to understand thank you!

[@TheBibleDIET]

What a blessing! Thank you so much it makes so much sense

[@RobMcGrath0]

@03:45 i know that this question might be out of the scope of this video, but regarding the liver and the hepcidin mechanism, are there conditions like diabetes, PCOS, fatty liver or hyperinsulinemia that could affect it?

[@fizakhuhro1097]

Do bones release transferrin? I've never read it in any of my biochemistry books im confused

[@muhammadfahar7814]

JIZAKALLAH ♥️ it helped me alot ♥️

[@lachlansun7969]

Good video, just wondering in the enterocytes, wouldn't Fe2+ be re-oxidised by the plasma ferroxidase ceruloplasmin to form Fe3+ in the bloodstream?

[@abhishekshukla9182]

Yes buddy, transferrrin can't bind with Fe II so it is converted to Fe III

[@Phosphoenoylpyruvate]

Hephaestin

[@florac642]

thank you so much for this lesson😭😭🙏🏻🙏🏻

[@ahlamzsager8787]

It's verrrryyyyyyy helpffffffful 😭👏🏻🌺🌺

[@endthem-ei8vm]

thank you very much for your work

[@Tiimaa]

Thank you so much for this video

[@radeshyamb170]

Good explanation... It is very easy to understand.

[@frizycameron]

any understanding of having low ferritin and how that could be elevated?

[@ButterflySimmer]

This is so helpful, thank you :)

[@NoorAytain]

Really helpful video. However ive studied in some books that transferrin is actually produced by the liver mostky not the bone. Please tell if its correct or maybe you made a mistake. Regards

[@pansel5633]

Fe3+ - duodenal cyto c = Fe2+, Fe2+ + divalent metal transport 1 = Fe2+ transport to cell , Fe2+ bound to ferritin So fe2+ transport into blood vuva ferroportin 1

[@Xtain]

Thank you!❤️

[@kertbuan3149]

Thanks for this. Subscribed. More vids to review from. ❤️

[@ريانالشمري-ل7غ]

Is the RDA for males is really 8g? Isn't the number applies on the (Recommended daily intake)?

[@leehauxwell1149]

Do you have anything to explain hemochromatosis?

[@aymanmohsen5932]

Thanks for your effort. I want to ask you what is the recommended daily iron dose for an anemic pregnant woman?

[@rinabegum3075]

40mg

[@suzettestroh2840]

What can be done to assist people with excess iron/ferritin , who does not excrete the iron. How can the process be healed or assisted?

[@RobMcGrath0]

If you're talking about haemochromatosis then there is blood donation....?

[@dr_iskandarov2916]

Excellent

[@fidosa8382]

i looooooooooove your videos

[@shahed8380]

Perfect👏🏻👏🏻

[@deborahuduebholo3030]

Wow blessings ma

[@sheilamiller5046]

Can you explain why iron can drop during pregnancy? Thanks 🙏🏼

[@moizazahid8970]

Thanks a ton

[@mohammadfomar825]

Thanks ! Sir

[@opus0872]

cheers for this

[@Zetsuke4]

The best video

[@vijayjoshi9154]

Since last one year my wife is suffering from iron deficiency, she is intolerant to iron supplements too.....Any suggestions ??????

[@aussiemedtutes4484]

Advise your wife to see a doctor. There are a number of ways to tackle iron deficiency anaemia, supplementation is usually adequate. However people (like your wife perhaps) often get GIT side effects from some supplements like ferrous sulphate. There are alternatives in such cases (lower dose, switch to ferrous gluconate etc), but again, your wife should speak to a doctor to figure out what alternatives will be right for her case.

[@Norse69]

eat liver

[@mariamabazeid5142]

Increase vitamin C consumption

[@coachtanki6137]

This can be example of those foods... vITAMIN A Found in cheese, liver, sweet potato, carrots vITAMIN B2 (RIbOFLAVIN) Found in dairy products, meat, green leafy vegetables vITAMIN C Found in citrus fruits, potatoes, strawberries COPPER Found in shellfi sh, nuts and cocoa From here... suplements are the best ... thanks

[@RobMcGrath0]

also check for PCOS and hyperinsulinaemia

[@janliezlvdandan6630]

Do bones produce transferrin?

[@emmanuelchikobwe5602]

Noop its the liver mum

[@mantasmalinauskas4557]

You was wrong, the transferrin basically produced by the liver

[@ehllarpearl]

And you are wrong to say "you was wrong"😂😂

[@tanukaur9281]

@@ehllarpearl haha

[@faizakamran4582]

iron binds transferrin and ferritin in fe3 form.kindly correct!

[@aniyeats]

Great video. I just noticed a few things: transferrin binds Fe3+ not Fe2+. Also, where are you getting that information about the recommended iron per day? I thought it was way less (i.e. males 1-2 mg per day and females 2-3mg per day)

[@jjmedicine]

Hi aniyeats! Thanks for the comment! The information on recommended dietary allowance comes from the national institutes of health (NIH). I believe what you are thinking is that, typically males will lose approximately 1-2mg of iron per day whereas females lose nearly twice that amount (2-3mg per day). You might be thinking that, if we are losing that amount per day, isn't that all we need to ingest per day? However, typically we only absorb a portion of what we ingest (approximately 10-20%), so we need to ingest about 10-20mg of iron per day in our diet. Hope that helps! Let me know if you have anymore questions :)

[@MelbourneMaster]

Nope the values are correct. It might be worth mentioning though that on a iron adequate diet (from the perspective of the pregnant mother) the child is born with a 4-6 months supply of iron, so imo you should be more concerned about avoiding getting too much iron. There is a bit of iron in breastmilk aswell. In these early months the child will not need the 0.27 mg of iron in supplements.

[@mouneeshb4u567]

Yeah transferrin binds to fe 3+

[@asmaaroi2437]

Thank u so much

[@lss8568]

So if I’m anemic, have significant calcium loss, and also a fatty liver, what do I do and how?! My doctor gave me ferrous sulfate and that’s it. I don’t feel better still.

[@syedalihaider2880]

isnt ferroportin transporter only takes fe3plus, it has to be reoxodized to fe2plus

[@saraabdulaziz4590]

Great explanation thank you so much

[@AbdulJabbar-hl9bm]

what about integrin moboliferrine pathaway

[@gustavoalmeida5572]

Hi everyone. I was wondering what part of the small intestine exactly is iron absorbed.

[@dianaviloria9397]

Duodenum

[@tjsingh4593]

Transferrin doesn’t bind to Fe2+ but it binds to Fe3+

[@asmaaghazaal9798]

thanks

[@giosarranable]

So what should I eat so I can absorb more zinc

[@basicmed7514]

vitamin c i think

[@coachtanki6137]

This can be example of those foods... vITAMIN A Found in cheese, liver, sweet potato, carrots vITAMIN B2 (RIbOFLAVIN) Found in dairy products, meat, green leafy vegetables vITAMIN C Found in citrus fruits, potatoes, strawberries COPPER Found in shellfi sh, nuts and cocoa From here... suplements are the best ... thanks

[@giosarranable]

@@coachtanki6137 ✊🏽💙

[@twiiter356]

Nice

[@sarahgh4069]

Precious

[@Kingpin682]

You didn't mention about hephaestin

[@sraboniafrin1878]

Which app u used to make this vedio?

[@krienbergproductions8844]

you have such a cute voice

[@ninjanicnic]

Update please

[@arudra1525]

Nice information...but you have to reduce the aaa...uuu.... In the middle of the conversation.. it makes us feel that you are not confident about it

[@Rajeswar07]

Thanks alot

[@mariocesarbenitez5552]

Thanks